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Werner syndrome

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Werner syndrome

  1. 1. Werner SyndromeEalish J EllisApril, 2012
  2. 2. Werner Syndrome: What Is It?-Werner Syndrome is a mutation of the WRN gene.-The WRN gene is a helicase enzyme which separates and unwindsdouble stranded DNA, which is necessary for DNA to be copied for celldivision.-It is also responsible for making the blue print of a gene for proteinproduction.-Lastly, it’s also believed to play a role in repairing DNA.
  3. 3. Werner Syndrome: What it does?✤ Werner Syndrome is a genetic disease which causes rapid aging.✤ A person who has this disease will age normally until puberty at that point the speed of aging will increase.✤ As seen in the opening slide a person who has aged ten years can look as though they’ve aged 25years.✤ Werner Syndrome also raises a persons chances of getting cancer.
  4. 4. Werner Syndrome: How you get it?✤ To inherit Werner Syndrome both copies of the WRN gene in the cells must be mutated.✤ When inherited, each parent carries one copy of the mutated gene.✤ Typically, parents will show no signs.
  5. 5. Werner Syndrome: The Numbers✤ In the United States, an estimated 1 in 200,000 individuals are affected by Werner Syndrome.✤ In Japan the syndrome is much more common affecting an estimated 1 in 20,000 to 1 in 40,000 individuals.
  6. 6. Werner Syndrome: Signs and Symptoms✤ A person with Werner Syndrome will show signs if the disease in their teenage years.✤ They typically will not experience a growth spurt during their teen years.✤ Their signs of aging such as gray hair and hair loss will occur in their 20’s.✤ In their 30’s things that may occur are cataracts, type 2 diabetes, and osteoporosis.
  7. 7. Werner Syndrome: The End✤ The most common cause of death for people diagnosed with Werner Syndrome is cancer or heart attack.✤ The life expectancy is average of 48 years.
  8. 8. Guess Her Age
  9. 9. Guess Her Age13
  10. 10. Guess Her Age
  11. 11. Guess Her Age21
  12. 12. Guess Her Age
  13. 13. Guess Her Age48
  14. 14. Guess Her Age
  15. 15. Guess Her Age 56
  16. 16. These are the effects of Werner Syndrome
  17. 17. Citations✤ "Werner Syndrome." - Genetics Home Reference. Web. 27 Mar. 2012. <http://ghr.nlm.nih.gov/condition/werner-syndrome>.✤ "Werner Syndrome ATP-dependent Helicase." Wikipedia. Wikimedia Foundation, 27 Mar. 2012. Web. 27 Mar. 2012. <http://en.wikipedia.org/ wiki/Werner_syndrome_ATP-dependent_helicase>.✤ "Werner Syndrome | Cancer.Net." Doctor-approved Cancer Information from ASCO. Web. 27 Mar. 2012. <http://www.cancer.net/patient/Cancer Types/Werner Syndrome>.

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