This document discusses the approach to patients presenting with neurosurgical emergencies. It begins by outlining the important components of the history and physical examination for these patients. Key aspects include a detailed history of presenting events, past medical history, medications, and focused neurological examination including vital signs, mental status, cranial nerves, and motor function. Common neurosurgical emergency presentations like altered mental status, headache, and pituitary apoplexy are then reviewed in terms of typical history, exam findings, important diagnostic tests, and initial management steps. Overall it provides guidance on evaluating and initially stabilizing patients with potential acute neurological conditions.
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The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
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Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
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• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
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1. 75 CME March 2013 Vol. 31 No. 3
Emergency presentation of neurosurgical conditions
Many neurosurgical conditions present in an acute fashion, and optimal outcome often
depends on prompt recognition and referral by general practitioners and emergency
room personnel. The approach to neurosurgical emergencies is discussed in this article.
P Semple, MB ChB, FCS (Neurosurg) (SA), MMed, PhD
Division of Neurosurgery, University of Cape Town
Patrick Semple is Associate Professor, Division of Neurosurgery, University of Cape Town, Principal Specialist and Head of Neurocritical Care, Groote
Schuur Hospital, Cape Town. His interests are neuroendoscopy, pituitary surgery and neurocritical care.
B J Malan, MB ChB
Division of Neurosurgery, University of Cape Town
Barend Malan is a final-year registrar in the Division of Neurosurgery, University of Cape Town. His interests are neurovascular surgery and neuro-
oncology.
Correspondence to: B J Malan (drbjmalan@yahoo.com)
Approach to a neurosurgical emergency
begins with an appropriate history of
surrounding events followed by general
examination and focused neurological
examination.[1]
This should be performed
while applying general supportive care. After
outlining a general approach to the patient
presenting with a neurosurgical emergency,
the more common clinical scenarios will be
discussed.
History
A detailed history of presenting events and
general medical history should be obtained
from the patient if possible, family members
or emergency service personnel and should
include the following:
Presenting events:
• rapidity of symptom onset or neurological
deterioration
• seizures
• nausea or vomiting
• recent or previous trauma
• recent febrile illness.
Previous medical history:
• hypertension and compliance with
treatment
• diabetes mellitus
• epilepsy
• known history of previous/underlying
malignancy/pituitary tumour
• HIV and antiretroviral treatment
• history of anticoagulant use.
Surgical history:
• previous neurosurgery, e.g. ventriculo-
peritoneal shunt.[1]
Examination
Clinical examination focuses on the
principles of ABCD, and supportive
management is instituted at the same time
as problems are identified.
Vital signs
Airway and breathing
Ensure adequate airway and oxygen
saturation above 95%. Cheyne Stokes
respiration is the most common abnormal
breathing pattern, characterised by periods
of hyperventilation alternating with periods
of apnoea. Consider intubation if Glasgow
coma scale (GCS) <8.
Circulation
Elevated blood pressure may be a reactive
phenomenon or reflect the underlying
cause. With increasing intracranial pressure
an acute rise in blood pressure may be
accompanied by bradycardia and decreased
respirations (Cushing’s reflex) and is a sign
of impending tonsillar herniation.
Temperature
Fever may indicate underlying CNS
infection.
General examination
Evidence of trauma – scalp bruising or
laceration, periorbital (raccoon eyes) or
retro-auricular bruising (Battle sign) and
CSF leak from the nose or ear.
Neurological examination
Level of consciousness
Level of consciousness is assessed using the
GCS (Table 1).[2]
The GCS is made up of the
sum of the best eye opening, best verbal
and best motor responses, with a total score
ranging from 3 to 15 (normal).
Fundoscopy and pupillary response
Fundoscopic examination for papilloedema
is an essential clinical skill. Pupils are
checked for both size and response to
Elevated blood pressure may
be a reactive phenomenon or
reflect the underlying cause.
Table 1. Glasgow Coma Scale
Best motor response 6 Obeys commands
5 Localises painful stimulus
4 Abnormal flexion
3 Decorticate posturing
2 Decerebrate posturing
1 No response
Best verbal response 5 Orientated
4 Confused speech
3 Words
2 Incomprehensible sounds
1 No response
Best eye opening response 4 Opens eyes spontaneously
3 Opens eyes to speech
2 Opens eyes to painful stimulus
1 No response
2. 76 CME March 2013 Vol. 31 No. 3
Neurosurgical emergencies
light. A unilateral dilated pupil suggests
the presence of a structural lesion with
uncal herniation. Pontine lesions result in
pinpoint pupils, while midbrain lesions are
associated with midposition fixed pupils.
Eye movements
Evaluate spontaneous eye movements and
the ocular reflexes – oculocephalic (doll’s
eye) and oculovestibular. Hemispheric
lesions involving the frontal eye fields result
in deviation of the eyes away from the side of
the associated hemiplegia. Brainstem lesions
involving the reticular formation in the pons
result in conjugate deviation of the eyes
toward the side of the associated hemiplegia.
Nystagmus may indicate cerebellar lesions.[1]
Cranial nerve examination
Third and sixth nerve palsies are common
indicators of raised intracranial pressure.
Other cranial nerve deficits may also be
present depending on the location of
pathology.[1]
Meningism
Remember that neck stiffness has a number
of causes and does not always mean
meningitis – performing a lumbar puncture
in a patient with tonsillar herniation will
have disastrous consequences (Table 2).
Focal motor deficits
Focal motor deficits include hemiparesis/
plegia and monoparesis and should be
documented during assessment of the motor
component of the Glasgow coma score.
Common presentations
• Acute loss of consciousness. Loss of
consciousness is a presentation common
to a variety of medical conditions and is
best assessed using the GCS, as described
above. The causes of coma are divided
into 2 major groups and common causes
of each are shown in Table 3. Metabolic
causes of acute loss of consciousness
are more likely to produce symmetrical
neurological deficits, compared with focal
deficits in structural causes.[3]
• Sudden-onset severe headache.
• Subarachnoid haemorrhage (SAH)
occurs when blood enters the
subarachnoid space, in the majority of
cases due to rupture of an intracranial
saccular aneurysm. It occurs most
commonly in the 5th - 6th decades.[4]
History
Sudden-onset severe headache, described
as ‘the worst headache of my life’, occurs in
80% of patients. Headaches are commonly
retro-orbital, radiate to the neck and often
occur during periods of intense activity or
straining. Vomiting is also common.[4]
Twenty
per cent of patients have a history of
preceding symptoms, including headache,
nausea, vomiting and dizziness, thought
to arise from small haemorrhages from
the aneurysm or acute expansion of the
aneurysm sac. Within seconds or minutes
following headache, patients may lose
consciousness, develop seizures or die.
All patients presenting with unusually
sudden or severe headaches should be
investigated for SAH.[5]
Examination
Findings include decreased level of
consciousness, neck stiffness and focal
neurological deficits. Focal deficits may
be due to mass effect from the aneurysm
(e.g. third nerve palsy in posterior
communicating artery aneurysms) or
intracerebral haematomas.
Investigation
Imaging
Uncontrasted CT scan of the brain is the
investigation of choice in suspected SAH
and may reveal blood in the cisterns at
the base of the brain, intraventricular
or intraparenchymal blood (Fig. 1).
Hydrocephalus may also be present. If
uncontrasted CT of the brain is negative,
a lumbar puncture should be performed to
establish the presence of xanthochromia,
unless a contraindication to lumbar puncture
is present.[6]
Laboratory
Full blood count (FBC), clotting profile,
urea, electrolytes and creatinine (UEC).
Initial management
• Monitor arterial oxygen saturation and
blood pressure
• Supplemental oxygen
• Intravenous access and fluid
administration, correct hyponatraemia
• Stool softeners to prevent straining
• Anticonvulsants, especially if seizures
occurred during the initial event.[6]
Table 2. Causes of neck stiffness
Meningitis
Subarachnoid haemorrhage
Tonsillar herniation (raised intracranial
pressure)
Cervical spine trauma
Table 3. Causes of acute loss of consciousness
Toxic/metabolic Structural
Electrolyte imbalance
Hypo/hypernatraemia
Endocrine
Hypoglycaemia
Diabetic ketoacidosis
Addison crisis
Toxins
Ethanol
Drug overdose
Organ failure
Uraemia
Hypoxaemia
Liver failure
Epilepsy
Vascular
Bilateral cortical/subcortical infarcts
Bilateral carotid artery stenosis
Bilateral di-encephalic infarcts
Infectious
Abscess
Empyema
Trauma
Neoplastic
Primary
Secondary
Increased intracranial pressure
Herniation from mass effect
Acute lateral shift of the brain
Fig. 1. Uncontrasted CT brain revealing
extensive subarachnoid blood in the basal
cisterns (arrow).
3. 77 CME March 2013 Vol. 31 No. 3
Neurosurgical emergencies
Pituitary apoplexy
Pituitary apoplexy results from haemor-rhage
or infarction of a pituitary adenoma, resulting
in acute tumour expansion with compression
of surrounding structures in the sellar region,
notably the optic nerves and hypothalamus.[7]
History
The patient may be known to have a pituitary
tumour,butinthemajoritypituitaryapoplexy
is the first presentation. Symptoms include
acute-onset headache, acute deterioration
in visual acuity or visual fields. Vomiting
often accompanies pituitary apoplexy. There
may be a preceding history of symptoms
suggestive of hypopituitarism (tiredness,
weight gain, decreased libido, menstrual
irregularities). Features of hormone excess
may also be present, e.g. Cushing’s disease,
acromegaly or hyperthyroidism.[8]
Examination
Hypotension and hypothermia may indicate
acute adrenal insufficiency secondary
to low cortisol. Common findings are
ophthalmoplegia, decreased visual acuity
and visual field deficits – most commonly
bitemporal hemianopia.[8]
Investigation
Imaging
A CT scan of the brain with and without
contrast may reveal a sellar or suprasellar
mass with evidence of haemorrhage, with or
without subarachnoid haemorrhage. MRI
is better for diagnosis and should be done
in all cases of suspected pituitary apoplexy
following an initial CT scan.[8]
Laboratory
FBC, UEC. Baseline endocrine bloods (T4,
TSH, FSH, LH, prolactin, GH and cortisol).[7]
Initial management
• ABC
• IV access and immediate administration
of hydrocortisone 100 mg
• Urinary catheter and monitoring of
urine output to monitor for diabetes
insipidus.[8]
Meningism with fever
Intracranial infections
Intracranial infections include brain abscess
and subdural empyema. These conditions
usually occur in the first 4 decades of life
and result from spread from contiguous
structures (oral cavity, sinuses, middle ear),
either directly or by retrograde venous
thrombosis, or haematogenous spread
in patients with valvular heart disease
(infective endocarditis), cyanotic congenital
heart disease and chronic suppurative lung
disease (bronchiectasis).[9]
History
Patients may have a history of recent febrile
illness, including dental infections, otitis
media, mastoiditis or sinusitis. Symptoms
are usually present for 1 - 2 weeks before
acute deterioration. Common symptoms
are headache (often progressive and severe,
localised to the side of the abscess), mental
status changes, high- or low-grade fever,
seizures, nausea and vomiting.[10]
Examination
Findings on physical examination include
fever, neck stiffness and signs of raised
intracranial pressure due to mass effect
from the lesion or associated cerebral
oedema. Note that some patients with brain
abscess do not have a fever. Focal deficits are
common and determined by the size and
location of the pus collection. Cerebellar
lesions result in cerebellar signs, while
supratentorial lesions lead to hemiparesis,
mentalstatuschangesandspeechdifficulties.
A thorough ENT, oral, cardiovascular and
chest examination should be performed to
identify a possible source of infection.[9]
Investigation
Imaging
CT brain, with and without contrast, reveals
a ring-enhancing lesion (location often
depends on the underlying cause) with
surrounding oedema in the case of an abscess
(Fig. 2) or enhancing subdural collection
in the presence of subdural empyema.
Opacification or air-fluid levels in the sinuses
may indicate sinusitis. Chest X-ray can reveal
evidence of pneumonia or bronchiectasis.[10]
Laboratory
FBC, UEC, septic markers (CRP/ESR)
and blood culture.[10]
Lumbar puncture is
contraindicated in the presence of decreased
level of consciousness or focal neurological
deficit.
Initial management
• ABCs
• Supplemental oxygen, intubation as
required (GCS<8)
• IVaccessandbroad-spectrumantibiotics
• Anti-seizure prophylaxis.[10]
Focal neurological deficits/
seizures
Acute-onset intracerebral
haematoma (ICH)
History
Spontaneous ICH usually occurs in patients
older than 55 years and is slightly more
common in men. Pre-existing hypertension
is commonly present and concurrent use of
oral anticoagulants should be determined.
In younger patients, structural lesions occur
morefrequentlyandahistoryofillicitdruguse
(e.g. cocaine) should be excluded. Common
symptoms include headache, vomiting, acute-
onset focal weakness and seizures.[11]
Examination
Elevated blood pressure may be an
indication of the underlying cause in
patients with chronic hypertension or a
reactive phenomenon secondary to raised
intracranial pressure. Excessive bruising
or bleeding suggest anticoagulant toxicity.
Focal neurological deficits are dependent
on haematoma location and include
hemiparesis, gaze palsy or other cranial nerve
palsy.[11]
Investigation
Imaging
Uncontrasted CT scan of the brain shows
hyperdense areas of acute haemorrhage.
Hypertensive bleeds often occur in
deep locations (basal ganglia, thalamus,
cerebellum). Younger patients with more
superficial haematomas or in atypical
locations are more likely to have an
Fig. 2. Contrasted CT brain revealing ring
enhancing cerebral abscess in the right
parieto-occipital area (arrow).
4. 78 CME March 2013 Vol. 31 No. 3
Neurosurgical emergencies
underlying vascular lesion, and further
investigation is warranted, e.g. CT
angiography.[11]
Laboratory
FBC, UEC, clotting profile.
Gradual progression
Progressive headache or neurological
deficits are suggestive of an expanding
mass lesion, most commonly intracranial
neoplasms, which can be either primary or
secondary.
History
A history of previous or current underlying
cancer may be present, as well as systemic
symptoms such as weight loss. Gradual
progression of pre-existing weakness,
progressive longstanding headache or
seizures are suggestive of a progressively
enlarging lesion or increasing cerebral
oedema around the tumour. Acute
deterioration may also occur due to haemor-
rhage into the tumour.
Examination
Alteredlevelofconsciousness,signsofraised
intracranial pressure and focal neurological
deficits are dependent on the location of the
lesion. Systemic examination should also be
performed to identify a possible underlying
primary tumour.[12]
Investigation
Imaging
CT brain, with and without contrast, may
reveal intrinsic or extrinsic mass lesions
(Fig. 3) with surrounding oedema, with or
without hydrocephalus. Further imaging is
directed at identifying a possible underlying
cause (CXR, ultrasound, etc.).[12]
Initial management
• General supportive measures
• Correction of coagulopathies should be
performed immediately.[11]
• Anti-seizure prophylaxis
• Steroids can be administered in the
presence of oedema surrounding a
suspected tumour.[12]
History of trauma
Extradural haematoma
Extradural haematomas are collections
of blood outside the dura and are most
commonly caused by skull fractures with an
associated vascular tear, following a direct
blow to the head. Clinically there may or
may not be a period of loss of consciousness,
often severe headache, vomiting and a
history of seizures. About 20% of patients
have the classic ‘lucid interval’ between
the initial trauma and neurological
deterioration.[13]
Subdural haematoma
Subduralhaematomasarethemostcommon
intracranial haematomas following trauma
and usually follow a high-speed impact
to the skull, which causes brain tissue to
decelerate relative to fixed dural structures,
leading to tearing of blood vessels. Brain
injury is often more severe and the patient is
more likely to present with a decreased level
of consciousness.[13]
Chronic subdural haematoma
In chronic subdural haematomas there is
usually a history of minor head trauma
some weeks prior to presentation.
Patients complain of severe, progressive
headache, seizures and decreased level of
consciousness.[13]
History
• Mechanism of injury – blunt or
penetrating assault, MVA
• Loss of consciousness or amnesia
• Seizures.
Examination
There is usually external evidence of trauma
– lacerations, bruising, palpable fractures and
CSF leak from the nose or ears suggestive of a
base of skull fracture. Clinical findings include
those of raised intracranial pressure, focal
neurological deficits and signs of herniation,
as discussed elsewhere in this issue.
Imaging
• Extradural haematoma – convex,
hyperdense extra-axial lesion with or
without midline shift (Fig. 4a). An
overlying fracture is often identified.
• Subdural haematoma – crescent-
shaped hyperdense lesion following the
contour of the cerebral hemisphere (Fig. 4b).
Parenchymal contusions are also common.
Fig. 3. Contrasted CT brain showing a
homogenously enhancing extra-axial lesion
in the interhemispheric fissure (parasaggital
meningioma).
Fig. 4a. Acute extradural haematoma:
biconvex hyperdense extra-axial lesion with
mass effect on the underlying hemisphere.
Fig. 4b. Subdural haematoma: hyperdense
extra-axial lesion following the contour of the
hemisphere.
Fig. 4c. Chronic subdural haematoma.
Hypodense extra-axial lesion with mass
effect.
5. 79 CME March 2013 Vol. 31 No. 3
Neurosurgical emergencies
• Chronic subdural haematoma – iso- to
hypodense collection over a hemisphere,
often with a significant midline shift
(Fig. 4c).[13]
Initial management
• Resuscitation according to ATLS
principles, ensuring adequate blood
pressure and oxygenation to prevent
secondary injury
• Anti-seizure prophylaxis
• Urgent neurosurgical referral for surgical
evacuation.
Previous neurosurgery
Ventriculoperitoneal shunt
dysfunction
History
Progressive headache, vomiting or
drowsiness are common complaints.
Patients who have experienced shunt
dysfunction before can often recognise
a specific pattern when their shunt is not
functioning, and very careful attention
should be paid to this history. Endoscopic
third ventriculostomy (ETV) has
recently been accepted as a treatment for
hydrocephalus. These patients do not have
a shunt but the ETV can also block, leading
to rapid clinical deterioration.
Examination
Assess level of consciousness, presence
of papilloedema and other signs of raised
intracranial pressure. Document any signs
of inflammation or swelling around the scalp
or abdominal incisions suggestive of shunt
infection or obstruction. The presence of
neck stiffness is a sign of possible meningitis
or shunt infection. Palpate the shunt tract
for possible disconnection or fractures.[14]
Investigation
Imaging
CT reveals ventriculomegaly with or without
periventricular lucency or generalised brain
swelling. Shunt series X-ray studies (SXR,
lateral neck, AP chest, AP abdomen) may
reveal disconnection or fracture along the
shunt tract.[14]
Laboratory
FBC, UEC and baseline septic markers for
possible shunt infection.
Initial management
Provide initial supportive care and urgent
neurosurgical consult.
Spinal compression
Various lesions may compress either
the spinal cord or the roots of the cauda
equina. This is one of the most commonly
missed neurosurgical emergencies and an
increasingly important cause of litigation.
Spinal cord compression
The most common causes of spinal cord
compression are listed in Table 4.[15]
Clinical presentation
• Paraplegia/paraparesis
• Quadriplegia/quadriparesis
• Urinary retention
• Impaired sensation below the level of
compression
• Hyperactive reflexes
• Plantar reflexes may be upgoing
• Clinical findings may develop over hours
or days.[15]
Investigation
• Plain film X-rays
• All patients need to be referred for urgent
MRI to determine the level and cause of
compression.[15]
Cauda equina compression
(CES)
Aetiology
Possible causes include a massively herniated
lumbar disc, tumour, trauma, spinal epidural
haematoma and spinal epidural abscess,[16]
resulting in dysfunction of multiple sacral
nerve roots within the lumbar spinal canal.
Clinical presentation
CES most commonly presents in an acute
fashion. Clinical findings include lower
back pain and sciatica (often bilateral), urine
incontinence, decreased anal sphincter
tone, saddle anaesthesia, motor weakness
involving more than one motor nerve root
and bilaterally decreased or absent Achilles
tendon reflexes.[16]
Investigation
All patients require an urgent MRI scan and
prompt referral to a neurosurgeon.
Conclusion
Neurosurgical conditions commonly
present as emergencies. and a high index
of suspicion should always be maintained
when assessing these patients in order to
ensure rapid diagnosis and prompt referral
to a neurosurgeon.
References available at www.cmej.org.za
Various lesions may
compress either the spinal
cord or the roots of the
cauda equina. This is one of
the most commonly missed
neurosurgical emergencies
and an increasingly
important cause of litigation.
Table 4. Causes of spinal cord compression
Degenerative Cervical/thoracic stenosis
Acute disc prolapse
Trauma Fractures
Fracture-dislocations
Infectious Spinal epidural abscess/empyema
Vascular Spinal epidural haematoma
Neoplastic Extradural: vertebral tumours (primary or metastases)
Intradural: extramedullary (e.g. meningioma or neurofibroma)
In a nutshell
• Neurosurgical conditions frequently
present as emergencies.
• A good history, general examination and
focused neurological examination pro-
vide vital diagnostic clues.
• Urgent imaging with CT or MRI is in-
dicated in all neurosurgical emergencies.
• Basic supportive care should be provided
to stabilise the patient.
• Urgent neurosurgical consult is required
in all cases.
Spontaneous ICH usually
occurs in patients older
than 55 and is slightly more
common in men.