Sciatica is a form of lower back pain caused by compression or irritation of the sciatic nerve, which runs from the lower back through the back of each leg. It causes pain, numbness, or tingling in the back of the thighs and legs. Sciatica is commonly caused by herniated discs in the spine pressing on the sciatic nerve and can also be due to spinal stenosis, spondylosis, or piriformis syndrome. Diagnosis is based on symptoms and physical exam maneuvers like the straight leg raise test. Treatment involves pain medication, physical therapy, injections, or surgery depending on severity. Preventive measures include maintaining good posture and back health through exercise and proper lifting techniques.