HPA presentation
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This presentation I created with the help of a fellow student for a Rogers Research Fellowship position I was awarded (Summer 2010). With another student and under the supervision of a professor, I carried out a neuroscience research study. At the culmination of the study we gave this presentation to the other researching students and professors at Lewis & Clark that summer, about 60 people.
![Why Look At Drinking Behavior This Way? ,[object Object],Prefrontal Lobe Impulsivity Drinking Behavior Personality/ Behavior Biological Brain](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
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HPA presentation
- 1. The Role of Hypothalamic-Pituitary-Adrenocortical Axis Activity , Prefrontal Lobe Function , and Impulsivity in Drinking Behavior Emma Alterman Krissy Lyon
- 8. HPA Axis Pathway Stress Alcohol Introduction Procedure Data Analysis Anticipated Results
- 14. Procedure BRIEF-A FHQ BIS-11 SAQ TSST ENTER LEAVE Baseline Saliva Sample DD Hello! Post-Stress Saliva Sample Introduction Procedure Data Analysis Anticipated Results
- 15. Procedure BRIEF-A FHQ BIS-11 SAQ TSST ENTER LEAVE Baseline Saliva Sample DD Post-Stress Saliva Sample Introduction Procedure Data Analysis Anticipated Results
- 17. Procedure BRIEF-A FHQ BIS-11 SAQ TSST ENTER LEAVE Baseline Saliva Sample DD Post-Stress Saliva Sample Introduction Procedure Data Analysis Anticipated Results
- 19. Procedure BRIEF-A FHQ BIS-11 SAQ TSST ENTER LEAVE Baseline Saliva Sample DD Post-Stress Saliva Sample Introduction Procedure Data Analysis Anticipated Results
- 21. Procedure BRIEF-A FHQ BIS-11 SAQ TSST ENTER LEAVE DD Change in Cortisol Post-Stress Saliva Sample Baseline Saliva Sample Introduction Procedure Data Analysis Anticipated Results
- 23. Procedure BRIEF-A FHQ BIS-11 SAQ TSST ENTER LEAVE Baseline Saliva Sample DD Post-Stress Saliva Sample Introduction Procedure Data Analysis Anticipated Results
- 25. Procedure BRIEF-A FHQ BIS-11 SAQ TSST ENTER LEAVE Baseline Saliva Sample DD Post-Stress Saliva Sample Introduction Procedure Data Analysis Anticipated Results
- 27. Procedure BRIEF-A FHQ BIS-11 SAQ TSST ENTER LEAVE Baseline Saliva Sample DD Post-Stress Saliva Sample Introduction Procedure Data Analysis Anticipated Results
- 29. Procedure BRIEF-A FHQ BIS-11 SAQ TSST ENTER LEAVE Baseline Saliva Sample DD Post-Stress Saliva Sample Introduction Procedure Data Analysis Anticipated Results
- 31. Procedure BRIEF-A FHQ BIS-11 SAQ TSST ENTER LEAVE Baseline Saliva Sample DD Post-Stress Saliva Sample Goodbye! : Introduction Procedure Data Analysis Anticipated Results
- 32. How it all relates: Family History of Alcoholism HPA axis & Cortisol BRIEF-A BIS-11 DD Self Assessment Questionnaire Family History Questionnaire Stressful Situation ELISA Impulsivity Drinking Behavior Introduction Procedure Data Analysis Anticipated Results Prefrontal Lobe Function
- 33. Data Analysis Introduction Procedure Data Analysis Anticipated Results
- 37. Questions?
Editor's Notes
- Alcohol Abuse : 31% of college students met criteria for diagnosis Death : 1,700 college students die each year from alcohol-related unintentional injuries Unsafe Sex : 400,000 students had unprotected sex 100,000 students report having been too intoxicated to know if they consented to having sex Academic Problems : About 25% of college students report academic consequences of their drinking
- Well rounded view of the problem Looking at how they all interact
- destroyerbeat.files.wordpress.com/.../brain.jpg frontal lobe minus motor area
- Damaged and/or underdeveloped Prefrontal lobe damage can increase impulsiveness and susceptibility to alcohol abuse Alcohol can negatively affect prefrontal lobe development and function
- Glucocorticoid = group of steroid hormones Cortisol is the main one in humans Corticoid releasing hormone/factor Adrenocorticotropic hormone
- Studies have shown that acute intake causes a stress-like cortisol response. We know that stress and alcohol both activate the HPA axis, which explains some phenomena. In individuals who are trying to quit drinking, stress activates the HPA axis which then can lead to alcohol consumption and even relapse because of the shared system. There is also the idea of self-medication. This system is involved in self-medication in that individuals may drink before a stressful situation to eliminate stress. This works because the alcohol stimulates the system, preparing the body for the stressor in the same way the body would respond to stress. Stress activation can trigger relapse/drinking Alcohol--> prepare ahead of time to deal with stress HPA-Alcohol consumption/alcohol craving Acute intake causes a stress-like cortisol response
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- K “ Blunted cortisol response to psychological stress has also been observed in individuals without current or prior alcohol use problems but who have a family history of alcoholism”
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- E Neuropsychological Test of prefrontal lobe Higher scores means lower executive functioning
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- E Circadian rhythms- Taken in the afternoon Better than blood
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- E Adapted TSST
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- E Higher score means more impulsive More sensitive to delay
- aspect of decision making in which smaller rewards with shorter delays are preferred to larger rewards with longer delays (Cite) BIS can look at personality DD in action/behavior Higher score, higher impulsivity WHY we use it? Most widely used Validity Fits what we are looking for Best Draft
- If needed, ALSO asked about drug use, cigarette use, caffeine use, exercise and sleeping disorders
- We debrief our participants
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- People will have a blunted cortisol response to a stressful situation if: frequently drink large amounts Lower executive functioning correlates to more alcohol use Inhibition subscale of BRIEF-A was significantly correlated with number of drinks and number of days of drinking
- E “ The evidence now is strong that the brain does not cease to mature until the early 20s in those relevant parts that govern impulsivity, judgment, planning for the future, foresight of consequences, and other characteristics that make people morally culpable.... ” Ruben Gur, MD, PhD Director, University of Pennsylvania Medical Center Interactions of everything Genetic/family influence Gender difference