1) Rice bran oil contains numerous bioactive compounds that provide various health benefits. It is rich in phytosterols, tocopherols, tocotrienols, polyphenols, and gamma-oryzanol which have anti-oxidative, anti-inflammatory, cholesterol-lowering, and other nutraceutical functions.
2) The bioactive compounds in rice bran oil have been shown to reduce risk of heart disease, obesity, cancer, and other chronic diseases through their anti-oxidative, anti-inflammatory, and hypolipidemic properties.
3) Further research is needed to fully understand the nutraceutical mechanisms of rice bran oil and maximize its health benefits through synerg
Role of Phytoestrogens in Breast CancerNeha Dhiman
because of the side effects caused by the synthetic drugs and therapies, it is better to rely on natural products. natural products has lot of benefits and risk is less.
introduction of phytosterols and their health benefits. how it does help in promoting good cholestrol in body and preventing from CVD and other major diseases. How it should take in diet. recent researches at phytosterols.
Natural sources of plant stanols and plant sterolsBenecol
Plant stanols and plant sterols, together called phytosterols, are clinically proven to lower cholesterol when about 2 g/day is used. They occur naturally in plant based foods, but only in small concentration. Some sources of plant stanols and plant sterols are presented in these slides.
Role of Phytoestrogens in Breast CancerNeha Dhiman
because of the side effects caused by the synthetic drugs and therapies, it is better to rely on natural products. natural products has lot of benefits and risk is less.
introduction of phytosterols and their health benefits. how it does help in promoting good cholestrol in body and preventing from CVD and other major diseases. How it should take in diet. recent researches at phytosterols.
Natural sources of plant stanols and plant sterolsBenecol
Plant stanols and plant sterols, together called phytosterols, are clinically proven to lower cholesterol when about 2 g/day is used. They occur naturally in plant based foods, but only in small concentration. Some sources of plant stanols and plant sterols are presented in these slides.
An Overview of Flax Seeds – Phytochemical Profile, Extraction & Dietary BenefitsAmalDhivaharS
Flax (Linum usitatissimum L.) or the Linseed, a cultivated food cum fibre crop well known in the textile industry, comes from the Linaceae family. Flaxseeds have a major significance in history since their first domestication in the Fertile Crescent region and are well known for their high nutritional and medicinal values. Flax seeds contain more than 70% of alpha-linolenic acid (ALA), an omega3 essential fatty acid that is known to suppress the proliferation of several cancer cell lines, along with certain unsaturated fatty acids such as oleic, linoleic and linolenic acids. Flaxseed oil (FSO) is looked up for the treatment of various ailments including rheumatoid arthritis, high cholesterol level, osteoarthritis, anxiety, vaginal infections, atherosclerosis, benign prostatic hyperplasia (BPH), attention deficit-hyperactivity disorder (ADHD) and so on. It is usually extracted from the flaxseeds by press and solvent extraction methods and was used for research purposes in the past years in the medicinal, pharmaceutical, and food industry. In the present study, the flaxseeds were powdered using a grinder and the FSO was extracted using a Clevenger apparatus by the hydro-distillation method. A comprehensive analysis of the phytochemical composition and alimental properties revealed that flaxseeds may have anti-cancer effects when consumed regularly as part of one's diet.
Cytotoxic Activity of Linum usitatissimum L. Essential oil against Lung Adeno...AmalDhivaharS
The Essential oils of numerous medicinal plants are reported to have significant anti-cancer effects due to the presence of active phytochemicals. Flax seeds (Linum usitatissimum L.) are found to be a rich source of alpha-linolenic acid (ALA), an essential fatty acid, which is a precursor to several omega-3 fatty acids, claimed to have lipid-lowering properties. It is also known to have enriched with certain unsaturated fatty acids such as oleic, linoleic and linolenic acids and relatively low glucosinolate content. In this study, we have extracted the essential oil from flaxseeds (FEO) through the Hydro-distillation method and analyzed its anti-cancer effects on A549 human lung adenocarcinoma cell line. The GC-MS analysis indicated the presence of various phytochemical compounds with antitumor properties such as hexadecanoic acid, cis - vaccenic acid, and isopropyl myristate. The Trypan blue and MTT assays conducted with concentrations ranging from 0.04 to 0.20 V/V% provided IC50 values of 0.11 and 0.16 V/V% respectively for cancer cell line growth inhibition. The cell line migration was also monitored using the wound-scratch assay with essential oil concentrations of 0.16 and 0.20 V/V% at the 24th hour. The essential oil could efficiently prevent the rapid migration of lung cancer cells when observed under an inverted microscope. Thus, the flaxseed essential oil treatment on A549 cancer cells exhibited a dose-dependent decrease in their viability and caused apoptosis induction. Therefore, flaxseeds have a greater potency to treat lung cancer cells and this work also proposes further in vivo studies to establish this natural medication as an eminent anti-cancer drug.
Development of Antioxidant Rich Functional Dairy Product and Study their Tota...Premier Publishers
Present investigation has featured the capability of functional dairy product fortified with essential oil has bearing antiradical properties that decolorize the stable DPPH radical. The antioxidant activity of Syzygium aromaticum (clove buds) and Cinnamomum verum (cinnamon) has found to possess inhibitory effect against reactive oxygen species (ROS) due to their high oxygen radical absorption capacity (ORAC) value. The target of the investigation is to set up the useful dairy item "coagulated cream", with the fortress of basic oils from S. aromaticum and C. Verum and blend of both the oils. In addition, determination of the total antioxidant activity of the product by DPPH (1,1-Diphenyl-2-picrylhydrazyl) assay in three different types of clotted cream sample prepared along with varying concentrations of S. aromaticum and C. Verum and combination of both the oils. Additionally, to compare the proximate quality and overall acceptability of the final product were analysed antioxidant analysis of the product reveals that the maximum DPPH antioxidant activity percentage was observed in combination of both essential oils from the S. aromaticum and C. Verum before treatment at 0.25% focus for example 70.9% while the IC50 esteem is 0.029ml at 0.75% focus shows a powerful antioxidant product in correlation with every single other samples.
How may coconut oil lower the risk of cancer risk when dietary fat is typically associated with higher risk of cancer?
This paper looks at the possible mechanism by which coconut oil MAY uniquely protect against cancer development.
Piccola Cucina is regarded as the best restaurant in Brooklyn and as the best Italian restaurant in NYC. We offer authentic Italian cuisine with a Sicilian touch that elevates the entire fine dining experience. We’re the first result when someone searches for where to eat in Brooklyn or the best restaurant near me.
At Taste Of Middle East, we believe that food is not just about satisfying hunger, it's about experiencing different cultures and traditions. Our restaurant concept is based on selecting famous dishes from Iran, Turkey, Afghanistan, and other Arabic countries to give our customers an authentic taste of the Middle East
Ang Chong Yi Navigating Singaporean Flavors: A Journey from Cultural Heritage...Ang Chong Yi
In the heart of Singapore, where tradition meets modernity, He embarks on a culinary adventure that transcends borders. His mission? Ang Chong Yi Exploring the Cultural Heritage and Identity in Singaporean Cuisine. To explore the rich tapestry of flavours that define Singaporean cuisine while embracing innovative plant-based approaches. Join us as we follow his footsteps through bustling markets, hidden hawker stalls, and vibrant street corners.
Key Features of The Italian Restaurants.pdfmenafilo317
Filomena, a renowned Italian restaurant, is renowned for its authentic cuisine, warm environment, and exceptional service. Recognized for its homemade pasta, traditional dishes, and extensive wine selection, we provide a true taste of Italy. Its commitment to quality ingredients and classic recipes has made it a adored dining destination for Italian food enthusiasts.
Roti Bank Hyderabad: A Beacon of Hope and NourishmentRoti Bank
One of the top cities of India, Hyderabad is the capital of Telangana and home to some of the biggest companies. But the other aspect of the city is a huge chunk of population that is even deprived of the food and shelter. There are many people in Hyderabad that are not having access to
1. 1
Rice Bran Oil's Unique Nutraceutical
Functions & Applications
Dr. Yiqun Wang, MPhil, PhD
Director of Research, Institute of Brain Chemistry & Human Nutrition, UK
Senior Researcher, Faculty of Medicine, London Imperial College, UK
Email: yiqun.wang@imperial.ac.uk
A Supplement to the Compendium of Materia Medica, 1765.
Item Title: Rice Oil
Content:This is a float layer on
rice congee in a boiling pot,
which is slippery as an oily
ointment. It is real strength to
nourish people, which good
quality will be got by cooking
the rice over 20kg. Shaoxing
Chinese doctor said a weak thin
person may become fatty strong,
which the power of nourishing
Yin will be better than the
prepared rhizome of rehmannia.
Take one bowl a day and it is
best without salt. ,,,,,,
Composition of Crude Rice Bran Oil
SaponifiableLipids:
%
90-96
Triglycerides 80-90
Diglycerides 2-10
Monoglycerides 1-2
Free Fatty acids 4-40
Phospholipids 1-2
Glycolipids 1-2
Wax 3-6
Steryl Esters 2-3
Oryzanol 1-2
UnsaponifiableMatters:
Phytosterols,Triterpenols, Hydrocarbons
Tocopherols, Tocotrienols
3-4.5
Fatty Acid Composition of Rice Bran Oil (RBO)
SFA MUFA PUFA RATIO
OIL SFA 16:1 18:1 20:1 18:2 18:3
SFA/MUF
A
PUFA/MU
FA
18:2/18:1
Canola 6 62 22 10 0.1 0.5 0.4
Corn germ 13 28 58 1 0.5 2.1 2.1
Cottonseed 26 1 19 54 1 1.3 2.8 2.8
Flaxseed 9 20 17 53 0.5 3.5 0.9
Olive 17 1 71 10 1 0.2 0.2 0.1
Palm 50 40 10 1.3 0.3 0.3
Peanut 19 48 2 32 0.4 0.6 0.7
Rice Bran 20 45 37 1 0.4 0.8 0.8
Safflower 9 13 78 0.7 6.0 6.0
Sesame 13 40 46 0.3 1.2 1.2
Soybean 15 24 54 7 0.6 2.5 2.3
Sunflower 12 19 68 1 0.6 3.6 3.6
Wheat germ 15 27 54 3 0.6 2.1 2.0
Diet, nutrition and the prevention of chronic diseases, Report of the joint WHO/FAO expert consultation
2. 2
Deaths From Diseases of the Heart*
United States: 1900-99
0
100
200
300
400
500
600
700
800
1900 10 20 30 40 50 60 70 80 90 99
Deaths in
thousands
Year
4 4.5 5 5.5 6 6.5 7 7.5
Suicide mortality in the U.S. from 1960 to 1999
and linoleic acid (18:2n- 6 en%) available in the food supply
Soy oil is the primary source of 18:2n-6.
Linoleic acid, 18:2n-6 (en%) per capita per day
from foods available for human consumption
10
10.5
11
11.5
12
12.5
13
13.5
Suiciderates/100,000bothsexes
Ageadjusted,CDCdata
r = 0.88
F =174
p < 0.00001
1950
1970
1975
1980
1985
1990
1955
1960 1965
1969
1995
1999
1998
1997
1996
1968
1967
1963
1957
1956
1979
1978
1988
γ-oryzanol, is a mixture of ferulic acid esters of triterpene alcohols and sterols
Three major compounds
Oryzanol in Rice Bran Oil (RBO)
Sources
&
Contents
Cycloartenyl ferulate 24-Methylenecycloartanyl
ferulate
Campesteryl ferulate
25-30% 35-40% 15-20%
Nutraceutical functions & applications of Oryzanol
Functions:
Neuroprotective
Anti-oxidative
Anti-atherosclerotic
Anti-ulcerogenic
Anti-cancerogenic
Anti-stress
Anti-diabetic
Anti-inflammatory
Antiallergenic
Muscle enhancing
Immune modulatory
Hypolipidemic
Hypocholesterolemic
Nourishing skin
Hormones stimulate
Effect on Menopause
Effects on Dementia
Other effects
------
Oil USM (%) Oil USM (%)
Cocoa butter 0.9 Rice bran 4.1
Coconut 1.2 Wheat germ 5.0
Cottonseed 1.5 Sesame 2.0
Groundnut 1.8 Olive 2.5
Palm 1.2 Mustard 2.0
Palm kernel 0.8 Soybean 1.6
Sunflower 1.3 Corn 2.8
Linseed 1.7 Kapok seeds 1.0
Safflower 1.3
Unsaponifiable Matters in Some Edible Oils
Unique Unsaponifiable Matter in Rice Bran Oil (RBO)
Components (%) RBO
Wheat Germ
Oil
Olive Oil
Hydrocarbons 18 7 30-50
Phytosterols 43 35 2
Triterpenols 28 9 19-34
Tocopherols 1 18 2-3
Others 10* 17** 18-37***
*Sterol esters **Methysterols ***Polyphenols
4. 4
Tocopherols &
Tocotrienols
Functions:
Anti-oxidative
Anti-tumor
Anti-inflammatory
Anti-aging
Cardioprotective
Anti-diabetic
Bone-protective
Immunomodulatory
HYDROCARBONS IN RICE BRAN OIL
Squalene:
Oil Squalene (%USM)
Rice bran oil 11.75
Palm oil 1.8-2.3
Olive oil 0.5-0.65
Walnut oil 2.83
Functions:
Oxygen carrying
Anti-oxidative
Hypolipidemic
Hepatoprotective
Cardioprotective
Anti-cancer
Anti-radiation
Anti-bacterial
Anti-fungal
Other effects
PHOSPHOLIPIDS IN RICE BRAN OIL
16:0 18:0 18:1 n-9 18:2 n-6 18:3 n-3
Soybean PC 20.5 4.9 20.2 48.9 5.5
Rice Bran PC 22.1 1.8 41.8 31.8 2.5
Rice Lyso-PC 18.2 1.5 43.5 35.1 1.7
PC: Phosphatidylcholine
Main Functions as Structural Lipids:
Forming the cell membrane
Regulating cellular activities
Joining circulation delivery system
GLYCOLIPIDS IN RICE BRAN OIL
Glycolipids: Glycosphingolipids and Glycoglycerolipids
Main Functions:
Anti-oxidant, anti-virus, anti-bacterial, anti-inflammatory, anti
atherosclerosis, Anti-inflammatory, anti-cancer, anti-tumor,
immune activity, etc
POLICOSANOL IN RICE BRAN OIL
Wax Policosanol (main C30, C28)
Functions:
Anti-fatigue . potent antioxidants,
promote proper arterial endothelial cell
function, inhibit platelet aggregation and
thrombosis, and serve as effective
treatments for intermittent claudication.
NUTRACEUTICAL SYNERGISMAMONG BIOACTIVE COMPOUNDS
•RBO is a nutraceutical oil of multi-bioactive synergism
•The pigments bioactivities in coloured rice bran synergize
with the bioactives in normal rice bran
•RBO blended with other oils eg. olive oil etc
•RBO with other nutraceutical foods
•Concentrated or refined RBO bioactives with other
bioactives
• ------
5. 5
Cicero, et al. 2001
Main effects of RBO components on plasma lipid pattern.
Current Studies on Nutraceutical Mechanisms
Hypercholesterolemia
inhibition mechanism
Antioxidation mechanism Anticancer mechanism
LIPIDOMICS AS A POWERFUL TOOL
TO STUDY NUTRACEUTICAL MECHANISM
Ferrri N, etal. Biomarkers, 2005
Banerjee,N., Chatterjee,S., Bhattacharjee, S., Bhattacharya, B., De, S. and Mukherjee, S., 2018. Rice branoil
consumption: Cardiovascular disease andobesityriskreduction. Journal of Pharmacy Research|Vol, 12(3),
p.402.
Yulianto, R. and Xuan, T.D., 2018.Antioxidant and Allelopathic Activities ofRice (Oryza sativa L.) Bran.
Journal of Horticulture and Plant Research,1, p.26.
Kurtys, E., Eisel,U.L., Hageman, R.J., Verkuyl, J.M., Broersen,L.M., Dierckx, R.A. and de Vries, E.F., 2018.
Anti-inflammatory effects of rice brancomponents. Nutrition reviews,76(5),pp.372-379.
Sivamaruthi, B.S., Kesika, P. and Chaiyasut, C., 2018.A comprehensive review onanti-diabetic propertyof
rice bran.AsianPacific Journal of Tropical Biomedicine,8(1),p.79.
Ha,S.J., Park, J., Lee, J., Song, K.M., Um, M.Y., Cho, S. and Jung, S.K., 2018. Rice bran supplement
prevents UVB-induced skin photoaging in vivo.Bioscience,biotechnology, and biochemistry, pp.1-9.
Moreau,R.A., Nyström, L., Whitaker, B.D., Winkler-Moser,J.K., Baer, D.J., Gebauer, S.K. and Hicks, K.B.,
2018.Phytosterols and their derivatives: Structural diversity,distribution,metabolism, analysis,and health-
promoting uses. Progress in lipidresearch.
New Publications of RBO R&D in 2018
SUMMARY& FURTHER WORK
• Further to understand the nutraceutical characteristics of
RBO
• To fully use more rice bran for producing more RBO
• To improve the processing technology of RBO and its
other products
• Further to study the RBO nutraceutical mechanism
• To fully take the unique nutraceutical roles of RBO
• To maximize the RBO nutraceutical functions by
synergism with other bioactives
• To balance the dietary intakes of RBO with other foods
• To improve and optimize the local dietary patterns
Thanks!