Creative Biolabs has made long-term commitment to the innovation and development of antibody research. During the past decade, our professional scientists have generated over 2000 custom monoclonal antibodies using various techniques to meet every single customer’s particular requirements. We are confident in generating tailored novel native alligator antibodies to facilitate our global clients’ research and project development.

1. alligator antibody

2. • Creative Biolabs can generate alligator monoclonal antibody through our unique Native™
Antibody Discovery Platform targeting native structure in vivo.
• Crocodile, or the American alligator (Alligator mississippiensis) in particular, is a kind of
fascinating animal for biologists, because of their living habit and marvelous immune
system. The wild American alligators are very territorial animals, most of them live in
marsh environment that harbor infectious microbes that may thrive on serious wounds,
which is rather common for the reptile during territorial disputes or by human activities.
These conflicts often leave with severe injuries such as gaping wounds and missing limbs.
But despite the fact that they live in septic environment with high possibility of a wound
infection, most alligators exhibit marvelous ability to heal their enormous wounds rapidly
without fatal infection. And further study of American alligator also suggests a
remarkable immune system should play a key role in these conditions.

3. • Considering the incredibly powerful immune system, American alligator is a novel choice for monoclonal antibody
discovery and research. The initial studies of crocodile immune system showed their antibodies are able to kill
bacteria that were resistant to penicillin, such as Staphylococcus aureus. Currently, Merchant has published his in
vitro studies based on serum from wild American alligator in Louisiana, which also indicated that American
alligators have a more resilient and effective immune system than that of humans. This powerful immune system
has shown the anti-parasitic, antifungal, antiviral and antibacterial properties, and is able to eradicate HIV virus in
particular (Merchant et al. 2003, 2005). In this way, antibody from alligators is potentially meaningful to be
established as a novel and valuable source in the discovery and development of relevant research realm.
• Comparing with other antibody production techniques, the Native™ Antibody Discovery Platform of Creative
Biolabs has been specially designed for discovering high specificity and affinity native monoclonal antibodies from
various species, such as American alligators. In addition, this high throughput platform is able to isolate large scale
of candidate antibodies with native paired heavy- and light-chains, which is known as one of the most efficient way
in developing alligator antibodies.

4. • Creative Biolabs has made long-term commitment to the innovation
and development of antibody research. During the past decade, our
professional scientists have generated over 2000 custom monoclonal
antibodies using various techniques to meet every single customer’s
particular requirements. We are confident in generating tailored
novel native alligator antibodies to facilitate our global clients’
research and project development.