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The Uses of Nanosensors: From
Smart Dust to Nano “Mother
Ships”
Jack Ealy Workshop
La Jolla, CA July 2006
Professor Michae...
Death on the Danube
The Economist, 2/15/00The Economist, 2/15/00
Environmental sampling
Field
Lab
Smart Dust
Kris Pister, UCB (1996)
Available:
•wireless radios
•data processing
•networking
protocols
Smart Dust
Kris Pister, UCB (1996)
Need:
•sensors
•power sources
Silicon vapor sensors
QuickTime™ and a
DV/DVCPRO - NTSC decompressor
are needed to see this picture.
Making a silicon nanostructure
20 µm
QuickTime™ and aH.263 decompressorare needed to see this picture.
Electrochemical mac...
Silicon nanostructures mimic the
beetle shell
chitinmultilaye
n = 1.73n = 1.40
Calloodes grayanus
2 mm
Chitin multilayer
Silicon nanostructures mimic the
beetle shell
Silicon multilayer
Silicon Microsensors
William R. Freeman, M.D.
and Lingyun Cheng, M.D.
Jacobs Retina Center
UCSD
Mother-Ships for Nanotherapies
color changes when
particle releases drug
Porous silicon
micro-particle in
the eye
Ruoslahti, Cancer Cell, 2002
UCSD Moores Cancer Center
NIH nanoTUMOR center
Erkki Ruoslahti, Burnham Inst.
Sangeeta Bhatia...
Backup slides
As with any new technology, reasonable concerns about
potential hazards are appropriate.
Hazards of nanotechnology
QuickTi...
Hazards of nanotechnology
Shvedova, A. A. et al. Exposure to carbon
nanotube material: assessment of nanotube
cytotoxicity...
Making a silicon nanostructure
20 µmQuickTime™ and aH.263 decompressorare needed to see this picture.
Encoded particles self-assemble
oxidize
alkylate
QuickTime™ and a
MPEG-4 Video decompressor
are needed to see this picture.
Magnetic manipulation of microparticles
Nature Mater. 2004, 3, 896-899.
30 nm magnanopartic
[O]
The Uses of Nanosensors: From Smart Dust to Nano “Mother Ships”
The Uses of Nanosensors: From Smart Dust to Nano “Mother Ships”
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The Uses of Nanosensors: From Smart Dust to Nano “Mother Ships”

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Environmental sampling,Smart Dust Kris Pister, UCB (1996),Silicon nanostructures mimic the beetle shell

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The Uses of Nanosensors: From Smart Dust to Nano “Mother Ships”

  1. 1. The Uses of Nanosensors: From Smart Dust to Nano “Mother Ships” Jack Ealy Workshop La Jolla, CA July 2006 Professor Michael J. Sailor UC San Diego Dept. of Chemistry and Biochemistry msailor@ucsd.edu http://chem-faculty.ucsd.edu/sailor/
  2. 2. Death on the Danube The Economist, 2/15/00The Economist, 2/15/00
  3. 3. Environmental sampling Field Lab
  4. 4. Smart Dust Kris Pister, UCB (1996) Available: •wireless radios •data processing •networking protocols
  5. 5. Smart Dust Kris Pister, UCB (1996) Need: •sensors •power sources
  6. 6. Silicon vapor sensors QuickTime™ and a DV/DVCPRO - NTSC decompressor are needed to see this picture.
  7. 7. Making a silicon nanostructure 20 µm QuickTime™ and aH.263 decompressorare needed to see this picture. Electrochemical machining of nanopores
  8. 8. Silicon nanostructures mimic the beetle shell chitinmultilaye n = 1.73n = 1.40 Calloodes grayanus 2 mm Chitin multilayer
  9. 9. Silicon nanostructures mimic the beetle shell Silicon multilayer
  10. 10. Silicon Microsensors
  11. 11. William R. Freeman, M.D. and Lingyun Cheng, M.D. Jacobs Retina Center UCSD
  12. 12. Mother-Ships for Nanotherapies color changes when particle releases drug Porous silicon micro-particle in the eye
  13. 13. Ruoslahti, Cancer Cell, 2002 UCSD Moores Cancer Center NIH nanoTUMOR center Erkki Ruoslahti, Burnham Inst. Sangeeta Bhatia, MIT Michael Sailor, UCSD Diagnostic Therapeutic Activation Targeting Self-Destruct Sensor Targeted Nanomachines
  14. 14. Backup slides
  15. 15. As with any new technology, reasonable concerns about potential hazards are appropriate. Hazards of nanotechnology QuickTime™ and a TIFF (Uncompressed) decompressor are needed to see this picture. University of Wisconsin, Madison Asbestos Management Program Heating/Chilling Plant: Furnace/Boiler Abatement (December 1997- January 1998) QuickTime™ and a TIFF (Uncompressed) decompressor are needed to see this picture. Asbestos fibers (Nikon, inc)
  16. 16. Hazards of nanotechnology Shvedova, A. A. et al. Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. J. Toxicol. Environ. Health A 66, 1909-1926 (2003). Derfus, A., Chan, W. & Bhatia, S. N. Probing the Cytotoxicity of Semiconductor Quantum Dots. Nano Lett. (2004). QuickTime™ and a TIFF (Uncompressed) decompressor are needed to see this picture. 5 nm CdSe (A. Paul Alivisatos, UC Berkeley)
  17. 17. Making a silicon nanostructure 20 µmQuickTime™ and aH.263 decompressorare needed to see this picture.
  18. 18. Encoded particles self-assemble oxidize alkylate QuickTime™ and a MPEG-4 Video decompressor are needed to see this picture.
  19. 19. Magnetic manipulation of microparticles Nature Mater. 2004, 3, 896-899. 30 nm magnanopartic [O]

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