what are intrinsic and extrinsic controls Solution Intrinsic controls often either metabolic or myogenic & these metabolic mechanisms or factors that regulated via auto regulation finally exerts their effects on vascular smooth muscles (arterioles) during tissue perfusion to gain adequate amount of blood. The extrinsic controls are the mainly neuronal mechanisms (sympathetic nervous system) or hormonal mechanism (rennin-angiotensin mechanism) that exerts their effects on vascular smooth muscles to maintain constant blood pressure finally lowers the movement of blood to the body part where it need lesser.