Seminar Presentation on How Important It Is To Incorporate BRM into Training and Research on Animals

1. APPLICATION OF BIORISK MANAGEMENT
FOR TRAINING AND RESEARCH ON ANIMALS
Abiodun A. Denloye, PhD, mesn, IFBA-CP, FSEAN
Dept of Zoology and Environmental Biology
Lagos State University, Nigeria.
Thursday 16th
February 2017
www.denloye.com
www.slideshare.net/abiodundenloye
twitter@AbiodunDenloye

2. OUTLINE
• What is Biorisk?
• Meaning and Scope of Biosafety
• Biosafety and Biosecurity
• Working with Animals and Associated Risks
• Biosafety Levels and Criteria
• Where is LASU?
• The Future is AMP: Laboratory Biorisk
Management.
• Regulations - CWA15793
• Where do I Fit in as a Zoologist?

3. What is Biorisk?
Risk associated with biological materials.
Biorisk = Biosafety + Biosecurity Risks
Slide 3

4. Meaning and Scope of Biosafety
• (1) Biosafety is “the discipline addressing the safe handling and
containment of infectious microorganisms and hazardous biological
materials” (CDC, 2010).
– This recognizes the subject with respect to microorganisms and hazardous biological
materials.
• (2) Biosafety is a concept that refers to the need to protect human
health and the environment from the possible adverse effects of the
products of modern biotechnology (Convention on Biological Diversity,
1992).
This is one of the issues addressed by the CBD
Biosafety refers to safe handling, containment, release and utilization of
infectious microorganisms and actually or potentially hazardous
biological materials including Genetically Modified Organisms (GMOs)
with a view to protecting human health, plants and the environment
from possible adverse effects.

5. Biosecurity
• Protection, control, and
accountability for valuable
biological materials in order to
prevent their unauthorized
access, loss, theft, misuse,
diversion or intentional release.
• A valuable biological material is a laboratory material
that requires administrative oversight, control,
accountability, and specific protective and
monitoring measures in the laboratory. Examples
include pathogens, toxins, non-pathogenic
organisms, vaccine strains, foods, GMOs, cell
components, genetic elements etc.

6. Biosafety and Biosecurity

7. Likelihood
Very
High
Consequences
Very
Low
Low
Moderate
High
RISK
Risk
25
You are at the zoo
observing a
mellow, tiger cub
located behind a
strong glass
window.

8. Working with Animals and Associated Risks
• Protozoans -
• Plasmodium (Malaria Parasite)
• Trypanosomes (Sleeping Sickness Parasite)
• Cryptosporidum etc
• Trichomona
• Arthropods –
• Insects eg. Mosquitoes, Sandflies, Black flies,
• Spiders (Poisonous bites)
• Scorpions (Poisonous stings)
• Birds –
• Chickens (Avian Influenza), wild birds etc
• Mammals –
• Bats (Ebola Virus Disease)
• Rodents (Lassa Fever)
• Monkeys (Ebola Virus Disease),
• Cats (Crypto)
• Dogs (Rabies)
Slide 8

9. Biosafety Levels and Criteria
• There are four Biosafety levels (BSL) designated according to the degree
of protection provided for the personnel, the environment and
community.
• BSL 1 – For work with agents not known to cause diseases to
immunocompetent individuals.
• BSL 2 – Builds on BSL 1. Suitable for work with agents that pose moderate
hazards to personnel and Environment.
• BSL 3 - For clinical, diagnostic, teaching, research, or production facilities
working with indigenous or exotic agents that may cause serious or
potentially lethal disease through the inhalation route of exposure.
• BSL 4 - For work involving dangerous and exotic agents that pose a high
individual risk of aerosol-transmitted laboratory infections and life-
threatening disease frequently fatal, for which there are no vaccines or
treatments, or a related agent with unknown risk of transmission.

10. Where is LASU?
• All laboratories are BSL 1 , even research labs.
• The available BSL 1 labs are substandard; no
conformity with specify standards for BSL 1s.
• Biorisk Management Introduced to LASU
Senate in 2016.
• Biosafety and Biosecurity incorporated into
GNS 301 (Logic and Science). Being taught for
the first time this session (2016/2017).

11. Future Outlook – The Future is AMP
• What is AMP?
• This is a universally accepted Model for Biorisk
Management System.
• A = Assessment
• M = Mitigation
• P = Performance

12. Risk Assessment
Strategy:
Source: CWA 15793:2011
Biorisk Management =
Assessment, Mitigation, Performance
28

13. Slide 13
Laboratory Biorisk Management
System or process to
control safety and
security risks associated
with the handling or
storage and disposal of
biological agents and
toxins in laboratories and
facilities

14. CWA 15793 – International
Approach
• Derived from the current WHO
Biosafety and Biosecurity
Guidelines
• Consistent with other
international standards such as
– ISO 9001/14001 and OSHAS18001
• Not country specific
– Local solutions possible
– Compliance with national and
local regulations mandatory
Slide 14

15. CWA 15793 – Major Sections
• Assessment
– Hazard Identification
– Risk Assessment
• Mitigation
– Good microbiological
technique
– Waste management
– Physical security
• Performance
– Performance measurement
and analysis of data
– Management review
Slide 15

16. CWA 15793 is Performance-Oriented
• Describes what needs to be achieved
• Allows organizations to determine how
best to achieve those objectives
• Not a technical document.
• Example:
Slide 16
4.4.4.5.3Waste Management
The organization shall establish and maintain an appropriate waste
management policy for biological agents and toxins

17. • The lab worker/trainer/supervisor etc could
be using animals bearing pathogens. He must
be fully protected and has to train his students
from getting infected.
• The zoology and Environmental biologist must
key into the provisions of CWA 15793-2011
and operate with the standard for safe and
secure work with AMP Model.

18. Where do I fit in as
a Zoologist?
• Researcher/Lecturer -
Entomologist, ornithologist,
Parasitologist, Geneticist,
mammalogist etc.
• Project supervisor/Consultant
• Animal Care Manager/Officer (CWA
15793 pp 23)
• Training in biosafety and biosecurity
through Seminars and Workshops
(CWA 15793 – 2011 section 4.4.2
• Project Assessment Experts
• Institutional Biosafety Committee
Member/Officer

19. •THANK YOU