Cathy Lu discusses principles for designing user interfaces for large data sets. She notes that data is growing exponentially but screens are limited, so UIs must handle limitless data. She advocates for "push not pull" interfaces that proactively surface insights instead of requiring users to manually pull reports. Data visualization should drive insights and decisions. UIs should create "stickiness" by remembering user customizations and recent accesses. Interfaces need to provide both breadth of aggregated data and depth of drill-downs to handle wide and deep data sets. Performance issues are addressed through feedback, asynchronous processing, and on-demand data fetching.