Telomerase inhibition is being explored as a potential cancer treatment. Telomeres protect the ends of chromosomes but shorten with each cell division, eventually causing genomic instability and cell death if they become too short. Cancer cells reactivate telomerase to maintain telomere length and immortality. Scientists hope to use telomerase inhibition to selectively target cancer cells. Research has also shown that modifying stem cells with the PIM-1 protein can rejuvenate aging heart cells by extending telomere length, offering potential regenerative therapies for heart disease. Advances in genetic research may allow for earlier disease detection and prevention.

1. Sandra Viviana Quiroz Restrepo
Molecular Biology
Teacher: Lina M Martínez
UPB
Medellín

6. In this article we want to prove
that inhibition of telomerase
that is reactivated when the
telomeres become too short,
the scientists plan to use this,
for cancer treatment, as it was
shown to be more effective for
combat malignant tumors,
avoiding damage to harmless
cells.

7.  During each cycle of cell division, small portions of
the ends of chromosomes are lost in DNA
replications.
 When the telomere gets too short, continuous
replication of DNA could completely remove the
telomeres, giving rise to genomic instability resulting
in a deterioration of the cell even lead to death.

8.  Scientists have thought that telomere length is a key indicator
of cancer risk, we have identified links between telomere length
and cancer mortality.
They found a doubling of cancer death with each decrease of
telomere length.

9. OBSERVATION

11.  This news was thought as a possible cure for patients with
heart disease
•The researchers successfully
modified stem cells in the
laboratory with PIM-1, a
Protein That Promotes cell
growth and survival growth,
rejuvenation Allowing modified
by the activity of cells mother,
by the enzyme telomerase
Achieved Which extends the
length of telomeres.

12. • Stem cells can be used to
counteract the aging process
of cardiac cells caused by
degradation of the telomere.
•Studies in mice and pigs in
their cells with lengthening
of telomeres leads to new
growth of heart tissue can
grow in four weeks

13.  It is considered as a viable treatment, make a modification
heart cells to regenerate heart muscle has been damaged by
causes such as ischemia and that also is overgrown.
 Currently, this patient may be offered stem cell therapies with
regenerative potential PIM-1 modification is a significant
advance for clinical treatment. "

14. OBSERVATION

15. MEDICAL UTILITY

16. MEDICAL UTILITY
These advances in genetic
research have brought the
opportunity to detect early
disease and can also be
complemented by
prevention.

17. MEDICAL UTILITY
FIGHTING CANCER BY INHIBITING
To discover that over time and that our body is constantly
regenerating causes shortening of telomeres size,
becoming more susceptible to suffer from cancer.
This encourages us some peace when we get older.

18. MEDICAL UTILITY
AGING HEART CELLS REJUVENATED BY
MODIFIED STEM CELLS
 With the discovery of this new protein PIM-1 and utility
of heart cells modify these cells affected mothers,
provide a broad spectrum of life, provided a new
alternative for the treatment of cardiovascular diseases.

19. BIBLIOGRAPHY
 MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 7.
ed. Medellín: UPB. Fac. de Medicina, 2012.68-73 p.
 -Pal. E. Fighting Cancer by
InhibitingTelomerase.ThetripleHelixonline [Internet
journal] 2012 Jul [access 12 of July of 2012]. Available:
http://triplehelixblog.com/2012/07/fighting-cancer-by-
inhibiting-telomerase/
 - Khan M. Wallach K. Aging heart cells rejuvenated by
modified stem cells. ScienceDaily[Internet journal] 2012
Jul [access 23 of July of 2012].Available:
http://www.sciencedaily.com/releases/2012/07/120723
171843.htm

20. MEN LOVE TO WONDER. THIS
IS THE SEED OF SCIENCE.
.
Ralph Waldo Emerson