4. The main difference in the percentage of the tropane alkaloids and calcium
oxalates.
Origin: The dried leaves and flowering
tops of Datura stramonium Linne, Fam.
Solanaceae.
6. Phyllotaxis: Simple, alternate
shape: ovate
Apex: acuminate,
Base: assymetric, petiolated,
Colour: hairy with dark green upper
surface to yellowish-green lower one.
The midrib: prominent on both surfaces.
The veins run from the midrib to the teeth at
angle of 45˚.
7. Very rare
Calyx: shortly pedicellate with green
tubular.
Corolla: white to purplish, funnel shaped.
Androecium: five epipetalous free
stamens.
Gynaecium: superior bilocular, bicarpellary.
8. Capsule containing numerous seeds on
axile placentation.
Reniform, dark to blackish in color with
reticulate surface.
14. Active Constituents:
1- About 0.2-0.7% alkaloids mostly of
hyoscyamine and atropine.
2- Flavonoids and tannins.
Atropine (dl-hyoscymaine) is formed
as a result of l-hyoscymaine
racemization.
Chemical test
Vitali-Morin’s test: for tropane
alkaloids (Solanaceous alkaloids)
15.
16.
17. Atropine, Hyoscyamine and Scoplamine (Hyoscine) are anticholinergic
agents.
1- increase heart rate (by depression of the vagus nerve),
2- They stimulate the respiratory center.
3- antispasmodic smooth muscles (uterus, bladder and biliary tract).
4- decrease gastric and saliva secretion,
5- Externally Atropine dilates the pupil of the eye (Mydriatic effect).
Atropine and Hyoscyamine CNS stimulant.
6- Scopolamine (Hyoscine) narcotic or sedative effect
18. Uses 1- antispasmodic especially in
bronchial asthma.
2- It suppress tremors in Parkinson’s
disease(anticholinergic).
3- Narcotic.
24. Color: pale green to yellowish, hairy.
Base: petiolate or nearly sessile.
Shape and size: vary.
Lamina: oval, rhomboidal to broadly elliptical, up to
15 cm long.
Apex: tapering to an equal base and accuminate,
Margin: entire or with 2-5 triangular acute teeth on
each side,
Surface: both surfaces densely hairy,
Mid-rib: broad, prominent on the lower surface, -
Venation: pinnate.
25. Cymose infloresence,
each shortly pedicillate, Usually have 5 petals,
5 sepals, 5 stamens, 2 carpels, 2 locules,
-hairy, leaf, bract.
Corolla: dried yellowish, sometimes with deep
colored patches, zygomorphic funnel shaped. .
Androecium: 5-epipetalous, unequal in length,
with purplish filaments and brownish and
sometimes purplish anthers.
Gynaecium: superior bilocular, bicarpellary.
31. Active Constituents:
1- About 0.7-1.5% of total alkaloids mostly as hyoscyamine.
2- Flavonoids and tannins.
Uses
1- As a source for preparing the alkaloid hyoscyamine.
2- As antispasmodic to relieve the griping caused by drastic
purgative.
3- As a cerebral and spinal sedative therefore used in insomnia.
32. Origin: dried leaves with or without
flowering and fruiting tops of Hyoscyamus
niger (Linn.), Family Solanaceae.
Indigenous to Europe,
two varieties annual and biennial Henbane
Active constituents:
About 0.14% alkaloids mainly hyoscyamine
and hyoscine.
Flavonoids and tannins.
33. Origin: The dried leaves and flowering
tops of Atropa belladonna Linne, Fam.
Solanaceae.
The main difference in
1- the percentage of the tropane alkaloids
2- the characteristic idioblasts with the
microsphenoids crystals of calcium
oxalates.
36. 3- upper and lower epidermal cells
of the leaf with sinuous walls,
covered with striated cuticle
showing anisocytic stomata,
glandular and non-glandular hairs.
1- Lignified
xylem vessels
and Spherical
pollen grains.
2- Fragments of palisade
tissue and parenchyma
containing microsphenoidal
crystals of calcium oxalate.
38. Active Constituents:
About 0.3-0.6% alkaloids (hyoscyamine,
hyoscine).
Volatile bases such as pyridine and N-
methylpyrolidine.
A fluorescent substance scopoletin.
Flavonoids and tannins.
39. Uses
treat the rigidity, tremor, excessive salivation, and
sweating caused by Parkinson's disease.
As a sedative to respiratory nerves to relief spasmodic
cough.
treat motion sickness, nausea, vomiting, abdominal
cramping and to reduce nighttime urination.
40. Origin: The dried whole plant of Catharanthus
roseus, formerly Vinca rosea L., Fam.
Apocynaceae.
41. Active Constituents:
Alkaloids of indole type, the most important of them are:
vinblastine, vincristine, vincrosidine and vincamine.
Other alkaloids as alstonine, ajmalicine and serpentine.
The leaf contains volatile oil which contains sulfurous
compounds in addition to organic acids.
Flavonoids and tannins.
Uses:
Vinblastine for neoplasma and Hodgkin’s disease.
Vincristine for leukemia in children.
Vincamine has a vasoregulatory action on cerebral
circulation.
42. Source: It’s derived from Ephedra sinica Stapf., E.
equisetina Bung., bothe indigenous to China; E.
gerardiana Wall, indigenous
to India, Family Gnetaceae.
43. The young branches are green, cylindrical,
branched from the base and so giving a low
tufted appearance.
The leaves are reduced to a sheath completely
surrounding the stem, and bearing minute
opposite and decussate, reddish-brown lamina.
Each terminating in a sharp, recurved point.
Older parts of the stem are covered with brown
cork with occasional silvery patches. It has an
aromatic odour when fresh and very slightly
bitter taste.
44. Active constituents:
The chief constituents are alkaloids l-ephedrine, d-
pseudoephedrine (which is easily converted to ephedrine).
Other alkaloids in small amounts as l-N-methylephedrine.
The drug is richest in ephedrine in the autumn.
Uses:
The action of ephedrine is similar to that of adrenaline but
is more prolonged.
It raises the blood pressure and relieves asthma and hay
fever.
It’s administered by mouth or hypodermally.
45. Origin: the young green tops of Cytisus scoparius
Fam. Leguminosae. Indigenous in Britain.
Active constituents:
•Volatile liquid alkaloid sparteine.
•Yellow crystalline flavone scoparin.
•Trace of liquid alkaloid gensiteine.
•Non volatile alkaloid sarothamnine.
Uses:
Heart tonic, diuretic in dropsy االستسقاء.