This patient likely has constrictive pericarditis based on the following:
1) Refractory edema despite diuretics suggesting impaired cardiac filling
2) History consistent with an etiology of post-pericarditis from RA
3) Clear lung fields on CXR rule out heart failure as cause of edema
A lecture discussing the role of Echocardiography in the evaluation and management of patients with different types of shock. From cardiogenic to hypovolemic to obstructive and distributive shock. A very useful guide for intensivists, cardiologists and all acute care physicians.
A lecture discussing the role of Echocardiography in the evaluation and management of patients with different types of shock. From cardiogenic to hypovolemic to obstructive and distributive shock. A very useful guide for intensivists, cardiologists and all acute care physicians.
commonly used for medical students, and helpful to use this ppt to study for them, and also a common man can understand very easily what is coarctation of aorta.
commonly used for medical students, and helpful to use this ppt to study for them, and also a common man can understand very easily what is coarctation of aorta.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
2. Jugular venous Pulse
“a” is RA contraction
“c” is bulging of TV
during RV systole.
“x” downward
displacement of TV.
“v” is atrial filling at
systole, TV closed.
“y” is passive atrial
emptying.
4. Jugular Venous Pulse
Prominent “x” descent:
Cardiac tamponade
Constrictive pericarditis
Absent “x” descent:
RV infarction
Prominent “v” wave:
Tricuspid regurgitation
Prominent “y” descent:
Constrictive pericarditis
Slow “y” descent:
TS and RA mixoma.
Absent “y” descent:
Cardiac tamponade
RV infarction
Prominent x and y:
Constrictive pericarditis
Prominent x and absent
y: Cardiac tamponade
Absent x and y: RV
infarct.
5. Questions
1. A 34 year-old patient is on Ma Huang for losing
weight. She presents with shortness of breath.
EKG shows wide complex tachycardia. HR is
140/min. Cannon “a” waves are present.
Cause?
a. Sinus tachycardia with WPW
b. Sinus tachycardia with aberrant conduction
c. Atrial fibrilation with aberrant conduction.
d. Ventricular tachycardia.
6. Murmurs
With inspiration: R side
murmurs increase, L side
decrease.
With standing: HCM and MVP
get louder.
With squatting or passive leg
raising: HCM and MVP
become softer and delayed.
With valsalva: HCM and MVP
get louder and longer.
With amyl nitrite inhalation
(decreases LV cavity): AR, MR
and VSD decrease while those
of HCM and AS increase.
With exercise (hand grip):
HCM and AS decrease.
With standing, valsalva, and
inhalation of amyl nitrited (all
decrease venous return or LV
cavity size): Murmurs of HCM
and MVP increase in intensity.
All others decrease.
With isometric exercise and
squatting (all increase LV
cavity size): Murmur of HCM
is decreased.
With isometric exercise and
valsalva: Murmur of AS is
decreased in intensity.
7. Questions
2. Murmur of which of the following increases with
valsalva and decreases with squatting:
a. Mitral Regurgitation.
b. Hypertrophic cardiomyopathy (HCM)
c. Aortic stenosis
3. What happens to the murmur of AS with
valsalva and hand-grip exercise?
a. Increase, decrease
b. Decrease, decrease
c. Decrease, increase.
9. Questions
A 44 y/o females has history of increasing SOB
with exertion over the last 3 months. PE: Fixed
split S2 with a murmur consistent with TR. Rest
of HPI is unremarkable. CXR: increased LA, RA,
RV and pulmonary circulation. What is the most
likely diagnosis?
a. Mitral regurgitation
b. Aortic stenosis
c. Hypertrophic obstructive cardiomyopathy
d. Atrial septal defect
e. Ventricular septal defect
10. Questions
A Wide splitting of S2 is representative of:
a. Normal sinus rhythm with RBBB.
b. Normal sinus rhythm with LBBB.
c. Hypertrophic cardiomyopathy.
Reversed splitting of S2 occurs in which:
a. ASD
b. RBBB
c. Hypertrophic cardiomyopathy
11. Heart sounds
2nd sound and opening snap of MS are best heard on the
base.
LSB: TR, AR, VSD, HCM
Apex: MR, MS, AS.
Below L clavicle: PS, PDA as continuous.
Radiation to L axila: MR.
Radiation to RSB and carotids: AS
Radiation all over the precordium: VSD
MS: Loud S1, Split S2, opening snap, rumbling diastolic
murmur in apex. Area <2.5 cm, symptoms correlate.
PR: Diastolic, decrescendo at LSB (Graham Steel)
12. Questions
6. A 52 y/o female presents with history of
increasing SOB and LE edema. CXR shows
pulmonary congestion, straightening of left heart
border and Kerle B lines. EKG: sinus
tachycardia with LAE, RBBB. PE: Loud S1,
opening snap and diastolic murmur at the apex,
and SEM in precordium. What is the diagnosis?
a. Aortic insufficiency
b. Mitral stenosis
c. Aortic stenosis
d. Hypertrophic obstructive cardiomyopathy.
13. Questions
7. A 33 y/o pregnant patient in second
trimester has SOB due to MS that is not
responding to medical treatment. ECHO
shows MV of 0.5cm. What is next step:
a. Mitral valvotomy after delivery.
b. Offer pregnancy termination.
c. Mitral valvotomy now.
d. Mitral valve replacement now
15. Questions
A 41 year-old asymptomatic female with
MVP and mitral regurgitation is presented.
An ECHO shows severe MR with EF of
50%. CAD is ruled out. What is your
advice regarding her treatment?
a. Refer for valve replacement.
b. Follow up closely.
c. Begin a diuretic plus ACE-inhibitor.
16. Aortic Stenosis
Aortic Stenosis HCM
Location of
murmur
Apex and R 2nd
intercostal space
radiating to
carotids.
LSB,
With thrill
Not radiating
Second
sound
No component A2 Present A2
Carotid
Pulse
Slowly rising Brisk or bifid
17. Aortic Stenosis
Grades:
Mild: Valve area of >1 cm2 or gradient < 40mmHg.
Moderate: Valve area of 0.75 to 1 cm2 or gradient 40-
70 mmHg.
Severe: Valve area <0.75 cm2 or gradient >70 mmHg.
Surgery: If symptoms. Angina, syncope,
dyspnea, CHF. If not, risk of death 10-20% per
year.
If not suitable for valve replacement
valvuloplasty is alternative.
18. Question
A 71 year-old females has dizzy spells with near
fainting. An echocardiogram shows calcified
aortic valve with area of 0.5cm2. The peak
systolic valve gradient is 90mmHg. She lives
alone and wants everything done for her. What
is the next step?
a. Coronary arteriography
b. ACE-Inhibitor
c. Exercise stress test
d. Exercise program with low dose diuretics
e. Aortic valve replacement
19. Question
A 73 years old patient with R hip fracture, noted
to have a SEM. Echo shows AV area of 0.76cm
and gradient of 50mmHg, normal LV function. Pt
is active and asymptomatic. What is the next
step?
a. Balloon valvuloplasty prior to surgery.
b. Cardiac catheterization.
c. Proceed with hip surgery.
d. Aortic valve replacement before hip surgery.
20. Questions
A 23 y/o male presents to the ER with witnessed
syncope while running to catch a bus. There was
no observed postictal state. At PE brisk carotid
upstroke. SEM 3/6 at LSB with a systolic thrill.
Murmur increase upon standing. What is the
most likeky diagnosis?
a. Rheumatic mitral regurgitation
b. Congenital aortic stenosis
c. Hypertrophic obstructive cardiomyopathy
d. Ebstein’s anomaly
21. DVT/PE prophylaxis
Start before or shortly after surgery.
Total knee replacement minimum duration
is 7 to 10 days with LMWH or warfarin.
Total hip replacement minimum duration is
28-42 days with LMWH or warfarin.
IPC only for patients at high risk of
bleeding.
22. Questions
A patient with PE is in shock. Next step?
a. Thrombolysis
b. Embolectomy
c. Heparin
A 63 year old construction worker with h/o 3
episodes of DVT on coumadin, INR 2.5 comes
again with DVT. What to do?
a. Increase dose of coumadin
b. Add low molecular weigth heparin
c. Greenfield filter
23. PAW=RA=RV=PA
Cardiac
Tamponade
Constrictive
Pericarditis
Right Ventricular
Infarction
Equal Diastolic
Pressures
Present Present Present/Absent
Calcification on X-
Ray, CT/MRI
Absent Present Absent
ECHO Effusion with
diastolic collapse
Thick/calcified
pericardium
Large RV size
EKG Low voltage and
elect. alternans
Low voltage ST elevation on
Right leads
Prominent X Present Present Absent
Prominent Y Absent Present Absent
Pericardial Knock Absent Present Absent
Pulsus Paradoxus Present Absent in 2/3 of pt Absent
Kussmaul sign Absent Present Absent/Present
24. Cardiac Tamponade
Causes: Viral, Metastasis, idiopathic, uremic, trauma,
cardiac rupture, aortic disection.
Features:
Depends on the rapidity of fluid accumulation.
Limited ventricular filling in diastole, absent Y
Low cardiac output, hypotension, tachycardia,
High jugular venous pressure with prominent x descent.
Paradoxical pulse, lungs clear, faint heart sounds
EKG: Electrical alternans, low voltage
Cath: Equalization of pressures (RA, RV, PA, PCWP)
Echocardiogram: RV, RA diastolic collapse, IVC dilation
Treatment: Pericardiocentesis, IV fluids, surgery.
25. Constrictive Pericarditis
Causes: Post acute pericarditis, surgery, trauma, RA, radiation, TB,
cancer, uremia.
Features:
Filling is reduced abruptly because thickened pericardium
Stroke volume is reduced, equalization of pressures.
High jugular venous pressure with prominent x and y descents, as M
shape.
Dip and plateau “square root” sign in L and R ventricular pressures
Pericardial knock, kussmaul’s sign, R and L heart failure.
EKG: Low voltage
ECHO: Rapid decrease in filling velocities, abnormal septum motion,
pericardial thickness in 80% of cases.
Radiology: May have calcification
Treatment: Pericardial resection with mortality 6-20%, diuretics,
sinus rhythm, may resolve within months or after antiinflamatory tx.
26. Restrictive Cardiomyopathy
Causes: Infiltrative, storage and collagen
diseases; radiation, anthracyclins.
Features:
Diastolic dysfunction, pulmonary congestion, may
advance to systolic dysfunction.
Dyspnea, JVD, Kussmaul’s, R side heart failure.
EKG: L or R BBB, L or R VH.
ECHO: LVH, homogeneous, dense walls, No
calcification.
Treatment: Diuretic, stem cell, deferoxamine,
pacemaker.
27. Acute Right Ventricular Infarction
Causes: Inferoposterior infarction
extension.
Features:
High jugular venous pressures, kussmaul
sign, hepatomegaly, hypotension.
Absent x and y.
Cath: Low PAP, low PCWP, High RV EDP.
EKG: ST elevation in RV4.
Echo: Enlarged hypokinetic RV.
28. Question
A 64 year old male with history of RA, presents with 10
month history of refractory severe lower extremity and
scrotal edema, ascitis despite diuretics. CXR with clear
lung fields and small bilateral pleural effusions, calcific
stipping of the cardiac silhouette. CVP has prominent x
and y, with spike and plateau tracing in RV. ECHO
showed normal septum thickness. What is the most
likely diagnosis?
A. Cor Pulmonale
B. Cardiac tamponade
C. Constrictive pericarditis
D. Amyloid cardiomyopathy
29. Question
A 54 year old male one day post-uncomplicated
IWMI. The nurse tells you that patient doesn’t
have complains but the BP is 80/45 and the HR
is 85. The neck veins are noticeable at the
angle of the jaw and the lungs are clear to
auscultation. At exam RR, no S3, no edema.
What to do next?
A. Cardiac catheterization
B. IV dobutamine/lasix
C. Atropine and then temporary pacemaker
D. IV fluids
30. Aortic Aneurysm
Localized >50% diameter increase involving all three
layers of the wall.
Risk factors: Age>60 years, smoking, HTN, dyslipidemia,
family history. If younger, think of Marfan, Ehler-Danlos ,
syphilis, Takayasu’s, trauma, bicuspid valve, aortic
coartation.
Most common in men, 3:1; infrarenal, mostly
asymptomatic, can present with compression symptoms,
distal embolism or rupture.
Surgery if growth more than 0.5cm/year, abdominal >55
mm in men, >45mm in women, ascending aortic >50mm,
and descending >60mm.
Patients with >45mm should have f/u 3 months.
Percutaneous repair is possible for infrarenal.
After surgery, evaluate every 6 months with CT or MRI.
31. Aortic dissection
Diagnosis often delayed owing to failure to consider it as a
possibility.
Risk factors: In younger than 70 years: Turner’s, cocaine, bicuspid
valve, collagen disorders-Marfan, Ehlers Danlos-, aortic coartation.
In older than 70years: HTN, diabetes, vasculitis and preexisting
aortic aneurysm.
Blood pass between lumen and media creating a false lumen.
Stanford A: Ascending aorta. 2:1. Involves aortic arch in 30%, worse
prognosis, surgical emergency. Mortality with surgery 10-30% and
without 50%.
Stanford B: The rest of aorta. Mortality with medical management
10% per year or better. Surgery if occlusion of major branch,
extension of dissection, Marfan. TX: BB, SBP 100-120, avoid
strenous activity, F/u at 3, 6, 12 months.
Presentation: Anterior or posterior CP, AR, MI, pleural or pericardial
effusion, mental status changes; splacnic, renal, LE, spine ischemia.
TEE, CT, MRI
32. Question
An elderly patient has chest pain radiating
to the back. BP is lower in left arm.
Diastolic murmur at LSB. EKG shows ST
depression all over, BP 250/130.
What is the immediate treatment?
a. Thrombolysis
b. Aspirin, lovenox. Abciximab.
c. Metoprolol and NTG or NTP.
d. Nicardipine
33. Question
What test will you do?
A. CT chest w/o contrast
B. MRI chest w/o contrast
C. TTE
D. TEE
Showed aortic dissection of ascending aorta.
Pain has improved. BP is normal. What to do
next?
Take patient for surgery
Continue medical therapy unless rupture or pain.
Wait for few days for patient to stabilize before
surgery.
34. Carotid Artery Disease
Stroke is third leading cause of death.
There are about 1 million strokes/year.
Carotid duplex for all symptomatic, for asymptomatic
with bruits if good candidate for revascularization, or any
going for CABG.
ASA has RRR 16% for fatal stroke and 28% for non fatal
stroke.
ASA is as good as CEA for symptomatic with <50% and
for asymptomatic with <60%.
Extended-release dipyridamole plus ASA superior to ASA
alone for secondary prevention.
Dual therapy as Clopidogrel plus ASA only for recurrent
events despite therapy with ASA. Higher risk of bleed.
35. Question
A patient with recent TIA and ipsilateral 50-
69% carotid stenosis, you will recommend:
A. Atherosclerotic risk factor modification
B. Antiplatelet therapy
C. Carotid endarterectomy
D. Carotid Arterial Stenting
E. A, B and C.
36. Bacterial Endocarditis
The fourth leading cause of life-threatening disease due
to infection.
Low incidence but high mortality.
2 major Duke criteria or 1 and 3 or 5 minor.
CHF occurs on 8-30% of patients.
Systemic embolization happens in up to half of cases, of
those 65% involve CNS.
Perivalvular abscess affect AV in 40%.
TTE has sensitivity of 50-80%
TEE has sensitivity of 95% for vegetations.
Tx: From 2 to 6 weeks.
37. DUKE CRITERIA
1. Positive blood culture for Infective Endocarditis
Typical microorganism on 2 or more blood cultures:
• Viridans streptococci, Streptococcus bovis (gallolyticus), or
HABCEK or • Community-acquired Staphylococcus aureus or
enterococci.
Continuous bacteremia:
• 2 positive cultures drawn >12 hours apart, or • all of 3 or a
majority of 4 separate cultures of blood (with first and last sample
drawn 1 hour apart)
Positive blood culture for CB or IgG titer >1:800.
2. Evidence of endocardial involvement
Positive echocardiogram for IE defined as :
Vegetation or
abscess or
new partial dehiscence of prosthetic valve
New valvular regurgitation (worsening or changing of preexisting
murmur not sufficient)
38. Duke criteria
Minor criteria :
Predisposition: predisposing heart condition or intravenous
drug use
Fever: temperature > 38.0° C (100.4° F)
Vascular phenomena: major arterial emboli, septic pulmonary
infarcts, mycotic aneurysm, intracranial hemorrhage,
conjunctival hemorrhages, and Janeway lesions
Immunologic phenomena: glomerulonephritis, Osler's nodes,
Roth spots and rheumatoid factor
Microbiological evidence: positive blood culture but does not
meet a major criterion as noted above¹ or serological evidence
of active infection with organism consistent with IE
Echocardiographic findings: consistent with IE but do not
meet a major criterion as noted above
¹ Excludes single positive cultures for coagulase-negative staphylococci,
diphtheroids, and organisms that do not commonly cause endocarditis.
39.
40. AB Prophylaxis for BE
Low risk:
Secundum ASD
Innocent murmur
CABG surgery
Pacemaker/ICD
MVP without MR
High risk:
Prosthetic valve
Cyanotic congenital
heart disease
Previous endocarditis
Moderate risk:
All other congenital
heart disease.
Bicuspid aortic valve
Acquired valve
disease
HCM
MVP with MR
41. Surgery Indications in Bacterial
endocarditis
About 20-50% will require surgery.
Hemodinamic instability due to valvular
regurgitation, destruction.
Cardiogenic shock
Perivalvular extension, abscess
Resistant infection
Fungal endocarditis
Vegetation >1cm in diameter
Recurrent distal emboli.
42. Question
A 62 years old patient has had aortic valve
replaced six months ago. He presents with
endocarditis of the valve with findings of
moderate CHF due to regurgitation. He is
treated for CHF and antibiotics are started. He
begins to improve with good response to the
treatment. EKG has new prolonged PR interval.
What is your next step?
A. Continue 2 more weeks with IV AB.
B. Surgery consult for AV reconstruction.
C. Discharge pt with IV AB by HHC.
D. Continue in hospital IV AB until 3 BC are negative.
43. Stress testing
Criteria for a “ Positive Treadmill Exercise Test”:
ST depression of > 0.1 mV (1mm) below the baseline, and lasting longer
than 0.08 msec.
High Risk Ischemic Response
Ischemia induced by low-level exercise* (less than 4 METs or heart rate < 100
bpm or < 70% of age-predicted heart rate) manifested by 1 or more of the
following:
Horizontal or downsloping ST depression > 0.1 mV
ST-segment elevation > 0.1 mV in noninfarct lead
Five or more abnormal leads
Persistent ischemic response >3 minutes after exertion
Typical angina
Exercise-induced decrease in systolic BP by 10 mm Hg
44. Stress testing
Intermediate:
Ischemia induced by moderate-level exercise (4 to 6 METs or HR 100 to 130
bpm (70% to 85% of age-predicted heart rate) with > 1 of the following:
Horizontal or downsloping ST depression > 0.1 mV
Persistent ischemic response greater than 1 to 3 minutes after exertion
Three to 4 abnormal leads
Low
No ischemia or ischemia induced at high-level exercise (> 7 METs or HR > 130
bpm (greater than 85% of age-predicted heart rate)) manifested by:
Horizontal or downsloping ST depression > 0.1 mV
One or 2 abnormal leads
Inadequate test
Inability to reach adequate target workload or heart rate response for age
without an ischemic response. For patients undergoing noncardiac surgery, the
inability to exercise to at least the intermediate-risk level without ischemia
should be considered an inadequate test.
46. Question
A patient with COPD,(having wheezing
and ronchi), and PVD, unable to walk even
one block needs a cardiac stress test.
EKG has RAE. BP is normal. Which one?
A. Dobutamine stress test
B. Exercise echocardiogram
C. Adenosine stress test
D. Exercise electrocardiography
48. Preoperative Evaluation
Risk Stratification Procedure Examples
Vascular (reported cardiac Aortic and other major vascular surgery
risk often > 5%) Peripheral vascular surgery
Intermediate (reported Intraperitoneal and intrathoracic surgery
cardiac risk generally 1%-5%) Carotid endarterectomy
Head and neck surgery Orthopedic
surgery Prostate surgery
Low† (reported cardiac Endoscopic procedures
risk generally <1% Superficial procedure
Cataract surgery Breast surgery
Ambulatory surgery
49. *Active cardiac conditions
Condition Examples
Unstable coronary
syndromes
Unstable or severe angina* (CCS class III or IV)†
Recent MI‡
Decompensated HF NYHA functional class IV;
Worsening or new-onset HF
Significant
arrhythmias
High-grade atrioventricular block
Mobitz II atrioventricular block
Third-degree atrioventricular heart block
Symptomatic ventricular arrhythmias
Supraventricular arrhythmias (including atrial
fibrillation) with uncontrolled ventricular rate (HR >
100 bpm at rest)
Symptomatic bradycardia
Newly recognized ventricular tachycardia
Severe valvular
disease
Severe aortic stenosis (mean pressure gradient
greater than 40 mm Hg, aortic valve area less than 1.0
cm2, or symptomatic)
Symptomatic mitral stenosis (progressive dyspnea
on exertion, exertional presyncope, or HF)
50. Can You… Can You…
1 Met Take care of yourself? 4
Mets
Climb a flight of stairs or
walk up a hill?
Eat, dress, or use the
toilet?
Walk on level ground at 4
mph (6.4 kph)?
Walk indoors around the
house?
Do heavy work around the
house like scrubbing floors
or lifting or moving heavy
furniture?
Walk a block or 2 on level
ground at 2 to 3 mph (3.2
to 4.8 kph)?
Participate in moderate
recreational activities like
golf, bowling, dancing,
doubles tennis, or throwing
a baseball or football?
4 Mets Do light work around the
house like dusting or
washing dishes?
≥ 10
Mets
Participate in strenuous
sports like swimming,
singles tennis, football,
basketball, or skiing?
51. Preoperative Evaluation
Revised Cardiac Risk Index or Clinical Risk Factors
Ischemic heart disease
History of MIAngina
Use of nitroglycerine
Q waves
Congestive heart failure
History of heart failure
Pulmonary edema
Paroxysmal nocturnal dyspnea
Peripheral edema, rales,
S3
History of Stroke or TIA
Diabetes on insulin therapy
Creatinine>2mg/dl.
53. Question
Which of the following is most important
pre-operative cardiac risk factor for non-
cardiac surgical procedures?
A. S4 gallop
B. S3 gallop
C. MI 10 months ago
D. Age over 70 years.
54. Question
A 71 year old male with h/o stable angina,
now needs vascular surgery in the leg.
What is your advice before clearing him for
surgery?
A. Proceed with surgery.
B. Exercise stress test with imaging.
C. Adenosine stress test
D. Avoid surgery
E. Cardiac catheterization
55. Acute Coronary Syndrome
Unstable Angina & NSTEMI
TIMI risk score:
Age 65 years or older
3 or more CAD traditional
risk factors
Documented CAD with
stenosis of 50%
ST segment deviation
2 or more anginal episodes
in the last 24hr
Aspirin use within the last 7
days
Elevated cardiac enzymes
Low risk: 0-2,
Conservative approach
with non-invasive stress
testing
Intermediate risk: 3-4
Initiate glycoprotein
IIb/IIIa inhibitor and early
invasive approach with
angiography
High risk: 5-7 or
persistent pain or
elevated troponin,
angiography
56. Question
A 51 year old patient comes with typical chest
pain, persistent after ASA, nitrates, betablocker,
02, morphine, statin, lovenox, is taken to the
cath, showing proximal LAD 70%, Cx 30%, RCA
30%, normal ejection fraction. What to do next?
CABG
PCI
Add ACEI
Thrombolysis
57. Indications for revascularization
For PCI
Unstable angina failing medical therapy or TIMI 3 or more
Unstable angina in patient with prior revascularization CABG or
PCI
ST elevation MI
Failed thrombolysis
Unable to do thrombolysis
MI complicated by shock, refractory ventricular arrythmia, CHF
or sudden death.
For CABG
Left main disease
2 vessel disease with proximal LAD w (+) ischemia or low EF,
most benefit seen in diabetic patients.
3 vessel disease
58. Thrombolysis
Indications for Tenecteplase: ST elevation >6hr
or continuos pain and elevation up to 12hr or
new LBBB with typical CP. Follow with CP, ST
segment, reperfusion arrythmia, enzymes.
Contraindications to thrombolytic therapy
Any prior intracranial hemorrage
Cerebral vascular lesion
CNS neoplasm
CVA <3 months except within 3 hours
Significant closed head injury <3 months
Active bleeding diathesis
Suspected aortic dissection
59. Question
A 52-year old diabetic patient is subjected
to coronary angiogram because of
persistent unstable angina. It shows 2
vessel disease with EF of 35%. What is
the treatment?
a. PTCA
b. CABG
c. Medical treatment
d. Thrombolysis
60. Question
A 61 y/o male had an uncomplicated anterior MI
over 24 hours ago develop syncope. Telemetry
showed V-tach, requiring electrical
cardioversion. What to do next?
Cardiac catheterization
Electrophysiologic studies
Echocardiography
Holter monitor
Signal-average ECG
61. Question
A diabetic patient has chest pain. Because of
anterior wall MI with ST elevation, TPA and
lovenox are started. Within 30min patient is
feeling better ST-T segment came back to
baseline but tele shows wide complex, NSVT.
What is your next step?
Observation only
Intravenous lidocaine
Emergent cardiac catheterization
Intravenous amiodarone
Electrophysiologic study
62. Complications post-MI
Rupture
Ventricular
Septum
Rupture
Papillary Muscle
Rupture
Myocardial Wall
Timing 2-14 days 2-10 days 2-7 days
Clinical findings Harsh loud
systolic thrill
LLSB
Acute
Pulmonary
edema, MR
murmur
Sudden chest
pain, shock,
JVD, death
New ST elev
Diagnostic
parameter
02 step-up in
RV
Severe MR,
LAE
Electro-
mechanical
dissociation
Management Nitro-
hydralazine
IAB
Surgery
Nitro
IAB
Surgery
Usually no
survival
63. Questions
Patient with IWMI whos BP goes down
from 90/60 to 60/20. Next step?, What is
the problem?
A patient with acute MI, doing well by the
second week after admission. Suddenly
pt goes into acute CHF, and a new thrill at
LLSB if found. What will the
hemodynamic monitoring show?
64. Question
A 64 y/o male with history of uncomplicated
AWMI 4 days ago has suddenly developed
increasing SOB, hypotension, tachycardia, neck
veins are distended, new gallop and a SEM.
PCWP is 34 with a large V-wave. Diagnosis?
Myocardial free-wall rupture
Large pulmonary embolism
Ventricular septal rupture
Ruptured chordae tendineae
Cardiac tamponade
65. Question
A patient with known hypertension, with no past
h/o MI is admitted to CCU with a large Q-wave
acute anterior MI. On the third day he is
suddenly found in shock without any pulse or
BP. EKG reveals new ST segment elevation with
what appears to be sinus rhythm. What is the
diagnosis?
A. Free wall rupture
B. Right Ventricle infarction
C. Papillary muscle rupture
D. Ventricular septal rupture