220601-biohackersummit-Eduard de Wilde.pdf
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I presented my top 10 anti-aging supplements at the Biohacker Summit in Helsinki. When we age, damage accumulates in the body, and in the end, we will die. When you combine the 6 hallmarks of aging with the 7 pillars of aging and the 7 targets of aging you will find 13 areas of damage. It is not unimaginable that you can reverse this damage by supplements alone. However, at the moment, massive funding is going into anti-aging research. New possibilities are merging at a rapid speed due to accelerating technological developments. However, at this moment, we can only use supplements to help to body fight some parts of the damage. So maybe instead of anti-aging, we should speak bout anti-damage supplements.
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220601-biohackersummit-Eduard de Wilde.pdf
- 1. 1 My top 10 Anti aging supplements
- 3. 3 The Issue Metabolism Damage Death
- 4. 4 Metabolism Damage Death The Issue
- 6. 6 Metabolism Damage Death The Issue
- 7. 7 Metabolism Damage Death The Issue
- 9. 9 Genomic instability Mitochondrial mutations and dysfunction Stem cel exhhaustion Epigenetic alterations Deregulated nutrient sensing Damage from Reactive Oxygen species Toxic stress DNA damage Dysfunctional and senescent cells Misfolded proteins extracellular junk Telomere attrition Cross-links and stiffening 9 hallmarks of aging Carlos Lopez-Otin et al 7 pillars of aging Brian Kennedy et al. Inflammation 7 targets of ageing Sense Research Damage https://trickle.app/drip/16938-researchers-have-proposed-common-hallmarks-of-pillars-of-the-aging-process/
- 10. 10 Question: Can you repair all this damage With supplements? Probably not
- 11. 11 However, We live in an exponentially changing world
- 12. 12
- 13. 13 • $ 40.000 • $ 500.000 • $ 100.000 • $ 10.000.000 • $ 100 • $ 22.000 • $ 700 • $ 1.000 • 3D printing • Industrial Robots • Drones • Human Genome • 400 in 7 years • 23x in 5 years • 142x in 5 years • 10.000x in 7 years Moore’s law in practice
- 14. 14 Current times demand exponential thinking
- 15. 15 Three fases according to Ray Kurzweil 1. Now: prevent and intercept the most common causes of death. Using nutrition, exercise, supplementation 2. 2025-2030: gene therapy, stem cells, organ cloning and printing, replacement cells, etc., to turn back our biological clocks 3. 2045: Singularity. Humans will begin merging with machines, allowing us to extend our lives indefinitely
- 19. 19 My shortlist Nicotinamide Riboside Astaxanthin Curcumin Nicotinamide Mono Nucleotide PQQ CoQ10 (Dyhidro)Berberine Collagen Chaga Reishi Vitamin D Magnesium Fish Oil Quercetin Fisetin Resveratrol Spermidine Chaga Urollithin A Alpha KetoGlutarate Sulforaphane Melatonin N-Acetyl-Cysteine 19 Tocotrienol Geranylgeraniol ECGC
- 20. 20 Criteria: 1. Backed by science 2. No side effects 3. Target different areas of damage 4. Allowed in the EU 5. Costs
- 21. 21 Magnesium € - Essential > 300 different biochemical reactions - Reduces inflammaging - Essential for enzymes that support DNA repair and replication - Supports the synthesis of collagen What is it? What does it - master mineral
- 22. 22 Glycine € - supports glutathione production - combined with N-Acestyl-Cysteine (Glynac) - lowers inflammation - support sleep - lowers blood sugar What is it? What does it - one of the simplest amino acids - found in legumes, dairy products and meat - building block of glutathione Source: researchgate.net
- 23. 23 Creatine € - improves muscle mass (sarcopenia) - improves strength - improves energy - improves insulin sensititvy What is it? What does it - amino acid located mostly in your body's muscles as well as in the brain. - seafood and red meat - The body's liver, pancreas and kidneys also can make about 1 gram of creatine per day. Source: https://www.researchgate.net/figure/Fig-1-The-main-effects-of-creatine-Cr-in-skeletal-muscle-cells-differentiation-in_fig1_280391472
- 24. 24 Fisetin € - reduces the amount of senescent cells - inhibits mTOR pathway - reduces inflammaging (ageing related low-grade inflammation) - reduces formaton of skin wrinkles - restore certain types of cancer What is it? What does it - bioactive molecule found in strawberries and apples https://www.sciencedirect.com/science/article/pii/B9780128229231000029
- 25. 25 Curcumin € - anti-inflammatory - support the body’s anti oxidant and detoxification system - Increase Brain-Derived Neurotrophic Factor (BDNF) What is it? What does it - active ingredient in Turmeric Xenohormesis
- 26. 26 Astaxanthin € - reduces oxidative stress - decreases inflammation - improves cognition - improves vision and eye adaptation - improves fertility What is it? What does it - a kind of carotenoid that belongs to the subclass of xanthophyll - produced by algae, bacteria and fungi
- 27. 27 Fish Oil € - improves heart health - support muscle growth - support mood memory and cognition - support immune system - Protects telomeres What is it? What does it - Essential fatty acids - EPA, DHA are most important - High quality is crucial
- 28. 28 Mushroom: Chaga and Reishi € What is it? What does it Chaga - parasitic mushroom - highest ORAC value of all food Reishi - Fungus Chaga - Anti-oxidant - Anti Tumor - supports immunity - blood sugar control Reishi - Anti aging - anti-oxidation, - immunomodulation - anti-neurodegeneration - Improves sleep by modulation of neurotransmitters https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758346/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124789/
- 29. 29 Spermidine €€ - Supports cognition and heart health, - Balances hormones and - Improves hair growth and fullness strength - Supports immune system - Stimulates autophagy What is it? What does it - a potent polyamine - wheat germ and fermented soy - As we age spermidine production begin to fall, reducing our cells' ability to trigger autophagy.
- 30. 30 Nicotinamide Riboside (NR) €€€ and Nicotinamide Mono Nucleotide (NMN) - Increases NAD+: cell repair and energy production - NMN works synergistically with Resveratrol (David Sinclair). - Resveratrol is needed to activate the sirtuin genes (which protect our DNA and epigenome), while NMN is required to fuel the sirtuins What is it? What does it - a form of vitamin B3 - precursor of NAD+
- 31. 31 1. Magnesium 2. Curcumin 3.Fish oil 4. Glycine 5. Creatine 6. Fisetin 7. Astaxanthin 8. Mushrooms (Chaga/Reishi) 9. Spermidine 10. Nicotinamide Riboside (and NMN) Summary
- 32. 32 11. DyhdroBerberine 12. Urollithin A 13. PQQ-Coq10 14. ECGC 15. Quercetin 16. Resveratrol 17. Tocotrienol 18. Melatonin Bonus: didn’t make the top 10 (but would make my top 25) 19. CA-AKG (Alpha KetoGlutarate) 20. Sulforaphane 21. Collagen 22. Selenium 23. N-Acetyl Cysteine 24. Geranylgeraniol (GG) 25. Vitamin D
- 33. 33 In the near future we can track everything Expensive urine or Valuable investment
- 34. 34 To put things in perspective What is your secret? 50 years ago I saw a Russian man on television who was 110 years old. He said that he reached that age by drinking Vodka each day. Since that day I have been drinking 2 vodka per day and it worked!
- 35. 35 Happy aging!