Slides from my Long Now Boston presentation, March 2017. We talked about the biological information being carried through deep time, where we are now, and where we'll be going in the future to understand the DNA codes. New tools will enable us to possibly change the course of evolution. Should we?

1. GENOMES ARE
THE LONG NOW
Mary Mangan, PhD
OpenHelix
March 6, 2017
@mem_somerville on twitter

2. ANSWERING AGE-OLD QUESTIONS
ALLOWING US TO ASK NEW ONES

3. ANCIENT SAMPLES CARRY IMPORTANT INFORMATION

4. THE NEVER-ENDING QUEST TO REWRITE THE TREE OF LIFE
www.rna-seqblog.com/
the-never-ending-quest-to-rewrite-the-tree-of-life
www.pbs.org/wgbh/nova/next/evolution/microbial-diversity

5. HOW WE ORGANIZE GENOME DATA TODAY

6. Copyright OpenHelix. No use
or reproduction without
express written consent
6
ORGANIZATION OF GENOMIC DATA
CONCEPTUAL LAYOUT OF A GENOME BROWSER PAGE
Reference genome: base position numbersequence
AnnotationTracks
chromosome band
predicted genes
phenotype and disease
evolutionary conservation
SNPs and structural variation
gap locations
known genes
repeated regions
microarray/expression data
more…
enhancer/promoter data
Links out to
more data

7. GENOME.UCSC.EDU
LIVE DEMO ATTEMPTED HERE (DEPENDS ON INTERNET CONNECTION)

8. GENOME.UCSC.EDU
DISCLOSURE: MY COMPANY HAS AN OUTREACH CONTRACT WITH UCSC GENOME BROWSER
TP53

9. TP53
Zoomed out
1.5x

10. FUTURE DIRECTIONS: PAN-GENOME DISPLAY

12. PERSONAL/PRECISION GENOMICS
& MISUSING GENOMICS

14. DE-EXTINCTION SCIENCE