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Stomach disorders


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Stomach disorders

  8. 8. INTRODUCTION The stomach is an organ between the esophagus and the small intestine. It is where digestion of protein begins. The stomach has three tasks. It stores swallowed food. It mixes the food with stomach acids. Then it sends the mixture on to the small intestine. There are many types of chronic disorders which affect the stomach. However since the symptoms are localized to this organ, the typical symptoms of stomach problems include nausea, vomiting, bloating, cramps, diarrhea and pain. Disorders of the stomach are very common and induce a significant amount of morbidity and suffering in the population. Data from hospitals indicate that more than 25% of the population suffers from some type of chronic stomach disorder including abdominal pain and indigestion. These symptoms occur for long periods and cause prolonged suffering, time off work and a poor quality of life.
  10. 10. DEFINITION Gastritis occurs when the lining of the stomach becomes inflamed or swollen. OR Gastritis, an inflammation or irritation of the lining of the stomach
  13. 13. INCIDENCEMortality rate of 65% (PHLEGMONOUS)No sexual predilectionMore common in adults, than in childrenSecond most common cancer-related death.Korea, Japan, China, Taiwan high rates.22,000 diagnosed annually in US.14th most common cancer.Difficult to cure, as advanced disease.
  14. 14. RISK FACTORSHelicobactor pylori infectionAgeGastric irritantsChemotherapy and radiation therapy
  15. 15. ETIOLOGYMedicationsMedical and surgical conditionsInfectionsIntake of spicy foodsAlcoholChemotherapy and radiationtherapySwallowed foreign bodies (paper clips orpins) Trauma
  16. 16. Chronic vomitingSmokingExtreme stressEating corrosive substancesPernicious anemiaBile reflux
  19. 19. CLINICAL FEATURES ASYMPTOMATIC Upper central abdominal pain Nausea and Vomiting Belching (if present, usually does not relieve the pain much) Bloating Feeling full after only a few bites of food Loss of appetite Unexplained weight loss
  20. 20.  In more severe gastritis, Bleeding may occur inside the stomach. Pallor, sweating, and rapid heart beat. Feeling faint or short of breath Chest pain or severe stomach pain Vomiting large amounts of blood Bloody bowel movements or dark, sticky, very foul-smelling bowel movements
  21. 21. DIAGNOSTIC EVALUATION complete history and physical exiamination H. pylori tests Breath test Tissue test Barium x rays Stool test Blood tests:  Blood cell count  Presence of H. pylori Urinalysis X-rays ECGs An electrocardiogram(ECG, EKG) might be ordered if the patients heartbeat is rapid or they are having chest pain. Stomach biopsy, to test for gastritis and other conditions
  22. 22. COMPLICATIONSBlood lossgastric cancerGI bleedingReflux esophagitisPUDChronic gastritis
  23. 23. MANAGEMENT MEDICAL MANAGEMENTDuring acute phase bed rest ,NPO,IV fluidsFluid and electrolyte balance (I/O Chart)For severe case NG tube intubationsubstances that trigger gastritis symptomsANTIEMETICS FOR VOMITING ANTACIDS
  24. 24. ANTIBIOTICSAmoxicillinClarithromycin (Biaxin)Metronidazole (Flagyl)TetracyclineCYTO PROTECTIVE AGENTSCoating agents: These medications protect thestomachs lining.Sucralfate (Carafate) - Coats and protects thestomach liningMisoprostol(Cytotec) -
  25. 25. Magnesium-containing antacids Aluminum-containing antacids Calcium-containing antacids H2 antagonist (ranitidine ,emetidine ) Proton pump inhibitors (PPIs) -omeprazole (Prilosec) For patient with perniciousanemia;regular vit B12 Injection blood transfusion and fluid replacement Stop taking aspirin, ibuprofen
  26. 26.
  27. 27. VAGOTOMY Vagotomy is the surgical cutting of the vagus nerve
  28. 28. PYLOROPLASTY (Pyloroplasty is anelective surgical procedure in which thelower portion of the stomach, the pylorus, iscut and resutured
  29. 29. Dietary management smaller, more frequent meals Avoid any foods which is irritating Limiting excessive use of alcoholFoods containing flavonoids,Mulltivitamins
  30. 30.  6-8 glasses of water Omega 3 fatty acids to redude inflammation Probiotics
  31. 31. NURSING DIAGNOSIS AND MANGAMENTPAIN related to irritation of gasric mucosaNausea and vomiting related to multipleetiologies as manifested by episodes ofnausea and vomitingFluid volumedeficit related to prolongedvomiting and inability to ingest digest andabsorb food and fluid as manifested bydecreased urinary output,increased urineconcentration,increased pulserate,hypotension
  32. 32. Anxiety related to lack of knowledge ofcause of the problegem,treatment plan andfollow up care as manifested byverbalization of lack of knowledgeRisk for altered nutrition less than bodyrequirement related to nausea andvomiting as manifested by lack of interestin food,weight loss.
  33. 33. PAIN INTERVENTIONS ASSESS INTENSITY DURATION AND LOCATION OF PAIN COMFORT POSITION AND MEASURES MEDICATIONS REVIEW FACTORS AGRAVETING PAIN DIETARY MODIFICATIONSNAUSEA AND VOMITING Observe for potential complications Position the patient: To prevent aspiration Conscious: semi fowler’s Unconscious: lateral Provide good oral care measures Suction mouth
  34. 34. FLUID VOLUME DEFICIT Moniter vital signs,capillary refill,status Daily fluidintake and output are monitored to detect early signs of dehydration (minimum 1.5 lit/day) Iv fluids 3L/day is administered usually Identify actions to regain optimal fluid balance Eg: Specific Fluid intake schedule ANXIETY Offer Supportive therapy to the patient Explain all the procedures before doing Provide calm and restful environment Help the patient to identify and initiate positive coping behaviors in the past
  35. 35. Nurses roleAssessmentGOALSimplementing interventions
  36. 36. PREVENTIONAvoid those things that irritate or inflame thestomachs lining.AspirinNSAIDsSmokingCaffeine and other caffeine-like substancesAlcohol
  37. 37. GASTRITIS FOLLOW UPAvoid those things that irritate thestomach or cause symptoms to flare up.Take all medications as prescribed by thehealth care provider.Return for medical attention if symptomsworsen or persist.Report any new symptoms to a health careprovider.
  38. 38. DEFINITION A peptic ulcer, also known as PUD or peptic ulcer disease is the most common ulcer of an area of the gastrointestinal tract that is usually acidic and thus extremely painful. It is defined as mucosal erosions equal to or greater than 0.5 cm. OR Peptic ulcer is the erosion of GI mucosa resulting from the action of HCL and pepsin that forms in the pylorus of stomach ,in the duodenum or in the esophagus
  39. 39. CLASSIFICATION By Region/LocationDuodenum (called duodenal ulcer)Oesophagus (called esophageal ulcer)Stomach (called gastric ulcer)Meckels diverticulum (called Meckels diverticulum ulcer; is very tender with palpation)
  40. 40. Modified Johnson Classification ofpeptic ulcers: Type I: Ulcer along the body of the stomach, most often along the lesser curve at incisura angularis along the locus minoris resistantiae. Type II: Ulcer in the body in combination with duodenal ulcers. Associated with acid oversecretion. Type III: In the pyloric channel within 3 cm of pylorus. Associated with acid oversecretion. Type IV: Proximal gastroesophageal ulcer Type V: Can occur throughout the stomach. Associated with chronic NSAID use (such as aspirin).
  41. 41. INCIDENCE The incidence of duodenal ulcers has dropped significantly during the last 30 years, while the incidence of gastric ulcers has shown a small increase, mainly caused by the widespread use of NSAIDs Nowadays peptic ulcer disease is about just as common among women than among men Duodenal ulcers are most frequent among individuals 30 to 55 years of age, while gastric ulcers are more common among individuals 55 to 70 years of age
  42. 42. RISK FACTORS An increased risk of peptic ulcers if: Smoking may increase the risk of peptic ulcers in people who are infected with H. pylori. Alcoholism Have uncontrolled stress
  43. 43.  Factors associated with an increased risk of duodenal ulcers in the setting of NSAID use include history of previous peptic ulcer disease, advanced age, female sex, high doses or combinations of NSAIDs, long-term NSAID use, concomitant use of anticoagulants, and severe comorbid illnesses. Little evidence suggests that caffeine intake is associated with an increased risk of duodenal ulcers.
  44. 44. ETIOLOGICAL FACTORSINFECTIONDRUGSHYPERSECRETORYGastrinomaBasophilic leukemiasCystic fibrosisShort bowel syndromeLifestyle factorsSevere physiologic stressGenetic factors
  45. 45. Additional etiologic factors Any of the following may be associated with PUD: Hepatic cirrhosis Chronic obstructive pulmonary disease Allergic gastritis and eosinophilic gastritis Cytomegalovirus infection Graft versus host disease Corrosive gastropathy Celiac disease Autoimmune disease
  46. 46. PATHOPHYSIOLOGYPeptic ulcers are defects in the gastric orduodenal mucosa that extend through themuscularis mucosa.Irritation of gastric or duodenal mucosadue to various etiological factorsEpithelial cells of the stomach andduodenum secrete mucus in response toirritation of the epithelial lining and as aresult of cholinergic stimulation
  47. 47. The superficial portion of the gastric andduodenal mucosa exists in the form of a gel layer,which is impermeable to acid and pepsin Other gastric and duodenal cells secrete bicarbonate, which aids in buffering acid that lies near the mucosa. Prostaglandins of the E type (PGE) increases the production of both bicarbonate and the mucous layer. In the event of acid and pepsin entering the epithelial cells, additional mechanisms are in place to reduce injury
  48. 48. Within the epithelial cells, ion pumps in thebasolateral cell membrane help to regulateintracellular pH by removing excess hydrogen ions. Through the process of restitution, healthy cells migrate to the site of injury Mucosal blood flow removes acid that diffuses through the injured mucosa and provides bicarbonate to the surface epithelial cells.
  49. 49. SIGNS AND SYMPTOMSBloating and abdominal fullness;Nausea, and copious vomiting;Loss of appetite and weight loss;PainHematemesisMelena (Nausea or vomitingUnexplained weight lossAppetite changes(loss of appetite)BloatingHeartburnWaterbrash
  50. 50. COMPLICATIONSGastrointestinal bleedingPerforationPenetrationGastric outlet obstruction.CancerExacerbationGastric outlet obstructionPeritonitis
  51. 51. DIAGNOSISHistory collection and physical examinationTesting for Bacterial InfectionBlood TesT Blood tests such asThe enzyme-linked immunosorbent assay(ELISA) CBC Breath Tests Tissue TestsBarium X-rays
  52. 52. MANAGEMENTGOALS OF TREATMENT The main goal for peptic ulcer treatment is the immediate relief of pain in the patient. to eliminate the conditions that aggravate it and to prevent recurrence. Relief of discomfort and protection of gastric mucosa from complications.
  53. 53.  3 stages in medical treatment. These are ; the preventive,( by providing information and educating the population on how to identify symptoms and avoiding the causes of the disease) curative and (where patients suffering the disease undergo treatment)  rehabilitation phases of treatment.( patient recovery and prevention of disease recurrence).
  54. 54. MEDICAL MANAGMENT Antibiotic medications Pain Relief through Medications Medications that block acid production and promote healing(PPI) Medications to reduce acid production. (H2 BLOCKERS) Antacids that neutralize stomach acid.
  55. 55. Medications that protect the lining ofyour stomach and small intestine NON MEDICAL MANAGEMENT.Lifestyle changesEating meals at regular intervals.avoid or manage stressful conditionsAvoid smokingMaintain proper diet and avoid food or beverages which upset the gastric mucosa like coffee, tea, colas and alcohol.
  56. 56. Ulcers that fail to healPeptic ulcers that dont heal withtreatment are called refractory ulcers. These reasons may include: Not taking medications according to directions. The fact that some types of H. pylori are resistant to antibiotics. Regular use of tobacco. Regular use of pain relievers that increase the risk of ulcers Extreme overproduction of stomach acid, such as occurs in Zollinger-Ellison syndrome An infection other than H. pylori Stomach cancer Other diseases that may cause ulcer-like sores in the stomach and small intestine, such as Crohns disease Treatment for refractory ulcers generally involves eliminating factors that may interfere with healing, along with using different antibiotics
  57. 57. SURGICAL INTERVENTIONS vagotomyVagotomy is the surgical cutting of the vagus nerve
  58. 58. Truncal or total abdominalvagotomy
  60. 60. Highly selective vagotomy (HSV)
  61. 61. Thoracoscopic vagotomy
  62. 62. PYLOROPLASTY (Widening theopening of the bottom of the stomach ANTRECTOMY surgical removal, of a part of the stomach known as the antrum
  63. 63. GASTRODUEODENOSTOMY(BILLROTH 1) Removal of lower portion of antrum of stomach(which contains cells that secrete gastrin)as well as small portion of dueodenum and pylorus.the remaining segment is anostomised with dueodenum
  64. 64. GASTROJEJUNOSTOMY(BILLROTH 2)Gastrojejunostomy (GJ) is a surgical procedure in which ananastomosis is created between the stomach and the proximalloop of the jejunum..
  65. 65. SUBTOTAL GASTRECTOMY WITHBILLROTH 1 AND 2 ANASTOMOSIS)Removal of distal part of stomach andanastomised with dueodenum and jejunum LOW HIGH
  66. 66. DIETARY MANAGEMENT IT INCLUDES; Avoiding spicy foods, coffee, and alcohol increasing consumption of bland foods and milk. Avoiding High–fiber diets INTAKE Diets high in vitamin A Avoid Green tea Probiotics
  67. 67. NURSING DIAGNOSIS ANDMANAGEMENT Nursing diagnosis Increased risk of GI bleeding and perforation of stomach, related to gastric or intestinal wall erosion. Increased risk of pyloric obstruction as complication of the peptic ulcer. increased risk of anemia due to acute or chronic GI bleeding, related to ulcer. Pain and heartburn, related to diagnosis of peptic ulcer.. Appetite changes and weight changes due to symptoms of the ulcer.increased risk of aspiration due to vomiting, related to ulcer. Anxiety related to the symptoms of disease and fear of the unknown.
  68. 68. Goals 1. Reduce or completely eliminate contributing factors. 2. Assist with stress management. 3. Promote adequate nutrition. 4. Prevent avoidable injury. 5. Then surgical intervention prescribed, prevent postoperative complications. 6. Relief or diminish symptoms.
  69. 69. Interventions1. Assess, report , and record signs and symptoms and reactions to treatment.2. Monitor fluids input and output closely.3. Administer antacid agents, analgesics, H2-receptors antagonists,anticholinergics, sedatives as prescribed, monitor for side effects.4. Monitor client’s vital signs and signs of possible GI bleeding or perforationclosely.5. Monitor laboratory tests results (CBC, electrolytes, Hb levels) for abnormalvalues.6. Undertake appropriate intervention in case of GI bleeding, vomiting, orperforation.7. Provide prescribed diet – avoid irritating foods, coffee, etc.8. Prepare client and his family for surgical intervention if required forrecurrent ulcer, hemorrhage, or perforation.9. For client after surgical intervention provide postoperative care and informabout possible postoperative complications, such as dumping syndrome.10. Provide emotional support to client, explain all procedures to decreaseanxiety and to obtain cooperation.11. Instruct client regarding disease progress, diagnostic procedures, treatmentand its complications, home care, daily activities, diet, restrictions and follow-up.
  70. 70. Nursingmanagement 1. Assess for chronic use of certain medications (such as aspirin, steroids). 2. Collect information of complaints that brought client to the hospital. 3. Obtain history of onset and progression of symptoms. 4. Obtain information of diet, use of alcohol and tobacco, ingestion of irritating foods, previous diseases or infections of GI tract, emotional stress. 5. Assess connection of pain attacks to meals, certain drugs, ingestion of coffee, alcohol. 6. Perform complete physical assessment including weight, vital signs, signs of GI bleeding, and acute abdomen. 7. Assess diagnostic tests and procedures for abnormal values. Evaluation 1. Reports increased comfort, decreased anxiety. 2. Verbalizes absence of heartburn and pain. 3. No evidence of nausea, vomiting, GI bleeding, or acute abdomen. 4. Maintains stable vital signs, fluid balance, and body weight. 5. Laboratory tests results shows no abnormalities. 6. No postoperative complications. 7. Demonstration of understanding of disease progress, diagnostic and treatment procedures, prevention, and need for follow-up.
  72. 72.  Zollinger-Ellison syndrome is a condition in which there is increased production of the hormone gastrin, causing the stomach to produce excess hydrochloric acid Zollinger–Ellison syndrome is a triad ofgastric acid hypersecretion,severe peptic ulceration, andnon-beta cell islet tumor of pancreas (gastrinoma)
  73. 73. Incidence andRisk factors Incidence Annual incidence is estimated at 1-2 cases per million. The condition is slightly more common in females than males (sex ratio of 1.3:1). ZES is usually diagnosed in the fifth decade of life Risk factors Multiple endocrine neoplasia type 1 syndrome, characterised by other endocrine tumours.
  74. 74. Causes Zollinger-Ellison syndrome is caused by tumors, usually found in the head of the pancreas and the upper small intestine. These tumors produce the hormone gastrin and are called gastrinomas. High levels of gastrin cause production of too much stomach acid.
  75. 75.  Due to tumours(gastrinomas) Production of excess gastrin Gastrin works on stomach parietal cells Secrete more hydrogen ions into the stomach lumen.
  76. 76.  In addition, gastrin acts as a trophic factor for parietal cells parietal cell hyperplasia. Increase in the number of acid-secreting cells cells produces acid at a higher rate development of multiple peptic ulcers in the stomach and duodenum (small bowel).
  77. 77. Signs and Symptoms Abdominal pain Diarrhea Vomiting blood (occasional) Signs include ulcers in the stomach and small intestine. Gnawing, burning pain in the abdomen This pain is usually located in the area between the breastbone and the navel. Sensation of pressure, bloating, or fullness This pain usually develops 30 to 90 minutes after a meal, and is often relieved by antacids. Pain or burning sensation in the abdomen that travels up toward the throat
  78. 78.  This is caused by heartburn, or gastroesophageal reflux and occurs when stomach contents back up into the esophagus Vomiting The vomit may contain blood or resemble coffee grounds. Diarrhea Stools may be foul smelling. Black, tarry stools Blood in the stools will turn them dark red or black, and make them tarry or sticky. Nausea Fatigue Weakness Weight loss
  79. 79. Diagnostic tests Tests include: Abdominal CT scan Calcium infusion test Endoscopic ultrasound Exploratory surgery Gastrin blood level Octreotide scan Secretin stimulation test
  80. 80. Complications Bleeding Perforation Fluid and electrolyte imbalance Complications Failure to locate the tumor during surgery Intestinal bleeding or hole (perforation) from ulcers in the stomach or duodenum Severe diarrhea and weight loss Spread of the tumor to other organs (most often liver and lymph nodes)
  81. 81. Treatment Medications Histamine H2-receptor antagonists  (such as famotidine and ranitidine) are used to slow down acid secretion proton pump inhibitors ::These drugs reduce acid production by the stomach, and promote healing of ulcers in the stomach and small intestine. They also relieve abdominal pain and diarrhea. omeprazole, lansoprazole, etc
  82. 82. Surgery Cure is only possible if the tumors are surgically removed, or treated with chemotherapy to remove a single gastrinoma is done if there is no evidence that it has spread to other organs (such as lymph nodes or the liver). Surgery on the stomach (gastrectomy) to control acid production is done rarely.
  83. 83. Prognosis Even with early diagnosis and surgery to remove the tumor, the cure rate is relatively low. However, gastrinomas grow slowly, and patients may live for many years after the tumor is discovered. Acid- suppressing medications are very effective at controlling the symptoms of too much acid production.
  84. 84. NURSING DIAGNOSISAND MANAGEMENT Nursing diagnosis 1. Increased risk of GI bleeding and perforation of stomach, related to gastric or intestinal wall erosion. 2. Increased risk of pyloric obstruction as complication of the peptic ulcer. 3. Increased risk of anemia due to acute or chronic GI bleeding, related to ulcer. 4. Pain and heartburn, related to diagnosis of peptic ulcer. 5. Appetite changes and weight changes due to symptoms of the ulcer. 6. Increased risk of aspiration due to vomiting, related to ulcer. 7. Anxiety related to the symptoms of disease and fear of the unknown.
  85. 85.  Stomach cancer, or gastric cancer, refers to cancer arising from any part of the stomach. Stomach cancer causes about 800,000 deaths worldwide per year. Gastric cancer was once the second most common cancer in the world. OR A gastric carcinoma is a malignant tumour arising from the epithelium of the stomach
  86. 86. INCIDENCE Stomach cancer is the fourth most common cancer worldwide It is more common in men and in developing countries. Frequency United States The American Cancer Society estimates that 21,130 cases of gastric cancer was diagnosed in the year 2009 (12,820 in men, 8,310 in women) and that 10,620 persons diedof the disease. Gastric cancer is the seventh leading cause of cancer deaths. International Once the second most common cancer worldwide, stomach cancer has dropped to fourth place, after cancers of the lung, breast, and colon and rectum. However, stomach cancer remains the second most common cause of death from cancer Ratesof the disease are highest in Asia and parts of South America and lowest in North America. The highest death rates are recorded in Chile, Japan, South America, and the former Soviet Union. Metastasis occurs in 80-90% of individuals with stomach cancer, with a six month survival rate of 65% in those diagnosed in early stages and less than 15% of those diagnosed in late stages.
  87. 87.  Mortality/Morbidity survival rate for curative surgical resection ranges from 30-50% for patients with stage II disease and from 10-25% for patients with stage III disease. The operative mortality rate less than 3%. high death rate (Approximately 800,000 per year) making it the second most common cause of cancer death worldwide after lung cancer Race The rates of gastric cancer are higher in Asian and South American countries than in the United States. Japan, Chile, and Venezuela have developed a very rigorous early screening program that detects patients with early stage disease (ie, low tumor burden). These patients appear to do quite well.
  88. 88.  In fact, in many Asian studies, patients with resected stage II and III disease tend to have better outcomes than similarly staged patients treated in Western countries. In the United States, Asian and Pacific Islander males and females have the highest incidence of stomach cancer, followed by black, Hispanic, white, American Indian, and Inuit populations. Sex In the United States, gastric cancer affects slightly more men than women Worldwide, however, gastric cancer rates are about twice as high in men as in women. Age Most patients are elderly at diagnosis. common in 50 – 70 yrs
  89. 89. STAGES The clinical stages of stomach cancer are: Stage 0. Limited to the inner lining of the stomach..  (Stage I)  (Stage 1A. Penetration to the second or third layers of the stomach. (Stage 1B).. the second layer and nearby lymph nodes..
  90. 90.  Stage II. Penetration to the second layer and more distant lymph nodes, or the third layer and only nearby lymph nodes, or all four layers but not the lymph nodes Stage III. Penetration to the third layer and more distant lymph nodes, or penetration to the fourth layer and either nearby tissues or nearby or more distant lymph nodes. Stage IV. Cancer has spread to nearby tissues and more distant lymph nodes, or has metastatized to other organs
  91. 91. ETIOLOGICAL FACTORS Diet Smoking . Helicobacter pylori infection Previous gastric surgery Genetic factors Li-Fraumeni syndrome familial adenomatous polyposis and Peutz-Jeghers syndrome Epstein-Barr virus Pernicious anemia Obesity Radiation exposure Bisphosphonates
  92. 92. DIFFERENTIAL DIAGNOSIS Esophagitis Gastric Ulcers Gastritis, Acute Gastritis, Atrophic Gastritis, Chronic Gastroenteritis, Bacterial Gastroenteritis, Viral Lymphoma, Non-Hodgkin Malignant Neoplasms of the Small Intestine
  93. 93. PATHOPHYSIOLOGY Initiation,prioliferation and progression The tumour growth is insiduos and follows a pattern of continuos infiltration. Cancer of stomach may spread by direct extension along the mucosal surface and infiltration through the gastric wall
  94. 94.  Once the stomach wall has been penetrated by tumour growth adjascent organs and structures that may become involed are the esophagus ,dueodenum , omentum,liver and pancreas Distant maetastasis is falicitated by rich lymphatic plexuses in the stomach wall. Seeding of tumour cells into the peritoneal cavity occurs late in the course of disease
  95. 95. CLINICAL FEATURES SYMPTOMS Abdominal fullness or pain which may occur after eat a small meal Dark stools Difficulty swallowing, which becomes worse over time Excessive belching General decline in health Loss of appetite Nausea Vomiting, which may contain blood Weakness or fatigue Weight loss SIGNS Diagnosis is often delayed because symptoms may not occur in the early stages of the disease.patients may self-treat symptoms that gastric cancer has in common with other, less serious gastrointestinal disorders (bloating, gas, heartburn, and a sense of fullness).
  96. 96. DIAGNOSTIC TESTS The following tests can help diagnose gastric cancer: History collection and physical examination Complete blood count (CBC) to check for anemia Esophagogastroduodenoscopy (EGD) with biopsy to examine the stomach tissue Stool test to check for blood in the stools Endoscopy: Upper Gastrointestinal Series/Barium Radiography Endoscopic Ultrasound Computed Tomography (CT) Scan Positron Emission Tomography (PET Magnetic Resonance Imaging (MRI) Chest X-Ray
  97. 97. COMPLICATIONS Mortality 1-2% Anastamotic leak, bleeding, ileus, transit failure, cholecystitis, pancreatitis, pulmonary infections, and thromboembolism. Late complications include dumping syndrome, vitamin B-12 deficiency, reflux esophagitis, osteoporosis.
  98. 98. MANAGEMENTSurgery Chemotherapy Radiation therapyBiological therapyRadical surgery
  99. 99. SurgeryEndoscopic mucosal resection(EMR)
  100. 100.  Endoscopic submucosal dissection (ESD)
  101. 101. Gatrectomy
  103. 103. ChemotherapySome drugs used in stomach cancer treatment have included: 5-FU (fluorouracil) capecitabine, BCNU (carmustine), methyl-CCNU (Semustine), and doxorubicin(Adriamycin), Mitomycin C, and cisplatin and taxotere Clinical researchers have explored the benefits of giving chemotherapy before surgery to shrink the tumor, or as adjuvant therapy after surgery to destroy remaining cancer cells.
  104. 104. Radiation Radiation therapy (also called radiotherapy) is the use of high-energy rays to damage cancer cells and stop them from growing. When used, it is generally in combination with surgery and chemotherapy, or used only with chemotherapy in cases where the individual is unable to undergo surgery. Radiation therapy may be used to relieve pain or blockage by shrinking the tumor for palliation of incurable disease.
  105. 105. Multimodality therapy While previous studies of multimodality therapy (combinations of surgery, chemotherapy and radiation therapy) gave mixed results The combination of chemotherapy and radiation therapy in patients with nonmetastatic, completely resected gastric cancer is benefited. Patients were randomized after surgery to the standard group of observation alone, or the study arm of combination chemotherapy and radiation therapy. Those in the study arm receiving chemotherapy and radiation therapy survived on average 36 months; compared to 27 months with observation
  106. 106. Residual Disease R Status Tumor status following resection. Assigned based on pathology of margins. R0- no residual gross or microscopic disease. R1- microscopic disease only. R2- gross residual disease. Long term survival only in R0 resection
  107. 107. “D” Nomenclature Describes extent of resection and lymphadenectomy. D1- removes all nodes within 3cm of tumor. D2- D1 plus hepatic, splenic, celiac, and left gastric nodes. D3- D2 plus omentectomy, splenectomy, distal pancreatectomy, clearance of porta hepatis nodes. Current standards include a D1 dissection only.
  108. 108. NURSING DIAGNOSIS AND INTERVENTIONS Pain related to underlying disease process and sideffects of surgery,chemotherapy and radiation therapy
  109. 109.  Imbalanced nutrition less than body requirements related to inability to ingest,digest or absorb nutrients
  110. 110.  Activity intolerance related to generalized weakness ,abdominal discomfort and nutritional deficits
  111. 111.  Anxiety related to lack of knowledge of diagnostic tests,unknown diagnostic outcomes,disease process
  112. 112.  Anticipatory grieving related to percoieved unfavourable diagnosis and impending death.
  113. 113. PREVENTION Avoiding risk factors and increasing protective factors may help to prevent stomach cancer and includes avoiding; Certain medications like NSAIDS Certain diet like spicy foods Smoking Alcoholism Stress Helicobacter infection
  114. 114. RESEARCH STUDY RESEARCH IN STOMACH CANCER Current Areas of Stomach Cancer Research Stomach cancer research scientists are testing new approaches for treatment, including: Anticancer drugs and drug combinations Different methods, doses, and schedules of radiation therapy Combination therapy (which includes chemotherapy, surgery, and radiation therapy). Other research trials are studying the effectiveness of using biological therapy to treat the disease. This therapy uses substances made by the body or in a laboratory to boost, direct, or restore the bodys natural defenses against cancer. This type of treatment is also called biotherapy or immunotherapy.
  115. 115. RESEARCH STUDIESRELATED TO GASTRITIS New study identifies potential vaccine to prevent gastritis, ulcer disease, gastric cancer February 2, 2011 A new study led by researchers at Rhode Island Hospital in collaboration with the University of Rhode Island (URI) and EpiVax. Inc, a privately owned vaccine development company in Providence, RI, has identified a potential vaccine capable of reducing colonization of Helicobacter pylori (H. pylori) -- known cause of gastritis, ulcer disease and cancer.
  116. 116. RESCENT RESEARCH RELATED TOGASTRIC CARCINOMA Risk of Cancer from Heartburn Pills The group of medicines which can alleviate heartburn quickly and is the most widely prescribed class of drugs in Britain can actually increase the risk of cancer, reveals a recent study. The group of medicines which can alleviate heartburn quickly and is the most widely prescribed class of drugs in Britain can actually increase the risk of cancer, reveals a recent study. Researchers said that the class of drugs commonly prescribed for heart burn known as proton pump inhibitors (PPIs), can increase the risk of cancer, heart disease and infections. Even though the drugs controlled symptoms of acid reflux, they actually increased the risk of cancer rather then reducing it. Peter Weissberg, medical director of the British Heart Foundation, said: "Doctors need to be sure they are really necessary." - JULY 25 2012
  117. 117. CONCLUSION There is a plethora of literature concerning gastritis and peptic ulcer disease caused by the bacterium Helicobacter pylori. Nevertheless, there is still much to be learned about this bacterium and its effects on the human body. It may not be known exactly how H. pylori is transmitted but at least we are able to detect and eradicate the bacterium with relative ease and efficiency. Many new ways to help prevent and inhibit the activity of H. pylori are being discovered. Now it is up to the scientists to discover even better ways to treat the disease caused by this bacterium and to find ways to prevent the disease. When H. pylori’s mode of transmission is finally discovered, it may lead to more efficient ways to prevent transmission and infection. As a nurse its very important to give health education as primary prevention and also secondary and tertiary prevention once disease occurred.
  118. 118. WE WANT MORE NURSES……
  119. 119.  THANK UUU….