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Morning case presentation
By Derso bewket (Idno_6083/07)
1
8/27/2019
Outline
2
• Socio-Demographic Data
• Clinical History
• Physical examination
• Investigation data
• Medication
• Pharmaceutical care plan
• Disease background
8/27/2019
IDENTIFICATION 3
 Name M.Z
Age 18 years old
Sex M
Card no. 832824
 Bed no. 13
 Address Dabat
 Admitted to the Internal medicine ward-D on 10/11/11
Patient stay 27 days
Ethnic origin ƒAmhara
Religion ƒorthodox
Occupation farmer 8/27/2019
Clinical History 4
Previous Admissions
November , 2011E.C, private clinic diagnosis pulmonary
tuberculosis and kalazar at shedy hospital
Chief complaints:- (general body swelling )GBS of 1
month duration
8/27/2019
HISTORY OF PRESENT ILLNESS 5
• This is 18 years old known TB patient for the last 2 month and 10 days
on anti TB medication
• Currently presented with GBS of 1 month duration the GBS started
from bilateral legs and gradually presented to abdomen. it associated
with easy fatigability during the normal activates.
• The patient also have SOB, orthopenea of of 02-03 pillows in the last
01 month
• The patient was having cough for the past 04 month productive blood
tingled sputum, night sweating , loss of appetite significant but un
quantified weight loss for which he was treated with anti TB
medication pas 04 month 8/27/2019
Cont… 6
• He has no Hx of contact with chronic cougher or Known TB patient
• He has no Hx of self /family Hx of HTN,DM
Past medical histories:- he has Hx of TB, kalazar& malaria epidemic area
Past medication histories :-
He has hx of kalazar treatment novmber 2011 at shedy hospital
Has hx of anti TB treatment 04 month back
Family histories:-there is no family Hx of TB, HTN,DM
Social histories:- he has alcohol drinker
Allargic histories :- there is no drug and food allergies
8/27/2019
Physical Diagnosis At admission 7
 G/A=ASL
V/S BP=110/70mmHg PR=100 RR=28 SO2= 100%
HEENT=pink conjunctive
LGS=no lephadnopathy
Respiratory =there is BBS heard over the right middle third of lung field
= decrease air entry over the left posterior 1/3of lung field
CVS= S1&S2are well heard
=JVP raise
Abd= full Abd move with respiration
 GUS= NO CVAT
 MSS= GII peating edema
IGI = no rash and pallor
CNS=conscious &oriented 8/27/2019
• Assessment NYHA class IV stage c 2o to DCMP with sever LV systolic
dysfunction(EF 15%)+ SCAP
8/27/2019
8
v/s
BP PR RR Tem so2
At admission 110/70 100 28 100%
16/11/11 100/70 92 22 36 95
18/11/11 110/80 87 21 36.5 94who
2211/11 100/60 96 23 36 95
24/11/11 100/60 92 24 36 94
25/11/11 >> 94 23 >> -
26/11/11 100/70 92 22 36.5 -
9
8/27/2019
Investigation
• 10/11/11
RBS 79mg/dl
U/A PH 6 5-8
Spg 1.030
Blood +3
Others NEG
 11/11/11
 Cr 0.75 0.6-1.1
Na 147 136-145mmol/l
K 5.34 3.5-5.1mmol/l
Chest X-ray cardiomegally with pulmonary arterial hypertension
10
8/27/2019
• 14/11/11
• Urea 93.73 16-48mg/dl
• Cr 1.48 0.6-1.1mg/dl
• SGOT 176.66 up to 32u/l
• SGPT 29.45 up to 31u/l
• BIIL T 5.82 up to 1mg/dl
• BILL D 4.45 up to 0.25mg/dl
• Serum protein 5.32 6.4-8.3g/dl
• Na 141 136-145mmol/l
• K 4.7 3.5-5.5mmol/l
• Cl 110 101-110mmol/l
11
8/27/2019
CBC
14/11/11
normal range level
• WBC 14.8 3.5-10x103/mm3 High
• RBC 6.12 3.8-5.8x106/mm3 High
• Hgb 12.2 11-18g/dl
• Hct 43 35-50%
• Plt 277 150-400
• Pct 0.176 0.1-0.5
• MCV 70 80-97fl low
• MCH 19.9 26.5-33.5 low
• MCHC 28.4 31.5-35g/dl low
• RDW 18.5 10-15 high
12
8/27/2019
Cont…
• %Lym 17.7% 17-49%
• %Mon3.5% 4-10% low
• %Gra 78.8% 43-76% high
16/11/11
Na 142 136-145mmol/l
K 2.7 3.5-5.1 low
SGOT 82 0-37u/l high
SGPT 54 0-47u/l high
Cr 0.72 0.6-1.1mg/dl
Cl 102 98-108
13
8/27/2019
20/11/11 22/11/11
• SGOT 74 high K 4.46
• SGPT 59 high Na 143.9
• BILLD 1.29(1.5 Cl 106.9
• BILLT ica 1.46(1.1-1.4) H
• TP 5.7 Tca 2.86(2.2-2.9)
Ph 8(5-8)
SGOT 49 H
SGPT 39
BILLD 1.52mg/dl
TP 6.2G/dl
alb 0.87g/dl
14
8/27/2019
Other diagnosis
15/11/11
• HCV NEG
• HbsAG NEG
9/11/11
Echo ST-Segment elevation on V1-V2
-T wave inversion on V2-V3
13/11/11
PICT NR
15
8/27/2019
Treatment
At admission
Vancomycin 1g iv bid
Ceftraxon 1g iv bid
Doxycline 100mg po bid
Dopamine20ug/kg
Omeprazole 20mg po bid
Hold anti TB
Digoxin 0.25mg iv loading then 0.125mg po/day
Lasix 20mg iv stat
16
8/27/2019
Cont…
Revised order 14/11/11
• Vancomycin 1g iv every other day (48hr)
• Dopamin 15ug/kg
• The rest same the previous data
15/11/11
Hold dopamine
Hold lasix
Added KCL60meqin 500ml NS
17/11/11 Lasix 20mg po
D/c Doxyclin
17
8/27/2019
Cont…
19/11/11 Revised order
• Vancomycin 1g iv bid
• Ceftraxon 1g iv bid
• Lasix 40mg iv bid
• Digoxin 0.125mg po/day
• Spirnolactone 25mg po/day
• Enalapril 2.5mg poBID
• KCL 60meqiv in500ml NS run over Q8hr 22dpm
20/11/11 Added order
• Added KCL 40meq iv in 500ml NS
23/11/11
D/c antibiotics
18
8/27/2019
Currently revised order
• Lasix 40mg iv bid
• Enalapril 5mg po bid
• Metoprolol succinate 25mg po/day
• Spironolacton 25mgpo/day
19
8/27/2019
Pharmaceutical care plan
Goal of therapy:
• To alleviate all symptoms(SOB, orthopenea , GBS) and improve quality
of life
• To Prevent further complications
• To decrease death and hospitalization
• To Improve survival
• Treat the precipitating cause
20
8/27/2019
Monitoring parameter
• Vital sign
• CBC
• Organ function test
 lever function test
 Renal function test
21
8/27/2019
Un necessary drug's
Doxycline not used fore SCAP
Addational drug therapy macrolid nessray
DTP
8/27/2019
22
23
8/27/2019
Definition
• Heart Failure is an abnormality of cardiac structure or function leading to failure of the
cardiac output to meet the body's metabolic requirements despite normal filling pressures.
• Clinically it is a syndrome consisting of typical symptoms (shortness of breath, fatigue,
orthopnea, ankle swelling) and signs (raised JVP, pulmonary crackles, displaced apex beat,
edem
24
8/27/2019
Form(type) of heart failure
 Systolic(with out) vs Diastolic(with reserved EF
 Left vs Right
 High output Vs Low output
 Acute Vs Chronic
 Forward Vs Backward
 Congenital vs Aquired
 Refractory vs Non refractory
25
• Systolic heart failure:- HF due to abnormalities in cardiac
contractility.
• HF with depressed EF (systolic HF) EF<40%
 Diastolic heart failure:- HF due to impaired cardiac relaxation or
abnormal ventricular filling.
 HF with preserved EF (Diastolic HF)EF>40-50%
26
Etiology 27
8/27/2019
Etiology
28
8/27/2019
29
NYHA heart failure classification
Class Patient Symptoms
I No limitation of physical activity. Ordinary physical activity does not cause undue
fatigue, palpitation, dyspnea (shortness of breath).
II Slight limitation of physical activity. Comfortable at rest. Ordinary physical activity
results in fatigue, palpitation, dyspnea (shortness of breath).
III Marked limitation of physical activity. Comfortable at rest. Less than ordinary activity
causes fatigue, palpitation, or dyspnea.
IV Unable to carry on any physical activity without discomfort. Symptoms of heart failure
at rest. If any physical activity is undertaken, discomfort increases.8/27/2019
• Stage A — High risk for HF, without structural heart disease or
symptoms
• Stage B — Heart disease with asymptomatic left ventricular
dysfunction
• Stage C — Prior or current symptoms of HF
• Stage D — Advanced heart disease and severely symptomatic or
refractory HF
30stages of HF
8/27/2019
Investigation
 CBC, UA, OFT(LFT, RFT and TFT),Electrolyte, Glucose, lipid
profile, BNP, cardiac markers
 CXR, ECG, ECHO
31
8/27/2019
H =Hypertension
E=Endocarditis
A=Anemia
R=Rheumatic fever
T=Thyrotoxicosis
F=Fever
A=Arrhythmia
I =Ischemia
L=Lung infection
S=Stress (emotional, physical, dietary…)
32
Precipitant factor
Non pharmacologic
• Reduce salt intake, avoid salt intake of >6g/day
• Avoid “salt replacement” tablets due to their high potassium content.
• Encourage patients to weigh themselves
• Reduction of weight in overweight and obese individuals
• Refraining from excessive alcohol consumption
• Avoid smoking. Patients should be offered smoking cessation advice
and support.
• Encourage low intensity physical activity amongst patients with
stable Heart Failure - Bed rest in hospitalized patients.
33
8/27/2019
Pharmacology
Initial therapy of severe Heart Failure (NYHA CLASS IV)
 Furosemide, 40mg iv
Add KCl 600mg, 1-2 tabs, twice per day or Spironolactone 25-50mg,
BID, if there is no renal impairment or hyperkalemia
ACE inhibtors or ARBS
N.B. Do not start ACE inhibitors/Angiotensin Receptor
Blockers until the patient is haemodynamically stable. For
patients with Left ventricular systolic dysfunction. Start with
low dose and increase gradually.
34
8/27/2019
Cont…
Beta blockers –
N.B. Beta blockers – should not be started in the acute management of
decompensated Heart Failure . After patient stabilization, beta
blockers can be started during discharge or as an out patient
management. Start with low dose and escalate gradually.
Digoxin, 0.125 mg once, P.O, daily
Dopamine, I.V infusion 1-5 ug /kg/minute up to 50 ug /kg/minute;
increase by 1- 4mcg/kg/minute at 10-to 30-minute intervals until
optimal response is obtained
35
8/27/2019
Reference
• Patient chart and pt interview
• Ethiopian standard treatment guideline 2014
• Uptodate 21.6
36
8/27/2019
37
8/27/2019

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morning case presentation

  • 1. Morning case presentation By Derso bewket (Idno_6083/07) 1 8/27/2019
  • 2. Outline 2 • Socio-Demographic Data • Clinical History • Physical examination • Investigation data • Medication • Pharmaceutical care plan • Disease background 8/27/2019
  • 3. IDENTIFICATION 3  Name M.Z Age 18 years old Sex M Card no. 832824  Bed no. 13  Address Dabat  Admitted to the Internal medicine ward-D on 10/11/11 Patient stay 27 days Ethnic origin ƒAmhara Religion ƒorthodox Occupation farmer 8/27/2019
  • 4. Clinical History 4 Previous Admissions November , 2011E.C, private clinic diagnosis pulmonary tuberculosis and kalazar at shedy hospital Chief complaints:- (general body swelling )GBS of 1 month duration 8/27/2019
  • 5. HISTORY OF PRESENT ILLNESS 5 • This is 18 years old known TB patient for the last 2 month and 10 days on anti TB medication • Currently presented with GBS of 1 month duration the GBS started from bilateral legs and gradually presented to abdomen. it associated with easy fatigability during the normal activates. • The patient also have SOB, orthopenea of of 02-03 pillows in the last 01 month • The patient was having cough for the past 04 month productive blood tingled sputum, night sweating , loss of appetite significant but un quantified weight loss for which he was treated with anti TB medication pas 04 month 8/27/2019
  • 6. Cont… 6 • He has no Hx of contact with chronic cougher or Known TB patient • He has no Hx of self /family Hx of HTN,DM Past medical histories:- he has Hx of TB, kalazar& malaria epidemic area Past medication histories :- He has hx of kalazar treatment novmber 2011 at shedy hospital Has hx of anti TB treatment 04 month back Family histories:-there is no family Hx of TB, HTN,DM Social histories:- he has alcohol drinker Allargic histories :- there is no drug and food allergies 8/27/2019
  • 7. Physical Diagnosis At admission 7  G/A=ASL V/S BP=110/70mmHg PR=100 RR=28 SO2= 100% HEENT=pink conjunctive LGS=no lephadnopathy Respiratory =there is BBS heard over the right middle third of lung field = decrease air entry over the left posterior 1/3of lung field CVS= S1&S2are well heard =JVP raise Abd= full Abd move with respiration  GUS= NO CVAT  MSS= GII peating edema IGI = no rash and pallor CNS=conscious &oriented 8/27/2019
  • 8. • Assessment NYHA class IV stage c 2o to DCMP with sever LV systolic dysfunction(EF 15%)+ SCAP 8/27/2019 8
  • 9. v/s BP PR RR Tem so2 At admission 110/70 100 28 100% 16/11/11 100/70 92 22 36 95 18/11/11 110/80 87 21 36.5 94who 2211/11 100/60 96 23 36 95 24/11/11 100/60 92 24 36 94 25/11/11 >> 94 23 >> - 26/11/11 100/70 92 22 36.5 - 9 8/27/2019
  • 10. Investigation • 10/11/11 RBS 79mg/dl U/A PH 6 5-8 Spg 1.030 Blood +3 Others NEG  11/11/11  Cr 0.75 0.6-1.1 Na 147 136-145mmol/l K 5.34 3.5-5.1mmol/l Chest X-ray cardiomegally with pulmonary arterial hypertension 10 8/27/2019
  • 11. • 14/11/11 • Urea 93.73 16-48mg/dl • Cr 1.48 0.6-1.1mg/dl • SGOT 176.66 up to 32u/l • SGPT 29.45 up to 31u/l • BIIL T 5.82 up to 1mg/dl • BILL D 4.45 up to 0.25mg/dl • Serum protein 5.32 6.4-8.3g/dl • Na 141 136-145mmol/l • K 4.7 3.5-5.5mmol/l • Cl 110 101-110mmol/l 11 8/27/2019
  • 12. CBC 14/11/11 normal range level • WBC 14.8 3.5-10x103/mm3 High • RBC 6.12 3.8-5.8x106/mm3 High • Hgb 12.2 11-18g/dl • Hct 43 35-50% • Plt 277 150-400 • Pct 0.176 0.1-0.5 • MCV 70 80-97fl low • MCH 19.9 26.5-33.5 low • MCHC 28.4 31.5-35g/dl low • RDW 18.5 10-15 high 12 8/27/2019
  • 13. Cont… • %Lym 17.7% 17-49% • %Mon3.5% 4-10% low • %Gra 78.8% 43-76% high 16/11/11 Na 142 136-145mmol/l K 2.7 3.5-5.1 low SGOT 82 0-37u/l high SGPT 54 0-47u/l high Cr 0.72 0.6-1.1mg/dl Cl 102 98-108 13 8/27/2019
  • 14. 20/11/11 22/11/11 • SGOT 74 high K 4.46 • SGPT 59 high Na 143.9 • BILLD 1.29(1.5 Cl 106.9 • BILLT ica 1.46(1.1-1.4) H • TP 5.7 Tca 2.86(2.2-2.9) Ph 8(5-8) SGOT 49 H SGPT 39 BILLD 1.52mg/dl TP 6.2G/dl alb 0.87g/dl 14 8/27/2019
  • 15. Other diagnosis 15/11/11 • HCV NEG • HbsAG NEG 9/11/11 Echo ST-Segment elevation on V1-V2 -T wave inversion on V2-V3 13/11/11 PICT NR 15 8/27/2019
  • 16. Treatment At admission Vancomycin 1g iv bid Ceftraxon 1g iv bid Doxycline 100mg po bid Dopamine20ug/kg Omeprazole 20mg po bid Hold anti TB Digoxin 0.25mg iv loading then 0.125mg po/day Lasix 20mg iv stat 16 8/27/2019
  • 17. Cont… Revised order 14/11/11 • Vancomycin 1g iv every other day (48hr) • Dopamin 15ug/kg • The rest same the previous data 15/11/11 Hold dopamine Hold lasix Added KCL60meqin 500ml NS 17/11/11 Lasix 20mg po D/c Doxyclin 17 8/27/2019
  • 18. Cont… 19/11/11 Revised order • Vancomycin 1g iv bid • Ceftraxon 1g iv bid • Lasix 40mg iv bid • Digoxin 0.125mg po/day • Spirnolactone 25mg po/day • Enalapril 2.5mg poBID • KCL 60meqiv in500ml NS run over Q8hr 22dpm 20/11/11 Added order • Added KCL 40meq iv in 500ml NS 23/11/11 D/c antibiotics 18 8/27/2019
  • 19. Currently revised order • Lasix 40mg iv bid • Enalapril 5mg po bid • Metoprolol succinate 25mg po/day • Spironolacton 25mgpo/day 19 8/27/2019
  • 20. Pharmaceutical care plan Goal of therapy: • To alleviate all symptoms(SOB, orthopenea , GBS) and improve quality of life • To Prevent further complications • To decrease death and hospitalization • To Improve survival • Treat the precipitating cause 20 8/27/2019
  • 21. Monitoring parameter • Vital sign • CBC • Organ function test  lever function test  Renal function test 21 8/27/2019
  • 22. Un necessary drug's Doxycline not used fore SCAP Addational drug therapy macrolid nessray DTP 8/27/2019 22
  • 24. Definition • Heart Failure is an abnormality of cardiac structure or function leading to failure of the cardiac output to meet the body's metabolic requirements despite normal filling pressures. • Clinically it is a syndrome consisting of typical symptoms (shortness of breath, fatigue, orthopnea, ankle swelling) and signs (raised JVP, pulmonary crackles, displaced apex beat, edem 24 8/27/2019
  • 25. Form(type) of heart failure  Systolic(with out) vs Diastolic(with reserved EF  Left vs Right  High output Vs Low output  Acute Vs Chronic  Forward Vs Backward  Congenital vs Aquired  Refractory vs Non refractory 25
  • 26. • Systolic heart failure:- HF due to abnormalities in cardiac contractility. • HF with depressed EF (systolic HF) EF<40%  Diastolic heart failure:- HF due to impaired cardiac relaxation or abnormal ventricular filling.  HF with preserved EF (Diastolic HF)EF>40-50% 26
  • 29. 29 NYHA heart failure classification Class Patient Symptoms I No limitation of physical activity. Ordinary physical activity does not cause undue fatigue, palpitation, dyspnea (shortness of breath). II Slight limitation of physical activity. Comfortable at rest. Ordinary physical activity results in fatigue, palpitation, dyspnea (shortness of breath). III Marked limitation of physical activity. Comfortable at rest. Less than ordinary activity causes fatigue, palpitation, or dyspnea. IV Unable to carry on any physical activity without discomfort. Symptoms of heart failure at rest. If any physical activity is undertaken, discomfort increases.8/27/2019
  • 30. • Stage A — High risk for HF, without structural heart disease or symptoms • Stage B — Heart disease with asymptomatic left ventricular dysfunction • Stage C — Prior or current symptoms of HF • Stage D — Advanced heart disease and severely symptomatic or refractory HF 30stages of HF 8/27/2019
  • 31. Investigation  CBC, UA, OFT(LFT, RFT and TFT),Electrolyte, Glucose, lipid profile, BNP, cardiac markers  CXR, ECG, ECHO 31 8/27/2019
  • 32. H =Hypertension E=Endocarditis A=Anemia R=Rheumatic fever T=Thyrotoxicosis F=Fever A=Arrhythmia I =Ischemia L=Lung infection S=Stress (emotional, physical, dietary…) 32 Precipitant factor
  • 33. Non pharmacologic • Reduce salt intake, avoid salt intake of >6g/day • Avoid “salt replacement” tablets due to their high potassium content. • Encourage patients to weigh themselves • Reduction of weight in overweight and obese individuals • Refraining from excessive alcohol consumption • Avoid smoking. Patients should be offered smoking cessation advice and support. • Encourage low intensity physical activity amongst patients with stable Heart Failure - Bed rest in hospitalized patients. 33 8/27/2019
  • 34. Pharmacology Initial therapy of severe Heart Failure (NYHA CLASS IV)  Furosemide, 40mg iv Add KCl 600mg, 1-2 tabs, twice per day or Spironolactone 25-50mg, BID, if there is no renal impairment or hyperkalemia ACE inhibtors or ARBS N.B. Do not start ACE inhibitors/Angiotensin Receptor Blockers until the patient is haemodynamically stable. For patients with Left ventricular systolic dysfunction. Start with low dose and increase gradually. 34 8/27/2019
  • 35. Cont… Beta blockers – N.B. Beta blockers – should not be started in the acute management of decompensated Heart Failure . After patient stabilization, beta blockers can be started during discharge or as an out patient management. Start with low dose and escalate gradually. Digoxin, 0.125 mg once, P.O, daily Dopamine, I.V infusion 1-5 ug /kg/minute up to 50 ug /kg/minute; increase by 1- 4mcg/kg/minute at 10-to 30-minute intervals until optimal response is obtained 35 8/27/2019
  • 36. Reference • Patient chart and pt interview • Ethiopian standard treatment guideline 2014 • Uptodate 21.6 36 8/27/2019