AMINO ACID METABOLISM

1. STUDY MATERIAL
ON
AMINO ACID METABOLISM
Presented By:
Ms. Sayali Dilip Powar
(M. Pharm )
Department of Pharmaceutical Chemistry,
@ Tatyasaheb Kore College of Pharmacy,
Warananagar
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2. General reactions of amino acid metabolism:
Transamination, deamination & decarboxylation, urea
cycle and its disorders
Catabolism of phenylalanine and tyrosine and their
metabolic disorders (Phenyketonuria, Albinism,
alkeptonuria, tyrosinemia)
Synthesis and significance of biological substances; 5-
HT, melatonin, dopamine, noradrenaline, adrenaline
Catabolism of heme; hyperbilirubinemia and jaundice
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3. Catabolism of Heme
• METABOLISM
• CATABOLISM
• ANABOLISM
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11. INTRODUCTION TO CATABOLISM OF
HEME
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13. HEME FUNCTIONS
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14. Catabolism of heme
• Hemoglobin  Heme
• Heme  Biliverdin by “Heme oxygenase”
• Biliverdin  Bilirubin by “Biliverdin reductase”
• Bilirubin  Bilirubin diglucuronide by “Bilirubin
glucuronyltransferase”
• Bilirubin diglucuronide  Urobilinogen by “Microbial
enzymes”
• Urobilinogen  Urobilin (To urine)
• Urobilinogen  Stercobilin (To feces)

15. BLOOD CELLS
Hemoglobin
Heme
INTESTINE AND KIDNEY
Urobilinogen
Urobilin
Excreted in Urine
Stercobilin
Excreted in Feces
Biliverdin
Bilirubin
LIVER
Bilirubin diglucuronide
Bilirubin

16. Catabolism of heme
• Bilirubin is a bile pigment, and is the excretory
end product of heme degradation.

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