In coeliac disease (CD), the ingestion of gluten-containing cereals results in small bowel mucosal inflammation and villous atrophy with crypt
hyperplasia resulting in malabsorption syndrome with symptoms such as diarrhoea and abdominal distension.
IgA anti tissue transglutaminase (tTG) or IgA (or IgG) deamidated gliadin peptide (DGP) should be used to monitor the response to gluten-free diet
[Take home message]
Positive symptoms should prompt clinicians to test for
1. IgA Anti-gliadin Ab (AGA)
2. IgA Anti-endomysium Ab(EMA)
3. IgA Anti-tissue transglutaminase Ab (tTG)
positive antibody results suggesting the potential benefit of a GFD.
[Take home message]
Positive symptoms should prompt clinicians to test for
1. IgA Anti-gliadin Ab (AGA)
2. IgA Anti-endomysium Ab(EMA)
3. IgA Anti-tissue transglutaminase Ab (tTG)
positive antibody results suggesting the potential benefit of a GFD.
