It icontains biology, classification, types and role of cell adhesion molecules and matrix proteins.

1. CELLADHESION MOLECULES AND
MATRIX PROTEINS
BY
SHIHANA.S
FIRST YEAR M.PHARM
DEPARTMENT OF PHARMACOLOGY
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2. CELLADHESION
 Cell combines to form tissues.
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3. TYPES OF CELLADHESION
• CELL-CELLADHESION • CELL-MATRIX ADHESION
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4. CELLADHESION MOLECULES (CAMs)
• Cell surface proteins
• Cell-cell adhesion may be homophilic or heterophilic interaction
• Specificity of cell-cell recognition
• Functions-
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5. BIOLOGY OF CAMs
• An intracellular domain
• A transmembrane domain
• An extracellular domain
STRUCTURE OF CAMs
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6. CLASSIFICATION OF CAMs
1. Calcium-independent
• IgSF CAMs
• Lymophocyte homing receptors
2. Calcium-dependent
• Integrins
• Cadherins
• Selectins
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7. CALCIUM-INDEPENDENT CAMs
1. IgSF CAMs
• Homophilic or heterophilic-70-110 amino acids.
• Large group of cell surface molecules-VCAM, NCAM, ICAM,
Nectins and Necl.
2. Lymphocyte homing receptors
• Addressins
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8. CALCIUM-DEPENDENT CAMs
• Integrins
o Heterodimeric proteins
o Structure
o Physiological role
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9. • Cadherins
o Homophilic interaction-150 aminoacids.
o E,N,P
o ECD
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10. • Selectins
o Heterophilic, bind with mucins
o Members-E,L,P
o PSGL-1
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11. ROLE OF CELLADHESION MOLECULES IN VARIOUS
DISEASES
• Inflammation
• Ischemic stroke
• Leukocyte adhesion deficiency
• Alzheimer’s disease
• Coronary artery disease
• Cancer-metastasis,prostate cancer
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12. MATRIX PROTEINS
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• Cell shapes, migration, proliferation, cell survival and metabolism.
• Consists of protein-carbohydrate complexes.
• Biology

13. CLASSIFICATION
1. Proteoglycans
2. Glycoproteins
• Structural proteins- Collagen and Elastin
• Adhesive proteins- Fibronectin and laminin
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14. 1. Proteoglycans
• Core proteins-covalently attached to long non-branched chains of GAGs.
• Hyaluronic acids, chondroitin sulfates, dermatan sulfates, heparin sulfate.
• Polysaccharide content 95%.
2. Glycoproteins
• Short branched oligosaccharides.
• Carbohydrate content less than 10%.
• Different types of glycoproteins.
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15. STRUCTURAL GLYCOPROTEINS
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 Collagen
• 25% of total content, 29 types.
• Stiff triple helix-3 peptide chains.
• Monosaccharides and disaccharides.
• Fibrillar collgens.

16. Elastin
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• Does not form stiff triple helix.
• Consists of flexible polypeptides.
• Microfibrils 10-20nm in diameter-fibrillins.

17. ADHESIVE GLYCOPROTEINS
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 Fibronectins
o Bind with other matrix proteins(strongest binding with collagen-III).
o Guide cellular movement.
o 20 types

18. Laminin
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• Cross linked trimeric adhesive proteins.
• Flexible-3 polypedtide chain(,,)-disulfide bond.

19. ROLE OF MATRIX PROTEINS IN VARIOUS DISEASES
1. Endocrine diseases
• Chronic pancreatitis- pancreatic fibrosis, chronic inflammatory
disease.
• Renal hypertrophy
2. Collagenosis
3. Cancer
4. COPD
5. Infectious diseases
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20. REFERENCE
1. Harsh Mohan. Text book of Pathology. 5th edition: 31,137-138.
2. Robbins and Cortan. Pathologic Basis of Disease. 9th edition:72-77.
3. Cyrus C, Jones EY. The Molecular Structure of Cell Adhesion Molecules.
Annual Review of Biochemistry. 1997; 66: 823–62.
4. Alexandros D, Athanasios GP, Michael C, Eleni E, Meletios AD. The Role
of Cell Adhesion Molecules (integrins / cadherins) in Prostate Cancer.
International Brazilian Society of Urology. 2011; 37(3): 302-306.
5. Zerrin S University of Anatolia, Department of Pharmacology. Cellular
Adhesion and Adhesion Molecules. Turkish Journal of Biology. 2001; 25: 1-
15.
6. https://en.wikipedia.org/wiki/Cell_adhesion_molecule.
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21. THANK YOU
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