Pharmacology Multiple choice questions

1. PRESENTED BY : VANARAJ RABARI
(M. PHARM PHARMACOLOGY)
PHARMACOLOGY MCQS
PART -1

2. ❂ Neuroaminidase is a ______________________.
1) One transmembrane protein
2) Two transmembrane protein
3) Three transmembrane protein
4) Four transmembrane protein

3. ❂The drug Tribavirim has a similar structure to
______________.
1) Thymine
2) Thymidine
3) Guanine
4) Guanosine

4. ❂Which drug inhibits neuraminidase enzyme?
1) Ratelgravir
2) Saquinavir
3) Indinavir
4) Oseltamivir

5. ❂Which drug inhibits viral DNA polymerase?
1) Aciclovir
2) Saquinavir
3) Laminadine
4) Zidovudine

6. ❂The following medicines are protease inhibitors except one:
1) Amprenavir
2) Atazanavir
3) Indinavir
4) Abacavir

7. ❂Which mammalian enzyme produces resistance to the
zidovudine effect?
1) γ (gamma) - DNA
2) β (beta) - DNA
3) α (alpha) - DNA
4) δ (delta) - DNA

8. ❂Which derivative is formed by the phosphorylation of
zidovudine ?
1) 5-Monophosphate
2) 5-Triphosphate
3) 15-Monophosphate
4) 15-Triphosphate

9. ❂ Cold sores are caused by __________________.
1) Varicella zoster
2) Typhi adenovirus
3) Rhino virus
4) Herpes labials

10. ❂Which host cell structure does infant diarrheal
rotavirus target?
1) Beta-adrenoceptors
2) Helper T lymphocytes CD4 glycoprotein
3) MHC (major histocompatibility complex) molecules
4) T-lymphocyte interleukin-2 receptor

11. ❂ What is the size of the virus?
1) 10-20 nm
2) 20-30 nm
3) 30-40 nm
4) 40-50 nm

12. ❂ Zilutein acts on the _____________ enzyme.
1) 5-lipooxygenase
2) 15-lipoxygenase
3) Glutatione 5-transferase
4) Gamma -glutamyl transpeptidase

13. ❂Which prostenoid is used in open-angle glaucoma?
1) Epoprostenol
2) Alprostadil
3) Latanoprost
4) Misoprostol

14. ❂Which prostanoid is used in primary pulmonary
hypertension?
1) Alprostadil
2) Epoprostenol
3) Gemeprost
4) Dinoprostone

15. ❂ Which prostanoid is used in postpartum
haemorrhage?
1) Dinoprostone
2) Misoprostol
3) Carboprost
4) Gemeprost

16. ❂ The following effects are seen after activation of the
ETA(endothelin ) receptor except for one:
1) Vasoconstriction
2) Bronchoconstriction
3) Stimulation of aldosterone secretion
4) Vasodilation

17. ❂Vitamin K is essential for the following clotting
factors except one:
1) Factor II (prothrombin)
2) Factor VII
3) Factor VIII
4) Factor IX (Christmas factor)

18. ❂Which vitamin is made in the intestine?
1) Vitamin K2
2) Vitamin K1
3) Vitamin B6
4) Vitamin B12

19. ❂Heparin intramuscular injection causes
___________________.
1) Hematomas
2) Thrombophilia
3) Coeliac disease
4) Obstructive jaundice

20. ❂ Heparin is not absorbed from the gut due to
______________________________.
1) It's charge and high molecular weight
2) It's charge and low molecular weight
3) Interaction with food
4) Interact with flora

21. ❂The following diseases are caused by deficiency of
Vitamin K except one:
1) Sprue
2) Celiac disease
3) Steatorrhea
4) Hematomas

22. ❂Which drug affects vitamin K?
1) Phenylbutazone
2) Cephalosporins
3) Sulfonamide
4) Moxalactum

23. ❂ All of the following drugs enhance the effect of anti-
coagulant agents except one:
1) Co-trimoxazole
2) Ciprofloxacin
3) Metronidazole
4) Carbamazepine

24. ❂Warfarin has a potentiation of effect in the following
disease conditions except one:
1) Liver disease
2) Fever
3) Thyrotoxicosis
4) Hypothyroidism

25. ❂Which medicine reduces the absorption of warfarin in
the gut?
1) Colestyramime
2) Carbamazepine
3) Rifampicin
4) Vitamin k

26. ❂Which drug antagonizes the GP 2b/2a receptors
(Glycoprotein IIb/IIIa)?
1) Hirudin
2) Ticlopidine
3) Abciximab
4) Clopidogrel

27. ❂ Clopidogrel exerts potential action with
_____________.
1) Chlorphenaramine
2) Omeprazole
3) Domeperidone
4) Chlorothiazide

28. ❂Which adenosine (p2Y) receptor antagonist causes side
effects of neutropenia and thrombocytopenia?
1) Ticlopidine
2) Clopidogrel
3) Prasugtel
4) None of the above

29. ❂ Fibrinolytic agents are contraindicated for the
following conditions except one:
1) Pregnancy
2) Uncontrolled hypertension
3) Internal bleeding
4) Uncontrolled hypotension

30. ❂ Orlistat is used in the treatment of obesity and is also
useful for ______________.
1) Type 2 diabetes
2) Type 1 diabetes
3) Gout
4) Atherosclerosis

31. ❂ Mercaptopurine is a metabolite of which drug?
1) Azathioprine
2) Mycophenolate mofetil
3) Leflunomide
4) Glucocorticoids

32. ❂The drug ciclosporin is obtained from ___________.
1) Bacteria
2) Virus
3) Fungus
4) Protozoa

33. ❂Which drug acts by scavenging toxic oxygen
metabolites produced by neutrophils?
1) Methotrexate
2) Penicillamine
3) Chloroquine
4) Sulfasalazine

34. ❂Which drug is used in the treatment of
hyperthyroidism?
1) Levothyroxine
2) Liothyronine
3) Propranolol
4) Cyproterone

35. ❂ Which is the osmotic laxative?
1) Docusate
2) Lactulose
3) Senna
4) Ispaghula

36. ❂Which are the potent anti-inflammatory agent?
1) Selective COX-2 (Cyclooxygenase) inhibitors
2) Non-Selective COX-2 (Cyclooxygenase) inhibitors
3) DMARDS (Disease-modifying antirheumatic drugs )
4) Glucocorticoids

37. ❂Which medication is used in the treatment of depression,
anxiety disorder and fibromyalgia?
1) Fluoxetine
2) Olanepine
3) Fluoxetine
4) Sibutramine

38. ❂Which medicine is used for the treatment
of fibromyalgia?
1) Nortriptyline
2) Amitriptyline
3) Duloxetine
4) Fluoxetine

39. ❂Amitriptyline is used for the treatment of depression
and _____________.
1) Anxiety disorder
2) Neuropathic pain
3) Fibromyalgia
4) Bipolar depression

40. ❂Which drug has the highest dependency liability?
1) Ethanol
2) Cannabis
3) Morphine
4) Mescaline

41. ❂ Disulfiram is contraindicated for
____________patient.
1) Hypertension
2) Hypotension
3) GERD (Gastroesophageal reflux disease)
4) Asthma

42. ❂ Bupropion is contraindicated for the patient with
_____________.
1) Seizure
2) Anxiety
3) Diabetes
4) Asthma

43. ❂Which drug inhibits both the cardiac output and the
release of meditators?
1) Adrenaline
2) Prostacyclin
3) Corticosteroids
4) Dobutamine

44. ❂What effect does somatostatin have on insulin and
glucagon?
1) Increase insulin,decrease glucagon
2) Increase insulin,increase glucagon
3) Decrease insulin, decrease glucagon
4) Decrease insulin,increase glucagon

45. ❂Which drug is responsible for the deficiency of folic
acid?
1) Warfarin
2) Omeprazole
3) Ethambutol
4) Phenytoin