This document discusses nutraceuticals and their health benefits. It defines nutraceuticals as foods or food components that provide medical or health benefits, including the prevention and treatment of disease. Some key points include: - Nutraceuticals include probiotics, prebiotics, antioxidants, herbs, and other functional food components. They are associated with preventing major diseases like heart disease, cancer, hypertension and diabetes. - Nutraceuticals are preferred over pharmaceuticals due to being natural, less toxic substances that consumers believe are safer. They are also seen as helping to reduce healthcare costs. - The document outlines various categories of nutraceuticals and provides examples of components and their health functions

1. Nutraceutical’s
let food be your medicine…
Presented By- Ganesh Singh Bhakuni
m.Pharm (p’cology)
ISCP Moga.
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2. Content’s
Introduction
Dietary supplemants
Probiotics
prebiotics
antioxidants
Herbal medicines
Advantage of nutraceutical
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3. INTRODUCTION
 The term “Nutraceutical” was coined from “Nutrition”
“Pharmaceutical” in 1989 by Stephen DeFelice MD, Founder
and Chairman of the Foundation for Innovation in Medicine
(FIM).
“Nutraceutical is any substance that is a food or apart of
food and provides medical or health benefits, including the
prevention and treatment of disease” or promotion of health.
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4.  The nutraceutical’s are associated with the prevention or
treatment of four major diseases like heart disease ,cancer
hypertension and diabetes.
Pharmaceuticals are substances which have (or have had)
patent protection as a result of expensive testing to conform to
the specifications of respective Governments.
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5.  However, many nutrients may never receive government
approval since no one could justify the expense of testing
requirements for substances that cannot be protected by
patent laws. Both pharmaceuticals and nutrients can cure and
prevent disease(s) but only pharmaceuticals have
governmental sanction.
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6. Disease
treatment
Health
benefit
DRUG
NUTRACEUTICAL
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PREVENTION

7. Advantage of nutraceuticals
 Nutraceutical have the potential to play a role in healthy eating
and to contribute to the prevention and treatment of diseases so
that how functional components in foods could expand the role of
disease prevention and treatment.
The nutraceuticals are preferred due to-
Since new molecule is difficult to discover and more expensive
and risky then ever before, many pharmaceutical companies are
now trying to nutraceuticals so that there is undoubtedly a very
huge and growing market .
The belief among consumers that these “food like substances” are
either harmless or least toxic as compared to conventional
pharmaceuticals .
Increased healthcare costs with conventional pharmaceuticals,
recent legislation and scientific discoveries. 7

8. Inappropriate dietary habits are seen as contributing to the
leading cause of deaths of due to coronary heart disease, certain
type of cancers etc. the role of nutraceuticals in treating these
Conditions is thus speculated.
Nutraceuticals are gaining popularity as people are relying on
them for safeguarding their health and avoiding side effects
associated with drugs as well Long history of use and better
patient tolerance as well as public acceptance Plants constitute to
be a major source of new lead generation
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9. CATEGORIES
DIETARY SUPPLEMENTS Probiotics, Prebiotics, Antioxidants, Enzymes,
etc.
HERBAL/ PHYTOCHEMICALS Herbs or Botanical products.
NUTRIENTS Vitamins, Minerals, Amino Acids, Fatty acids,
etc.
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10. probiotic
Probiotics are live microbial food ingredients, which are beneficial
to health.Colon is the most densely populated region of the
gastrointestinal tract and harbors an estimated 500 different
bacterial species.
Probiotic bacterial species
The various types of bacteria that are having the probiotics
characteristics are-
Lactobacilli
Lactobacillus rhamnosus
Lactobacillus reuteri
Lactobacillus case
Bifidobacterium breve
Streptococcus
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11. Prebiotics are the substances, which reach to colon in intact form
i.e. without getting depleted by the gastric pH and digestive acids.
These prebiotics also selectively promote the growth of colonel
probiotic bacteria; hence they act as fertilizers for these bacteria.
These are collective term for non-digestive but a fermentable
dietary carbohydrate that may selectively stimulates growth of
certain bacterial groups’ resident in the colon, such as
Bifidobacteria, Lactobacilli considered to be beneficial for the
human host.
inulin, which is soluble dietary fibres and resistant to digestive
enzyme and thus reaches to large intestine or colon essentially
intact, where it is fermented by resistant bacteria, Lactobacilli.
PREBIOTICS
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13. ANTIOXIDANTS
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 Antioxidants are quite large in number and diverse in nature which
oppose the process of oxidation largely by neutralizing free radicals
at relatively small concentrations have the potential to inhibit to
inhibit the oxidants chain reactions .
Dietary antioxidants and some accessory molecules, such as zinc
and certain vitamins are important in maintaining free radical
scavenging systems, biosynthetic capacity, membranes, enzymes .
 Antioxidants are found in the vegetable oils. eg- Soybean oil, canola
oil, corn oil, oat oil, wheat germ oil, palm oil, evening prime rose oil.
Like tocopherols (vitamin E) lower the susceptibility of LDL
oxidation and also reduce platelet’s role in thrombus formation.

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17. Classification of antioxidants
Vitamins Vitamin C, vitamin E
Carotenoids β-Carotine, lycopine
Thiols lipoic Acid, gutathione
Enzymes Co-Enzyme Q-10, super oxide dismastase Selenium
Minerals, copper, manganese, zinc
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18. Herbals:
Aloe vera: Anti-inflammatory, emollient, wound healing,
Evening Primrose oil: Dietary supplement of linoleic acid, treatment of
atopic eczema,
Garlic: Antibacterial, antifungal, antithrombotic, antiinflammatory,
Ginger: carminative, antiemetic, treatment of dizziness
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19. Ginseng: Adaptogen,
Green tea: Antioxidant, reduces risk of CVD, enhances humoral and
cell mediated Immunity,
Vegetables, fruits, whole grain, herbs, nuts and various seeds
contain an abundance of phenolic compounds, terpenoids, sulphur
compounds, pigments etc. that has been associated with protection /
treatment of certain disease conditions,
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20. Phytochemicals:
Phytochemicals could provide health benefits as:
1. Substrate for biochemical reactions
2. Cofactors of enzymatic reactions
3. Inhibitors of enzymatic reactions
4. Absorbents that bind to & eliminate undesirable constituent in the
intestine.
5. Scavengers of reactive or toxic chemicals
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21. Various Phytochemicals
Phytochemicals Source Role
Tocotrienols &
tocopherols
Grains Suppressed the growth of diverse
tumors cell lines via initiation of
apoptosis and concomitant arrest of
cells in the G1 phase of the cell cycle
Carotenoids Fruits &
vegetables
Antioxidants, protects against
uterine, prostate, colorectal, lung
and digestive tract cancers, and
protection to other antioxidants.
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22. Flavonoids Grapes, wines Action against free radicals, free
radicals mediated cellular
signaling, inflammation,
allergies, platelet aggregation, &
hepatotoxins
Catechin & gallic
acids
Grapes, berries,
cocoa, green tea,
acacia spp.
Antioxidants, free radical
scavenging ability, inhibition of
eicosanoid synthesis, reduces
CHD
Isoflavonoids Soybeans Treating cancers & osteoporosis
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23. Vitamins like Compounds
L- Carnitine: Helps in oxidation of fatty acids, role in oxidative
phosphorylation,
Choline: Lipotropic agent, used to treat fatty liver and disturbed fat
metabolism,
Inositol: For amino acid transport and movement of Potassium and sodium,
Taurine: Helps in retinal photoreceptor activity, bile acid conjugation, WBC
antioxidant activity, CNS neuromodulation, platelet aggregation, cardiac
contractibility, sperm motility, insuline activity,
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24. Minerals:
Calcium: essential for bone and teeth, maintaining bone strength,
nerve, muscle and glandular function, blood clotting,

Iron: energy production, Hb, oxygen transport,
 Magnesium: for healthy nerve and muscle function, bone formation,
Phosphorous: energy production, phosphorylation process, bone and
teeth, for genetic material,
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25. NUTRACEUTICALS AVAILABLE IN MARKET
Brand name Components Function
Betatene Carotenoids Immune function
Xangold Lutein esters Eye health
Lipoec -lipoic acid Potent antioxidant
Generol Phytosterol CHD reduction
Premium probiotics probiotics Intestinal disorder
Soylife Soyabean
phytoestrogen
Bone health
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26. Brand name Components Function
Z-trim Wheat Zero calorie fat replacer
Linumlife Lignan extract flax Prostate health
Fenulife Fenugreek
galactomannon
Control blood sugar
Teamax Green tea extract Potent antioxidant
Marinol  3 FA, DHA, EPA Heart health protection
Clarinol CLA Weight loss ingredient
Cholestaid Saponin Reduce cholesterol
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27. APPLICATIONS OF NUTRACEUTICALS
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Class /components source Potential benifit
Beta-carotene Carrots, various fruits Neutralizes free
radicals, which may
damage
cells; bolsters cellular
antioxidant defenses
Lycopene Tomatoes May contribute to
maintenance of
prostate
Monosaturated fatty
acids
Tree nuts May reduce risk of
coronary heart disease
Flavonols Onions, apples, tea,
broccoli Neutralize free radical,
which may damage
cells;bolster
cellular,antioxidation
defences

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Soy protein Soybeans and soy-
based food
May reduce risk of coronary
heart disease
Lactobacilli,
bifidobacteria
Yogurt, other dairy and
nondairy applications health and systematic
immunity
May improve
gastrointestinal

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The Food Safety and Standard Rules, 2011 have been issued and
have become effective from 5th May, 2011. The Food Safety and
Standard Authority has also issued regulations with respect to
Licensing and Registration of food business, Packing and Labeling,
Food products standard and additive etc. The Acts,Rules and
Regulations are now implemented from 5th August, 2011. Thus,
there is now one single legislation and specified authorities to
regulate manufacture, distribution and of sale nutraceuticals,
functional foods anddietary supplements in India.

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