1. Infectious diseases in literature
Part 2.
Pavlov State Medical University,
Department of Infectious diseases
and Epidemiology,
St-Petersburg, Russia
Dr. Andrey Dyachkov
E-mail: cd4@inbox.ru
22.09.2012

2. In this quiz you have to find out:
1.From which book we took a
description of disease?
2.Which infectious disease is
described?
Then you can learn
a little bit about it

3. Here comes a description of a disease from a book:
Her chariot is an empty hazelnut,
Made by the joiner squirrel or old grub,
Time out o' mind the fairies' coachmakers.
And in this state she 'gallops night by night
Through lovers' brains, and then they dream of love;
O'er courtiers' knees, that dream on cursies straight;
O'er lawyers' fingers, who straight dream on fees;
O'er ladies' lips, who straight on kisses dream,
Which oft the angry Mab with blisters plagues,
Because their breaths with sweetmeats tainted are.

4. This hint can help you to figure out a name of a book.

5. William Shakespeare «Romeo and Juliet»
William Shakespeare (26 April 1564
(baptised) – 23 April 1616) was an
English poet and playwright, widely
regarded as the greatest writer in the
English language and the world's pre-
eminent dramatist
Between 1585 and 1592, he began a
successful career in London as an
actor, writer, and part owner of a
playing company called the Lord
Chamberlain's Men
The famous Globe Theatre was built in
1599 by Shakespeare's playing
company and closed in 1642.
A modern reconstruction of the Globe,
named "Shakespeare's Globe",
opened in 1997 approximately 750
feet from the site of the original
theatre.

6. In Romeo and Juilet plagues on lips was related to sweets but there
were many other theories of disease nature and development
Description of disease is found in Hyppocrates works and word “herpes” is a
Greek word that means “to creep or crawl”.
Roman times, the emperor Tiberius tried to stop an outbreak of mouth herpes by
prohibiting kissing at public events and ceremonies.
First modern publication of the link between genital organs and Herpes was
published in 1736 by John Astruc, doctor for King Louis XIV.

7. History of Herpes Simplex Virus
Jean Baptiste Emile Vidal, a French
dermatologist, in 1893 reported evidence that
Herpes was infectious.
In Germany W. Gruter in 1912 showed that fluid
from human HSV lesions can cause keratitis in
rabbits and then could be transmitted serially from
rabbit to rabbit. It is to him that the virology
community gives credit for the isolation of HSV.
In the 1930s, one of the milestones of HSV
biology was the observation made by Andrews
and Carmichael that recurrent infections occurred
only in adults who carried neutralizing antibodies
– an occurrence in sharp contrast to the
behaviour of other known infectious agents at that
time.
It was Schneweis and Nahmias who proposed
that two different types of HSV caused these
infections – one for involvement of the mouth and
the other of the genital tract.

8. History of Herpes Simplex Virus
First, in 1938, Doerr stated that HSV
infection in man resulted from the
endogenous production and were not
caused by exogenous infection.
Dr Gertrude Elion, one of the leading
figures in the discovery of first
selective inhibitor of HSV aciclovir
(1977).
Gertrude B. Elion (1918 - 1995) and
George H. Hitchings (1905 — 1998)
had been working together since 1945
and in 1988 won the Noble Prize for
their work on the treatment of disease
and organ transplantation.

9. Later sexual revolution made a herpes
a topic of piblic discussions

10. HSV can cause

Labial and genital herpes but
cuold have atypical localisation at
any site on skin

Keratoconjunctivitis

Meningitis

Encephalitis

Esophagitis

In HIV-infected
patients HSV can
cause long healing
ulcers (more then 1
month) — picture on
the right

11. HSV encephalitis was first described in 1940s. Disease could be seen during
primary infection and in patients with reccurent labial and genital herpes.
Temporal lobes involment with aphasia and other focal neurological
symptoms are typical. CSF examination usually shows mononuclear
pleocytosis (please note that in early stage could be neutrophil) with
normal sugar and moderate protein increase.

12. Please visit our Facebook group «Infectious diseases for doctors» to find
photous and new clinical cases from infectious diseases hospital.
http://www.facebook.com/groups/414509858598674/

13. Botkin's infectious diseases hospital was found
in St-Petersburg in 1882