3. WHY USE DIAGNOSTICS?
Ocular media and fundus examination
Enhancing retinal photography; optical coherence
tomography
Refraction through cataracts when pupils are small
Cycloplegic refraction
Techniques where anesthesia is required
4. CYCLOPLEGIA
It is the paralysis of the ciliary
muscle of the eye, resulting in loss
of accommodation.
5. CYCLOPLEGICS
Cycloplegics work by binding to effector sites in the
ciliary muscle thereby blocking action of acetylcholine.
Pupillary dilation is an (unwanted) side effect and its
onset precedes cycloplegia.
The optometrist should ensure there are no angle
anomalies before instillation of cycloplegic drop.
6. CYCLOPLEGICS
Cycloplegics are most often used in
children in the presence of esotropia or
esophoria or when latent hypermetropia is
suspected.
Another use is to impose penalization of a
dominant eye in amblyopia.
8. ATROPINE
Atropine is a strong cycloplegic agent.
Atropine Sulphate is used 0.5% and 1% as eye
drops; and 1% eye ointment.
Muscarinic antagonist.
Peak effect of the drug is in 2-3 days.
Duration is 7-10 days.
9. TROPICAMIDE
Tropicamide (Midriacyl) is also a short-duration
cycloplegic available in 0.5% and 1% solutions.
For young adults 3 to 4 drops of the 1% solution,
separated by a few minutes, will bring about full
cycloplegia in about 30 minutes.
Recovery occurs within 6-8 hours.
10. CYCLOPENTOLATE
Short duration cycloplegic agent available in
0.5% and 1% solutions.
Cycloplegia occurs within 30 to 45 minutes and
persists for as long as 24 hours.
For children aged 6 to 16, one drop of 1%
solution
For adults one drop of 0.5% solution.
11. SIDE EFFECTS
Blurring of vision
Patient cannot read
Photophobia
Dry mouth
Flushing of the face
Fever
13. MYDRIATICS
Mydriatics dilate the pupil to facilitate a more
thorough examination of the fundus, lens
periphery and vitreous. They are mostly used on
elderly patients, as older pupils are usually smaller
and lens opacities and abnormal retinal
conditions are not uncommon.
14. MODE OF ACTION
The pupil dilator muscle is innervated by
the sympathetic nervous system and
sympathomimetic drugs will cause a
contraction of the dilator muscle causing
mydriasis. Sympathomimetic drugs also
have little effect on accommodation.
15. MYDRIATICS USES
Mydriatics are used to examine properly the ocular
media and ocular fundi
Retinoscopy through small pupil and cataract
Recent onset of floating vitreous opacities, especially if
accompanied by the symptoms of flashing light.
Fundus photography.
16. ANTIMUSCARIANIC MYDRIATICS
TROPICAMIDE
1. Tropicamide is the antimuscarinic mydriatic of choice today.
2. Normally available in 0.5% and 1.0% strengths, the weaker
solution is used most often for mydriasis; the 1% strength is used
for cycloplegia.
3. Tropicamide is quick in onset and short in duration (Onset in 20-
30 minutes and duration of cycloplegic effect is 6-8 hours)
17. All cycloplegics can be used as mydriatics but
the effect is usually too long lasting. The
following have been used in the past:
18. CYCLOPENTOLATE
The mydriatic concentration of cyclopentolate is
0.1% (compared with 0.5% and 1.0% for
cycloplegia). However, this strength is no longer
available and if cyclopentolate is used as a
mydriatic then significant cycloplegia will
accompany its use.
19. HOMATROPINE
At one time, homatropine was the principal
mydriatic. The mydriatic effect commences in
10–20 min and is maximal in 30–40 min.
Recovery takes the same time as
cyclopentolate if a miotic is not used, but it can
be as prolonged as 3 day.
20. CONTRAINDICATIONS
Patients using pilocarpine for the treatment of glaucoma
Narrow-angle glaucoma
Abnormally shallow anterior chamber (due to the risk of angle-
closure glaucoma)
Dislocation of the crystalline, or an intraocular lens
An intraocular lens of the anterior chamber or iris-supported
type.
22. PHENYLEPHRINE
Mydriasis commences in about 10 min and is maximal in
30 min; the mydriasis lasts for several hours.
There is little doubt that sympathomimetics produce less
effect on accommodation than antimuscarinics, and some
authors (Kanski 1969) suggest that phenylephrine
produces mydriasis without any cycloplegic effect at all.
24. MODE OF ACTION
Sensory information passes along nerve fibres via electrical
impulses, or action potentials. When the nerve is at rest, the
interior has a negative charge. An action potential is generated
by the influx of sodium ions into the interior of the nerve, giving
it a positive charge (depolarization). The nerve fibre is returned
to its resting potential (negative state) by the efflux of potassium
ions (repolarization). The action potential is then generated
along the axon by successive depolarization and repolarization
of adjacent regions.
25. INDICATIONS FOR USE
Foreign body removal
Tonometry
Contact lens fitting
Gonioscopy
Certain diagnostic procedures like
Schirmer’s test.
26. ANESTHETICS
Among the topical anaesthetics, the most widely used
agents are proparacaine hydrochloride 0.5% (Alcaine),
benoxinate 0.5% and tetracaine 0.5%.
The instillation of 1 drop of these compounds renders
the corneal epithelium insensate within 15 seconds.
Reapplication will enhance the anaesthetic effect