Werner Syndrome: What Is It?-Werner Syndrome is a mutation of the WRN gene.-The WRN gene is a helicase enzyme which separates and unwindsdouble stranded DNA, which is necessary for DNA to be copied for celldivision.-It is also responsible for making the blue print of a gene for proteinproduction.-Lastly, it’s also believed to play a role in repairing DNA.
Werner Syndrome: What it does?✤ Werner Syndrome is a genetic disease which causes rapid aging.✤ A person who has this disease will age normally until puberty at that point the speed of aging will increase.✤ As seen in the opening slide a person who has aged ten years can look as though they’ve aged 25years.✤ Werner Syndrome also raises a persons chances of getting cancer.
Werner Syndrome: How you get it?✤ To inherit Werner Syndrome both copies of the WRN gene in the cells must be mutated.✤ When inherited, each parent carries one copy of the mutated gene.✤ Typically, parents will show no signs.
Werner Syndrome: The Numbers✤ In the United States, an estimated 1 in 200,000 individuals are affected by Werner Syndrome.✤ In Japan the syndrome is much more common affecting an estimated 1 in 20,000 to 1 in 40,000 individuals.
Werner Syndrome: Signs and Symptoms✤ A person with Werner Syndrome will show signs if the disease in their teenage years.✤ They typically will not experience a growth spurt during their teen years.✤ Their signs of aging such as gray hair and hair loss will occur in their 20’s.✤ In their 30’s things that may occur are cataracts, type 2 diabetes, and osteoporosis.
Werner Syndrome: The End✤ The most common cause of death for people diagnosed with Werner Syndrome is cancer or heart attack.✤ The life expectancy is average of 48 years.
Citations✤ "Werner Syndrome." - Genetics Home Reference. Web. 27 Mar. 2012. <http://ghr.nlm.nih.gov/condition/werner-syndrome>.✤ "Werner Syndrome ATP-dependent Helicase." Wikipedia. Wikimedia Foundation, 27 Mar. 2012. Web. 27 Mar. 2012. <http://en.wikipedia.org/ wiki/Werner_syndrome_ATP-dependent_helicase>.✤ "Werner Syndrome | Cancer.Net." Doctor-approved Cancer Information from ASCO. Web. 27 Mar. 2012. <http://www.cancer.net/patient/Cancer Types/Werner Syndrome>.