For Knowledge Exploration.

1. PRESENTATION
ON
MUPIROCIN 2% OINTMENT
Prepared by:
Biplob Kumar Sarker,
B. Pharm, M. Pharm

2. DISEASE PART
Skin Infection:
Skin infection is an infection of the skin.
1. Bacterial Skin Infection
2. Fungal Skin Ifcection

3. BACTERIAL SKIN INFECTION
Bacterial skin infections include:
 Impetigo:
 Impetigo is a highly contagious bacterial skin
infection most common among pre-school children.
 It is primarily caused by Staphylococcus aureus,
and sometimes by Streptococcus pyogenes.
 Erysipelas:
 Erysipelas is an acute streptococcus bacterial
infection of the deep epidermis with lymphatic
spread.

4.  Cellulitis:
Cellulitis is a diffuse inflammation of connective
tissue with severe inflammation of dermal and
subcutaneous layers of the skin.

5. IMPETIGO
Overview:
 Impetigo is a common skin infection caused by
streptococcus (strep) or staphylococcus (staph)
bacteria.
 If you have a cut, bite (insect, human or animal)
graze, eczema or injury to the skin, this usually
heals but sometimes bacteria can enter the body
and grow there, causing inflammation and infection.

6. WHO GETS IMPETIGO?
 It is most common in children, infants and people
who have lower immune function for some reason.
 Impetigo is very easily spread to other parts of your
body or other people.
 Also more common if children or adults are living in
poor or crowded houses

7. CONTI…
 Impetigo is contagious, meaning it is easy to
spread it to other parts of your body or to other
people such as family members or classmates
 If the fluid that oozes from impetigo blisters touches
an open area on your skin, you may get impetigo
too.

8. SYMPTOMS
 Impetigo often starts as a single blister or red lesion
 Blisters may fill with pus or yellow honey coloured
fluid
 Also starts as any lesion that doesn't heal and
develops a crusty scab
 Common sites are skin lesions on the face, lips,
arms, or legs, that spread to other areas

9. TREATMENT OPTION
Remove crusted area by washing with
saline or antibacterial soap (1 to 3 times
each day).
Apply topical antibiotic or antiseptic
ointment if prescribed.

10. Medicon introduces
Pirocin 2%
Ointment

11. PRODUCT PROFILE
 Brand Name : Pirocin
 Generic Name : Mupirocin
 Therapeutic Group :Antibacterial
 Official specification : BP
 Dosage Form : 2% Ointment
 Strength : 20 mg
 Pack Size : 10 gm tube

12. INDICATION
PIROCIN ointment is indicated for
the topical treatment of impetigo due
to:
Staphylococcus aureus and
Streptococcus pyogenes

13. MECHANISM OF ACTION
 Mupirocin reversibly binds to bacterial isoleucyl-
tRNA synthetase, an enzyme which promotes the
conversion of isoleucine and tRNA to isoleucyl-
tRNA.
 Prevention of this enzymes from functioning
properly results in the inhibition of bacterial prote in
and RNA synthesis.

14. DOSAGE AND ADMINISTRATION
 A small amount of Pirocin 2% ointment should be
applied to the affected area three times daily for
upto 10 days.
 The area treated may be covered with gauze dres
sing if desired.

15. TARGET DOCTORS
-Skin and VD Specialist
-Medicine Specialist
- Potential GPs
-RMP/PC

16. MAJOR COMPETITORS
Brand Name Company
Bactron Oint. Biopharma
Bactoderm Oint. UniDerma
Bactroban Oint. GlaxoSmithKline
Bactrocin Oint. Square
Dermoban Oint. Opsonin
Mupi Oint. Alco
Mupibac Oint. Pharmasia
Mupiderm Oint. Healthcare
Mupiron Oint. SK+F
Muroderm Oint. General
Muron Oint. Drug Int.
Trego Oint. Incepta

17. SPECIAL BENEFITS OF PIROCIN
 Offers treatment superiority over oral antibiotic
therapy in Impetigo.
 Ensures better clinical response and pathogen
eradication rate.
 Effective and safe in the treatment of primary and
secondary skin infection.
 Offers treatment superiority over oral Flucloxacillin
and Erythromycin.

18. CONT………..
 Low incidence of adverse effects and cross-
resistance.
 Shows excellent activity against gram-positive
staphylococci and streptococci.
 Fewer adverse effects than systemic antibiotics.
 Easier to administration.
 Short term treatment option.