described about baby care powders , types of ingredients used in formulation of baby powders and evaluation of baby care powders

1. EVALUATIONOF BABYCAREPOWDERS
• Presented by
Kalyani. A
M.Pharmacy(pharmaceutical analysis)
Krupanidhi college of pharmacy
Bangalore

2. BABY CARE PRODUCTS
• Intended for use on new born babies to children up to 5
years
• Functional rather than decorative
• Criteria for consideration during development
High quality raw material
Non irritant substances
Allergen free
pH- skin friendly
Addition of anti-oxidants, chelating agents, skin protective ingredients.

3. Baby Cosmetics Types
• Cosmetics/protective
 Face/body creams
 Baby oil
 Baby powder
• Cleaning cosmetics
 Bath products
 Soaps and shampoos
 Cleansing milk
 Baby wipes

4. Baby powders
• Absorb moisture
• Prevent irritation of fragile skin
• Talc – (natural hydrous
magnesium silicate)
• Contamination with clostridium tetanie

5. • The particle size and shape is very important. The best
cosmetic grades of domestic and imported talc are imperative
and should pass through a 325 mesh screen(44 microns).
• The optimum range for a baby powder is 10-40 microns.
• Micro pulverization may be used to disperse the perfume oils
uniformly throughout the powder.
• Baby powders are used as lubricants in skin folds to prevent
chafing, to absorb perspiration and relieved prickly heat, and to
impart a clean pleasant fragrance to the baby’s skin.
• 3 to 5 % zinc and magnesium stearate were used to give
velvety smoothness to the powder and later on replaced by
lithium stearate which is non toxic and has a high degree of
water repellency and oil absorbency.

6. • Olive oil can also be added in place of zinc stearate to
improve adherence and emollience on the skin to impart
greater water repellency to the powder.
• Colloidal kaolin (a hydrated aluminum silicate ) is used in
baby powder for its high moisture absorptive capacity.
• Excellent emollient effects may be achieved by the
incorporation of 0.5 to 1.5% cetyl and stearyl alcohol in
baby powders.
• The starches used in baby powder as the major ingredients in
place of talc with 0.5% methyl benzethonium chloride as a
antiseptic. They don’t dust as talc and have absorption
capacity or moisture.
• The disadvantages with the starch is that it forms a sticky paste
when moistened with water and act as substrate for bacteria

7. • A chemically modified corn starch known as DRY FLO is
available as an ester which imparts repellent characteristic to
the starch molecules.
• The perfume selected must have great stability against
oxidation and polymerization.
BABY POWDER FORMULATION
Ingredients Wt.%
Talc 90.25%
Lithium stearate 2.50
Olive oil -
Kaolin 5.00
Zinc oxide 2.00
perfume 0.25
Ingredients Wt.%
Talc 90.25%
Lithium stearate 2.50
Olive oil -
Kaolin 5.00
Zinc oxide 2.00
perfume 0.25

8. Baby powder - Formulation
Corn starch 99.70
Rice starch 99.70
Dry flo 99.70
Talc 49.70
Calcium undecylenate
Hyamine 10-X 0.05
perfume 0.25

9. Baby powder - Formulation
Ingredient Wt.%
Talc 77.90
Starch 20.00
Zinc oxide 2.00
Perfume 0.10

10. Evaluation of baby powders
• Determination of matter insoluble in boiling water
1g (wetted with spirit)
+
200 ml water
+
Boiled
+
Filtered
+
dried and weighed

11. Evaluation of baby powders
• Test for solubility of colors:
1gm + 50ml water
+
boiled , filtered
+
filtrate 10ml solution
+
15ml spirit
Reflux & filtered
Colorless or faintly colored

12. Evaluation of baby powders
• Determination of fineness:
10gms in 150μ sieve
Running tap water
Residue dried
Weighed

13. Evaluation of baby powders
• Determination of moisture and volatile matter:
5gms in porcelain dish
dried and weighed

14. Evaluation of baby powders
• Determination of pH of aq. Suspension:
10 gm. + 90ml of water-suspension (within 5mins)
pH meter

15. • Pay off
Measure of adherence to the puff or skin
Incorrect compaction, adversely effects this pressure

16. Evaluation of baby powders
• Pressure testing
Penetrometer
Penetration of a sharp metal point into pressed
powder

17. Evaluation of baby powders
• Breakage testing:
Godet dropped onto a wooden board from 8 to 10
in. height– chip or. break

18. Microbiological evaluation
• 1. Test for microbial count
• 2. Investigation for the presence of specific micro-organisms
• 3. PET(preservative Efficacy Test)
Establishment of microbial limits
1. Products of baby, eye, mucus membrane- 100 cfu/g in 0.5 g
of product
2. Other products-1000 cfu/ g in 0.1 g of product
3. Pathogenic micro-organisms- pseudomonas aeruginosa,
staphylococcus aureus & C. albaicans must not be detected.

19. Test for microbial count
• Sample preparation:
 10% homogenous solution on suspension is prepared with sterile buffered peptone saline
solution at pH 7
 Non soluble products- 0.1% Tween 80
• Bacterial & fungal counts:
 1 ml of solution +15ml melted agar
 Bacteria- TSA(TRYPTIC SOY AGAR)-30 to 35o c for 5 days
 yeast & moulds- SCA (STARCH CASEIN AGAR) – 20 to 25o c for 7 days
 Anaerobic plate count –used for talc and powders
 Clostridium tetani
 MLA, preredused 5% defibrinated sheep blood
 Anaerobic jar (5 to 10 % CO2)
 Subcultured – cooked meat broth – incubated at 35o c for 2 days
 Detection- differential spore stain

20. Investigation for the presence of
specific Micro-organism
• Enterobacteria & other gram –ve organisms:
 1ml of solution +100ml EEB( Enterobacteria Enrichment Broth)-
incubated - 35o to 37o c for 24-48 hrs.
 Subcultured-VRBG(VOILET RED BLUE GLUCOSE) agar- 35o to 37o c
for 18-24 hrs.
 Detection:
• E.coli:
 1ml + 100ml Mac. Conkey broth- 43o to 45o c for 18-24 hrs.
 Subcultured- Mac. Conkey agar - 43o to 45o c for 18-24 hrs.
 Lactose fermenting g-ve- detected.

21. • Pseudomonas aeruginosa:
o 1ml +100ml TSB-35º to 37º c for 24-48 hrs.
o Subcultured- Cetrimide agar- 35º to 37º c for 24-48 hrs.
o detected
• Staphylococcus aureus:
o 1ml +100ml TSB-35º to 37º c for 24-48 hrs.
o Subcultured- Baird Parker- 35º to 37º c for 24-48 hrs.
o detected

22. • Molecular diagnosis:
Very rapid (27hrs)
ATP bioluminescence
PCR assay

23. Preservative efficacy test

24. THANK YOU