1. mêçéÜóä~ñáëI=jÉí~éÜóä~ñáë C=qÜÉê~éó
jÉêá~ä=cçêìã=çå=_oa
PMíÜ ëÉéíÉãÄÉê Ó Nëí çÅíçÄÉê OMNM
`¨ÇêáÅ=abwfbo
cê~åÅÉ=oìãáå~åí=qÉÅÜåáÅ~ä pÉêîáÅÉë

2. ProphylaxisProphylaxis
Healthy animals treated.
No BRD outbreak in the herd...

3. ProphylaxisProphylaxis
Herd management!
Vaccinations!
Antibiotics?

4. WhyWhy BRD &BRD & antibiopreventionantibioprevention inin
the real life?the real life?
Fattening
Breeding herd
Veal
calves

5. FatteningFattening
 France, Assie 2009
 1167 young beef animals
 1083 brought in
 84 born at fattening site
 71 herds
 18,1% morbidity
 1,2% for those born at fattening site
 19,4% for those bought outside

6. FatteningFattening
 Losses analysis
 Mortality (67%)
 Treatment costs
(16%)
 Management costs
(14%)
Losses analysis
0
0,1
0,2
0,3
0,4
0,5
0,6
0,7
0,8
0,9
1
Mortality Treatment
costs
Management
costs

7. BreederBreeder herdherd
 France, Assie 2009
 7496 non-weaned calves
 156 herds
 17% morbidity
 Income impact
 From -2% to -20%

8. BreederBreeder herdherd
 Treatment costs are always minor, regarding zootechnical
losses
 Prevention management & income impact...
Losses analysis and income impact of BRD, depending on the
incidence
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
Low incidence
(22% of herds)
Mild incidence
(17% of herds)
High incidence
(28% of herds)
Severe cases
(12% of herds)
Zootechnical losses
Treatment and
manpower
Income impact

9. VealVeal calvescalves
 3 years survey
 42000 veal calves
 78 herds
Prim’Holstein veals
Bucket AMF All
Respiratory Diseases
Nb of collective treatments
Veals individually treated %
Relapse
Other breed veals
Bucket AMF All
Respiratory Diseases
Nb of collective treatments
Veals individually treated %
Relapse

10. WhateverWhatever thethe breedingbreeding systemsystem isis,,
preventionprevention isis fundamentalfundamental
 Herd management
 Vaccinations
 Antibiotics?
 Only in very specific situations
 Veterinary prescription
 ZACTRAN is the « tool » to avoid
antibioprevention

11. mêçéÜóä~ñáëI=jÉí~éÜóä~ñáë C=qÜÉê~éójÉí~éÜóä~ñáë

12. MetaphylaxisMetaphylaxis
« Healthy » animals treated
because of BRD outbreak on other
animals close to them

13. UsualUsual metaphylaxismetaphylaxis strategystrategy
Curative treatment on sick animals
+
Metaphylactic treatment on at-risk animals

14. TargetedTargeted metaphylaxismetaphylaxis
Curative treatment on sick animals
+
Metaphylactic treatment on a part of at-risk animals
Thanks to extraordinary PK/PD parameters of
ZACTRAN

15. Focus on...Focus on...
Extraordinary PK/PD parameters

16. Gamithromycin concentration in broncho-alveolar cells
0
2
4
6
8
10
12
14
16
18
20
0
1
day
2
days
3
days
4
days
5
days
6
days
7
days
8
days
9
days
10
days
11
days
12
days
13
days
14
days
15
days
Time after injection
µg/ml
MIC90 Mannheimia haemolytica
MIC90 Pasteurella multocida & Histophilus somni
FastFast,, hugehuge concentration*, longconcentration*, long
lasting in thelasting in the heartheart of theof the lunglung
Fast acting
< 30 minutes after one subcutaneous shot
Huge concentration
18 to 36 times the MIC90
Long lasting

17. TargetedTargeted metaphylaxismetaphylaxis
 Deux-Chaises (Allier)
 March-July 09
 Aim
o Assess the efficacy of
ZACTRAN in
metaphylactic and
curative treatments, in
natural conditions

18. FieldField studystudy descriptiondescription
 167 cattle from 8 different sources
 Males and females
 4.5 months to 11 months of age
 188 to 420 kg
 Limousin and Charolais

19. A confortableA confortable housinghousing
 16 pens, 8 on each side of the aisle
 Bedded on straw (deep litter system)
 Straw added every 2-3 days, 3 kg per animal
 Constant level trough
 Water from network (quality controlled water)
This is prophylaxis!

20. AA sanesane housinghousing
 ‘All-in All out’
 Disinfected
 Insecticide, virucidal and bactericidal
This is prophylaxis!

21. AA sanesane feedingfeeding
 Food
 Baled hay on arrival
 Gradual shift towards a mixed ration
based on maize silage + concentrate
(triticale, soybeans, grain corn, beet
pulp, bran, minerals)
 Fed once a day
This is prophylaxis!

22. AA completecomplete preventionprevention
 The farmer manages the cattle as
normal!
 Weighing the day after arrival
 Vaccinations
 RSV, BVD, PI3 , IBR
 Deworming
 Ivomec D
This is prophylaxis!

23. 4 days after arrival4 days after arrival……
 13 clinical cases
 Allocation to 3 groups
 Group 1: 13 clinical cases
 Group 2: 62 animals metaphylaxis
 Group 3: 92 animals monitored and
treated on a case by case basis

24. DecisionDecision criteriacriteria forfor
targetedtargeted metaphylaxismetaphylaxis
 Sick animals (5-10%)
 Body weight < 270 kg
« Farmer’s experience »

25. Groups 2 and 3 : aGroups 2 and 3 : a
pertinentpertinent choicechoice
 Weight is a major BRD risk factor

26. D 0D 0
13 patients13 patients  3 groups of animals3 groups of animals
Group 1Group 1 Group 2Group 2
Group 3Group 3

27. Housing of the 3 groupsHousing of the 3 groups
7 meters

28. 7 meters
DD11
10 patients in Group 310 patients in Group 3

29. 7 meters
DD22
5 patients more in Group 35 patients more in Group 3

30. 7 meters
DD33
4 patients more in Group 34 patients more in Group 3

31. 7 meters
DD66
2 patients more in Group 32 patients more in Group 3

32. 7 meters
DD77
4 patients more in Group 34 patients more in Group 3

33. 7 meters
DD88
1 patient more in Group 31 patient more in Group 3

34. 7 meters
AtAt DD88
26 patients in Group 326 patients in Group 3

35. Complete prevention atComplete prevention at DD+14+14 ...and...and
for thefor the restrest of theof the breedingbreeding timetime
7 meters

36. EconomicalEconomical analysisanalysis of theof the
targetedtargeted metaphylaxismetaphylaxis

37. IndividualIndividual treatmenttreatment costscosts
 Prevention is better than cure... And cheaper
also!
17,63 €3,64 €10,62 + 3,37 = 13,99 €Curative
13,19 €2,57 €10,62 €Metaphylaxis
Global
cost per
present
animal
Manpower
cost per
present
animal
Treatment cost per
present animal
250 kg

38. TargetedTargeted metaphylaxismetaphylaxis
isis profitableprofitable
Treatment cost per present animal
0
2
4
6
8
10
12
14
16
18
0% 5% 10% 15% 20% 25% 30% 35% 40% 45% 50% 55% 60% 65% 70% 75% 80% 85% 90% 95% 100%
Percentage of sick animals in Group 3
€/presentanimal
Global metaphylaxis
Targeted metaphylaxis + curative x%
Targeted metaphylaxis
The curative case-by-case management
is permitted thanks to
ZACTRAN PK/PD parameters

39. ZACTRAN allowsallows a more profitable monitoring ofa more profitable monitoring of
BRDBRD outbreaksoutbreaks inin youngyoung cattlecattle fatteningfattening herdsherds
 The « classical » strategy
 Curative treatment on sick animals
+ Metaphylactic treatment on all the others
 A new strategy thanks to ZACTRAN PK/PD
parameters
 Curative treatment on sick animals
+ Metaphylactic treatment on some* of the others
+ Other animals monitored and treated on a case by case
basis
* Decision criteria
<270 kg body weight for instance

40. mêçéÜóä~ñáëI=jÉí~éÜóä~ñáë C=qÜÉê~éóqÜÉê~éó
Great thanks to
Maurizio Bonfanti

41. TherapyTherapy
Efficiency
Safety
Practicality

42. ItalianItalian fieldfield ssttuuddyy
 Aim
o ZACTRAN vs Tulathromycin in BRD treatment

43. 24 Limousin24 Limousin heifersheifers withwith
severesevere BRDBRD
 Date of arrival: 3 December 08
 Prophylaxis on the first day after arrival
 IBR, PI3 ,BVD, RSV
 Ivomec Plus
 Trial start
 BRD outbreak
 End of the trial
 14 days after treatment
Avanti, avanti...
Porca miseria...
Limousines...

44. 24 Limousin24 Limousin heifersheifers withwith
severesevere BRDBRD
 ZACTRAN group
 13 animals
 258 ± 32 kg
 Tulathromycin group
 11 animals
 259 ± 33 kg

45.  ZACTRAN group
 4/13 relapses
 Tulathromycin group
 9/11 relapses
D1
 ZACTRAN group
 13 animals
 258 ± 32 kg
 Tulathromycin group
 11 animals
 259 ± 33 kg
D2D3D4D5D6D7D8D9D10D11D12D13D14

46. Less reLess re--treatment intreatment in
zactranzactran groupgroup

47. TherapyTherapy
 Excellent results
 In line with many reports from
clinicians
 Profitable
 Less re-treatment
 Less manpower needed

48. ProphylaxisProphylaxis,, metaphylaxismetaphylaxis && TherapyTherapy
 ZACTRAN allows new BRD
management strategies
 Thanks to it’s PK/PD parameters
 Fast acting
 Long lasting
 Huge concentration above MIC
 Curative
 Metaphylaxis
 Profitable thanks to less mortality
 Safety

49. AcknowledgementsAcknowledgements
Andy Forbes
You all here

50. Thanks for your attention
Any questions?