Dm1 adc
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This ADC product is composed of an anti-HER2 antibody conjugated via [14C]-SMCC linker to DM1 (trastuzumab-SMCC-DM1). It has demonstrated a response in HER2-positive breast cancer treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
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![dm1 adc
• This ADC product is composed of an anti-HER2 antibody conjugated
via [14C]-SMCC linker to DM1 (trastuzumab-SMCC-DM1). It has
demonstrated a response in HER2-positive breast cancer treatment
by a MOA (Mechanism of Action) of microtubules depolymerizing.](https://image.slidesharecdn.com/dm1adc-190516060627/85/Dm1-adc-1-320.jpg)
![• Specifications
• Antibody OverviewTrastuzumab
• Antibody IsotypeIgG1
• Linker[14C]-SMCC
• DrugDM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
• Drug Class/Description Class: Maytansinoid Description: Maytansinoids are
a group of cytotoxins structurally similar to rifamycin, geldanamycin, and
ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-
member lactam (ansa macrolide) structure originally isolated from the
Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or
near the vinblastine-binding site, which interfere the formation of
microtubules and depolymerize already formed microtubules, inducing
mitotic arrest in the intoxicated cells](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
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•Physical
•Biological
•Mechanical
•Chemical
Storageonlypreservesquality.Itneverimprovesquality.
Itisadvisabletostartstoragewithqualityfoodproduct.Productwithinitialpoorqualityquicklydepreciates
Gadgets for management of stored product pests_Dr.UPR.pdf
Insectsplayamajorroleinthedeteriorationoffoodgrainscausingbothquantitativeandqualitativelosses
Wellprovedthatnogranariescanbefilledwithgrainswithoutinsectsastheharvestedproducecontainegg(or)larvae(or)pupae(or)adultinsectinthembecauseoffieldcarryoverinfestationwhichcannotbeavoidedindevelopingcountrieslikeIndia
Simpletechnologiesfortimelydetectionofinsectsinthestoredproduceandtherebyplantimelycontrolmeasures
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Dm1 adc
- 1. dm1 adc • This ADC product is composed of an anti-HER2 antibody conjugated via [14C]-SMCC linker to DM1 (trastuzumab-SMCC-DM1). It has demonstrated a response in HER2-positive breast cancer treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
- 2. • Specifications • Antibody OverviewTrastuzumab • Antibody IsotypeIgG1 • Linker[14C]-SMCC • DrugDM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine) • Drug Class/Description Class: Maytansinoid Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19- member lactam (ansa macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells
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