DiGeorge syndrome is caused by a deletion on chromosome 22 which disrupts normal development. It is characterized by hyperparathyroidism which causes high thyroid hormones, congenital heart defects which impair blood flow, and cleft lip and/or palate. Other symptoms include poor circulation seen as a bluish skin tone, failure to gain weight, weakness, and muscle issues. The genetic mutation is usually a deletion of part of chromosome 22, removing around 3 million nucleotides and genes. This deletion leads to changes in mRNA and proteins that alter cellular functions. DiGeorge syndrome has a 50% chance of being inherited and affecting each generation.