1. NEW
TARGETS
IN
INVESTIGATION
TO
ACHIEVE
M
ORE
EFFECTIVE
AND
SAFER
M
EDICINES
M
ARÍA
ALEJANDRA
M
AYA
THIRD
SEMESTER
M
O
LECULARBIO
LO
GY
TEACHER:LINA
M
ARÍA
M
ARTÍNEZSÁNCHEZ

2. FOLDING

3. FOLDING

4. Genetic mapping is a method that facilitates
the location of specific genes.
First it was used to find single
gene diseases, nowadays
scientists are trying to find the
genes involved in polygenic
diseases

5. Montreal Heart Institute
January 12, 2015
Personalized
therapy for
cardiovascular
disease.

6. This discovery will push
the farmaceuticals to
get new treatments for
a certain kind of
patiens.
The team led by Drs
Jean-Claude Tardif and
Marie-Pierre Dubé
performed the analysis

7. Personalized medicines
offers precision which
increases the
probability of better
treatment results.
Exists the opportunity to work on
atherosclerosis due to the results of vessels
thickness

8. the veracity of this study
was shown by the
investigators that tested
multiple genetic markers
to demostrate that the
positive results were
observed only in the
dalcetrapib group.

9. OBSERVATIONS
The personalized therapy
give the patient a
response to their unique
needs. A better way to
make sure our patients
will respond to treatment,
and their quality living will
improve, due to the safety
included in the
determined genetic
profile.

10. Improving
antibiotics
to treat
staph
infections
Saint Louis University
January 23, 2015

11. the mechanism which
bacteria become resistant
to antibiotics give us a
world of opportunities to
block that mechanism,
making the antibiotic really
effective independent.

12. Applied to many
resistant pathogens
The mechanism prefers to install
recidues that stops genetic
activity, giving time to the
bacteria to defend it self

13. evolutionary mechanism developed by
bacteria to counteract the type of
antibiotics called macrolides.

14. OBSERVATIONS
I hope that the scientist look after
the improving of antibiotics by
the inhibition of ribosome
stalling mechanism. This could
be very effective in treating
severe infetions. Also it could
make a difference between the
irrational use of antibiotics and
the methodic use of them for
only the right strain of infection,
and prevent the creation of new
strains

15. Medical
utilities

16. Treatment for heart diseases
Treatment for atherosclerotic
Infection treatment
Discover the genes in polygenic diseases
Personalized treatments
Stop formation of strains
Inhibit the protective mechanism of bacteria
Increase the response to medicines

17. These advances encourage the
continuation in research to find the
real effective drugs and reach the
personalized therapy.

18. Efficacy and safety are the
greatest goals for pharmaceutical products
The knowledge in this area has grown
up really fast. It doesn´t amaze anyone
that each team have come to this
meaningful results.

19. BIBLIOGRAPHY
*Personalized therapy for cardiovascular disease,
Montreal Heart Institute , 2015. [Internet] 2015 Jan
[Fecha de acceso 28 febrero de 2015]. Disponible en:
http://www.sciencedaily.com/releases/2015/01/15011
2181327.htm
*Improving antibiotics to treat staph infections, Saint
Louis University, 2015. [Internet] 2015 Jan [Fecha de
acceso 28 febrero de 2015]. Disponible en:
http://www.sciencedaily.com/releases/2015/01/15012
3135108.htm
*Martínez Sánchez ,L.M.; Vargas Grisales, N.; Toro
Montoya A.E.; Pamplona Sierra, A.P.; Quevedo Orrego, E.
(2012). Biología molecular. Séptima edición. Medellín,
Colombia. Editorial Universidad Pontificia Bolivariana. Pp:
142, 143