Project outcome and summary or finding of the project - Identification of Drug Targets from Bacterial Genome

1. Chapter - VI Summary
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Identification and Validation of Drug Targets
151
Chapter VI
SUMMARY
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 Comprehensive data mining and review was conducted to devise novel
strategies for genome based drug target identification.
 A web-based application is developed using java applying this strategic
approach for identification of genome based drug targets.
 Using this computational tool, drug targets were identified for a
selected list of 80 pathogenic microbes. A total of 8171 drug targets
were predicted from these 80 pathogenic microbes.
 The predicted targets were analyzed for its functional role using
bioinformatics tools.
 Novel approaches were designed to validate these predicted drug
targets. These predicted targets were validated by comparing with the
existing list of approved /proposed drug targets.
 Data analysis for the Mycobacterium tuberculosis showed 53 drug
targets. Comparison of these 53 targets showed it is highly conserved
among the Mycobacterial group of organisms and only two targets
matched with the approved drug targets from Drug Bank database.

2. Chapter - VI Summary
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Identification and Validation of Drug Targets
152
 These predicted drug targets were organized in a highly intuitive web
based database to promote public research in drug discovery and
development.
 The database was designed using JSP implementing AJAX concepts
for effective querying methods.
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