The Role of Bioinformatics in The Drug Discovery ProcessAdebowale Qazeem
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The Role of Bioinformatics in The Drug Discovery Process, is an undergraduate seminar presentation in the department of Biochemistry, Faculty of life Sciences, University of Ilorin, Ilorin.
The Role of Bioinformatics in The Drug Discovery ProcessAdebowale Qazeem
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The Role of Bioinformatics in The Drug Discovery Process, is an undergraduate seminar presentation in the department of Biochemistry, Faculty of life Sciences, University of Ilorin, Ilorin.
DRUG DESIGN BASED ON BIOINFORMATICS TOOLSNIPER MOHALI
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Drug design is a very complex process it takes many more times but using the these specific tools we can reduce complex process and save the time and produce a effective new drug that will be helpful in heath environment.
Pharmacophore modeling: A continuously evolving tool for computational drug d...Simone Brogi
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In the latest two or three years progressive
applications of pharmacophore modeling continue to appear in literature. Pharmacophore based parallel screening, for instance, has been introduced in 2006. Moreover, in 2008, a survey discussing the prospective impact of virtual screening techniques in the
discovery of bioactive natural products has been published.
Computer-Aided Drug Designing (CADD) is a specialized discipline that uses computational methods to simulate drug-receptor interactions
CADD methods are heavily dependent on bioinformatics tools, applications, and databases
Molecular target and development modelsAmjad Afridi
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Molecular targets are cellular or tissue structures that are intended to be visualized by means of molecular imaging.
Different biological structures can potentially serve as imaging targets.
These Targets ranging from gene mutations, mRNA levels, protein levels, DNA, RNA and enzyme activities.
In silico drug designing is the drug design which can be carried out in silicon chip,i.e., within computers. The slides are helpful to know a brief description about in silico drug designing.
DRUG DESIGN BASED ON BIOINFORMATICS TOOLSNIPER MOHALI
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Drug design is a very complex process it takes many more times but using the these specific tools we can reduce complex process and save the time and produce a effective new drug that will be helpful in heath environment.
Pharmacophore modeling: A continuously evolving tool for computational drug d...Simone Brogi
Â
In the latest two or three years progressive
applications of pharmacophore modeling continue to appear in literature. Pharmacophore based parallel screening, for instance, has been introduced in 2006. Moreover, in 2008, a survey discussing the prospective impact of virtual screening techniques in the
discovery of bioactive natural products has been published.
Computer-Aided Drug Designing (CADD) is a specialized discipline that uses computational methods to simulate drug-receptor interactions
CADD methods are heavily dependent on bioinformatics tools, applications, and databases
Molecular target and development modelsAmjad Afridi
Â
Molecular targets are cellular or tissue structures that are intended to be visualized by means of molecular imaging.
Different biological structures can potentially serve as imaging targets.
These Targets ranging from gene mutations, mRNA levels, protein levels, DNA, RNA and enzyme activities.
In silico drug designing is the drug design which can be carried out in silicon chip,i.e., within computers. The slides are helpful to know a brief description about in silico drug designing.
Computer-aided design (CAD) is the use of computers (or workstations) to aid in the creation, modification, analysis, or optimization of a design: 3  This software is used to increase the productivity of the designer, improve the quality of design, improve communications through documentation, and to create a database for manufacturing: 4  Designs made through CAD software are helpful in protecting products and inventions when used in patent applications. CAD output is often in the form of electronic files for print, machining, or other manufacturing operations. The terms computer-aided drafting (CAD) and computer-aided design and drafting (CADD) are also used
In spite of extensive effort by industry and academia to develop new drugs, there are still several diseases that are in need of therapeutic agents and have yet to be developed.
10 years the identification rate of disease-associated targets has been higher than the therapeutics identification rate.
Nevertheless, it is apparent that computational tools provide high hopes that many of the diseases under investigation can be brought under control.
Provide statistical and computational tools for biologically based activities such as genetic analysis, measurement of gene expression, and gene function determination. Develop software or applications for scientific or technical use.
Explore new Frontiers in Medicine with AI (2).pdfNeomatician
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Welcome to the future of drug discovery and development! Artificial Intelligence (AI) is transforming the landscape of pharmaceutical research, particularly in drug repurposing. This brochure guides you through the ways AI is revolutionizing the process and contributing to the discovery of new therapeutic applications for existing drugs.
Explore new Frontiers in Medicine with AI.pdfAnne Marie
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Welcome to the future of drug discovery and development! Artificial Intelligence is transforming the landscape of pharmaceutical research, particularly in drug repurposing. This video guides you through the ways Artificial Intelligence is revolutionizing the process and contributing to the discovery of new therapeutic applications for existing drugs.
Computer Added Drug Design is one of the latest technology of medicine world. This short slide will help you to know a little about CADD.If you want to know a vast plz go throw the reference book.
Objective of the presentation:
• To give clue about recent applications that are added to
pharmaceutical industry
Introduction
• Biotechnology is a broad field that can be incorporate into agriculture,
industry, environment, food science, and pharmaceuticals. • Pharmaceutical companies use biotechnology in the advancement of
humankind in terms of healthcare such as: âś“ Manufacturing drugs
âś“ Vaccinations
âś“ Pharmacogenomics*
âś“ Gene therapy
âś“ and Others
*Pharmacogenomics, also known as pharmacogenetics, is the study of an individual’s genes and how it responds to certain medicines.
A vaccine is a biological preparation to establish a type of immunity known as artificial active immunity to a particular disease.
The main objective used to improve immunity, the antigen is known as a vaccine
Introduction cont…
25 January 2023
4 • There are various classes of biotechnology based products that are produced
for the treatment or prevention of different pathological conditions like ➢ Growth factors
➢ Hormones
➢ Vaccines and
➢ Monoclonal antibodies
➢ Antibiotics
➢ Blood factors
➢ Cytokines
➢ Enzymes
âś“In the future, biopharmaceuticals may be used against the AIDS, different
types of cancer, asthma, Parkinson’s and Alzheimer’s disease
Introduction conti…
25 January 2023
5 • The conventional pharmaceutical formulations are relatively simple
molecules manufactured mainly through
• trial and error technique for treating the symptoms of a disease or illness. • Since recent biotechnology applications are incorporated into
pharmaceutical companies
• This trial and error technique has been overtaken and production of
biopharmaceuticals are oversimplified.
6
Introduction cont…
• Some of the recent applications in pharmaceutical biotechnology are listed below:
1. High - Throughput Screening
2. In Silico Pharmacology
3. Microarray Technology
4. Chemical Proteomics
5. HTP RNAi Screening
6. Nanotechnology
❖ OTHERS…
25 January 2023
The primary purpose of screening is to identify members of a chemical library that interact in a defined way with a selected system
25 January 2023
7 • HTS, as the name indicates, is a drug discovery process that enables a
biochemical or cellular event to be reproducibly and rapidly tested against
chemical entities many hundreds of thousands of times. • HTS utilizes robotics, liquid handlers, data processing, considerable software,
and sensitive detection systems,
â–Ş To quickly conduct vast numbers of biochemical, genetic, or
pharmacological tests
1. High - Throughput Screening (HTS)
8
HTS cont…
• The objective of HTS is to rapidly identify active compounds (hits) that
modulate a particular target, pathway, or biochemical/cellular event. • These are used as starting points for medicinal chemical optimization
during pharmacological probe or
LF Energy Webinar: Electrical Grid Modelling and Simulation Through PowSyBl -...DanBrown980551
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Do you want to learn how to model and simulate an electrical network from scratch in under an hour?
Then welcome to this PowSyBl workshop, hosted by Rte, the French Transmission System Operator (TSO)!
During the webinar, you will discover the PowSyBl ecosystem as well as handle and study an electrical network through an interactive Python notebook.
PowSyBl is an open source project hosted by LF Energy, which offers a comprehensive set of features for electrical grid modelling and simulation. Among other advanced features, PowSyBl provides:
- A fully editable and extendable library for grid component modelling;
- Visualization tools to display your network;
- Grid simulation tools, such as power flows, security analyses (with or without remedial actions) and sensitivity analyses;
The framework is mostly written in Java, with a Python binding so that Python developers can access PowSyBl functionalities as well.
What you will learn during the webinar:
- For beginners: discover PowSyBl's functionalities through a quick general presentation and the notebook, without needing any expert coding skills;
- For advanced developers: master the skills to efficiently apply PowSyBl functionalities to your real-world scenarios.
Kubernetes & AI - Beauty and the Beast !?! @KCD Istanbul 2024Tobias Schneck
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As AI technology is pushing into IT I was wondering myself, as an “infrastructure container kubernetes guy”, how get this fancy AI technology get managed from an infrastructure operational view? Is it possible to apply our lovely cloud native principals as well? What benefit’s both technologies could bring to each other?
Let me take this questions and provide you a short journey through existing deployment models and use cases for AI software. On practical examples, we discuss what cloud/on-premise strategy we may need for applying it to our own infrastructure to get it to work from an enterprise perspective. I want to give an overview about infrastructure requirements and technologies, what could be beneficial or limiting your AI use cases in an enterprise environment. An interactive Demo will give you some insides, what approaches I got already working for real.
Let's dive deeper into the world of ODC! Ricardo Alves (OutSystems) will join us to tell all about the new Data Fabric. After that, Sezen de Bruijn (OutSystems) will get into the details on how to best design a sturdy architecture within ODC.
Slack (or Teams) Automation for Bonterra Impact Management (fka Social Soluti...Jeffrey Haguewood
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Sidekick Solutions uses Bonterra Impact Management (fka Social Solutions Apricot) and automation solutions to integrate data for business workflows.
We believe integration and automation are essential to user experience and the promise of efficient work through technology. Automation is the critical ingredient to realizing that full vision. We develop integration products and services for Bonterra Case Management software to support the deployment of automations for a variety of use cases.
This video focuses on the notifications, alerts, and approval requests using Slack for Bonterra Impact Management. The solutions covered in this webinar can also be deployed for Microsoft Teams.
Interested in deploying notification automations for Bonterra Impact Management? Contact us at sales@sidekicksolutionsllc.com to discuss next steps.
GDG Cloud Southlake #33: Boule & Rebala: Effective AppSec in SDLC using Deplo...James Anderson
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Effective Application Security in Software Delivery lifecycle using Deployment Firewall and DBOM
The modern software delivery process (or the CI/CD process) includes many tools, distributed teams, open-source code, and cloud platforms. Constant focus on speed to release software to market, along with the traditional slow and manual security checks has caused gaps in continuous security as an important piece in the software supply chain. Today organizations feel more susceptible to external and internal cyber threats due to the vast attack surface in their applications supply chain and the lack of end-to-end governance and risk management.
The software team must secure its software delivery process to avoid vulnerability and security breaches. This needs to be achieved with existing tool chains and without extensive rework of the delivery processes. This talk will present strategies and techniques for providing visibility into the true risk of the existing vulnerabilities, preventing the introduction of security issues in the software, resolving vulnerabilities in production environments quickly, and capturing the deployment bill of materials (DBOM).
Speakers:
Bob Boule
Robert Boule is a technology enthusiast with PASSION for technology and making things work along with a knack for helping others understand how things work. He comes with around 20 years of solution engineering experience in application security, software continuous delivery, and SaaS platforms. He is known for his dynamic presentations in CI/CD and application security integrated in software delivery lifecycle.
Gopinath Rebala
Gopinath Rebala is the CTO of OpsMx, where he has overall responsibility for the machine learning and data processing architectures for Secure Software Delivery. Gopi also has a strong connection with our customers, leading design and architecture for strategic implementations. Gopi is a frequent speaker and well-known leader in continuous delivery and integrating security into software delivery.
The Art of the Pitch: WordPress Relationships and SalesLaura Byrne
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Clients don’t know what they don’t know. What web solutions are right for them? How does WordPress come into the picture? How do you make sure you understand scope and timeline? What do you do if sometime changes?
All these questions and more will be explored as we talk about matching clients’ needs with what your agency offers without pulling teeth or pulling your hair out. Practical tips, and strategies for successful relationship building that leads to closing the deal.
Search and Society: Reimagining Information Access for Radical FuturesBhaskar Mitra
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The field of Information retrieval (IR) is currently undergoing a transformative shift, at least partly due to the emerging applications of generative AI to information access. In this talk, we will deliberate on the sociotechnical implications of generative AI for information access. We will argue that there is both a critical necessity and an exciting opportunity for the IR community to re-center our research agendas on societal needs while dismantling the artificial separation between the work on fairness, accountability, transparency, and ethics in IR and the rest of IR research. Instead of adopting a reactionary strategy of trying to mitigate potential social harms from emerging technologies, the community should aim to proactively set the research agenda for the kinds of systems we should build inspired by diverse explicitly stated sociotechnical imaginaries. The sociotechnical imaginaries that underpin the design and development of information access technologies needs to be explicitly articulated, and we need to develop theories of change in context of these diverse perspectives. Our guiding future imaginaries must be informed by other academic fields, such as democratic theory and critical theory, and should be co-developed with social science scholars, legal scholars, civil rights and social justice activists, and artists, among others.
GraphRAG is All You need? LLM & Knowledge GraphGuy Korland
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Guy Korland, CEO and Co-founder of FalkorDB, will review two articles on the integration of language models with knowledge graphs.
1. Unifying Large Language Models and Knowledge Graphs: A Roadmap.
https://arxiv.org/abs/2306.08302
2. Microsoft Research's GraphRAG paper and a review paper on various uses of knowledge graphs:
https://www.microsoft.com/en-us/research/blog/graphrag-unlocking-llm-discovery-on-narrative-private-data/
UiPath Test Automation using UiPath Test Suite series, part 3DianaGray10
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Welcome to UiPath Test Automation using UiPath Test Suite series part 3. In this session, we will cover desktop automation along with UI automation.
Topics covered:
UI automation Introduction,
UI automation Sample
Desktop automation flow
Pradeep Chinnala, Senior Consultant Automation Developer @WonderBotz and UiPath MVP
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
PHP Frameworks: I want to break free (IPC Berlin 2024)Ralf Eggert
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In this presentation, we examine the challenges and limitations of relying too heavily on PHP frameworks in web development. We discuss the history of PHP and its frameworks to understand how this dependence has evolved. The focus will be on providing concrete tips and strategies to reduce reliance on these frameworks, based on real-world examples and practical considerations. The goal is to equip developers with the skills and knowledge to create more flexible and future-proof web applications. We'll explore the importance of maintaining autonomy in a rapidly changing tech landscape and how to make informed decisions in PHP development.
This talk is aimed at encouraging a more independent approach to using PHP frameworks, moving towards a more flexible and future-proof approach to PHP development.
1. APPLICATIONS OF BIOINFORMATICS IN DRUG DISCOVERY AND PROCESS RESEARCH Dr. Basavaraj K. Nanjwade M.Pharm., Ph.D Associate Professor Department of Pharmaceutics JN Medical College KLE University, Belgaum- 590010 20/03/2008 Dept. of Pharmaceutics