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Automated Clinical Decision Support for Type-2 Diabetes
THE PROBLEM
‘One Size fits all’ approach no longer works
Broad Based Prescriptions
11 Drug classes to treat Type-2 Diabetes
No Big-Data driven solution
Petabytes of data on EHR just being stored
and not used for aiding physicians’ day-to-
day activities
Individual Incompatibility
‘Biological algorithm’ can take into
consideration only a limited no. of factors
prior to making prescription decision
Individual Incompatibility
‘Biological algorithm’ can take into
consideration only a limited no. of factors
prior to making prescription decision
03
01 02
THE IMPLICATIONS
Incompatible Medications
1 2 3 4
THE SOLUTION
Physician Ordered Prescription Guidance Platform for Type 2 Diabetes
Doctor Performs
Diagnosis
Doctor conducts patient
interview,
clinical investigations &
diagnoses
patient with Type-2
Diabetes
EMR Data
Extraction
Precision Rx extracts
patient info (clinical
observations, lab results,
ADR history) from the EMR
relevant for making a
prescription decision
Big Data
Analysis
Precision Rx parses the
patient data
through a Supervised ML
Model,
benchmarking the patient
medical data
against similar patients’
data from
across the world
Prescription
Guidance Report
Precision Rx generates a
prescription guidance
report sorting all 11 T2D
drug classes based on
potential toxicity/efficacy
for the patient. The Doctor
can now make a data-
driven and statistically
sound prescription decision
Drug Response
Modelling
Precision Rx models out
projected drug responses
for the 11 T2D Drug
classes for the current
patient and attributes
risk/toxicity scores for all
the 11 drug classes
THE TEAM
Magic behind the lens
Yash Sagar Santani Puneet Chadha Christin Bivens Pallav Prakash Michael Melnick Bellari Kanjilal
CEO Ops & Biz Dev Data Science Business Strategy ML Architect Data Scientist
OUR ADVISORS
Expert feedback & Domain Expertise
Dr. Rachel M. Shing Dr. Yasmin Sarfraz Dr. Riaz Sirajuddin Ales Varabyou
Integrated
Healthcare Systems
Stand-Alone
Physician FacilitiesUniversity Hospitals
TARGET
CUSTOMERS
Kaiser Permanente,
Ascension, Veterans
Affairs
Johns Hopkins University,
Vanderbilt, OU Med,
Stanford
Local facilities with >=6
physicians
REVENUE MODEL
How to make money
*APU – Active Physician User. Internal KPI to be used to track customer acqusition
END MARKET SIZE
Patient Population Size & Growth
MARKET SIZING
Addressable Market*
*Retrieved from: Henry Kaiser Foundation (2019): Available from: https://www.kff.org/other/state-indicator/primary-care-physicians-by-field/ and
https://www.kff.org/other/state-indicator/physicians-by-specialty-area/
Doctor Shadowing
6 local doctors – regularly treat
T2D patients
Shadowing, questioning,
continuous feedback loop for
2.5 months
Clinical Workflow
Construction
First static digitized version of
workflow for selecting optimum
HbA1C band & drug class for
T2D patient
Neatly documented
methodology for treating T2D
patients
ML modelling
Initiated
Parsed through 30,000 patients’
worth of data from OSU-CHSI’s*
Cerner EHR Export
Findings, outcomes, model
selection + Cerner Data Tier 2.0
Access
MOVING FORWARD
ML Model training, testing, optimization and inter-model benchmarking
TRACTION
Progress Till Date & Steps Moving Forward
*Oklahoma State University’s Centre for Health Systems Innovation
Jul
2020
Proof Of Concept
Ready
Model selection and
optimization
accomplished, Cerner
Data fully utilized
Prototype Ready
Additional testing and
training of model with
more data
Oct
2020
Seed Round Raised
Runway to develop
shippable product +
conduct pilot studies
Nov
2020
MVP ready
Shippable product ready
for pilot testing studies
Apr
2021
Large-Scale Trial
Live study with an
integrated provider
network facility
Jul
2021
Series A Financing
Raised
Large-scale
implementation, EHR
integration and customer
acquisition initiated
Feb
2022
DEVELOPMENT LIFECYCLE
Action-Plan
OneOme Quest PGx Geneticure Promethease Aevus PRx
Disease group
specialization
Privately funded
Big Data Analysis
Physician Ordered
EHR System
Integration
Machine Learning
Modelling
SaaS Business
Model
Revenue Generation
Currently
Recurring Revenue
Generation Model
Genetic Counselor
support
COMPETITION
i2E inc, OCAST
$52k
PRE-SEED ROUND
Money raised to-date
SEED ROUND
Round specifics
Aevus PRx
Seed Raise
INVESTMENT
$400,000
PRE-MONEY
VALUATION
$2,225,000
POST-MONEY
VALUATION
$2,625,000
ROUND CLOSE
DATE
NOV 2020
QUESTIONS ?

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Aevus Seed Deck 2020 | Target Raise=: $420k

  • 1. Automated Clinical Decision Support for Type-2 Diabetes
  • 2. THE PROBLEM ‘One Size fits all’ approach no longer works Broad Based Prescriptions 11 Drug classes to treat Type-2 Diabetes No Big-Data driven solution Petabytes of data on EHR just being stored and not used for aiding physicians’ day-to- day activities Individual Incompatibility ‘Biological algorithm’ can take into consideration only a limited no. of factors prior to making prescription decision Individual Incompatibility ‘Biological algorithm’ can take into consideration only a limited no. of factors prior to making prescription decision 03 01 02
  • 4. THE SOLUTION Physician Ordered Prescription Guidance Platform for Type 2 Diabetes Doctor Performs Diagnosis Doctor conducts patient interview, clinical investigations & diagnoses patient with Type-2 Diabetes EMR Data Extraction Precision Rx extracts patient info (clinical observations, lab results, ADR history) from the EMR relevant for making a prescription decision Big Data Analysis Precision Rx parses the patient data through a Supervised ML Model, benchmarking the patient medical data against similar patients’ data from across the world Prescription Guidance Report Precision Rx generates a prescription guidance report sorting all 11 T2D drug classes based on potential toxicity/efficacy for the patient. The Doctor can now make a data- driven and statistically sound prescription decision Drug Response Modelling Precision Rx models out projected drug responses for the 11 T2D Drug classes for the current patient and attributes risk/toxicity scores for all the 11 drug classes
  • 5. THE TEAM Magic behind the lens Yash Sagar Santani Puneet Chadha Christin Bivens Pallav Prakash Michael Melnick Bellari Kanjilal CEO Ops & Biz Dev Data Science Business Strategy ML Architect Data Scientist
  • 6. OUR ADVISORS Expert feedback & Domain Expertise Dr. Rachel M. Shing Dr. Yasmin Sarfraz Dr. Riaz Sirajuddin Ales Varabyou
  • 7. Integrated Healthcare Systems Stand-Alone Physician FacilitiesUniversity Hospitals TARGET CUSTOMERS Kaiser Permanente, Ascension, Veterans Affairs Johns Hopkins University, Vanderbilt, OU Med, Stanford Local facilities with >=6 physicians REVENUE MODEL How to make money *APU – Active Physician User. Internal KPI to be used to track customer acqusition
  • 8. END MARKET SIZE Patient Population Size & Growth
  • 9. MARKET SIZING Addressable Market* *Retrieved from: Henry Kaiser Foundation (2019): Available from: https://www.kff.org/other/state-indicator/primary-care-physicians-by-field/ and https://www.kff.org/other/state-indicator/physicians-by-specialty-area/
  • 10. Doctor Shadowing 6 local doctors – regularly treat T2D patients Shadowing, questioning, continuous feedback loop for 2.5 months Clinical Workflow Construction First static digitized version of workflow for selecting optimum HbA1C band & drug class for T2D patient Neatly documented methodology for treating T2D patients ML modelling Initiated Parsed through 30,000 patients’ worth of data from OSU-CHSI’s* Cerner EHR Export Findings, outcomes, model selection + Cerner Data Tier 2.0 Access MOVING FORWARD ML Model training, testing, optimization and inter-model benchmarking TRACTION Progress Till Date & Steps Moving Forward *Oklahoma State University’s Centre for Health Systems Innovation
  • 11. Jul 2020 Proof Of Concept Ready Model selection and optimization accomplished, Cerner Data fully utilized Prototype Ready Additional testing and training of model with more data Oct 2020 Seed Round Raised Runway to develop shippable product + conduct pilot studies Nov 2020 MVP ready Shippable product ready for pilot testing studies Apr 2021 Large-Scale Trial Live study with an integrated provider network facility Jul 2021 Series A Financing Raised Large-scale implementation, EHR integration and customer acquisition initiated Feb 2022 DEVELOPMENT LIFECYCLE Action-Plan
  • 12. OneOme Quest PGx Geneticure Promethease Aevus PRx Disease group specialization Privately funded Big Data Analysis Physician Ordered EHR System Integration Machine Learning Modelling SaaS Business Model Revenue Generation Currently Recurring Revenue Generation Model Genetic Counselor support COMPETITION
  • 13. i2E inc, OCAST $52k PRE-SEED ROUND Money raised to-date
  • 14. SEED ROUND Round specifics Aevus PRx Seed Raise INVESTMENT $400,000 PRE-MONEY VALUATION $2,225,000 POST-MONEY VALUATION $2,625,000 ROUND CLOSE DATE NOV 2020