This document discusses sociocultural responses to HIV/AIDS in Africa from the perspective of an expert in Senegal. It notes some progress made in reducing HIV prevalence, increasing access to treatment, and prevention of mother-to-child transmission, but that more rapid prevention efforts are still needed. It examines how culture and biomedical research can be better integrated, cultural concepts that could inform youth education, and social networks and concepts that could support women and vulnerable groups. Communication challenges and opportunities to build on social capital and cultural heritage for HIV prevention are also discussed.