David Cano Q

4. The mitosis is the more important
part in the DNA replication and in
it, we find the principal step of the
regulation
Cancer is the most important
problem of the DNA and involve the
replication, mediate by the DNA
polymerase.

5. ADCT, CRT sign agreements to
develop ADCs against cancer
Cancer Research Technology
(CRT), the commercial arm of
Cancer Research UK, and
Switzerland-based ADC
Therapeutics Sarl (ADCT)
announce today that they
have signed agreements to
develop cancer treatments
called Antibody Drug
Conjugates (ADCs) using
CRT antibodies and peptides,
and ADCT's 'warhead' and
linker chemistries.
ADCT, CRT sign agreements to
develop ADCs against
cancer
News Medical July 6 2012

6. ADCT, CRT sign agreements to
develop ADCs against cancer
Its important in the The antibody
investigation of cancer component selectively
treatment targets the cancer
cells to deliver tumor-
destroying chemicals
which are internalized
into the cancer cell
while avoiding
damage to healthy
tissue

7. ADCT, CRT sign agreements to develop
ADCs against cancer
ADCT's toxic
chemicals interact
with DNA without
disrupting the
double helix
structure
which avoids
triggering DNA
repair processes
- with the
prospect that
this will prevent
drug resistance

8. ADCT, CRT sign agreements to
develop ADCs against cancer
1
• Once inside the cancer cell, the linker degrades and
the active toxin is released, binding to the
cell's DNA and killing the cancer cell.
2
• ADCT's toxic chemicals interact with DNA without
disrupting the double helix structure which avoids
triggering DNA repair processes - with the prospect
that this will prevent drug resistance
3
• ADCT's warheads are based on proprietary
pyrrolobenzodiazepines (PBDs) technology
developed by London-based Spirogen Limited

9.  I think that this new is very
relevant in the way that is a
big base to future studies of
cancer and all types of
treatments about it and with
that they can be a beginning
to help a lot of lives

10. Secrets of Parasites' Replication
Unraveled
Advances have not come
easily, in part because these
parasites have the most
complex mitochondrial
genome structure in
nature, say Klingbeil and
Concepción-Acevedo
Klingbeil says, "so if we can
inhibit the replication process
and take away the
kDNA, the parasites will die.
That's one way we might be
able to kill them.“
ScienceDaily July 10, 2012

11. Secrets of Parasites' Replication
Unraveled
Advances have
not come
easily, in part
because these
parasites have
the most complex
mitochondrial They finally could
genome structure have an idea
in nature
around how can do
more investigations
about DNA taking
part of the
parasities

12. Secrets of Parasites' Replication
Unraveled
Klingbeil says, "so if we can inhibit the
replication process and take away the
kDNA, the parasites will die. That's one
way we might be able to kill them."
kDNA is found as a nucleoid in the
mitochondrion, where it holds many
copies of catenated or networked
minicircles and maxicircles
These molecules pass information on to
daughter cells via DNA polymerases
whose job it is to copy all circles in the
network

13. Secrets of Parasites' Replication
Unraveled
Trypanosomes have six mtDNA
polymerases, while humans have just one
To figure out how these trypanosomal
polymerases know when to initiate DNA
replication set up immunofluorescence
experiments focused on tracking mtDNA
polymerase ID (POLID)
Their ultimate success would be to find a
chemical to inhibit POLID from carrying
out its role during replication and target
all parasites with kDNA structures

14.  In my opinion this new
start to take relevance in
the way that use this
investigation in parasites,
to make more studies
about the mitochondrial
DNA but in humans and
with that can make
some important findings

15. ADCT, CRT sign agreements to
develop ADCs against cancer
 This provides a very promising and rapid
route to develop ADCs for cancer
therapy

16.  Potent PBD-based warheads combined
with CRT's leading tumor-
targeting antibodies and peptides
ADCT, CRT sign agreements to
develop ADCs against cancer

17. Secrets of Parasites' Replication
Unraveled
 It is an important step to do investigation
about the hereditary obesity in humans
 The mitochondrial DNA is relationship
with this hereditary problem

18. Secrets of Parasites' Replication
Unraveled
 This important discovery explains how
POLID engages in kDNA replication and
opens up new avenues to study and
intervene in mitochondrial protein
dynamics

19.  Martinez S, Lina Maria. Biología
Molecular. 7 ed Medellín: UPB. Fac
Medicina
 ADCT, CRT sign agreements to develop
ADCs against cancer. News Medical.
(July 6, 2012)
 Secrets of Parasites' Replication
Unraveled. ScienceDaily. (July 10, 2012)

20. THANKS