Amino acids are the building blocks of proteins. There are about 300 amino acids that occur in nature, but only 20 are used to build proteins. Each amino acid contains an amino group, a carboxyl group, a hydrogen atom, and a side chain that gives each amino acid its unique properties. At physiological pH, amino acids exist as zwitterions with both a positive and negative charge. The order and types of amino acids linked together determines a protein's structure and function. Amino acids can be classified based on their structure, side chain properties, nutritional needs, and metabolic fate.
This presentation the chemical structure of natural amino acids. It also classifies amino acids according to several criteria e.g., structure (aliphatic, aromatic, and heterocyclic amino acids), reaction (Neutral, acidic and basic amino acids), polarity (polar and nonpolar amino acids), and metabolic fate ( glucogenic, ketogenic and glucoketogenic amino acids)
Chemistry of amino acids with their clinical applicationsrohini sane
A comprehensive presentation on Chemistry of Amino acids with their clinical applications for MBBS , BDS, B Pharm & Biotechnology students to facilitate easy- learning.
Table of Contents
What are Amino Acids?
Properties of Amino acids
Physical Properties
Chemical Properties
Structure of Amino acids
Classification of amino acids on the basis of R-group
Classification of amino acids on the basis of nutrition
Essential amino acids (Nine)
Non-essential amino acids (Eleven)
Classification of amino acids on the basis of the metabolic fate
Functions of Amino acids
- Amino acids are the building blocks of proteins. They contain an amino group, a carboxyl group, an alpha carbon and different side chains attached to the alpha carbon.
- At physiological pH, amino acids exist as zwitterions with both positive and negative charges. There are 20 common amino acids that make up proteins. The order and structure of amino acids determines the structure and function of proteins.
- Amino acids can be classified based on their structure, side chains, nutritional requirements and metabolic fate. Many amino acids are essential and must be obtained through diet. Amino acids play important roles in human health and disease.
It contain more information about Amino acids and their structure. Then , contain both physical and chemical properties. Next Classification of amino acids based on nutritional requirements, based on metabolic fate, Position of NH2 group, etc.,
Amino acids are the building blocks of proteins. There are about 300 amino acids that occur in nature, but only 20 are used to build proteins. Each amino acid contains an amino group, a carboxyl group, a hydrogen atom, and a side chain that gives each amino acid its unique properties. At physiological pH, amino acids exist as zwitterions with both a positive and negative charge. The order and types of amino acids linked together determines a protein's structure and function. Amino acids can be classified based on their structure, side chain properties, nutritional needs, and metabolic fate.
This presentation the chemical structure of natural amino acids. It also classifies amino acids according to several criteria e.g., structure (aliphatic, aromatic, and heterocyclic amino acids), reaction (Neutral, acidic and basic amino acids), polarity (polar and nonpolar amino acids), and metabolic fate ( glucogenic, ketogenic and glucoketogenic amino acids)
Chemistry of amino acids with their clinical applicationsrohini sane
A comprehensive presentation on Chemistry of Amino acids with their clinical applications for MBBS , BDS, B Pharm & Biotechnology students to facilitate easy- learning.
Table of Contents
What are Amino Acids?
Properties of Amino acids
Physical Properties
Chemical Properties
Structure of Amino acids
Classification of amino acids on the basis of R-group
Classification of amino acids on the basis of nutrition
Essential amino acids (Nine)
Non-essential amino acids (Eleven)
Classification of amino acids on the basis of the metabolic fate
Functions of Amino acids
- Amino acids are the building blocks of proteins. They contain an amino group, a carboxyl group, an alpha carbon and different side chains attached to the alpha carbon.
- At physiological pH, amino acids exist as zwitterions with both positive and negative charges. There are 20 common amino acids that make up proteins. The order and structure of amino acids determines the structure and function of proteins.
- Amino acids can be classified based on their structure, side chains, nutritional requirements and metabolic fate. Many amino acids are essential and must be obtained through diet. Amino acids play important roles in human health and disease.
It contain more information about Amino acids and their structure. Then , contain both physical and chemical properties. Next Classification of amino acids based on nutritional requirements, based on metabolic fate, Position of NH2 group, etc.,
Amino acids are the building blocks of proteins. There are 20 standard amino acids that make up proteins. Amino acids have a general structure that includes an amino group, a carboxyl group, and a side chain. They can be classified based on their structure, side chain properties, nutritional requirements, and metabolic fate. Common properties of amino acids include being crystalline solids, existing as zwitterions with an isoelectric point, and having chirality with L and D isomers. Amino acids undergo various reactions due to their amino, carboxyl, and side chain groups.
General structure of amino acid
Specific learning objective (SLO): Amino acid as Ampholytes (acid and base), Zwitter ions.
Classification of amino acid on the basis of side chain, chemical composition, Nutritional Requirement and metabolic fate.
Derived amino acids.
Optical properties of amino acids.
Acid-Base properties and Buffer characteristic.
Biological Important Peptides
Proteins based on nutritional value
The document discusses the basic structure and properties of amino acids. It begins by explaining that amino acids are the building blocks of proteins and there are 20 different amino acids used in protein synthesis. It then describes the common structure of amino acids, including the alpha carbon, amino group, carboxyl group, hydrogen, and variable side chain. The document proceeds to classify and discuss the properties of different amino acids, including their chemical properties, polarity, essential/nonessential status, and effects on metabolism. It concludes by listing the one-letter codes for the 20 standard amino acids used in proteins.
This document provides an overview of amino acids and peptide bonds. It defines amino acids as organic compounds containing amino and carboxyl groups that are the building blocks of proteins. There are 20 standard amino acids that make up proteins in the human body. The document discusses the structures, properties, classifications, and importance of amino acids. It also describes how amino acids bond together via peptide bonds to form polypeptide chains and proteins. Key topics covered include the structures of the 20 standard amino acids, their classification by properties like polarity and essentiality, and chemical reactions involved in identifying amino acids.
This document provides an overview of amino acids and peptide bonds. It defines amino acids as organic compounds containing amino and carboxyl groups that are the building blocks of proteins. There are 20 standard amino acids that make up proteins in the human body. The document discusses the structures, properties, classifications, and importance of amino acids. It also defines peptide bonds as covalent bonds formed between the amino group of one amino acid and the carboxyl group of another amino acid, linking them together in a polypeptide chain. Key reactions and tests for identifying amino acids are also outlined.
Amino acids are the building blocks of proteins. They contain an amino group, a carboxyl group, and a unique side chain. There are 20 standard amino acids used in protein construction. Amino acids can be classified based on the properties of their side chains as nonpolar, polar, or charged. Nonpolar amino acids have hydrophobic side chains and tend to be found in the interior of proteins. Polar and charged amino acids have hydrophilic side chains and are often found on the surface of proteins, where they can form hydrogen bonds and ionic interactions important for protein structure and function.
Amino acids are the building blocks of proteins. There are over 300 amino acids found in nature but only 20 are used in protein construction. Amino acids contain an amino group, a carboxyl group, a hydrogen atom, and a variable side chain. They can be classified based on their chemical, physical, and nutritional properties. Amino acids link together via peptide bonds to form polypeptides and proteins. The difference between peptides and proteins is that peptides contain less than 50 amino acids while proteins contain 50 or more amino acids.
This document discusses amino acids, which are the building blocks of proteins. It covers the basic chemistry, structures, properties and classification of the 20 naturally occurring amino acids. Key points include:
- Amino acids have a central carbon atom bonded to an amino group, a carboxyl group, a hydrogen atom and a side chain that gives each amino acid its unique properties.
- They exist as zwitterions at physiological pH and are amphoteric.
- The 20 amino acids can be classified based on properties like acid/base characteristics, structure of the side chain, and whether they are essential or nonessential to humans.
- Amino acids join together via peptide bonds to form polypeptide
This document discusses amino acids and their properties. It begins by explaining that amino acids are organic compounds that contain amine and carboxyl groups and have different R groups. Proteins are composed of chains of amino acids linked by peptide bonds. There are 20 standard amino acids that are the building blocks of proteins. The document then classifies amino acids based on their R groups and discusses their structures, chemical properties, and roles in the body.
Amino acids structure classification & function by KK Sahu sirKAUSHAL SAHU
This document provides an overview of amino acids, including their structure, classification, properties, and functions. It discusses that amino acids are the building blocks of proteins and there are 20 common amino acids. They are classified based on the composition of their side chains, number of amino and carboxyl groups, and polarity. Key points covered include their amphoteric nature, ionization states, titration curves, essential vs. nonessential amino acids, and roles in biochemical pathways and protein structure.
Amino acids are the building blocks of proteins. There are 20 common amino acids that make up proteins. Each amino acid contains an amino group, a carboxyl group, an alpha carbon, and a unique side chain. At physiological pH, amino acids exist as zwitterions with a positively charged amino group and negatively charged carboxyl group. Amino acids can be classified based on their structure, side chains, nutritional requirements, and metabolic fate. The order and types of amino acids determine a protein's structure and function.
chemistry of amino acid and proteins.pptxSwarupDas67
The document discusses amino acids, which are the building blocks of proteins. It describes that there are 20 primary amino acids that make up protein structures. It classifies amino acids based on their structure, side chain properties, and nutritional requirements. It provides details on the different categories of amino acids, including their structures, properties, and roles in the body. It also discusses how amino acids are named and abbreviated.
- Amino acids are the building blocks of proteins. The 20 common amino acids contain different functional groups like carboxylic acids, amines, and alcohols.
- At physiological pH, amino acids exist as zwitterions with both a positive and negative charge. They can behave as both acids and bases.
- The isoelectric point is the pH at which the amino acid has no net charge as it exists predominantly in its zwitterionic form. Titration curves can be used to determine the pKa values and isoelectric point of an amino acid.
The document provides information on amino acids including their history, classification, structure and properties. It discusses how amino acids were first discovered in 1806 and classified based on nutritional requirements, polarity, metabolic fate and structure. Key points include that amino acids have an amino group and carboxyl group, exist in ionized forms in biological systems, and 20 are used as building blocks of proteins. Their physical properties like solubility, isoelectric point and ability to act as ampholytes are also covered.
Amino acids are biologically important organic compounds composed of amine (-NH2) and carboxylic acid (-COOH) functional groups, along with a side-chain specific to each amino acid. The key elements of an amino acid are carbon, hydrogen, oxygen, and nitrogen, though other elements are found in the side-chains of certain amino acids. About 500 amino acids are known and can be classified in many ways. They can be classified according to the core structural functional groups' locations as alpha- (α-), beta- (β-), gamma- (γ-) or delta- (δ-) amino acids; other categories relate to polarity, pH level, and side-chain group type (aliphatic, acyclic, aromatic, containing hydroxyl or sulfur, etc.). In the form of proteins, amino acids comprise the second-largest component (water is the largest) of human muscles, cells and other tissues.Outside proteins, amino acids perform critical roles in processes such as neurotransmitter transport and biosynthesis.
This document discusses the key properties and functions of amino acids. It begins by explaining that amino acids serve various roles in metabolism as building blocks of proteins and as precursors for other molecules. It then describes the general structure of alpha amino acids, including the carboxyl group, amino group, and side chain. The document emphasizes that most alpha amino acids are chiral compounds that exist in D- and L-configurations, and proteins incorporate only the L-form. It also classifies the 20 standard amino acids based on the properties of their side chains, and notes which are essential for humans. Finally, it outlines the structure of a peptide bond and its implications for protein structure.
Amino acids are the building blocks of proteins. They join together through peptide bonds to form polypeptide chains. There are over 300 amino acids but only 20 are commonly found in mammalian proteins. Amino acids have various roles like forming enzymes, hormones, antibodies and being precursors for other important molecules. They are amphoteric due to possessing both amino and carboxyl groups. Amino acids differ in their physical and chemical properties like color, solubility, isomerism and reactions.
Amino acids are the building blocks of proteins. They join together through peptide bonds to form polypeptide chains. There are over 300 amino acids described in nature but only 20 are commonly found in mammalian proteins. Amino acids have various roles including forming enzymes, hormones, antibodies and being precursors for other important molecules. They are also important for buffering pH changes and participating in metabolic reactions through side chain functional groups.
Amino acids are the building blocks of proteins. There are 20 standard amino acids that make up proteins. Amino acids have a general structure that includes an amino group, a carboxyl group, and a side chain. They can be classified based on their structure, side chain properties, nutritional requirements, and metabolic fate. Common properties of amino acids include being crystalline solids, existing as zwitterions with an isoelectric point, and having chirality with L and D isomers. Amino acids undergo various reactions due to their amino, carboxyl, and side chain groups.
General structure of amino acid
Specific learning objective (SLO): Amino acid as Ampholytes (acid and base), Zwitter ions.
Classification of amino acid on the basis of side chain, chemical composition, Nutritional Requirement and metabolic fate.
Derived amino acids.
Optical properties of amino acids.
Acid-Base properties and Buffer characteristic.
Biological Important Peptides
Proteins based on nutritional value
The document discusses the basic structure and properties of amino acids. It begins by explaining that amino acids are the building blocks of proteins and there are 20 different amino acids used in protein synthesis. It then describes the common structure of amino acids, including the alpha carbon, amino group, carboxyl group, hydrogen, and variable side chain. The document proceeds to classify and discuss the properties of different amino acids, including their chemical properties, polarity, essential/nonessential status, and effects on metabolism. It concludes by listing the one-letter codes for the 20 standard amino acids used in proteins.
This document provides an overview of amino acids and peptide bonds. It defines amino acids as organic compounds containing amino and carboxyl groups that are the building blocks of proteins. There are 20 standard amino acids that make up proteins in the human body. The document discusses the structures, properties, classifications, and importance of amino acids. It also describes how amino acids bond together via peptide bonds to form polypeptide chains and proteins. Key topics covered include the structures of the 20 standard amino acids, their classification by properties like polarity and essentiality, and chemical reactions involved in identifying amino acids.
This document provides an overview of amino acids and peptide bonds. It defines amino acids as organic compounds containing amino and carboxyl groups that are the building blocks of proteins. There are 20 standard amino acids that make up proteins in the human body. The document discusses the structures, properties, classifications, and importance of amino acids. It also defines peptide bonds as covalent bonds formed between the amino group of one amino acid and the carboxyl group of another amino acid, linking them together in a polypeptide chain. Key reactions and tests for identifying amino acids are also outlined.
Amino acids are the building blocks of proteins. They contain an amino group, a carboxyl group, and a unique side chain. There are 20 standard amino acids used in protein construction. Amino acids can be classified based on the properties of their side chains as nonpolar, polar, or charged. Nonpolar amino acids have hydrophobic side chains and tend to be found in the interior of proteins. Polar and charged amino acids have hydrophilic side chains and are often found on the surface of proteins, where they can form hydrogen bonds and ionic interactions important for protein structure and function.
Amino acids are the building blocks of proteins. There are over 300 amino acids found in nature but only 20 are used in protein construction. Amino acids contain an amino group, a carboxyl group, a hydrogen atom, and a variable side chain. They can be classified based on their chemical, physical, and nutritional properties. Amino acids link together via peptide bonds to form polypeptides and proteins. The difference between peptides and proteins is that peptides contain less than 50 amino acids while proteins contain 50 or more amino acids.
This document discusses amino acids, which are the building blocks of proteins. It covers the basic chemistry, structures, properties and classification of the 20 naturally occurring amino acids. Key points include:
- Amino acids have a central carbon atom bonded to an amino group, a carboxyl group, a hydrogen atom and a side chain that gives each amino acid its unique properties.
- They exist as zwitterions at physiological pH and are amphoteric.
- The 20 amino acids can be classified based on properties like acid/base characteristics, structure of the side chain, and whether they are essential or nonessential to humans.
- Amino acids join together via peptide bonds to form polypeptide
This document discusses amino acids and their properties. It begins by explaining that amino acids are organic compounds that contain amine and carboxyl groups and have different R groups. Proteins are composed of chains of amino acids linked by peptide bonds. There are 20 standard amino acids that are the building blocks of proteins. The document then classifies amino acids based on their R groups and discusses their structures, chemical properties, and roles in the body.
Amino acids structure classification & function by KK Sahu sirKAUSHAL SAHU
This document provides an overview of amino acids, including their structure, classification, properties, and functions. It discusses that amino acids are the building blocks of proteins and there are 20 common amino acids. They are classified based on the composition of their side chains, number of amino and carboxyl groups, and polarity. Key points covered include their amphoteric nature, ionization states, titration curves, essential vs. nonessential amino acids, and roles in biochemical pathways and protein structure.
Amino acids are the building blocks of proteins. There are 20 common amino acids that make up proteins. Each amino acid contains an amino group, a carboxyl group, an alpha carbon, and a unique side chain. At physiological pH, amino acids exist as zwitterions with a positively charged amino group and negatively charged carboxyl group. Amino acids can be classified based on their structure, side chains, nutritional requirements, and metabolic fate. The order and types of amino acids determine a protein's structure and function.
chemistry of amino acid and proteins.pptxSwarupDas67
The document discusses amino acids, which are the building blocks of proteins. It describes that there are 20 primary amino acids that make up protein structures. It classifies amino acids based on their structure, side chain properties, and nutritional requirements. It provides details on the different categories of amino acids, including their structures, properties, and roles in the body. It also discusses how amino acids are named and abbreviated.
- Amino acids are the building blocks of proteins. The 20 common amino acids contain different functional groups like carboxylic acids, amines, and alcohols.
- At physiological pH, amino acids exist as zwitterions with both a positive and negative charge. They can behave as both acids and bases.
- The isoelectric point is the pH at which the amino acid has no net charge as it exists predominantly in its zwitterionic form. Titration curves can be used to determine the pKa values and isoelectric point of an amino acid.
The document provides information on amino acids including their history, classification, structure and properties. It discusses how amino acids were first discovered in 1806 and classified based on nutritional requirements, polarity, metabolic fate and structure. Key points include that amino acids have an amino group and carboxyl group, exist in ionized forms in biological systems, and 20 are used as building blocks of proteins. Their physical properties like solubility, isoelectric point and ability to act as ampholytes are also covered.
Amino acids are biologically important organic compounds composed of amine (-NH2) and carboxylic acid (-COOH) functional groups, along with a side-chain specific to each amino acid. The key elements of an amino acid are carbon, hydrogen, oxygen, and nitrogen, though other elements are found in the side-chains of certain amino acids. About 500 amino acids are known and can be classified in many ways. They can be classified according to the core structural functional groups' locations as alpha- (α-), beta- (β-), gamma- (γ-) or delta- (δ-) amino acids; other categories relate to polarity, pH level, and side-chain group type (aliphatic, acyclic, aromatic, containing hydroxyl or sulfur, etc.). In the form of proteins, amino acids comprise the second-largest component (water is the largest) of human muscles, cells and other tissues.Outside proteins, amino acids perform critical roles in processes such as neurotransmitter transport and biosynthesis.
This document discusses the key properties and functions of amino acids. It begins by explaining that amino acids serve various roles in metabolism as building blocks of proteins and as precursors for other molecules. It then describes the general structure of alpha amino acids, including the carboxyl group, amino group, and side chain. The document emphasizes that most alpha amino acids are chiral compounds that exist in D- and L-configurations, and proteins incorporate only the L-form. It also classifies the 20 standard amino acids based on the properties of their side chains, and notes which are essential for humans. Finally, it outlines the structure of a peptide bond and its implications for protein structure.
Amino acids are the building blocks of proteins. They join together through peptide bonds to form polypeptide chains. There are over 300 amino acids but only 20 are commonly found in mammalian proteins. Amino acids have various roles like forming enzymes, hormones, antibodies and being precursors for other important molecules. They are amphoteric due to possessing both amino and carboxyl groups. Amino acids differ in their physical and chemical properties like color, solubility, isomerism and reactions.
Amino acids are the building blocks of proteins. They join together through peptide bonds to form polypeptide chains. There are over 300 amino acids described in nature but only 20 are commonly found in mammalian proteins. Amino acids have various roles including forming enzymes, hormones, antibodies and being precursors for other important molecules. They are also important for buffering pH changes and participating in metabolic reactions through side chain functional groups.
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1. Amino Acids
Amino Acids are the building units of proteins. Proteins are
polymers of amino acids linked together by what is called “
Peptide bond”.
There are about 300 amino acids occur in nature. Only 20
of them occur in proteins. (Standard amino acids)
2. Amino Acids are named mostly on the basis of their sources. (trivial
names)
Asparagine was first found in asparagus, and glutamate in wheat
(gluten).
Naming and numbering of amino acids
3. Each amino acid has 4 different groups attached to α-
carbon (which is C-atom next to COOH). These 4 groups
are :
Amino group
COOH group
Hydrogen atom and side
Chain (R)
R
Amino acids differs in terms of “R” group.
This group affect the nature, solubility and interactions of amino acids.
Structure of amino acids
4.
5. Chiral carbon/asymmetric center
If a carbon atom is bonded to four different groups it is called as the
asymmetric or chiral carbon.
The α-carbon of amino acids is attached to four different chemical
groups is a chiral or optically active carbon atom.
Glycine is the exception.
Chiral carbon Achiral carbon
Optical properties of amino acids
6. Stereoisomers
Chiral carbon can rotate the plane polarized light in to two
directions either in right or to left direction and generate
stereoisomers.
Those amino acids which rotate plane polarized light in
right direction are called dextro-rotatory, dextro = right
(D) and those rotating light in left are levo-rotatory, levo =
left (L).
7. How to write the structure of D and L amino acids???
The reference structure is glyceraldehyde.
Almost all amino acids in human body exist in L-configuration
8. Enantiomers
The stereoisomers which are non-superimposable mirror
images of each other are called enantiomers.
D and L forms of the amino acids are enantiomers.
Chiral carbon
Optical rotation
Stereoisomers
Non-superimposable mirror images
9.
10.
11.
12.
13.
14. Of 20 amino acids two amino acids have sulfur in side chain
Cysteine and Methionine.
What is cystine?
Only Cysteine form disulfide bonds methionine cannot.
15.
16. Some features of neutral amino acids
Only one amino acid has achiral alpha carbon
Glycine
Neutral Sulfur containing amino acids:
Cysteine and Methionine. What is cystine?
Neutral, hydroxyl group containing amino acids:
Serine, Tyrosine and Threonine
Amino acids with amide group in side chain:
They are amide forms of aspartate and glutamate in which side chain
COOH groups are amidated.
17. Amino acids with aromatic side chain
Phenyl alanine: It’s alanine in which one hydrogen of CH3 is
substituted with phenyl group. So it’s called
phenyl alanine
Tyrosine:
Tryptophan: indole ring
Proline is an imino acid not amino acid
18. III- Classification on basis of nutritional value:
1- Essential amino acids: These amino acids can’t be formed in
the body and so, it is essential to be taken in diet. Their deficiency
affects growth, health and protein synthesis.
2- Non essential amino acids: These are the rest of amino acids
that are formed in the body in amount enough for adults and
children. They are the remaining 10 amino acids.
3- Conditionaly essential or semiessential amino acids: These
are formed in the body but not in sufficient amount for body
requirements especially in children.
19. Hydroxylysine and hydroxyproline, are found in the collagen
and gelatin proteins.
γ-Carboxyglutamic acid is the part of blood clotting protein
prothrombin.
N-methyllysine is a constituent of myosin.
Sone amino acids are not the part of proteins???
Ornithine and citrulline act as the intermediates in the urea
cycle
Uncommon amino acids
20. Simple monoamino monocarboxylic amino acid have weak
acidic and weak basic groups within a single molecule.
Some times side chain contain additional ionizable groups which
also act as acid and base.
Acid-Base properties of amino acids
21. Any protonated specie can donate its proton if it is present
in the solution whose pH is either equal to the pKa or
greater than pKa of that specie.
• pKa is an equilibrium constant.
• pH is an indication of hydrogen ion content in a
solution
22. 22
Isoelectric point (pI)
The pH at which the amino acid exists largely in a neutral, zwitterionic
form (amphoteric molecule).
pI = 1/2 (pKa1 + pKa2)
For the simplest amino acid, , pKa1= 2.34 and pKa2 =
9.6, pI = 5.97
23. Titration curve of monoamine and monocarboxylic acid
amino acid
Acid can donate proton when pH of
system becomes equal to or greater than
pKa of acid.
pKa of –COOH = 2.34
pKa of –NH3+ = 9.60
24.
25.
26. Titration curve of amino acids having acidic side chain
pK1 of –COOH = 2.19
pK2 of –NH3+ = 9.67
pKr (side chain -COOH) = 4.25
27. pI =
pKa1 + pKa3
2
pI = 2.7
Isoelectric point (pI) of acidic amino acids
28. Titration curve of amino acids having basic side chain
pK1 of –COOH = 1.82
pK2 of –NH3+ = 9.17
pKr (side chain -NH) = 6.0
29. pI =
pKa2 + pKa3
2
pI = 9.7
Isoelectric point (pI) of basic amino acids
30. Can exist as a positive ion if the solution is more acidic than its pI
Can exist as a negative ion if the solution is more basic than its pI
31. ACIDIC AND BASIC PROPERTIES OF AMINO
ACIDS
• Amino acids in aqueous solution contain weakly
acidic α-carboxyl groups and weakly basic α-amino
groups.
• Thus can act as buffers.
• pH = pKa + log [A-]/[HA]
