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Biology Futures

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Melanie Swan
Melanie Swan

A look at future directions for biology. Personalized genomics is a key step in moving towards individualized medicine and preventative interventions. The traditional trial and error approach of molecular biology is being replaced by the direct design of synthetic biology. Synthetically developed energy solutions could have a substantial impact on natural resource demand.

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Biology Futures The revolution in personalized genomics and synthetic biology: technological status and ethical issues Melanie Swan MS Futures Group +1-650-681-9482 [email_address] www.melanieswan.com June 14, 2008 Slides: http//www.melanieswan.com/presentations/biology_futures.ppt
[object Object],[object Object],[object Object],[object Object],[object Object],Summary June 14, 2008
Agenda ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],June 14, 2008
Key genomics tools June 14, 2008 ,[object Object],[object Object],[object Object],[object Object],[object Object],Sources: http://www.economist.com/background/displaystory.cfm?story_id=7854314, http://www.molsci.org/%7Ercarlson/Carlson_Pace_and_Prolif.pdf DNA Synthesizer Variation: SNP
Status of DNA sequencing June 14, 2008 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Ensembl gene browser
Genetic testing revolution ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],June 14, 2008 1 http://www.forbes.com/free_forbes/2007/0618/052_2.html
Direct-to-consumer genomics service 23andme June 14, 2008 580,000 SNPs scanned and mapped to 78 conditions
23andme colorectal cancer marker June 14, 2008
Direct-to-consumer genomics controversy June 14, 2008 Drawbacks Advantages ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Implications of personalized genomics June 14, 2008 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Synthetic biology revolution ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],June 14, 2008
BioBricks: Registry of Standard Biological Parts ,[object Object],June 14, 2008 Source: http://partsregistry.org (MIT)
BioBricks example: measurement device selection June 14, 2008
BioBricks example: obtain part sequence June 14, 2008
Synthetic biology status ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],June 14, 2008
Biofuels ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],June 14, 2008 Algal Oil
Biofood ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],June 14, 2008 In vitro meat Corn images: http://www:science-interactive.co.uk Wild type corn Enhanced corn
Implications of synthetic biology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],June 14, 2008 Spore Creature Creator
Bioethics and society ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],June 14, 2008
Ethics of new technology: dual-use debate June 14, 2008 “ evil” Technophobic (Bill Joy) “ good” Technophilic (Ray Kurzweil) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Biological warfare and public health ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],June 14, 2008
Ethics: practitioner standards ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],June 14, 2008 1 http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0060073
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Ethics: intellectual property June 14, 2008
Pedagogy and scientific method ,[object Object],[object Object],[object Object],June 14, 2008 1 http://en.wikipedia.org/wiki/Synthetic_biology ,[object Object],[object Object],[object Object],“ From this combination of passion and inventiveness I sense that students are reinventing literacy. Literacy has been boiled down to reading and writing, but the means have changed since the Renaissance. In a very real sense post-digital literacy now includes 3D machining and microcontroller programming.” – Neil Gershenfeld, MIT 1
Advances in brain research ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],June 14, 2008
Innovations underway ,[object Object],[object Object],[object Object],[object Object],June 14, 2008 Second Health Operating Theatre, Second Life Teraradiology Telemedicine da Vinci Robotic Surgery OR-Live.com
Long-term biology futures ,[object Object],[object Object],[object Object],[object Object],[object Object],June 14, 2008 Image: Natasha Vita-More, Primo Posthuman
[object Object],[object Object],[object Object],[object Object],[object Object],Summary June 14, 2008
Resources ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],June 14, 2008
Thank you Melanie Swan MS Futures Group +1-650-681-9482 [email_address] www.melanieswan.com Slides: http//www.melanieswan.com/presentations/biology_futures.ppt Provided under an open source Creative Commons 3.0 license

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Biology Futures

  • 1. Biology Futures The revolution in personalized genomics and synthetic biology: technological status and ethical issues Melanie Swan MS Futures Group +1-650-681-9482 [email_address] www.melanieswan.com June 14, 2008 Slides: http//www.melanieswan.com/presentations/biology_futures.ppt
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  • 7. Direct-to-consumer genomics service 23andme June 14, 2008 580,000 SNPs scanned and mapped to 78 conditions
  • 8. 23andme colorectal cancer marker June 14, 2008
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  • 13. BioBricks example: measurement device selection June 14, 2008
  • 14. BioBricks example: obtain part sequence June 14, 2008
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  • 30. Thank you Melanie Swan MS Futures Group +1-650-681-9482 [email_address] www.melanieswan.com Slides: http//www.melanieswan.com/presentations/biology_futures.ppt Provided under an open source Creative Commons 3.0 license