Characterization and Validation of Point Mutation in Breast Cancer 1 (BRCA1) ...paperpublications3
Abstract: Bovine mastitis is a very common and multietiological disease of dairy cattle which leads to huge economic losses to the dairy industry globally. In this study, the bovine breast cancer 1, early onset gene (BRCA1) was taken as a candidate gene for mastitis resistance. Breast cancer 1 (BRCA1) is one of the genes which predispose organism to early-onset breast cancer, and is involved in DNA damage repair, cell cycle regulation, transcriptional regulation, and other important pathways to suppress tumor and maintain genome stability. A total of 120 Sahiwal cattle were selected to characterize the targeted region of intron 6 of BRCA1 gene for polymorphism screening and their association with mastitis. A 321bp PCR fragment of BRCA1 gene encompassing the targeted region of intron 6 was amplified and digested with Hha I to screen for the reported SNPs having significant association with SCS. Genotype analysis using PCR-RFLP revealed a monomorphic banding pattern. Sequencing was also carried out to explore the in silico screened SNPs which are deposited in dbSNP. The result indicates highly conserved sequence in Sahiwal cattle. Therefore, reported as well as in silico SNPs cannot be considered as a universal marker for mastitis in all the breeds. Since, present study has formulated the results based on a relatively small sample; further studies are required to screen these SNPs in large samples.
Assessment of Solid Waste Management among Households in Kaptembwa Location i...paperpublications3
Abstract: Solid waste disposal remains one of the major challenges of urbanization in developed and developing countries. The sanitary state of an area, particularly the sub-urban areas is influenced by waste handling practices by the residents and the measures put in place for safe waste collection and disposal. The objective of this study was to assess disposal mechanisms of solid waste among households in Kaptembwa location in Nakuru West Sub-County. The research adopted social inquiry design where a structured questionnaire was administered to household heads, oral interviews and focus group discussions were also conducted. The unit of analysis was the household selected in four estates. The study population was 400 households and a sample size of 200 households. The selection of the household units for data collection was based on simple random sampling. The data was analyzed using the Statistical Package for the Social Sciences (SPSS) computer software (version 17) and results presented by descriptive statistics (graphs and tables). Inferential statistics was also used to show the relationships between independent and dependent variables. The findings and recommendations of this study provide information not only to the Kaptembwa residents but also residents living in low income of urban and peri-urban areas to adopt best practices in solid waste management to improve environmental quality and enhance the health status by reducing the incidence of disease outbreaks. This can be achieved by the implementation of some key research recommendations which includes use of smart shopping to avoid the excess use of polythene bags, proper sorting and storage of waste, using improvised storage receptacles such as disposable cartons and dust bins as well as engaging the Community Based Organization (CBO) dealing with waste collection, transportation and disposal.
Проект "Зимняя сказка" группа № 4 ГБОУ школа № 64 СП № 2
1. Проект:
«Зимняя сказка».
ПОДГОТОВИЛА И ПРОВЕЛА
ВОСПИТАТЕЛЬ ВТОРОЙ МЛАДШЕЙ ГРУППЫ №4:
ВАРТАНЯН НАРИНЕ ГЕГАМОВНА
ГОСУДАРСТВЕННОЕ БЮДЖЕТНОЕ ОБЩЕОБРАЗОВАТЕЛЬНОЕ УЧРЕЖДЕНИЕ
Г. МОСКВЫ «ШКОЛА № 64»
СТРУКТУРНОЕ ПОДРАЗДЕЛЕНИЕ №2
2. Актуальность:
Ребенок в дошкольном возрасте активно познает мир во всем многообразии. В процессе познания
окружающего он исследует предметы и объекты, их свойства, качества. Он делает много открытий и
создает интересные, порой оригинальные продукты в виде рисунка, стихотворения и т.д.
Развитие творческих способностей детей невозможно без помощи и сотрудничества родителей, где в
результате образуется детско–взрослое общение.
Цель проекта: ознакомление детей с окружающим миром, развитие речи, обогащение словаря,
развитие художественно творческих навыков, физическое развитие детей.
Задачи:
1.Развивать познавательную активность дошкольника,
2.Воспитывать интерес к творчеству, любовь к художественному творчеству.
3. Взаимодействие с семьями воспитанников.
3. Вид проекта: среднесрочный (декабрь – февраль2016 – 2017 год)
Тип проекта: познавательно – творческий
Участники проекта: дети второй младшей группы ( 3-4 года), воспитатели и родители.
Этапы проекта:
1. Подготовительный
1. Изучить, подготовить материал по теме ( беседы с детьми, опыты со снегом).
2. Подобрать детскую художественную литературу для чтения
3. Подобрать дидактические игры.
4. Подобрать музыкальные произведения для разучивания
5. Разобрать памятки, буклеты, для родителей.
2. Организационный этап
1. НОД,
2. Беседа,
3. Опыты со снегом и водой,
4. Чтение художественной литературы,
5. Наблюдение на прогулке,
6. Рассматривание иллюстрации , репродукции картин, фотографии,
7. Дидактические, сюжетно –ролевые , подвижные игры и др.
8. Разучивание стихов, песен.
3.Заключительный этап
1. Выставка совместных работ детей и родителей.
2. Презентация.
