Xu Resume

1. 1
Xihui Xu
1629 E. Jefferson Street ⏐ Rockville, Maryland 20852 ⏐Phone: 307-220-3828 ⏐ Email: xihuixu@gmail.com
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KEY QUALIFICATIONS
• Extensive experience in pharmacology and toxicology;
• Extensive experience in regulatory affairs, clinical research, and preclinical (in vivo and in vitro) research;
• Extensive experience in reviewing manuscripts for more than 20 journals;
• Extensive experience in writing experiment protocols, grant proposals, and peer-reviewed manuscripts;
• Authored 30 publications in journals that span across multiple disciplines in cardiovascular disease, liver
disease, neuroscience and biology;
• Knowledgeable in statistical methods (Excel, GraphPad Prism) used to analyze and interpret data;
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WORKING EXPERIENCE
National Institutes of Health, National Heart, Lung, and Blood Disease Institute, Rockville,
Maryland
Post-doctoral Fellow: Laboratory of Obesity and Aging Research
January 2015- present
Research Focus: 1. Uncover the role of mitochondrial nuclease in the development of hepatic carcinoma and
prostate cancer in a mouse model.
Research Focus: 2. Use high fat diet-induced mouse obesity model to study the role of mitochondrial DNA
fragmentation in the development of non-alcoholic fatty liver disease.
Research Focus: 3. Uncover the role of mitochondrial DNA fragmentation in the maintenance of cardiac
function and structure under pathophysiological conditions.
School of Pharmacy at University of Wyoming, Laramie, Wyoming
Research Scientist
01/2014- 12/2014
• Research: Use mouse and mammalian cell model to study mitochondrial quality control in the onset and
development of obesity and alcoholic cardiomyopathy
• Teaching: PHCY6220 Fall 2014 (Pathophysiology II); PHCY6230 Fall 2014 (Pharmacology I)
• Mentoring: one PhD candidate student, one PharmD candidate student, and two undergraduate students
School of Pharmacy at University of Wyoming, Laramie, Wyoming
Post-doctoral Fellow
03/2013- 12/2013
• Research: Use mouse and mammalian cell model to study if and how autophagy regulates metabolic
syndrome and heart function maintenance
• Mentoring: PharmD candidate student and undergraduate student
Shanghai RAAS Blood Products Co. Ltd., Shanghai, China
Regulatory Affair Specialist
01/ 2007- 06/ 2007
• To ensure company's pharmaceutical products comply with the regulations of Chinese SFDA;
• Developing and writing explanations for new product licenses and license renewals;
• Monitoring and setting timelines for license variations and renewal approvals;
• Planning and developing product clinical trials and interpreting trial data;
• Specifying storage, labeling and packaging requirements.

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Shanghai Xinyi Pharmaceutical Co. Ltd., Shanghai, China
Clinical Research Associate
06/ 2006- 12/ 2006
• Collecting, collating and evaluating scientific data that has been researched by colleagues;
• Planning and developing product clinical trials and interpreting trial data;
• Meeting with physicians to overview clinical trials;
• Collect and organize clinical data to report to Shanghai SFDA.
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EDUCATION
School of Pharmacy at University of Wyoming, Laramie, Wyoming
PhD in Biomedical Science: School of Pharmacy
2007-2013
Research Goal: Uncover the role of autophagy in the maintenance of cardiac function under stress conditions
• Use different mouse models and cell lines to study how autophagy is regulated by different stress inducers
• Confirm the role of autophagy in the maintenance of cardiac function under different pathological conditions
School of Pharmacy at Soochow University (China)
Master’s Degree in Pharmacology
2003-2006
Research Goal: Develop novel strategies to control cerebral ischemia/ reperfusion
• Used a rat model to study the neuroprotective effect of prostaglandin A1 and lithium against cerebral
ischemia
• Studied the role of heat shock protein in the development of cerebral ischemia/ reperfusion
School of Pharmacy Soochow University
Bachelor Degree in Pharmacy
1999-2003
Research Project: Vascular protective role of puerarin in diabetic rats
• Used a rat model to study diabetes-induced vascular dysfunction
• Studied the vascular protective effect of puerarin in diabetic rats.
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AWARDS
• Mountain West CRT-IN Conference Travel Award 2014
• BCVS Abstract Travel Grant (AHA) 2013
• C-CRAM Outstanding Researcher Award 2013
• ACRE-CnAHA symposium award (Second Prize) 2013
• 2012 BCVS Abstract Travel Grant (AHA) 2012
• ACRE-CnAHA symposium award (Outstanding Presentation) 2012
• CHS Student Research Seed Grant; Grand Rounds Research Day Student Travel Award, College of
Health Science; Graduate Student Travel Award, University of Wyoming, Laramie WY 2011
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PROFESSIONAL MEMBERSHIPS
• Society of Neuroscience 2007- 2010
• American Heart Association 2011- 2014
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ADMINISTRATIVE SERVICE
• Lead Judges- 2016 NIH Graduate Student Research Symposium Poster Session

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• Graduate student members of the UW Graduate Council 2010- 2011
• Moderator for Wyoming Undergraduate Research Day 2011
• Moderator for Wyoming Undergraduate Research Day 2013
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PEER-REVIEWED PUBLICATIONS:
Publication as first and/or corresponding author
1. Xu X, Pang J, Chen Y, Bucala R, Zhang Y, Ren J. Macrophage Migration Inhibitory Factor (MIF) Deficiency
Exacerbates Aging-Induced Cardiac Remodeling and Dysfunction Despite Improved Inflammation: Role of
Autophagy Regulation. Sci Rep. 2016; In Press
2. Xu X, Ren J. Macrophage migration inhibitory factor (MIF) knockout preserves cardiac homeostasis
through alleviating Akt-mediated myocardial autophagy suppression in high-fat diet-induced obesity. Int J
Obes. 2015, 39 (3): 387- 96
3. Roe N*, Xu X*, Kandadi M, Weiser-Evans M, Ren J. Targeted Deletion of PTEN in Cardiomyocytes
Renders Cardiac Contractile Dysfunction through Interruption of Pink1-AMPK Signaling and Autophagy.
Biochim Biophys Acta. 2015; 1852 (2): 290- 8. (*Equal Contributions)
4. Ren SY, Xu X. Role of autophagy in metabolic syndrome-associated heart disease. Biochim Biophys Acta.
2015; 1852 (2): 225- 31. (Corresponding Author)
5. Zhang Y*, Xu X*, Ceylan-Isil AF, Dong M, Ren J. Ablation of Akt2 Protects against Lipopolysaccharide-
Induced Myocardial Contractile Dysfunction: Role of the Akt Ubiquitination E3 Ligase TRAF6. J Mol Cell
Cardiol. 2014; 74: 76- 87. (*Equal Contributions)
6. Xu X, Roe N, Weiser-Evans MC, Ren J. Inhibition of mammalian target of rapamycin with rapamycin
reverses hypertrophic cardiomyopathy in mice with cardiomyocyte-specific knockout of PTEN.
Hypertension. 2014, 63(4): 729- 39.
7. Xu X, Hua Y, Nair S, Bucala R., Ren J. Macrophage Migration Inhibitory Factor (MIF) Activates Mitophagy
to Ameliorate Pressure Overload-Induced Cardiac Hypertrophy. Hypertension. 2014; 63(3): 490- 9.
8. Xu X, Bucala R, Ren J. Macrophage Migration Inhibitory Factor Deficiency Augments Doxorubicin-Induced
Cardiomyopathy: Role of Autophagy. J Am Heart Assoc. 2013; 2 (6):e000439.
9. Xu X, Benjamin D. Pacheco, Ling Leng, Richard Bucala, Jun Ren. Macrophage Migration Inhibitory Factor
Plays a Permissive Role in the Maintenance of Cardiac Contractile Function under Starvation through
Regulation of Autophagy. Cardiovasc Res. 2013; 99(3): 412- 21.
10. Xu X, Lindsay K. Hueckstaedt, Jun Ren. Deficiency of Insulin-Like Growth Factor 1 Attenuates Aging-
Induced Changes in Hepatic Function: Role of Autophagy. J Hepatol. 2013; 59(2): 308- 17.
11. Xu X, Ren J. Cardiac stem cell regeneration in metabolic syndrome. Curr Pharm Des. 2013; 19(27): 4888-
92.
12. Xu X, Hua Y, Sreejayan N, Zhang Y, Ren J. Akt2 Knockout Preserves Cardiac Function in High Fat Diet-
Induced Obesity by Rescuing Cardiac Autophagosome Maturation. J Mol Cell Biol. 2013; 5(1):61-3.
13. Xu X, Ren J. Unmasking the janus faces of autophagy in obesity-associated insulin resistance and cardiac
dysfunction. Clin Exp Pharmacol Physiol. 2012; 39(2):200-8.
14. Xu XH, Hua YN, Zhang HL, Wu JC, Miao YZ, Han R, Gu ZL, Qin ZH. Greater stress protein expression
enhanced by combined prostaglandin A1 and lithium in a rat model of focal ischemia. Acta Pharmacol Sin;
2007; 28(8):1097-104.
15. Xu X, Gu Z, Qin Z. Neuroprotective actions and underlying molecular mechanisms of lithium. Chinese
Journal of New Drugs. 2006; 15(2): 87- 92.
16. Xu XH, Zhang HL, Han R, Gu ZL, Qin ZH. Enhancement of neuroprotection and heat shock protein
induction by combined prostaglandin A1 and lithium in rodent models of focal ischemia. Brain Res. 2006;
1102(1):154-62.
Additional publication
1. Ren J, Xu X, Wang Q, Ren SY, Dong M, Zhang Y. Permissive role of AMPK and autophagy in adiponectin
deficiency-accentuated myocardial injury and inflammation in endotoxemia. J Mol Cell Cardiol. 2016; In
press

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2. Yang L, Gao JY, Ma J, Xu X, Wang Q, Xiong L, Yang J, Ren J. Cardiac-specific overexpression of
metallothionein attenuates myocardial remodeling and contractile dysfunction in L-NAME-induced
experimental hypertension: Role of autophagy regulation. Toxicol Lett. 2015; 237 (2): 121- 32.
3. Guo R, Xu X, Babcock SA, Zhang Y, Ren J. Aldehyde dehydrogenase-2 plays a beneficial role in
ameliorating chronic alcohol-induced hepatic steatosis and inflammation through regulation of autophagy. J
Hepatol.2015; 62 (3): 647- 56.
4. Wang X, Cao Y, Shen M, Wang B, Zhang W, Liu Y, He X, Wang L, Xia Y, Ding M, Xu X, Ren J. DIDS
reduces ischemia/reperfusion-induced myocardial injury in rats. Cell Physiol Biochem. 2015; 35 (2): 676-
88.
5. Wang Q, Yang L, Hua Y, Nair S, Xu X, Ren J. AMP-activated protein kinase deficiency rescues paraquat-
induced cardiac contractile dysfunction through an autophagy-dependent mechanism. Toxicol Sci. 2014;
142 (1): 6- 20.
6. Zhu X, Hu N, Chen X, Zhu MZ, Dong H, Xu X, Luo F, Hua Y, Nair S, Samson WK, Xiong L. Neuronostatin
attenuates myocardial contractile function through inhibition of sarcoplasmic reticulum Ca2+-ATPase in
murine heart. Cell Physiol Biochem. 2014; 33 (6): 1921- 32.
7. Zhang Y, Xu X, Ren J. mTOR overactivation and interrupted autophagy flux in obese hearts: a dicey
assembly. Autophagy. 2013; 9 (6): 939- 41.
8. Ceylan-Isik AF, Kandadi MR, Xu X, Hua Y, Chicco AJ, Ren J, Nair S. Apelin administration ameliorates
high fat diet-induced cardiac hypertrophy and contractile dysfunction. J Mol Cell Cardiol. 2013; 63: 4- 13.
9. Dong M, Hu N, Hua H, Xu X, Kandadi MR, Guo R, Jiang S, Nair N, Hu D, Ren J. Chronic Akt activation
attenuated lipopolysaccharide-induced cardiac dysfunction via Akt/GSK3β-dependent inhibition of
apoptosis and ER stress. Biochim Biophys Acta. 2013; 1832 (6): 848- 63.
10. Hua Y, Xu X, Shi GP, Chicco AJ, Ren J, Nair S. Cathepsin K Knockout Alleviates Pressure Overload-
Induced Cardiac Hypertrophy. Hypertension. 2013; 61(6): 1184- 92.
11. Flynn FW, Jensen DD, Thakar A, Xu X, Flynn SW, Zhang Z. Neurokinin 3 receptor forms a complex with
acetylated histone H3 and H4 in hypothalamic neurons following hyperosmotic challenge. Am J Physiol
Regul Integr Comp Physiol. 2011; 301(3): R822-31.
Chapter edited
1. Xu X and Ren J. Regulation of Autophagy in Obesity-Induced Cardiac Dysfunction. In: Autophagy: Caner, Other
Pathologies, Inflammation, Immunity, and Infection. Elsevier 2013 pp. 329- 40.
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RESEARCH SUPPORT:
1. College of Health Science Student Research Grant Xu, X (PI) 07/01/11- 06/30/12
Role of MIF in Abdominal Aortic Constriction-Induced Autophagic Flux Change in Murine Heart
The goal of this project is to assess the role of macrophage migration inhibitory factor (MIF) deficiency and
autophagy on pressure overload-induced cardiac hypertrophy.
Role: PI.
2. NIH INBRE 5P20RR016474 Ren, J (PI) 05/01/13-04/30/14
Role of autophagy in cardiac function maintenance in high diet-induced obesity
The goal of this study is to evaluate the role of autophagy in the maintenance of cardiac homeostasis in a
mouse model of high fat diet-induced obesity
Role: Primary PI of the pilot project.
3. NIH PRAT (F12) Grant Xu, X (PI) Pending
Role of endonucleaseG in the development of nonalcoholic fatty liver disease
The goal of this study is to study the role of endonucleaseG in the maintenance of hepatic mitochondrial fatty
acid oxidation and the development of nonalcoholic fatty liver disease
Role: Primary PI of the pilot project.