This document provides information on the chemical composition of cells. It discusses the most common elements in cells, including carbon, oxygen, hydrogen and nitrogen. It also lists important chemical compounds like amino acids, carbohydrates, lipids, nucleic acids and water. Nucleic acids include DNA and RNA, with DNA found in the nucleus and RNA acting as a messenger. The document emphasizes the importance of water as the universal solvent, transport medium and in biochemical reactions.
Intravenous fluid therapy, Resuscitation, Fluid and electrolyte levels in the body, intracellular and extracellular compartments, IV fluid therapy is used to maintain homeostasis, Resuscitation, Routine maintenance, Replacement, Redistribution and Reassessment.
The maintenance functions which are happening inside our body and inside the body of all the living organisms to maintain the living being are life processes.
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1 major chemical composition of living thing [biochemistry]محمود ځاځی
MAJOR CHEMICAL COMPONENTS OF THE LIVING ORGANISMS
Medical Biochemistry
Molecular Principles of Structural Organization of Cells
CHEMICAL COMPOSITION OF LIVING ORGANISMS
In the human organism there are 70 elements of the Periodic Table, which may be divided in four groups:
Macrobiogenic elements (>1%) O, C, N, H, Ca, P.
Oligobiogenic elements (0,1-1%) Na, K, Cl, S, Mg, Fe.
Microbiogenic elements (<0.01%)>50years 45-50%)
the content varies depending on the metabolic processes in the specified tissue (10% in the fat tissue, 65-70% in other tissues, 80% in the blood and kidney)
maintained at the necessary level through intake (2 liters/day) or produced in the metabolic processes (0.3 liters/day)
Distribution:
In the cells (intracellular)
Outside the cells
extracellular fluids (12-16%),
blood plasma (5%),
lymph (2%)
Within closed cavities (intra-cavity water)(1-3%): cerebrospinal fluid, intraocular, pericardial, synovial fluid etc
WATER
Functions:
Dissolution and stabilization of biological molecules and ions in the fluids of the organisms
Heat balance control - uptake, conservation, distribution and release of heat
Transport – supply of nutrients and excretion of waste products
Mechanical (by hydration) – assistance in maintaining intracellular pressure and shape of cells
Structural – forming an interlayer between the polar ends of protein and lipids in biological membranes
Synthetic (anabolic) – substrate in the synthesis of biological compounds
Hydrolytic (catabolic) – substrate in the bond-breaking processes
Energetic (electron donating)
The cell functions are dependent on:
The total amount of intra and extracellular water
Hydration of sub-cellular structures
Aqueous microenvironment of macromolecules
INORGANIC IONS
INORGANIC IONS
Functions
Bioelectric functions – development of potential difference across the cell membrane (neurons, muscle cells)
Osmotic functions – control of osmotic and hydro-osmotic pressure
Structural – metal ions constituents of macromolecules (proteins, heme)
Regulatory – cations exert regulatory action
directly binding to enzymes, influencing their activity and rate of the chemical reactions in the cell, or
Indirectly, influencing the hormonal regulation
Transport –
electrons are transported by the cytochromes, enzymes containing Fe2+ or Fe3+ and Cu2+;
oxygen is bound to Fe2+ in the structure of hemoglobin
Energetic – inorganic phosphate in ATP
Mechanical (support) – Ca and P ions are constituents of bones (strength)
Synthetic – complex molecules contain I- (hormones), SO42- (ester sulfuric compounds)
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The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
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6. Chemical compounds
22 mmaajjoorr ggrroouuppss
in the Cell
•ORGANIC COMPOUND – chemical
compound that contain the element of
Organic
compounds
Inorganic
compounds
•INORGANIC COMPOUND – constitute
non-living matter carbon and & do hydrogen
not contain carbon.
11. Nucleic Acids
• 2 types of nucleic acid:
DNA
(Deoxyribonucleic acid)
RNA
(Ribonucleic acid)
12. DEOXYRIBONUCLEIC ACIDS
(DNA)
It is double stranded polynucleotide.
22 ssttrraannddss twisted aarroouunndd eeaacchh ootthheerr..
IItt wwiillll ffoorrmm double helix (Watson and Crick)
Can be found in nucleus..
Also can be found in chloroplast and
mitochondria..
Contain genetics information that can inherited
from parents to offspring.
13. RIBONUCLEIC AACCIIDD ((RRNNAA))
Found in cytoplasm, ribosome and and
nucleus.
Copies information carries by DNA for use
in protein synthesis (act as messenger)
It is also genetics material in virus.
14. Phosphate group
Pentose sugar
Nitrogenous base
The structure of a nucleotide Structure of DNA
15. The importance of water
in the cell
Most important inorganic chemical
compound.
Makes up 70% of our body.
70 – 90% weight of cell
It is important because its chemical
properties and physical properties.
Present in cell, lymph, blood plasma and
interstitial fluid.
16. Function of water
1) Polar molecule
- Means : molecule with an equal
distribution of charge.
- Have +ve charge end & -ve charge end.
- It attract one another.
- Considered as solvent of life (universal
solvent)
- Can dissolve many ionic compound eg,
salt, sugar
18. 2) Transport medium
- Transport medium in blood, lymphatic,
excretory and digestive system and in
vascular tissues of plants.
- Blood plasma made of 90% water.
- Water dissolve the sugar, amino acids,
and gases.
- All this substances will transport to all
parts of the body.
- Waste product excreted from body
trough urine.
19. 3) Medium for biochemical reactions
- Can occur if there is water
- Example; water use for breaking downs
protein, lipids and sugars in food.
4) Maintenance stable internal environment
- Concentration water & inorganic salt important
maintain osmotic balance.
- For activities & life process in cell.
- Importance in maintaining body temperature.
- Eg; excess heat through perspiration, urination
and defecation.
22. Concept Map
Organic Compound Chemical compounds
in the cell
Nucleic Acid Water
DNA RNA
Polar molecule
Transport medium
Medium
Biochemical reaction
Lubrication
Support
High Cohesion
Buffer
Cooling Agent
Maintenance stable
internal environment
24. Classes of carbohydrate
• simplest sugar
• represent aldehydes or ketones
of from 3-6 carbons in length.
• Glucose "blood sugar"
• Fructose "fruit sugar"
• Galactose the breakdown of
lactose.
1. monosaccharide
glucose
D-glucose
(ring structure)
25. Classes of carbohydrate
2. disaccharide
• made by connecting two simpler molecules.
•the removal of water from between the two molecules
condensation
condensation
Glucose + glucose Maltose + water
hydrolysis
disaccharide
26. Formation ooff ssuuccrroossee (( ccaannee ssuuggaarr))
condensatio
n
hydrolysis
Glucose + fructose sucrose + water
disaccharide
condensation
Glucose + galactose lactose + water
hydrolysis
disaccharide
Formation of lactose ( milk sugar)
Remember !!!! Only maltose and lactose are reducing sugar
while sucrose is non-reducing sugar
30. Amino acids, peptides and protein
• A.a. contains :
1. amino group
2. carboxylic acid
group
3. side chain
gp/R group
31. Amino acids are linked together by
peptide bonds
Polypeptides : peptides ( up to 50 a.a)
protein (longer)
32.
33. Fatty acids and lipids
• Contain :
1. one carboxylic acid
2. with long HC chain
•Are monocarboxylic acids
• Usually contain even number of C atoms
• water insoluble
• E storage
Alkyl gp
Contains
C & H atoms
Carboxyl
O
RCH gp 2 C
OH
34. •unsaturated f.a. = contain double bond
•Saturated f.a = only single bond (saturated with hydrogens!)
•
35. Fatty acids are combined with one glycerol to form a fat
molecule triglycerol
Through a process :esterification/dehydration/condensation