This document discusses periodontal treatment considerations for medically compromised patients. It covers how medical conditions like hemorrhagic disorders, renal disease, liver disease, pulmonary disease, infectious diseases, pregnancy, and prosthetic joint replacements can impact periodontal therapy. For each condition, it provides details on oral manifestations, necessary consultations and lab tests, and modified treatment approaches to minimize health risks. Conservative, non-surgical periodontal treatments are often recommended where possible for medically complex patients.