February 4, 2016 K Workshop Mitchell D. Wong, MD, PhD Professor of Medicine Executive Co-Director, Specialty Training and Advanced Research (STAR) Program Director, UCLA CTSI KL2 Program Co- Leader, Research Education, Training and Career Development Program

1. UCLA CTSI KL2
Translational Science Award
Mitchell Wong, MD, PhD
Director, KL2 Program

2. Award Overview
• Career development support for junior
faculty within the UCLA CTSI Consortium
• Interdisciplinary, translational science
(basic, clinical and HSR)
• Similar in structure to K08/K23 award

3. Support
• Annual award, renewable for up to 3 years and
contingent on the UCLA CTSI competitive
renewal.
• Support
– $75k salary plus benefits
– $25k research support
– $4k for tuition or coursework
– $2k for travel
– $1500 for statistical support in addition to in-
kind support from DOM Stats

4. Eligibility
• Doctoral level research degree or professional
degree (with advanced research training)
• Faculty level title as of July 1, 2016 at a UCLA
CTSI Institution
• Commit 75% of effort to translational research
and aims of the KL2 (50% minimum for some
specialties like surgery)
• U.S. Citizen or non-citizen national, permanent
U.S. resident

5. Eligibility (Prior/Pending Grants)
• May have had a small grant (R03, R21)
• May have had prior K12 funding (total K funding
cannot exceed 5 years)
• Cannot have:
– Prior or current PI of a NIH R01 or equivalent grant
(direct costs>$100k per year)
– Prior or current PI of a K08/K23 award
– Prior or current PI of a VA Career Development or R01
Equivalent grant
– PI of a pending K award application, pending R award in
similar area
– Current co-investigator funding on an R01/Project grant

6. Future Funding for KL2
• KL2 Awardees may apply for K08/K23 or VA CDAs
– Must relinquish KL2 if awardee receives NIH/VA CDA
– Total CDA funding (KL2 + individual CDA) cannot
exceed 5 years. Some institutes (i.e. NICHD, NHLBI)
allow 6 years.
• KL2 Awardees may apply for R01, Program grants
– Must maintain 75% effort on KL2 in year 1
– May decrease to 50% effort in last 2 years of K support

7. Selection Criteria
1. Proposed research- Quality, innovation, significance,
feasibility, promise for future funding, relevance to
interdisciplinary, translational research
2. Candidate- Training, productivity, promise
3. Mentor- Track record in mentorship and research,
commitment to candidate
4. Educational Plan- Well described and planned, fit with
research plan, provides candidate with new skill set
5. (Environment)- Commitment from institution,
department/division, availability of support and
resources to conduct research and educational plan

8. Application Components
• Letter of intent- Name, mentor, title, biosketch, specific aims
(to help KL2 selection committee identify appropriate
reviewers)
• Project Summary/Abstract (30 lines of text)
• Specific Aims (1 page)
• Application (12 pages)- Research, Education and Career Plan
• Training in the Responsible Conduct of Research (1 page)
• Mentor’s Letter (2 pages)
• Institutional Letter (2 pages) from department chair or division
chief
• Letters of support (2 max)
• Candidate’s CV and NIH Other Support Pages
• Mentor’s NIH Biosketch
• Budget and budget justification
• References
• Data and Safety Monitoring Plan (when applicable)
• Appendices allowable (e.g. letter of support for use of
equipment or data)

9. Timeline with CTSI Renewal
• The 2016 awards will be contingent on the
renewal of the UCLA CTSI.
• Letter of intent deadline: Feb. 1, 2016
• Application deadline: Feb. 22, 2016
• Awardees will be notified in May/June
2016.
• Grant start date July 1, 2016.
• Funds will not be released until IRB/IACUC
approval(s) are received.

10. 10

11. The Grant Library
•Currently K Grant Proposals, U Grant Proposals and
new format NIH Biosketches
•Secure platform for sharing grants
•Video instructions on how to request access:
•http://ctsi.ucla.edu/funding/pages/sample
•TO access:
•http://intranet.ctsi.ucla.edu
11

12. 12

13. 13