1. Alcoholism

2. Winemaking Tradition Requiring the Fermentation of the Sugar in Grapes with Yeast to Form Alcohol

3. Engraving of ‘Gin Lane’ by William Hogarth (1697-1764) showing the popular opinion that the ‘lower classes’ drank gin and got drunk.

10. CNS Progressive Effects Death 410 + Lossbladder,dif breath, slowHR Cc,fb,cere,bs, entire brain Unconsci, coma, death poss 310-400 Slurred speech, blance, temp Cc,fb,cere, brainstem Aggression, stupor, depress 210-300 Reason, obnox, perceptions Cc,fb, cerebellum Mood swing, sad anger, mania 110-200 Fine coordinat, Visual tracking Cc and forebrain Pleasure, numb feelings, sleep 60-100 Alertness Judgement Cerebral Cortex Relax, sense of wellness, loss of inhibition 10-50 Impaired Brain Changes BAC (mg%)

12. Alcohol Induced Brain Damage

15. Effect of Chronic EtOH on the Liver Healthy Fatty Cirrhotic

21. Selective Significant Drug Interactions with Alcohol GI bleeding Additive ASA NSAIDs n/v/flushing, HA, sweating, inc HR hypotension, Accumulation of acetaldehyde Disulfiram metronidazole Enhanced CNS depressant effects Additive Antihistamines, antidepressants, opioids, sed-hyp, antianxiety, antipsychotic drugs Possible Effect Mechanism Substances

23. Craniofacial Malformations Normal Exposed to Alcohol

29. Kindling Model