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TRIGEMINAL
NERVE
1
INDIAN DENTAL ACADEMY
Leader in Continuing Dental Education
www.indiandentalacademy.com
Contents
• Introduction
• Cranial nerves
• Trigeminal ganglion
• Trigeminal nerve
 Opthalmic branch
 Maxillary branch
 Mandibular branch
• Disturbances associated with trigeminal nerve
 Trigeminal neuralgia
 Paratrigeminal syndrome
 Sphenopalatine neuralgia
 Auriculotemporal syndrome
• Nerve blocks associated with trigeminal nerve branches
• Clinical examination of trigeminal nerve
• Trigeminal nerve injuries
• Conclusion
• References 2www.indiandentalacademy.com
NERVOUS SYSTEM
Central nervous system
Peripheral nervous
system
Brain and spinal cord
Autonomic and somatic
nervous system
I
N
T
R
O
D
U
C
T
I
O
N
B.D. Chaurasia 4th edition
3www.indiandentalacademy.com
Structure of nerve
Axon
Fasciculi
Nerve fibre
Nerve
Endoneurium
Perineurium
Epineurium
I
N
T
R
O
D
U
C
T
I
O
N
Peter. L. Williams, grays anatomy, 38th edition,1995
4www.indiandentalacademy.com
C
R
A
N
I
A
L
N
E
R
V
E
S
Motor nerves: III IV VI XI
XII
Sensory nerves I II VIII
Mixed nerves V VII IX X
Associated with
parasympathetic ganglion
III VII IX X
Peter. L. Williams, grays anatomy, 38th edition,1995 5www.indiandentalacademy.com
T
R
I
G
E
M
I
N
A
L
G
A
N
G
A
L
I
O
N
Trigeminal gangalion
Gasserian/semilunar
Sensory cell bodies of
three branches of
trigeminal
Lies in a depression on
the petrous apex, within a
dural fold called the
meckal cave
Cunningham’s manual of practical anatomy, volume 3,
3rd edition 6www.indiandentalacademy.com
7
Trigeminal nerve
overview
www.indiandentalacademy.com
T
R
I
G
E
M
I
N
A
L
N
E
R
V
E
Trigeminal nerve
Tres meaning three and
geminus meaning twin Largest cranial nerve
Mixed nerve
Sensory to greater part of
the scalp, teeth and the
oral and nasal cavity
Motor supply is to
muscles of mastication
and extraocular muscles
5th cranial nerve
Cunningham’s manual of practical anatomy, volume 3,
3rd edition 8www.indiandentalacademy.com
T
R
I
G
E
M
I
N
A
L
N
E
R
V
E
MOTOR ROOT SENSORY ROOT
TWO ROOTS
Within pons and medulla
oblongata
Semilunar gangalion
Foramen ovale along with
mandibular nerve
MOTOR ROOT
Muscles of mastication
Mylohyoid
Anterior belly of digastric
Tensor tympani
Tensor veli palatine
Cunningham’s manual of practical anatomy, volume 3,
3rd edition
9www.indiandentalacademy.com
T
R
I
G
E
M
I
N
A
L
N
E
R
V
E
SENSORY ROOT
Fibres arise in trigeminal
ganglion
Opthalmic nerve
Leaving from concave
surface of ganglion
Cunningham’s manual of practical anatomy, volume 3,
3rd edition 10
Maxillary nerve
Mandibular nerve
www.indiandentalacademy.com
B
R
A
N
C
H
E
S
Main divisions
Opthalmic
Wholly Sensory division
Superior and smallest
division
Leaves cranium through
Superior orbital fissure
3 branches
Lacrimal
Frontal
Nasocilliary
Cunningham’s manual of practical anatomy, volume 3,
3rd edition 11www.indiandentalacademy.com
O
P
T
H
A
L
M
I
C
N
E
R
V
E Peter. L. Williams, grays anatomy, 38th edition,1995
12www.indiandentalacademy.com
O
P
T
H
A
L
M
I
C
N
E
R
V
E
Lacrimal nerve
Smallest branch
Ends in the skin of upper
eyelid
Lacrimal gland and
conjunctiva
Pierces orbital septum
Peter. L. Williams, grays anatomy, 38th edition,1995
13www.indiandentalacademy.com
O
P
T
H
A
L
M
I
C
N
E
R
V
E
Frontal nerve
Largest branch
Skin of forhead and scalp
Mucous membrane of
frontal sinus and
pericranium
Enter orbit through
superior orbital fissure
Supraorbital branch Supratochlear branch
Upper eyelid
Lower part of forhead
Peter. L. Williams, grays anatomy, 38th edition,1995
14www.indiandentalacademy.com
O
P
T
H
A
L
M
I
C
N
E
R
V
E
Nasocilliary nerve
Branches in orbit
In nasal cavity
Supply mucous
membrane of nose
Branches in nasal cavity
Long ciliary nerve
Supply iris , cornea
Posterior ethmoi nerve
Posterior
ethmoid,sphenoidal air
cells
Anterior ethmoidal nerve
Anterior ethmoid, frontal
paranasal
Nasal conchae, anterior
nasal wall
Tip and ala of nose
On face supply lacrimal
gland. Both eyelids and
skin over nasal bridge
Branches on face
 B.D. Chaurasia 4th edition
15www.indiandentalacademy.com
M
A
X
I
L
L
A
R
Y
N
E
R
V
E
Maxillary nerve
Wholly sensoryBegins at trigeminal
ganglion
Enter orbit through
inferior orbital fissure
and appears on face
through infra orbital
foramen
Leaves through foramen
rotundum
Peter. L. Williams, grays anatomy, 38th edition,1995
16www.indiandentalacademy.com
M
A
X
I
L
L
A
R
Y
N
E
R
V
E
Maxillary nerve branches
Cranium
Pterygopalatine fossa
Infraorbital canal
Face
Cranium
Pterygopalatine fossa
Infraorbital canal
Face
Peter. L. Williams, grays anatomy, 38th edition,1995
17www.indiandentalacademy.com
M
A
X
I
L
L
A
R
Y
N
E
R
V
E
Middle superior alveolar
nerve
Anterior superior
alveolar nerve
Posterior superior
alveolar nerve
Peter. L. Williams, grays anatomy, 38th edition,1995
18www.indiandentalacademy.com
M
A
N
D
I
B
U
L
A
R
N
E
R
V
E
Largest division
Large sensory root, small
motor root
Mandibular nerve
Motor root medial to
sensory
Main trunk 2-3mm
Small anterior and large
posterior branch
 B.D. Chaurasia 4th edition
19www.indiandentalacademy.com
M
A
N
D
I
B
U
L
A
R
N
E
R
V
E
Branches of mandibular
nerve
Peter. L. Williams, grays anatomy, 38th edition,1995
20www.indiandentalacademy.com
M
A
N
D
I
B
U
L
A
R
N
E
R
V
E
Meningeal branch
Nerve to medial
pterygoid
Branches of undivided
nerve
Enter skull through
foramen spinosum
Supply dura of middle
and anterior cranial fossa
Slender branch
Supply deep part of
muscle
Also tensor tympani and
tensor velli palati muscle
 B.D. Chaurasia 4th edition
21www.indiandentalacademy.com
M
A
N
D
I
B
U
L
A
R
N
E
R
V
E
Buccal nerve
Anterior division
Passes between two
heads of lateral pterygoid
Emerge under ramus and
anterior border of
masseter
Supply skin over anterior
part of buccinator and
mucous membrane lining
buccal surface of gums
 B.D. Chaurasia 4th edition
22www.indiandentalacademy.com
M
A
N
D
I
B
U
L
A
R
N
E
R
V
E
Massetric nerve Passes through
mandibular notch
Deep temporal nerve
Nerve to lateral pterygoid
Supply masseter muscle
Passes above upper head
of lateral pterygoid
Turn above infratemporal
crest and sink into
temporalis
2 branches supplying
each muscle head
 B.D. Chaurasia 4th edition
23www.indiandentalacademy.com
M
A
N
D
I
B
U
L
A
R
N
E
R
V
E
Branches of posterior
division
Auriculotemporal nerve
Traverse upper part of
parotid gland
Auricular branch
Articular branch
Cunningham’s manual of practical anatomy, volume 3,
3rd edition 24
Temporal branch
www.indiandentalacademy.com
M
A
N
D
I
B
U
L
A
R
N
E
R
V
E
Lingual nerve
Lies between ramus and
medial pterygoid.
Antriomedial to inferior
alveolar nerve
Base of tongue behind 3rd
molar
Medial to submandibular
duct
Peter. L. Williams, grays anatomy, 38th edition,1995
25www.indiandentalacademy.com
M
A
N
D
I
B
U
L
A
R
N
E
R
V
E
Carries sensation from
Anterior two third of the
tongue
Oral mucosa on the floor
of the oral cavity
Lingual gingiva associated
with lower teeth
Peter. L. Williams, grays anatomy, 38th edition,1995
26www.indiandentalacademy.com
M
A
N
D
I
B
U
L
A
R
N
E
R
V
E
Inferior alveolar nerve
Large terminal branch of
posterior division
Originates deep to the
lateral pterygoid muscle
in association with
lingual nerve
Passes between
sphenomandibular
ligament and ramus
 B.D. Chaurasia 4th edition
27www.indiandentalacademy.com
M
A
N
D
I
B
U
L
A
R
N
E
R
V
E
Inferior alveolar nerve
Mylohyoid branch which
supply mylohyoid muscle
Enter the mandibular
foramen
Branches into mental
nerve and incisive nerve
Peter. L. Williams, grays anatomy, 38th edition,1995
28www.indiandentalacademy.com
I
N
T
R
O
D
U
C
T
I
O
N
29www.indiandentalacademy.com
g
a
n
g
l
i
o
n
Ganglion associated with
trigeminal nerve:
 B.D. Chaurasia 4th edition
30www.indiandentalacademy.com
g
a
n
g
l
i
o
n
Ciliary ganglion
Sensory root
Sympathetic root Plexus around opthalmic
artery
Nasocilliary nerve
Parasympathetic root Occulomotor nerve
Peter. L. Williams, grays anatomy, 38th edition,1995
31www.indiandentalacademy.com
g
a
n
g
l
i
o
n
Only structurally related
to maxillary nerve
Sphenopalatine/Pterygopalatine
gangalion
 B.D. Chaurasia 4th edition
32
Sensory root
Sympathetic root
Plexus around internal
carotid artery
Maxillary nerve
Secrotomotor root Greater petrosal nerve
www.indiandentalacademy.com
g
a
n
g
l
i
o
n
Nasal
Sphenopalatine/Pterygop
alatine gangalion
Palatine
Orbital
 B.D. Chaurasia 4th edition
33
Pharyngeal
www.indiandentalacademy.com
g
a
n
g
l
i
o
n
Otic ganglion
Parasympathetic ganglion
Topographically –
Mandibular nerve
Functionally –
Glossopharyngeal nerve
Situated in infratemporal
fossa below foramen
ovale
 B.D. Chaurasia 4th edition
34www.indiandentalacademy.com
g
a
n
g
l
i
o
n
Otic ganglion
 B.D. Chaurasia 4th edition
35
Sensory root
Sympathetic root
Plexus around middle
meningeal artery
Auriculotemporal nerve
Secrotomotor root Lesser petrosal nerve
www.indiandentalacademy.com
g
a
n
g
l
i
o
n
Submandibular ganglion
Lies superficial to
hyoglossus muscle in
submandibular region
Topographically – lingual
branch of mandibular
nerve
Fumctionally – Facial
nerve
Peter. L. Williams, grays anatomy, 38th edition,1995
36www.indiandentalacademy.com
D
I
S
T
U
R
B
A
N
C
E
S
A
S
S
O
C
I
A
T
E
D
Trigeminal neuralgia
Fothergill’s disease/Tic
douolourex
Sudden, unilateral,
lancinating, recurrent
pain
Right side more
commonly effected
Cranial nerve functional anatomy, Stanley Monkhouse 37
Attack last from few
seconds to several
minutes
Presence of trigger zones
www.indiandentalacademy.com
D
I
S
T
U
R
B
A
N
C
E
S
A
S
S
O
C
I
A
T
E
D
Etiology
Cranial nerve functional anatomy, Stanley Monkhouse 38
Intracranial tumours
Intravascular
abnormalities
Multiple sclerosis Post traumatic neuralgia
Viral etiologyDental etiology
www.indiandentalacademy.com
D
I
S
T
U
R
B
A
N
C
E
S
A
S
S
O
C
I
A
T
E
D
Pathophysiology
Cranial nerve functional anatomy, Stanley Monkhouse 39www.indiandentalacademy.com
D
I
S
T
U
R
B
A
N
C
E
S
A
S
S
O
C
I
A
T
E
D
Bilateral cases
Maxillary division
Mandibular division
Opthalmic division
All 3 divisions
Both maxi and
mandibular
3 %
66%
49%
16%
19%
1%
Cranial nerve functional anatomy, Stanley Monkhouse 40www.indiandentalacademy.com
D
I
S
T
U
R
B
A
N
C
E
S
A
S
S
O
C
I
A
T
E
D
Treatment
Peripheral neurectomy Alcohol injection into
peripheral nerve area
Injection of boiling water
into ganglion
Surgical sectioning of
trigeminal sensory root
Cranial nerve functional anatomy, Stanley Monkhouse 41
Microsurgical
decompression of
trigeminal root
www.indiandentalacademy.com
D
I
S
T
U
R
B
A
N
C
E
S
A
S
S
O
C
I
A
T
E
D
Paratrigeminal
syndrome/Raeder’s
syndrome
Middle aged males
Severe hedache pain in
area distibution of
trigeminal nerve
Signs of ocular
sympathetic paralysis
No sweating on the
affected side
Cranial nerve functional anatomy, Stanley Monkhouse 42www.indiandentalacademy.com
D
I
S
T
U
R
B
A
N
C
E
S
A
S
S
O
C
I
A
T
E
D
Sphenopalatine neuralgia
Lower half
headache/Sludders
headache
Vasoconstriction of
vessels supplying nasal
mucosa
Deviated nasal septum Vasodialation of internal
maxillary artery
Cranial nerve functional anatomy, Stanley Monkhouse 43www.indiandentalacademy.com
D
I
S
T
U
R
B
A
N
C
E
S
A
S
S
O
C
I
A
T
E
D
Sphenopalatine neuralgia
Unilateral paroxysm of
intense pain for 15 min to
several hours
Alarm clock hedache
Male > female
1st episode occur before
40 years of age
Cranial nerve functional anatomy, Stanley Monkhouse 44
Sneezing, discharge and
epiphoraNo trigger zones
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D
I
S
T
U
R
B
A
N
C
E
S
A
S
S
O
C
I
A
T
E
D
Treatment
Alcohol injection into the
ganglion
Surgical correction of
septal defects
Cranial nerve functional anatomy, Stanley Monkhouse 45
Drugs like ergotamine
and methysergideResection of ganglion
www.indiandentalacademy.com
D
I
S
T
U
R
B
A
N
C
E
S
A
S
S
O
C
I
A
T
E
D
Auriculotemporal
syndrome
Frey syndrome
Due to reinnervation of
sweat glands by
parasympathetic salivary
fibres
Mainly after some
surgical operation like
removal of parotid gland
Sweating and flushing of
the involved side during
eating
Cranial nerve functional anatomy, Stanley Monkhouse 46www.indiandentalacademy.com
N
E
R
V
E
B
L
O
C
K
S
Posterior superior
alveolar nerve block
Tuberosity
block/zygomatic block
Pulp of maxillary 3rd
molar, 2nd and 1st molar
(except MB root of 1st
molar), buccal
periosteum and bone
Malamad SF. Handbook of local anesthesia. 6th ed. Missouri: Elsevier;201347www.indiandentalacademy.com
N
E
R
V
E
B
L
O
C
K
S
Middle superior alveolar
nerve block
Pulps of maxillary 1st and
2nd premolar, MB root of
1st molar, buccal
periosteum and bone
Malamad SF. Handbook of local anesthesia. 6th ed. Missouri: Elsevier;201348www.indiandentalacademy.com
N
E
R
V
E
B
L
O
C
K
S
Anterior superior
alveolar nerve block
Infraorbital nerve block
Pulp of maxillary central
incisor to the canine.
In 72% of cases pulp of
maxillary premolars and
MB root of 1st molar.
Buccal periosteum and
bone of these teeth.
Lower eyelid, lateral
aspect of nose, upper lip.
Malamad SF. Handbook of local anesthesia. 6th ed. Missouri: Elsevier;201349www.indiandentalacademy.com
N
E
R
V
E
B
L
O
C
K
S
Greater palatine nerve
block
Anterior palatine nerve
block
Posterior portion of hard
palate and overlying
tissues, anteriorly till the
1st PM and medially till
the midline.
Malamad SF. Handbook of local anesthesia. 6th ed. Missouri: Elsevier;201350www.indiandentalacademy.com
N
E
R
V
E
B
L
O
C
K
S
Nasopalatine nerve block
Incisive nerve block
Anterior portion of hard
palate and overlying
tissues, mesial from the
right 1st PM to the mesial
of the left 1st PM.
Malamad SF. Handbook of local anesthesia. 6th ed. Missouri: Elsevier;201351www.indiandentalacademy.com
N
E
R
V
E
B
L
O
C
K
S
Maxillary nerve block
Second division block/V2
nerve block
Pulpal anaesthesia of
maxillary teeth on the
side of the block.
Buccal periodontium and
bone overlying these
teeth.
Soft tissue and bone of
the hard palate and part
of the soft palate medial
to midline.
Skin of lower eyelid, side
of nose, cheek and upper
lip.
Malamad SF. Handbook of local anesthesia. 6th ed. Missouri: Elsevier;201352www.indiandentalacademy.com
N
E
R
V
E
B
L
O
C
K
S
Inferior alveolar nerve
block
Mandibular block
Mandibular teeth to the
midline.
Body of the mandible,
inferior portion of ramus.
Buccal mucoperiosteum,
mucous membrane
anterior to mental
foramen.
Anterior 2/3rd of tongue
and floor of oral cavity.
Lingual soft tissues and
periosteum.
Malamad SF. Handbook of local anesthesia. 6th ed. Missouri: Elsevier;201353www.indiandentalacademy.com
N
E
R
V
E
B
L
O
C
K
S
Mandibular nerve bolck
3rd division nerve
block/Gow Gates
technique
Mandibular teeth to the
midline.
Body of the mandible,
inferior portion of ramus.
Buccal mucoperiosteum,
mucous membrane on
the side of injection.
Anterior 2/3rd of tongue
and floor of oral cavity.
Lingual soft tissues and
periosteum.
Skin over zygoma and
temporal region.
Malamad SF. Handbook of local anesthesia. 6th ed. Missouri: Elsevier;201354www.indiandentalacademy.com
N
E
R
V
E
B
L
O
C
K
S
Vazirani akinosi tecnique
Closed mouth
mandibular nerve block
Mandibular teeth to the
midline.
Body of the mandible,
inferior portion of ramus.
Buccal mucoperiosteum,
mucous membrane
anterior to mental
foramen.
Anterior 2/3rd of tongue
and floor of oral cavity.
Lingual soft tissues and
periosteum.
Malamad SF. Handbook of local anesthesia. 6th ed. Missouri: Elsevier;201355www.indiandentalacademy.com
N
E
R
V
E
B
L
O
C
K
S
Incisive nerve block
Buccal mucous
membrane anterior to
mental foramen till
midline.
Lower lips.
Pulp of premolars,
canines and incisors.
Malamad SF. Handbook of local anesthesia. 6th ed. Missouri: Elsevier;201356www.indiandentalacademy.com
C
L
I
N
I
C
A
L
E
X
A
M
I
N
A
T
I
O
N
Clinical examination of
trigeminal nerve
Use sterile sharp item on
forehead, cheek and jaw.
Sensory function
Motor function
While cleching of teeth,
firmnes of masseter will
be felt on both sides
Trigeminal Nerve Injuries. Michael Miloro;2013 57www.indiandentalacademy.com
T
R
I
G
E
M
I
N
A
L
N
E
R
V
E
I
N
J
U
R
I
E
S
Trigeminal nerve injuries
Neuropraxia
Axontmesis
Neurotmesis
Types
Trigeminal Nerve Injuries. Michael Miloro;2013 58www.indiandentalacademy.com
T
R
I
G
E
M
I
N
A
L
N
E
R
V
E
I
N
J
U
R
I
E
S
Trigeminal nerve injuries
Trigeminal Nerve Injuries. Michael Miloro;2013 59www.indiandentalacademy.com
T
R
I
G
E
M
I
N
A
L
N
E
R
V
E
I
N
J
U
R
I
E
S
Causes of Trigeminal
nerve injuries
LA injections
Cosmetic surgery
Orthognathic surgery
Maxillofacial trauma
Tumours and oncologic
surgery
Salivary gland surgery
Trigeminal Nerve Injuries. Michael Miloro;2013 60www.indiandentalacademy.com
T
R
I
G
E
M
I
N
A
L
N
E
R
V
E
I
N
J
U
R
I
E
S
Extraction of mandibular
3rd molar
Endodontic treatment
Trigeminal Nerve Injuries. Michael Miloro;2013 61www.indiandentalacademy.com
Conclusion
62www.indiandentalacademy.com
REFERENCES:
 B.D. Chaurasia 4th edition
 Cunningham’s manual of practical anatomy, volume 3,
3rd edition
 Tubbs RS, Loukas M, May WR, Cohen-Gadol AA. A variation of the infraorbital
nerve: its potential clinical consequence especially in the treatment of
trigeminal neuralgia: case report. Neurosurgery. 2010 Sep; 67
 Malamad SF. Handbook of local anesthesia. 6th ed. Missouri: Elsevier;2013
 Peter. L. Williams, grays anatomy, 38th edition,1995
 Trigeminal Nerve Injuries. Michael Miloro;2013
 Cranial nerve functional anatomy, Stanley Monkhouse
63www.indiandentalacademy.com
THANK YOU
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