Advances in Medicine about proteins

1. Protein ZEB1 and resistance to
radiation therapy, and antibodies to
damage lungs
Presented by:
• María Gabriela Novoa Villada
Third Semester
Molecular Biology

4. Proteins
Are
Macromolecules
Functional unit are
amino acids
Principal functions:
• Enzymes.
• Antibodies.
• Regulation many process.
• Buffers.
• Receptors.
Single gen
Components

5. Sugary, lung-damaging bacteria
subvert antibodies
August 11, 2014
Antibodies
Normally
Destroyed
pathogenic bacteria
With
complement
proteins
forming pores in the
membrane
Bacterial lysis

6. Pulmonar
infections
Production
IgG2
No Bacterial
lysis
Bacterium
Pseudomonas
Goes to
1.Cough
2.Chest pain
3.Discouragement
Bronchiectasis

7. Researchers at
the University of
Birmingham
studied
Subgroup with
bronchiectasis
IgG2
In all
patients Find
IgG2 was observed adhered to extra large
sugars in membrane of Psueomona ,
preventing its destruction

8. IgG2
Is not yet known its
antibacterial
mechanism
But
It has allowed to
understand why vaccines
with extra-long sugars
cause more severe disease

9. Personal opinion
In my opinion the studies aimed to find
antibodies that prevent adequate
treatment of diseases, provide insight into
the different mechanism and avoid
reducing the risks and adverse effects
they bring. Likewise to find new
alternatives to treatment and drugs.

10. Protein ZEB1 promotes breast
tumor resistance to radiation
therapy
August 4, 2014
Protein ZEB1
Resistance with
radiation therapy
in patients with
cancer
Induces the
behavior of
tumor cells like
mother cells

11. Radio therapy:
• Induces cell death through
“Breaks DNA”.
• Kills tumor cells making them
less able to repair DNA

12. ZEB1
Promove
repair DNA
after radio
therapy
through activate
increases the
response
pathway to DNA
damage
ATM gene
stabilizes ChK1
protein
USP7
enzyme
active

13. ZEB1
Epithelial-mesenchymal
transition (EMT)
Confers radio-resistant
properties
and property of
mother cells
Healing
Induce
Tumoral cells

14. Personal opinion
In my opinion these studies provide insight into new
related resistance mechanisms of different cancer
treatments. Knowing proteins and enzymes
associated with it, allows to consider new strategies
and possible treatments aimed at combating
proteins, preventing the development of new
cancers and less aggressive treatment, even
death.

15. Both studies help develop
new treatments and drugs,
focused on preventing the
development of pulmonary
diseases and resistance to
cancer treatments

16. Is very interesting to know how the body is
able to produce antibodies against itself,
allowing to development treatments focused
on avoiding harm to self. Mechanisms not yet
understood.

17. Cancer, especially breast
cancer, has been
increasing in the last
years. The studies
focused on finding new
causes resistance to
different treatments, give
a breakthrough in
medicine, allowing to
know possible causes of
treatment failure.

18. Through studies conducted with
genetics and molecular biology may
come to find new explanations to many
unknown events in medicine today. It is
important to develop these types of
studies in order to find the explanation
for problems such as resistance to
treatment and the development of more
severe disease.

19. Refereces
• Journal reference: Peijing Zhang, Yongkun Wei, Li Wang, Bisrat G. Debeb, Yuan
Yuan, Jinsong Zhang, Jingsong Yuan, Min Wang, Dahu Chen, Yutong Sun, Wendy A.
Woodward, Yongqing Liu, Douglas C. Dean, Han Liang, Ye Hu, K. Kian Ang, Mien-
Chie Hung, Junjie Chen, Li Ma. www.sciencesdaily.com. August 4, 2014.
News Available in: http://www.sciencedaily.com/releases/2014/08/140804102940.htm
• Journal reference: T. J. Wells, D. Whitters, Y. R. Sevastsyanovich, J. N. Heath, J.
Pravin, M. Goodall, D. F. Browning, M. K. O'Shea, A. Cranston, A. De Soyza, A. F.
Cunningham, C. A. MacLennan, I. R. Henderson, R. A. Stockley.
www.sciencesdaily.com. August 11,2014. News Available in:
http://www.sciencedaily.com/releases/2014/08/140811124322.htm
• Martínez Sánchez, Lina María; Grisales Vargas, Natalia; Toro Montoya, Eduardo
Andrés; Sierra Pamplona, Ana Paulina; Orrego Quevedo, Esteban. (2013). Biología
Molecular. 7ª Edición. Editorial Universidad Pontificia Bolivariana. pp: 112-115.