Dermo epidermal junction

D ermo – E pidermal J unction Presented by Adel A. Al-Ghamdi Dermatology Department King Fahd Hospital of university

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object]

Origin of Basement Membrane ,[object Object],[object Object],[object Object],[object Object]

Functions of basement membrane ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Ultrastructure of DEJ ,[object Object],[object Object],DEJ 1 ST ZONE 2 ND ZONE 3 RD ZONE Sub basal lamina Lamina densa Tonofilement, Hemidesmosomes Anchoring filement complexs

First zone ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Second zone ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object]

Third zone ( the sub basal lamina) ,[object Object],[object Object],[object Object],[object Object]

Ubiquitous Components of Basement Membrane Type IV collage Laminin Nidogen/Entactin Heparan sulfate proteoglycan

Type IV Collagen ,[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object]

Laminin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Nidogen / Entactin ,[object Object],[object Object],[object Object],[object Object]

Heparan sulfate proteoglycan ,[object Object],[object Object],[object Object],[object Object]

Epithelial-Specific Basement membrane Components Hemidesmosome Anchoring filaments Epithelial lamina densa Anchoring fibrils & anchoring plaques

Hemidesmosome (HD) ,[object Object],[object Object],[object Object]

Major Hemidesmosomal Antigens 240-kDa protein BPAG1 180-kDA protein BPAG2 Plectin Integrin alpha6 beta4

BPAG1 ,[object Object],[object Object],[object Object]

BPAG2 ,[object Object],[object Object],[object Object],[object Object]

Plectin ,[object Object],[object Object],[object Object],[object Object],[object Object]

Integrin alpha6 beta4 ,[object Object],[object Object],[object Object],[object Object]

Anchoring filaments ,[object Object],[object Object]

Major Anchoring filament Antigens Laminin 5 125-kDa 19-DEJ-1 105-kDa Ladinin LAD-1

Laminin 5 (alpha3 beta3 gamma 2) ,[object Object],[object Object],[object Object],[object Object],[object Object]

125-kDa protein ,[object Object]

19-DEJ-1 antigen ,[object Object],[object Object],[object Object]

105-kDa Antigen ,[object Object],[object Object],[object Object]

Ladinin & LAD-1 ,[object Object],[object Object]

Epithelial Lamina Densa ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Anchoring fibrils & Anchoring plaques ,[object Object],[object Object],[object Object],[object Object],[object Object]

EBS EBS MD EBS GABEB JEB Herlitz JEB Dystrophic EB WWW.SMSO.NET

Dermo epidermal junction

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