2. Outline
2
• Socio-Demographic Data
• Clinical History
• Physical examination
• Investigation data
• Medication
• Pharmaceutical care plan
• Disease background
8/27/2019
3. IDENTIFICATION 3
Name M.Z
Age 18 years old
Sex M
Card no. 832824
Bed no. 13
Address Dabat
Admitted to the Internal medicine ward-D on 10/11/11
Patient stay 27 days
Ethnic origin ƒAmhara
Religion ƒorthodox
Occupation farmer 8/27/2019
4. Clinical History 4
Previous Admissions
November , 2011E.C, private clinic diagnosis pulmonary
tuberculosis and kalazar at shedy hospital
Chief complaints:- (general body swelling )GBS of 1
month duration
8/27/2019
5. HISTORY OF PRESENT ILLNESS 5
• This is 18 years old known TB patient for the last 2 month and 10 days
on anti TB medication
• Currently presented with GBS of 1 month duration the GBS started
from bilateral legs and gradually presented to abdomen. it associated
with easy fatigability during the normal activates.
• The patient also have SOB, orthopenea of of 02-03 pillows in the last
01 month
• The patient was having cough for the past 04 month productive blood
tingled sputum, night sweating , loss of appetite significant but un
quantified weight loss for which he was treated with anti TB
medication pas 04 month 8/27/2019
6. Cont… 6
• He has no Hx of contact with chronic cougher or Known TB patient
• He has no Hx of self /family Hx of HTN,DM
Past medical histories:- he has Hx of TB, kalazar& malaria epidemic area
Past medication histories :-
He has hx of kalazar treatment novmber 2011 at shedy hospital
Has hx of anti TB treatment 04 month back
Family histories:-there is no family Hx of TB, HTN,DM
Social histories:- he has alcohol drinker
Allargic histories :- there is no drug and food allergies
8/27/2019
7. Physical Diagnosis At admission 7
G/A=ASL
V/S BP=110/70mmHg PR=100 RR=28 SO2= 100%
HEENT=pink conjunctive
LGS=no lephadnopathy
Respiratory =there is BBS heard over the right middle third of lung field
= decrease air entry over the left posterior 1/3of lung field
CVS= S1&S2are well heard
=JVP raise
Abd= full Abd move with respiration
GUS= NO CVAT
MSS= GII peating edema
IGI = no rash and pallor
CNS=conscious &oriented 8/27/2019
8. • Assessment NYHA class IV stage c 2o to DCMP with sever LV systolic
dysfunction(EF 15%)+ SCAP
8/27/2019
8
11. • 14/11/11
• Urea 93.73 16-48mg/dl
• Cr 1.48 0.6-1.1mg/dl
• SGOT 176.66 up to 32u/l
• SGPT 29.45 up to 31u/l
• BIIL T 5.82 up to 1mg/dl
• BILL D 4.45 up to 0.25mg/dl
• Serum protein 5.32 6.4-8.3g/dl
• Na 141 136-145mmol/l
• K 4.7 3.5-5.5mmol/l
• Cl 110 101-110mmol/l
11
8/27/2019
13. Cont…
• %Lym 17.7% 17-49%
• %Mon3.5% 4-10% low
• %Gra 78.8% 43-76% high
16/11/11
Na 142 136-145mmol/l
K 2.7 3.5-5.1 low
SGOT 82 0-37u/l high
SGPT 54 0-47u/l high
Cr 0.72 0.6-1.1mg/dl
Cl 102 98-108
13
8/27/2019
14. 20/11/11 22/11/11
• SGOT 74 high K 4.46
• SGPT 59 high Na 143.9
• BILLD 1.29(1.5 Cl 106.9
• BILLT ica 1.46(1.1-1.4) H
• TP 5.7 Tca 2.86(2.2-2.9)
Ph 8(5-8)
SGOT 49 H
SGPT 39
BILLD 1.52mg/dl
TP 6.2G/dl
alb 0.87g/dl
14
8/27/2019
15. Other diagnosis
15/11/11
• HCV NEG
• HbsAG NEG
9/11/11
Echo ST-Segment elevation on V1-V2
-T wave inversion on V2-V3
13/11/11
PICT NR
15
8/27/2019
16. Treatment
At admission
Vancomycin 1g iv bid
Ceftraxon 1g iv bid
Doxycline 100mg po bid
Dopamine20ug/kg
Omeprazole 20mg po bid
Hold anti TB
Digoxin 0.25mg iv loading then 0.125mg po/day
Lasix 20mg iv stat
16
8/27/2019
17. Cont…
Revised order 14/11/11
• Vancomycin 1g iv every other day (48hr)
• Dopamin 15ug/kg
• The rest same the previous data
15/11/11
Hold dopamine
Hold lasix
Added KCL60meqin 500ml NS
17/11/11 Lasix 20mg po
D/c Doxyclin
17
8/27/2019
18. Cont…
19/11/11 Revised order
• Vancomycin 1g iv bid
• Ceftraxon 1g iv bid
• Lasix 40mg iv bid
• Digoxin 0.125mg po/day
• Spirnolactone 25mg po/day
• Enalapril 2.5mg poBID
• KCL 60meqiv in500ml NS run over Q8hr 22dpm
20/11/11 Added order
• Added KCL 40meq iv in 500ml NS
23/11/11
D/c antibiotics
18
8/27/2019
19. Currently revised order
• Lasix 40mg iv bid
• Enalapril 5mg po bid
• Metoprolol succinate 25mg po/day
• Spironolacton 25mgpo/day
19
8/27/2019
20. Pharmaceutical care plan
Goal of therapy:
• To alleviate all symptoms(SOB, orthopenea , GBS) and improve quality
of life
• To Prevent further complications
• To decrease death and hospitalization
• To Improve survival
• Treat the precipitating cause
20
8/27/2019
21. Monitoring parameter
• Vital sign
• CBC
• Organ function test
lever function test
Renal function test
21
8/27/2019
24. Definition
• Heart Failure is an abnormality of cardiac structure or function leading to failure of the
cardiac output to meet the body's metabolic requirements despite normal filling pressures.
• Clinically it is a syndrome consisting of typical symptoms (shortness of breath, fatigue,
orthopnea, ankle swelling) and signs (raised JVP, pulmonary crackles, displaced apex beat,
edem
24
8/27/2019
25. Form(type) of heart failure
Systolic(with out) vs Diastolic(with reserved EF
Left vs Right
High output Vs Low output
Acute Vs Chronic
Forward Vs Backward
Congenital vs Aquired
Refractory vs Non refractory
25
26. • Systolic heart failure:- HF due to abnormalities in cardiac
contractility.
• HF with depressed EF (systolic HF) EF<40%
Diastolic heart failure:- HF due to impaired cardiac relaxation or
abnormal ventricular filling.
HF with preserved EF (Diastolic HF)EF>40-50%
26
29. 29
NYHA heart failure classification
Class Patient Symptoms
I No limitation of physical activity. Ordinary physical activity does not cause undue
fatigue, palpitation, dyspnea (shortness of breath).
II Slight limitation of physical activity. Comfortable at rest. Ordinary physical activity
results in fatigue, palpitation, dyspnea (shortness of breath).
III Marked limitation of physical activity. Comfortable at rest. Less than ordinary activity
causes fatigue, palpitation, or dyspnea.
IV Unable to carry on any physical activity without discomfort. Symptoms of heart failure
at rest. If any physical activity is undertaken, discomfort increases.8/27/2019
30. • Stage A — High risk for HF, without structural heart disease or
symptoms
• Stage B — Heart disease with asymptomatic left ventricular
dysfunction
• Stage C — Prior or current symptoms of HF
• Stage D — Advanced heart disease and severely symptomatic or
refractory HF
30stages of HF
8/27/2019
33. Non pharmacologic
• Reduce salt intake, avoid salt intake of >6g/day
• Avoid “salt replacement” tablets due to their high potassium content.
• Encourage patients to weigh themselves
• Reduction of weight in overweight and obese individuals
• Refraining from excessive alcohol consumption
• Avoid smoking. Patients should be offered smoking cessation advice
and support.
• Encourage low intensity physical activity amongst patients with
stable Heart Failure - Bed rest in hospitalized patients.
33
8/27/2019
34. Pharmacology
Initial therapy of severe Heart Failure (NYHA CLASS IV)
Furosemide, 40mg iv
Add KCl 600mg, 1-2 tabs, twice per day or Spironolactone 25-50mg,
BID, if there is no renal impairment or hyperkalemia
ACE inhibtors or ARBS
N.B. Do not start ACE inhibitors/Angiotensin Receptor
Blockers until the patient is haemodynamically stable. For
patients with Left ventricular systolic dysfunction. Start with
low dose and increase gradually.
34
8/27/2019
35. Cont…
Beta blockers –
N.B. Beta blockers – should not be started in the acute management of
decompensated Heart Failure . After patient stabilization, beta
blockers can be started during discharge or as an out patient
management. Start with low dose and escalate gradually.
Digoxin, 0.125 mg once, P.O, daily
Dopamine, I.V infusion 1-5 ug /kg/minute up to 50 ug /kg/minute;
increase by 1- 4mcg/kg/minute at 10-to 30-minute intervals until
optimal response is obtained
35
8/27/2019
36. Reference
• Patient chart and pt interview
• Ethiopian standard treatment guideline 2014
• Uptodate 21.6
36
8/27/2019