The Uses of Nanosensors: From Smart Dust to Nano “Mother Ships”
1. The Uses of Nanosensors: From
Smart Dust to Nano “Mother
Ships”
Jack Ealy Workshop
La Jolla, CA July 2006
Professor Michael J. Sailor
UC San Diego
Dept. of Chemistry and Biochemistry
msailor@ucsd.edu
http://chem-faculty.ucsd.edu/sailor/
2. Death on the Danube
The Economist, 2/15/00The Economist, 2/15/00
14. Ruoslahti, Cancer Cell, 2002
UCSD Moores Cancer Center
NIH nanoTUMOR center
Erkki Ruoslahti, Burnham Inst.
Sangeeta Bhatia, MIT
Michael Sailor, UCSD
Diagnostic
Therapeutic
Activation
Targeting Self-Destruct
Sensor
Targeted Nanomachines
17. As with any new technology, reasonable concerns about
potential hazards are appropriate.
Hazards of nanotechnology
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University of Wisconsin, Madison Asbestos Management Program
Heating/Chilling Plant: Furnace/Boiler Abatement (December 1997-
January 1998)
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Asbestos fibers (Nikon, inc)
18. Hazards of nanotechnology
Shvedova, A. A. et al. Exposure to carbon
nanotube material: assessment of nanotube
cytotoxicity using human keratinocyte cells. J.
Toxicol. Environ. Health A 66, 1909-1926
(2003).
Derfus, A., Chan, W. & Bhatia, S. N. Probing the
Cytotoxicity of Semiconductor Quantum Dots.
Nano Lett. (2004).
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5 nm CdSe
(A. Paul Alivisatos, UC
Berkeley)
19. Making a silicon nanostructure
20 µmQuickTime™ and aH.263 decompressorare needed to see this picture.
Samples collected in the field are transported back to the laboratory for more detailed analysis. The delay reduces the effectiveness of remediation efforts. Santa Margarita Ecological Reserve, Aug 2002
2 chips fabbed in 0.25um CMOS “ Mote on a chip” worked, missing radio RX 900 MHz transceiver worked “ The Smart Dust project is probing microfabrication technology's limitations to determine whether an autonomous sensing, computing, and communication system can be packed into a cubic millimeter mote (a small particle or speck) to form the basis of integrated, massively distributed sensor networks.” - Computer , 34 , 44-51 (2001). Records set for low power CMOS ADC 8 bits, 100kS/s [email_address] Microprocessor 8 bits, 1MIP [email_address] 900 MHz radio 100kbps, “bits in, bits out” 20 m indoors 0.4mA @ 3V
2 chips fabbed in 0.25um CMOS “ Mote on a chip” worked, missing radio RX 900 MHz transceiver worked “ The Smart Dust project is probing microfabrication technology's limitations to determine whether an autonomous sensing, computing, and communication system can be packed into a cubic millimeter mote (a small particle or speck) to form the basis of integrated, massively distributed sensor networks.” - Computer , 34 , 44-51 (2001). Records set for low power CMOS ADC 8 bits, 100kS/s [email_address] Microprocessor 8 bits, 1MIP [email_address] 900 MHz radio 100kbps, “bits in, bits out” 20 m indoors 0.4mA @ 3V
Scattering the reflection is given over a wider angle (the color appear constant from every direction) alters the reflection from the multilayer reflector to achieve both a diffuse reflection and a weak reflectance in each direction Diffraction is caused by a surface with a repeating pattern. If the pattern size is of the order of the wavelength of incidence light, then different wavelengths of lights are reflected at different angles. Figure: (A) Calloodes grayanus , which results in a diffuse green reflection. (B) Anoplognathus parvulus , which results in a directional, gold (specular) reflectance. [email_address]
Scattering the reflection is given over a wider angle (the color appear constant from every direction) alters the reflection from the multilayer reflector to achieve both a diffuse reflection and a weak reflectance in each direction Diffraction is caused by a surface with a repeating pattern. If the pattern size is of the order of the wavelength of incidence light, then different wavelengths of lights are reflected at different angles. Figure: (A) Calloodes grayanus , which results in a diffuse green reflection. (B) Anoplognathus parvulus , which results in a directional, gold (specular) reflectance. [email_address]
Encoded microparticles use a nanoporous Si or SiO 2 material. Methods to load, seal, and trigger release of small molecule, peptide, or protein-based drugs have been developed.
Multifunctional particles to diagnose and treat disease Modular – each part adaptable to generic nanoparticle system First step – targeting nanoparticles – something our group began looking at a few years ago…
University of Wisconsin/Madison Environmental Health, Safety & Risk Management Asbestos Management Program Image Page Heating/Chilling Plant: Furnace/Boiler #1 Abatement (Phase II) December 1997-January 1998