select all that apply to ground substance Solution Lets us see what is ground substance. It is an amorphous gel-like or a transparent flud substance surrounding the cells,present in the connective tissue . The ground substance and fibers between cells in a connective tissue (most abundant tissues in the body-functions : binding and supporting; consists of relatively few cells in a generous matrix ) are surrounded and supported by matrix called as extracellular matrix. The Ground substance includes all the other components of the extracellular matrix excluding fibers (Eg: collagen and elastic fibers). Depending upon the tissue, the components of the ground substances vary . Ground substance is primarily composed of water, proteoglycans,glycosaminoglycans (most notably hyaluronan-hyaluronic acid), calcium and glycoproteins. In cytology, it may also refers to cytosol or protoplasm. The stroma is the tissue that forms the ground substance, base or the foundation, or the framework of an organ, as opposed to its functional parts (parenchyma)..