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svqrTelomerase inhibition is being explored as a potential cancer treatment. Telomeres protect the ends of chromosomes but shorten with each cell division, eventually causing genomic instability and cell death if they become too short. Cancer cells reactivate telomerase to maintain telomere length and immortality. Scientists hope to use telomerase inhibition to selectively target cancer cells. Research has also shown that modifying stem cells with the PIM-1 protein can rejuvenate aging heart cells by extending telomere length, offering potential regenerative therapies for heart disease. Advances in genetic research may allow for earlier disease detection and prevention.
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Hallmarks of Aging summary
The paper proposes 9 hallmarks of aging based on accumulated cellular damage over time: 1) genomic instability, 2) telomere attrition, 3) epigenetic alterations, 4) loss of proteostasis, 5) deregulated nutrient sensing, 6) mitochondrial dysfunction, 7) cellular senescence, 8) stem cell exhaustion, and 9) altered intercellular communication. Some hallmarks like cellular senescence are beneficial at low levels but harmful in excess. The hallmarks represent primary damage, compensatory responses turned pathological over time, and integration of various damage types systemically.
DNA REPLICATION NEWS
The document discusses DNA replication and recent research findings. It begins with an introduction to DNA replication and how it allows cells to duplicate their genome during cell division. It then summarizes two recent studies: one finding that the replication stress response protein SMARCAL1 plays a key role in maintaining telomere stability, and the other showing that the protein APOBEC can induce mutations by taking advantage of single-stranded DNA during replication of the lagging strand. The studies provide new insights into cancer cell replication pathways and genes that could be targeted for new cancer therapies.
PSP1 skills group presentation on ageing
A group collaborative effort of independent research pooled together to answer the question of why we age.
Erythrose defeat Cancer
Cancer cells divide rapidly and may spread to other organs. They rely mainly on fermentation rather than respiration, producing lactate. Controlling cell division can control cancer. Cancer cells differ from normal cells in that they can divide but not differentiate into specialized cell types. Increasing cellular respiration, such as by using the sugar erythrose, stops cell division and causes cancer cells to differentiate or die while leaving normal cells unharmed. Studies show erythrose kills various cancer cell lines at concentrations that do not harm normal cells, and it inhibits tumor growth in mice without side effects.
Insects as Model in Aging Research
Insects such as fruit flies, ants, wasps, and bees are commonly used as models in aging research due to their short lifecycles and genetic similarities to humans. Key hallmarks of aging that are studied using insect models include changes in mitochondria, loss of protein homeostasis, and damage accumulation. Recent research has investigated anti-aging drugs such as resveratrol found in red wine and rapamycin, with resveratrol shown to provide benefits by stimulating anti-aging proteins and rapamycin demonstrating limited effects through tumor suppression in mice. New publications continue to provide insight into aging processes and potential reversal in model organisms.
Cancer Cells Die with Erythrose
Cancer cells mainly depend on fermentation to produce energy and divide, while normal cells rely more on cellular respiration. Increasing cellular respiration, especially in mitochondria and cytosol, can stop cell division of both cancer and normal cells. Studies have found that the sugar erythrose is able to increase cellular respiration in cancer cells through its conversion to carbon dioxide and water without residue, causing cancer cell lines of various types to die at an erythrose concentration of around 4mM, while having similar effects on growth as glucose on normal cells up to 30mM. Erythrose shows potential as a targeted cancer treatment by increasing cellular respiration in cancers to kill them without damaging normal tissues.
Control Cancer by Increasing Cellular Respiration with Erythrose
1) Increasing cellular respiration, such as by providing the sugar D-erythrose, can control cancer by inhibiting cancer cell division and initializing cancer cell differentiation into non-dividing cells.
2) Cancer cells mainly depend on fermentation rather than respiration for energy, whereas differentiated non-dividing cells rely on respiration. D-erythrose can increase cellular respiration in both cancer and normal cells.
3) Studies have shown D-erythrose effectively kills various cancer cell lines in culture at low concentrations, inhibits tumor growth in vivo, and does not appear toxic to normal cells. This suggests it may control cancer by turning cancer cells into non-dividing cells.
Mesenchymal stem cell therapy
This document discusses mesenchymal stromal/stem cell (MSC) mechanisms of immunomodulation and homing. It describes how MSC can directly abrogate the pro-inflammatory functions of immune cells like T cells, macrophages, dendritic cells, neutrophils, and B cells. MSC suppress T cell proliferation and promote regulatory T cell phenotypes through cell contact and secretion of factors like IDO, PGE2, TGF-β, and HLA-G. MSC also inhibit the differentiation of TH17 cells and promote an anti-inflammatory environment. The mechanisms of MSC homing and persistence in vivo are still being investigated.
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Hallmarks of Aging summary
The paper proposes 9 hallmarks of aging based on accumulated cellular damage over time: 1) genomic instability, 2) telomere attrition, 3) epigenetic alterations, 4) loss of proteostasis, 5) deregulated nutrient sensing, 6) mitochondrial dysfunction, 7) cellular senescence, 8) stem cell exhaustion, and 9) altered intercellular communication. Some hallmarks like cellular senescence are beneficial at low levels but harmful in excess. The hallmarks represent primary damage, compensatory responses turned pathological over time, and integration of various damage types systemically.
DNA REPLICATION NEWS
The document discusses DNA replication and recent research findings. It begins with an introduction to DNA replication and how it allows cells to duplicate their genome during cell division. It then summarizes two recent studies: one finding that the replication stress response protein SMARCAL1 plays a key role in maintaining telomere stability, and the other showing that the protein APOBEC can induce mutations by taking advantage of single-stranded DNA during replication of the lagging strand. The studies provide new insights into cancer cell replication pathways and genes that could be targeted for new cancer therapies.
PSP1 skills group presentation on ageing
A group collaborative effort of independent research pooled together to answer the question of why we age.
Erythrose defeat Cancer
Cancer cells divide rapidly and may spread to other organs. They rely mainly on fermentation rather than respiration, producing lactate. Controlling cell division can control cancer. Cancer cells differ from normal cells in that they can divide but not differentiate into specialized cell types. Increasing cellular respiration, such as by using the sugar erythrose, stops cell division and causes cancer cells to differentiate or die while leaving normal cells unharmed. Studies show erythrose kills various cancer cell lines at concentrations that do not harm normal cells, and it inhibits tumor growth in mice without side effects.
Insects as Model in Aging Research
Insects such as fruit flies, ants, wasps, and bees are commonly used as models in aging research due to their short lifecycles and genetic similarities to humans. Key hallmarks of aging that are studied using insect models include changes in mitochondria, loss of protein homeostasis, and damage accumulation. Recent research has investigated anti-aging drugs such as resveratrol found in red wine and rapamycin, with resveratrol shown to provide benefits by stimulating anti-aging proteins and rapamycin demonstrating limited effects through tumor suppression in mice. New publications continue to provide insight into aging processes and potential reversal in model organisms.
Cancer Cells Die with Erythrose
Cancer cells mainly depend on fermentation to produce energy and divide, while normal cells rely more on cellular respiration. Increasing cellular respiration, especially in mitochondria and cytosol, can stop cell division of both cancer and normal cells. Studies have found that the sugar erythrose is able to increase cellular respiration in cancer cells through its conversion to carbon dioxide and water without residue, causing cancer cell lines of various types to die at an erythrose concentration of around 4mM, while having similar effects on growth as glucose on normal cells up to 30mM. Erythrose shows potential as a targeted cancer treatment by increasing cellular respiration in cancers to kill them without damaging normal tissues.
Control Cancer by Increasing Cellular Respiration with Erythrose
1) Increasing cellular respiration, such as by providing the sugar D-erythrose, can control cancer by inhibiting cancer cell division and initializing cancer cell differentiation into non-dividing cells.
2) Cancer cells mainly depend on fermentation rather than respiration for energy, whereas differentiated non-dividing cells rely on respiration. D-erythrose can increase cellular respiration in both cancer and normal cells.
3) Studies have shown D-erythrose effectively kills various cancer cell lines in culture at low concentrations, inhibits tumor growth in vivo, and does not appear toxic to normal cells. This suggests it may control cancer by turning cancer cells into non-dividing cells.
Mesenchymal stem cell therapy
This document discusses mesenchymal stromal/stem cell (MSC) mechanisms of immunomodulation and homing. It describes how MSC can directly abrogate the pro-inflammatory functions of immune cells like T cells, macrophages, dendritic cells, neutrophils, and B cells. MSC suppress T cell proliferation and promote regulatory T cell phenotypes through cell contact and secretion of factors like IDO, PGE2, TGF-β, and HLA-G. MSC also inhibit the differentiation of TH17 cells and promote an anti-inflammatory environment. The mechanisms of MSC homing and persistence in vivo are still being investigated.
Folding plegable
1. The p53 protein, known as the "guardian of the genome", plays an important role in protecting against cancer by preventing DNA mutations. Scientists have discovered that p53 is activated during meiosis to closely monitor DNA breaks and repairs, helping prevent mutations from being passed onto gametes.
2. Researchers discovered that the Mec1 protein in yeast acts as the "guardian of the genome" by repairing damaged DNA and replication machinery. Mec1 phosphorylates the SLX4 protein, triggering it to anchor to the replication machinery and perform repairs.
3. Understanding how proteins repair DNA damage provides insights that could lead to new approaches for curing diseases caused by genetic mutations, such as cancer
cellular adaptation presentation (2)
Cellular Adaptation
as cells encounter stresses they undergo functional or structural adaptations to maintain viability / homeostasis.
Injury - altered homeostasis
if limits of the adaptive response are exceeded or if adaptation not possible, a sequence of events called cell injury occurs.
Reversible Cell Injury
removal of stress results in complete restoration of structural & functional integrity.
b) Irreversible Cell Injury / Cell Death
if stimulus persists or is severe enough from the start, the cell suffers irreversible cell injury and death.
2 main morphologic patterns: necrosis & apoptosis.
Adaptations are reversible changes in the size, number, phenotype, metabolic activity, or functions of cells in response to changes in their environment.
Physiologic adaptations are responses of cells to normal stimulation by hormones or endogenous chemical mediators
Pathologic adaptations are responses to stress that allow cells to modulate their structure and function and thus escape injury.
Hypertrophy refers to an increase in the size of cells, that results in an increase in the size of the affected organ
The hypertrophied organ has no new cells, just larger cells.
Types:
a) physiologic b) pathologic
Causes:
a) increased functional demand b) hormonal stimulation
Taiga telomeres
Telomeres are repetitive DNA sequences that cap the ends of chromosomes and protect them from deterioration. They naturally shorten each time a cell divides until a limit is reached, known as the Hayflick limit, after which the cell stops dividing or dies. Telomerase is an enzyme that can lengthen telomeres and counteract their shortening, allowing cells to divide indefinitely. Telomere length is correlated with aging, with shorter telomeres associated with increased risk of age-related diseases. Factors like smoking, obesity, stress and inflammation can accelerate telomere shortening while healthy behaviors like exercise and nutrition may help maintain telomere length and slow aging.
Review paper ms 1 revised2
Stem cells, particularly autologous stem cells extracted from a patient's own bone marrow, show promise in treating multiple sclerosis (MS). Studies have found autologous stem cell transplantation after immunosuppression can reduce progression of MS, especially for patients with relapsing-remitting MS rather than primary progressive MS. While stem cells may not cure MS completely, they can help regenerate myelin sheaths and slow the degenerative effects of the disease on the nervous system. More research is still needed but stem cell therapy offers new opportunities for delivering high doses of immunosuppression to potentially stop MS progression.
Interesting medical news presentation
Here I show to you very interesting research news and medical utility. We can see the future of the epigenetics and molecular medicine.
Universidad Pontificia Bolivariana
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Peripheral neuropathyumbilicalcord
This chapter discusses perspectives on employing mesenchymal stem cells from Wharton's jelly of the umbilical cord for peripheral nerve repair. It provides background on regenerative medicine and peripheral nerve injuries. Various biomaterials that have been tested as scaffolds for delivering mesenchymal stem cells in models of rat sciatic nerve injury are described, including chitosan-silicate hybrid, collagen, PLGA90:10, poly(DL-lactide-e-caprolactone), and poly(vinyl alcohol) with conductive materials. The importance of a multidisciplinary approach to tissue engineering the peripheral nerve through development of biomaterials, cell therapies, and preclinical studies is emphasized.
the usage of matched MHC in IPSCs-CM transplantation
cardiomyocytes derived from MHC-homozygous induced pluripotent stem cells exhibit reduced Allogeneic immunogenicity MHC non human primates
Cellular ageing
Cellular ageing is the progressive decline in cellular function and viability caused by genetic abnormalities and the accumulation of damage over time. There are several theories that attempt to explain the aging process, including evolutionary, molecular, cellular, and systemic theories. At the cellular level, ageing is caused by DNA damage from both endogenous and exogenous sources, as well as telomere shortening after each cell division. Other factors that contribute to cellular ageing include defective protein homeostasis, disrupted nutrient sensing pathways, and a decline in cellular repair mechanisms. Premature ageing disorders provide insights into how disrupting certain ageing processes can accelerate ageing. While cellular senescence limits cell proliferation and acts as a tumor suppressor, it is
Cell
The document summarizes key components and functions of eukaryotic cells. It describes the cell membrane as composed of proteins, lipids, and carbohydrates that act as a selective barrier. It also discusses several intracellular organelles - the nucleus, mitochondria, endoplasmic reticulum, Golgi complex, ribosomes, lysosomes - and their roles in processes like protein synthesis, energy production, metabolism, and waste digestion. The plasma membrane, organelles, and their specialized functions allow cells to carry out life's processes.
Understanding cancer -- patient-genetic_background
While a cancer genome profile provides information, it does not tell the full story on its own. A patient's genetic background, which varies between individuals due to inherited and environmental factors, also influences cancer risk and treatment outcomes. This background includes single nucleotide variations across the genome as well as variations in genes related to drug metabolism and cancer susceptibility. Additional epigenetic and non-coding factors can also indirectly affect gene expression and cancer predisposition within a person. Understanding all of these intrinsic patient-specific influences is important for a complete diagnosis and personalized cancer care.
Central dogma of genetic information
The central dogma of genetics describes how DNA is transcribed into RNA and then translated into proteins. RNA is divided into messenger RNA, ribosomal RNA, and transfer RNA. MicroRNAs help regulate gene expression and can provide information about cell types like stem cells versus cancer cells. A study found that while fat cell levels of the protein PPAR gamma varied, levels of steroid receptor coactivators SRC-2 and SRC-3 remained stable, and these coactivators control PPAR gamma activity to regulate fat accumulation. Identifying compounds targeting the SRC-PPAR gamma interaction could provide alternative diabetes therapies.
Dr. David Guillespie - Identificación de dianas de daño en el DNA en la terap...
Presentación del Dr. David Guillespie, investigador contratado por el CIBICAN - Universidad de La Laguna gracias al Proyecto Europeo IMBRAIN, en relación a los resultados alcanzados durante la ejecución del mismo y los planes de futuro. La misma se presentó durante las Jornadas IMBRAIN llevadas a cabo el 13 de Octubre de 2015 en la Sección de Física en la Universidad de La Laguna
Umbilical cord wj_viable_msc.watson2015_(1)
This document discusses the potential use of mesenchymal stem cells (MSCs) derived from Wharton's jelly (WJ) of the human umbilical cord for regenerative medicine applications. MSCs from WJ present several advantages over other stem cell sources, including reduced immunogenicity, increased proliferative capacity, and ability to differentiate into various cell types. The document reviews potential applications of WJ-MSCs in cell therapy for cancer, liver disease, peripheral nerve damage, cardiovascular and connective tissue repair, and obesity/diabetes. However, challenges remain in optimizing isolation methods and tracking techniques for clinical applications of WJ-MSCs.
Cell evolution
The document discusses two studies related to cells and medical applications. The first study investigated how bacteria can modify their cell walls to become resistant to antibiotics by changing peptidoglycan structure. The second study discusses the development of programmable RNA vaccines that can be rapidly produced in nanomaterials to provide protection against diseases like Ebola and influenza within days. Both studies demonstrate the importance of continued biological research on cells to develop new treatment methods and address issues like antimicrobial resistance and pandemic outbreaks.
Cell aging
Aging is characterized by a declining ability to respond to stress and increased risk of disease. Differences in maximum lifespan between species correspond to different rates of aging, affected by genetic factors. Cells lose the ability to divide and function through the process of senescence. Traditional theories of aging include programmed and stochastic theories. More recent theories include molecular, cellular, and system-level theories. The free radical theory proposes that oxidative damage from free radicals produced during metabolism accumulates over time and causes aging. Telomere shortening leads to cell senescence.
Pre-mRNA splicing and human disease
This document summarizes research on how aberrant pre-mRNA splicing can cause human disease. It notes that 25% of inherited disease-causing mutations affect splicing enhancers and silencers. The study aims to validate mutations in PINK1, a gene associated with Parkinson's disease, that create splicing silencer hexamers and are predicted to disrupt splicing. The researchers will transfect cells with PINK1 reporter constructs containing wild-type or mutant sequences and use RT-PCR and gel electrophoresis to analyze changes in splicing patterns caused by the mutations.
Dna repair mechanism
DNA repair mechanisms based on new technologies and findings, to combat diseases caused by DNA damage
Presentacion del plegable biologia molecular
Stem cells may hold promise for treating ALS. A study found that transplanting stem cells into mice with ALS improved their neuromuscular activity, representing hope for patients. Additionally, a new cheap and easy CRISPR technique using the Cas9 protein and RNA could revolutionize gene therapy by allowing targeted editing of DNA. This technique has potential applications for curing diseases like HIV. Transplanting stem cells and using Cas9 represent new treatment alternatives for certain diseases.
Presentation1
The document discusses how youth today are incorporating digital technologies into their dating practices in new ways. It describes the history of contemporary dating and how social media allows teens to casually flirt and maintain continuous contact with romantic partners. Teens craft norms around language use and carefully edit messages to appear casual while establishing intimacy online. They also manage relationships publicly on social networks and must digitally "sweep up" remnants after breakups.
Presentation1
This document discusses how youth today are incorporating digital technology into their dating practices and intimate relationships in novel ways. It describes how teens use mobile phones, instant messaging, and social media to flirt and maintain relationships, demonstrating affection through both private and public online channels. While online communication allows a "controlled casualness", breaking up digitally is seen as disrespectful by teens' consensus. Social network profiles reflect the status and seriousness of their relationships.
THE STUDY OF CHROMOSOMES, A LIFE EXPECTANCY
1) The document discusses using telomerase inhibition as a potential cancer treatment by avoiding damage to normal cells. Telomeres protect chromosome ends but shorten with each cell division.
2) Researchers found links between shorter telomere length and increased cancer risk and mortality. They also discuss using a protein called PIM-1 to modify stem cells and rejuvenate aging heart cells by extending telomere length.
3) The findings suggest potential new therapies for cardiovascular disease by regenerating damaged heart muscle through modified stem cells, as well as opportunities for early cancer detection and prevention through genetic research on telomere length.
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Folding plegable
1. The p53 protein, known as the "guardian of the genome", plays an important role in protecting against cancer by preventing DNA mutations. Scientists have discovered that p53 is activated during meiosis to closely monitor DNA breaks and repairs, helping prevent mutations from being passed onto gametes.
2. Researchers discovered that the Mec1 protein in yeast acts as the "guardian of the genome" by repairing damaged DNA and replication machinery. Mec1 phosphorylates the SLX4 protein, triggering it to anchor to the replication machinery and perform repairs.
3. Understanding how proteins repair DNA damage provides insights that could lead to new approaches for curing diseases caused by genetic mutations, such as cancer
cellular adaptation presentation (2)
Cellular Adaptation
as cells encounter stresses they undergo functional or structural adaptations to maintain viability / homeostasis.
Injury - altered homeostasis
if limits of the adaptive response are exceeded or if adaptation not possible, a sequence of events called cell injury occurs.
Reversible Cell Injury
removal of stress results in complete restoration of structural & functional integrity.
b) Irreversible Cell Injury / Cell Death
if stimulus persists or is severe enough from the start, the cell suffers irreversible cell injury and death.
2 main morphologic patterns: necrosis & apoptosis.
Adaptations are reversible changes in the size, number, phenotype, metabolic activity, or functions of cells in response to changes in their environment.
Physiologic adaptations are responses of cells to normal stimulation by hormones or endogenous chemical mediators
Pathologic adaptations are responses to stress that allow cells to modulate their structure and function and thus escape injury.
Hypertrophy refers to an increase in the size of cells, that results in an increase in the size of the affected organ
The hypertrophied organ has no new cells, just larger cells.
Types:
a) physiologic b) pathologic
Causes:
a) increased functional demand b) hormonal stimulation
Taiga telomeres
Telomeres are repetitive DNA sequences that cap the ends of chromosomes and protect them from deterioration. They naturally shorten each time a cell divides until a limit is reached, known as the Hayflick limit, after which the cell stops dividing or dies. Telomerase is an enzyme that can lengthen telomeres and counteract their shortening, allowing cells to divide indefinitely. Telomere length is correlated with aging, with shorter telomeres associated with increased risk of age-related diseases. Factors like smoking, obesity, stress and inflammation can accelerate telomere shortening while healthy behaviors like exercise and nutrition may help maintain telomere length and slow aging.
Review paper ms 1 revised2
Stem cells, particularly autologous stem cells extracted from a patient's own bone marrow, show promise in treating multiple sclerosis (MS). Studies have found autologous stem cell transplantation after immunosuppression can reduce progression of MS, especially for patients with relapsing-remitting MS rather than primary progressive MS. While stem cells may not cure MS completely, they can help regenerate myelin sheaths and slow the degenerative effects of the disease on the nervous system. More research is still needed but stem cell therapy offers new opportunities for delivering high doses of immunosuppression to potentially stop MS progression.
Interesting medical news presentation
Here I show to you very interesting research news and medical utility. We can see the future of the epigenetics and molecular medicine.
Universidad Pontificia Bolivariana
Medicina School
Peripheral neuropathyumbilicalcord
This chapter discusses perspectives on employing mesenchymal stem cells from Wharton's jelly of the umbilical cord for peripheral nerve repair. It provides background on regenerative medicine and peripheral nerve injuries. Various biomaterials that have been tested as scaffolds for delivering mesenchymal stem cells in models of rat sciatic nerve injury are described, including chitosan-silicate hybrid, collagen, PLGA90:10, poly(DL-lactide-e-caprolactone), and poly(vinyl alcohol) with conductive materials. The importance of a multidisciplinary approach to tissue engineering the peripheral nerve through development of biomaterials, cell therapies, and preclinical studies is emphasized.
the usage of matched MHC in IPSCs-CM transplantation
cardiomyocytes derived from MHC-homozygous induced pluripotent stem cells exhibit reduced Allogeneic immunogenicity MHC non human primates
Cellular ageing
Cellular ageing is the progressive decline in cellular function and viability caused by genetic abnormalities and the accumulation of damage over time. There are several theories that attempt to explain the aging process, including evolutionary, molecular, cellular, and systemic theories. At the cellular level, ageing is caused by DNA damage from both endogenous and exogenous sources, as well as telomere shortening after each cell division. Other factors that contribute to cellular ageing include defective protein homeostasis, disrupted nutrient sensing pathways, and a decline in cellular repair mechanisms. Premature ageing disorders provide insights into how disrupting certain ageing processes can accelerate ageing. While cellular senescence limits cell proliferation and acts as a tumor suppressor, it is
Cell
The document summarizes key components and functions of eukaryotic cells. It describes the cell membrane as composed of proteins, lipids, and carbohydrates that act as a selective barrier. It also discusses several intracellular organelles - the nucleus, mitochondria, endoplasmic reticulum, Golgi complex, ribosomes, lysosomes - and their roles in processes like protein synthesis, energy production, metabolism, and waste digestion. The plasma membrane, organelles, and their specialized functions allow cells to carry out life's processes.
Understanding cancer -- patient-genetic_background
While a cancer genome profile provides information, it does not tell the full story on its own. A patient's genetic background, which varies between individuals due to inherited and environmental factors, also influences cancer risk and treatment outcomes. This background includes single nucleotide variations across the genome as well as variations in genes related to drug metabolism and cancer susceptibility. Additional epigenetic and non-coding factors can also indirectly affect gene expression and cancer predisposition within a person. Understanding all of these intrinsic patient-specific influences is important for a complete diagnosis and personalized cancer care.
Central dogma of genetic information
The central dogma of genetics describes how DNA is transcribed into RNA and then translated into proteins. RNA is divided into messenger RNA, ribosomal RNA, and transfer RNA. MicroRNAs help regulate gene expression and can provide information about cell types like stem cells versus cancer cells. A study found that while fat cell levels of the protein PPAR gamma varied, levels of steroid receptor coactivators SRC-2 and SRC-3 remained stable, and these coactivators control PPAR gamma activity to regulate fat accumulation. Identifying compounds targeting the SRC-PPAR gamma interaction could provide alternative diabetes therapies.
Dr. David Guillespie - Identificación de dianas de daño en el DNA en la terap...
Presentación del Dr. David Guillespie, investigador contratado por el CIBICAN - Universidad de La Laguna gracias al Proyecto Europeo IMBRAIN, en relación a los resultados alcanzados durante la ejecución del mismo y los planes de futuro. La misma se presentó durante las Jornadas IMBRAIN llevadas a cabo el 13 de Octubre de 2015 en la Sección de Física en la Universidad de La Laguna
Umbilical cord wj_viable_msc.watson2015_(1)
This document discusses the potential use of mesenchymal stem cells (MSCs) derived from Wharton's jelly (WJ) of the human umbilical cord for regenerative medicine applications. MSCs from WJ present several advantages over other stem cell sources, including reduced immunogenicity, increased proliferative capacity, and ability to differentiate into various cell types. The document reviews potential applications of WJ-MSCs in cell therapy for cancer, liver disease, peripheral nerve damage, cardiovascular and connective tissue repair, and obesity/diabetes. However, challenges remain in optimizing isolation methods and tracking techniques for clinical applications of WJ-MSCs.
Cell evolution
The document discusses two studies related to cells and medical applications. The first study investigated how bacteria can modify their cell walls to become resistant to antibiotics by changing peptidoglycan structure. The second study discusses the development of programmable RNA vaccines that can be rapidly produced in nanomaterials to provide protection against diseases like Ebola and influenza within days. Both studies demonstrate the importance of continued biological research on cells to develop new treatment methods and address issues like antimicrobial resistance and pandemic outbreaks.
Cell aging
Aging is characterized by a declining ability to respond to stress and increased risk of disease. Differences in maximum lifespan between species correspond to different rates of aging, affected by genetic factors. Cells lose the ability to divide and function through the process of senescence. Traditional theories of aging include programmed and stochastic theories. More recent theories include molecular, cellular, and system-level theories. The free radical theory proposes that oxidative damage from free radicals produced during metabolism accumulates over time and causes aging. Telomere shortening leads to cell senescence.
Pre-mRNA splicing and human disease
This document summarizes research on how aberrant pre-mRNA splicing can cause human disease. It notes that 25% of inherited disease-causing mutations affect splicing enhancers and silencers. The study aims to validate mutations in PINK1, a gene associated with Parkinson's disease, that create splicing silencer hexamers and are predicted to disrupt splicing. The researchers will transfect cells with PINK1 reporter constructs containing wild-type or mutant sequences and use RT-PCR and gel electrophoresis to analyze changes in splicing patterns caused by the mutations.
Dna repair mechanism
DNA repair mechanisms based on new technologies and findings, to combat diseases caused by DNA damage
Presentacion del plegable biologia molecular
Stem cells may hold promise for treating ALS. A study found that transplanting stem cells into mice with ALS improved their neuromuscular activity, representing hope for patients. Additionally, a new cheap and easy CRISPR technique using the Cas9 protein and RNA could revolutionize gene therapy by allowing targeted editing of DNA. This technique has potential applications for curing diseases like HIV. Transplanting stem cells and using Cas9 represent new treatment alternatives for certain diseases.
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the usage of matched MHC in IPSCs-CM transplantation
the usage of matched MHC in IPSCs-CM transplantation
Understanding cancer -- patient-genetic_background
Understanding cancer -- patient-genetic_background
Dr. David Guillespie - Identificación de dianas de daño en el DNA en la terap...
Dr. David Guillespie - Identificación de dianas de daño en el DNA en la terap...
Viewers also liked
Presentation1
The document discusses how youth today are incorporating digital technologies into their dating practices in new ways. It describes the history of contemporary dating and how social media allows teens to casually flirt and maintain continuous contact with romantic partners. Teens craft norms around language use and carefully edit messages to appear casual while establishing intimacy online. They also manage relationships publicly on social networks and must digitally "sweep up" remnants after breakups.
Presentation1
This document discusses how youth today are incorporating digital technology into their dating practices and intimate relationships in novel ways. It describes how teens use mobile phones, instant messaging, and social media to flirt and maintain relationships, demonstrating affection through both private and public online channels. While online communication allows a "controlled casualness", breaking up digitally is seen as disrespectful by teens' consensus. Social network profiles reflect the status and seriousness of their relationships.
THE STUDY OF CHROMOSOMES, A LIFE EXPECTANCY
1) The document discusses using telomerase inhibition as a potential cancer treatment by avoiding damage to normal cells. Telomeres protect chromosome ends but shorten with each cell division.
2) Researchers found links between shorter telomere length and increased cancer risk and mortality. They also discuss using a protein called PIM-1 to modify stem cells and rejuvenate aging heart cells by extending telomere length.
3) The findings suggest potential new therapies for cardiovascular disease by regenerating damaged heart muscle through modified stem cells, as well as opportunities for early cancer detection and prevention through genetic research on telomere length.
Sample266
This document discusses improving a library collection by addressing several problems: separating adult and juvenile materials into distinct children's spaces, enhancing accessibility for patrons with disabilities, and ensuring an adaptive collection and tools are available.
The New Era of Customer Service
The document discusses how the internet and rise of social media have changed customer expectations and behaviors. Traditional advertising is no longer as effective, as customers now demand more personalized experiences and interactions. The document advocates using social media platforms like Facebook, blogs, and Twitter to engage and interact with customers in order to build a loyal customer base through positive experiences and word-of-mouth referrals. It also stresses the importance of listening to customers and adapting business strategies to meet their changing needs and preferences.
Implementation prototype
The document summarizes usability testing done on a mockup of a library services webpage redesign. Two testers with different backgrounds completed tasks to find account information. Based on their feedback, the designer made changes like replacing links with expandable sections and reorganizing information for clarity. Both testers could then efficiently complete tasks, showing the redesign successfully implemented the "Center Stage" pattern to prioritize key account information while supporting other user needs.
Presentation1
This document discusses how youth today are incorporating digital technology into their dating practices and intimate relationships in novel ways. It describes how teens use mobile phones, instant messaging, and social media to flirt and maintain relationships, with an emphasis on cultivating a tone of "controlled casualness" online. Teens view social media as central to their relationships, for communicating affection, indicating relationship status, and dealing with breakups online by untangling digital remnants of past relationships from their profiles and networks.
Destination Wedding
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise boosts blood flow and levels of neurotransmitters and endorphins which elevate and stabilize mood.
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4) Several studies showed progress using stem cells to generate liver/pancreas cells and potentially treat diseases, provide proof that non-fetal stem cells can treat Parkinson's, and engineer blood cells to generate cancer
Biologia molecular Laura Cuartas Q
Lem4 is a protein that coordinates the activity of kinases and phosphatases on target proteins essential for cell division. It plays an important role in ensuring the nuclear envelope disappears and reassembles correctly during cell division. Telomeres and the telomerase enzyme are involved in cell aging and linked to increased cancer risk if telomeres are shortened. Stress and anxiety can negatively impact telomere length through emotional responses.
Biologia molecular
Lem4 is a protein that coordinates the activity of kinases and phosphatases on target proteins essential for cell division. It plays an important role in ensuring the nuclear envelope disappears and reassembles correctly during cell division. Telomeres and the telomerase enzyme are involved in cell aging and linked to increased cancer risk if telomeres are shortened. Stress and anxiety can negatively impact telomere length through emotional responses.
Stem cell aging research today for a healthier tomorrow
A resume of the role of stem cells in tissue maintenance ,tissue damage , and the factors affecting stem cell integrity .
STEmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmmm.mmmmmmmmmmmmmmmmM CELL RESEARCH AND THE...
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Regeneration with Dr. David Steenblock
Dr. David Steenblock has been specializing in regenerative medicine for over 40 years. This power point discusses how stem cells can regenerate the body and help you heal. To learn more about stem cell treatments, call 1-800-300-1063.
Aging and animal biotechnology
It is about aging and how aging is tried to controlled by different sort of methods and animals models are used in the testing the products created by science. It explains the different theories of aging in a very detailed manner. And the very least includes different animal models like mouse and monkey on which these treatments are applied and checked the effects of them that how we can control aging. We, can never say that controlling aging is something about that we are becoming immortal it is totally about finding the factors which can reduce tha aging and aging related diseases.
Regenerative Medicine Essay
Regenerative medicine aims to repair damaged organs and tissues using stem cells. Stem cells have the unique ability to renew themselves and differentiate into other cell types. The two main types are embryonic stem cells found in early embryos, and adult stem cells found in tissues like bone marrow. Stem cells are characterized by their ability to self-renew and differentiate. Regenerative medicine uses stem cells to treat diseases like leukemia, Parkinson's, heart disease, and thalassemia. Tissue engineering also plays a role by developing biological substitutes using principles of chemistry, biology, materials science and engineering. Cells used can come from autologous, allogenic, cell line, or xenogenic sources.
Stem cell therapy
This document provides an overview of stem cell therapy and research. It discusses the history of stem cell research from the first bone marrow transplant in 1968 to cloning experiments in the 1990s and 2000s. It defines stem cells as the foundation for organs and tissues that can self-renew and differentiate. Sources of stem cells include embryonic, adult, and induced pluripotent stem cells. Potential uses include treating diseases like diabetes, Parkinson's, and heart disease. However, challenges remain around ethical issues, delivery methods, and preventing tumor growth or rejection.
Biologia molecular
The document discusses cell division and the role of telomeres, p53 pathway, and dynein protein in maintaining proper cell cycle checkpoints and symmetric cell division. It summarizes that telomeres prevent chromosome fraying but shorten with each cell division, and cells can activate telomerase to continue dividing. The p53 pathway normally arrests cells with DNA damage, but loss of this function allows damaged cells to divide uncontrollably and potentially cause cancer. Dynein protein helps correct mistakes in cell division symmetry by driving cell membrane movements. Understanding these processes could help develop treatments for cancer, aging, or diseases caused by cell division errors.
Recent trends in a treatment of diseases by using stem cells
Recent trends in a treatment of diseases by using stem cellsMARTHA SRINIVAS : JOGINPALLY B.R PHARMACY COLLEGE
Stem cells are unspecialized cells that have the potential to develop into many different types of cells. They are vital for development, growth, maintenance, and repair of organs and tissues. There are two main types of stem cells - embryonic stem cells which are derived from embryos, and adult stem cells which are found in tissues. Stem cell research offers promise for treating diseases like diabetes, rheumatoid arthritis, and neurological disorders by regenerating damaged cells and tissues. While stem cell therapies are still being researched, they may provide new treatment opportunities in the future for conditions that currently have limited treatment options.Plegable molecular
The document discusses two scientific studies. The first study found that a specific stage in the cell cycle (G1 phase) being altered can lead to uncontrolled cell growth and cancer development when telomeres are shortened. The second study discovered that after a heart attack in zebrafish, muscle cells from the undamaged atrium migrated into the damaged ventricle and transformed into ventricular cells, helping regenerate the heart tissue and restore cardiac function.
Stem cell technolog
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Martin Pera stem cells and the future of medicine
This document discusses stem cell research and regenerative medicine. It begins by defining regenerative medicine and stem cells. It describes different types of stem cells including tissue stem cells and embryonic stem cells. It discusses some clinical uses of tissue stem cells and limitations. It then covers the discovery of human embryonic stem cells in 1998 and their potential uses and challenges. The rest of the document discusses various stem cell research projects at USC including using stem cells to study disease, induced pluripotent stem cells, and stem cell-based therapies for conditions like macular degeneration and HIV/AIDS.
Evidence that hyperplasia is possible in the aged
The document discusses cardiac growth and aging. It notes that the heart grows through embryogenesis, postnatal development, maturity and senescence in response to physiological and pathological stimuli. Cardiac growth is mediated by developmental programs, mechanical load and growth factors. With aging, the heart undergoes morphological changes including increased wall thickness and arterial stiffness. The number of cardiomyocytes decreases with age due to apoptosis and necrosis. Stem cells have been identified that reside in the heart and give rise to new cardiomyocytes, offering potential regenerative therapies for age-related cardiac changes and disease. The presence of c-kit+ progenitor cells was examined in young and old hearts, finding they expressed c-kit but at lower levels in older hearts.
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- 1. Sandra Viviana Quiroz Restrepo Molecular Biology Teacher: Lina M Martínez UPB Medellín
- 6. In this article we want to prove that inhibition of telomerase that is reactivated when the telomeres become too short, the scientists plan to use this, for cancer treatment, as it was shown to be more effective for combat malignant tumors, avoiding damage to harmless cells.
- 7. During each cycle of cell division, small portions of the ends of chromosomes are lost in DNA replications. When the telomere gets too short, continuous replication of DNA could completely remove the telomeres, giving rise to genomic instability resulting in a deterioration of the cell even lead to death.
- 8. Scientists have thought that telomere length is a key indicator of cancer risk, we have identified links between telomere length and cancer mortality. They found a doubling of cancer death with each decrease of telomere length.
- 9. OBSERVATION
- 11. This news was thought as a possible cure for patients with heart disease •The researchers successfully modified stem cells in the laboratory with PIM-1, a Protein That Promotes cell growth and survival growth, rejuvenation Allowing modified by the activity of cells mother, by the enzyme telomerase Achieved Which extends the length of telomeres.
- 12. • Stem cells can be used to counteract the aging process of cardiac cells caused by degradation of the telomere. •Studies in mice and pigs in their cells with lengthening of telomeres leads to new growth of heart tissue can grow in four weeks
- 13. It is considered as a viable treatment, make a modification heart cells to regenerate heart muscle has been damaged by causes such as ischemia and that also is overgrown. Currently, this patient may be offered stem cell therapies with regenerative potential PIM-1 modification is a significant advance for clinical treatment. "
- 14. OBSERVATION
- 15. MEDICAL UTILITY
- 16. MEDICAL UTILITY These advances in genetic research have brought the opportunity to detect early disease and can also be complemented by prevention.
- 17. MEDICAL UTILITY FIGHTING CANCER BY INHIBITING To discover that over time and that our body is constantly regenerating causes shortening of telomeres size, becoming more susceptible to suffer from cancer. This encourages us some peace when we get older.
- 18. MEDICAL UTILITY AGING HEART CELLS REJUVENATED BY MODIFIED STEM CELLS With the discovery of this new protein PIM-1 and utility of heart cells modify these cells affected mothers, provide a broad spectrum of life, provided a new alternative for the treatment of cardiovascular diseases.
- 19. BIBLIOGRAPHY MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 7. ed. Medellín: UPB. Fac. de Medicina, 2012.68-73 p. -Pal. E. Fighting Cancer by InhibitingTelomerase.ThetripleHelixonline [Internet journal] 2012 Jul [access 12 of July of 2012]. Available: http://triplehelixblog.com/2012/07/fighting-cancer-by- inhibiting-telomerase/ - Khan M. Wallach K. Aging heart cells rejuvenated by modified stem cells. ScienceDaily[Internet journal] 2012 Jul [access 23 of July of 2012].Available: http://www.sciencedaily.com/releases/2012/07/120723 171843.htm
- 20. MEN LOVE TO WONDER. THIS IS THE SEED OF SCIENCE. . Ralph Waldo Emerson