This document contains a series of multiple choice questions related to pharmacology. The questions cover topics such as: which drug is a sulfonamide with anti-epileptic effects; which P450 isoenzyme metabolizes certain drugs; the water content and volumes of different body compartments; drug mechanisms like carbonic anhydrase inhibitors; routes of administration; drug binding proteins; classes of antihypertensives; lipid proteins; chemotherapy drugs; diabetes types; opioid properties; antipsychotics; and treatments for conditions like migraine, arrhythmias, anxiety and depression. Answer options for each multiple choice question are provided.

1. PRESENTED BY : VANARAJ RABARI
(M. PHARM PHARMACOLOGY)
PHARMACOLOGY MCQS
PART - 2

2. ❂ Which sulfonamide compound has anti-epileptic
effect?
1) Sulfanilamide
2) Zonisamide
3) Sulfamethoxazole
4) Sulfasalazine

3. ❂Which p450 isoenzyme is responsible for the
metabolism of cyclophosphamide and methadone?
1) CYP2C9
2) CYP2C8
3) CYP1A2
4) CYP2B6

4. ❂Which isoenzyme p450 is responsible for the effects of
alcohol and paracetamol?
1) CYP2E1
2) CYP2B6
3) CYP1A2
4) CYP2D6

5. ❂ By weight, the amount of water in the body is
________________.
1) 0.661/kg
2) 0.771/kg
3) 0.551/kg
4) 0.441/kg

6. ❂ The total extracellular volume of the body by weight
is ____________.
1) 0.31/kg
2) 0.51/kg
3) 0.41/kg
4) 0.21/kg

7. ❂ The plasma volume per body weight is
_____________.
1) 0.041/kg
2) 0.051/kg
3) 0.061/kg
4) 0.071/kg

8. ❂Which medicine is a carbonic anhydrase inhibitor?
1) Fentanyl
2) Dorzolamide
3) Buprenorphine
4) Diazepam

9. ❂ Which medicine is taken by the sublingual route?
1) Tetracycline
2) Indometacin
3) Thyroxine
4) Glyceryl trinitrate

10. ❂Which protein does warfarin bind to?
1) Albumin
2) β-globulin
3) Tubulin
4) Endothelin

11. ❂ Plasma has a pH of ___________.
1) 7.2
2) 7.4
3) 3
4) 8

12. ❂ Picrotoxin act on the_______________________________.
1) ATP-sensitive K+ channels
2) GABA gated Cl- channels
3) Voltage gated Cl- channels
4) Renal tubule Na+ channels

13. ❂ Which drug is an estrogen receptor antagonist?
1) Chlorpromazine
2) Propranolol
3) Tamoxifen
4) Naloxone

14. ❂Which drug is responsible for blocking the renal tubule
Na+ channel?
1) Amiloride
2) Tetrodotoxin
3) Local anaesthetics
4) Divalent cations(cd+2)

15. ❂ Which substance is a dopamine (D2) receptor agonist?
1) Ethinylestradil
2) Bromocriptine
3) Isoprenaline
4) Vareniciline

16. ❂ Which drug inhibits thymidine kinase enzyme?
1) Saquinavir
2) Sildenafil
3) Aciclovir
4) Captopril

17. ❂ Which drug is responsible for producing neutropenia
and agranulocytosis?
1) Thioureylenes
2) Levothythyroxine
3) Liothyronine
4) Radioiodine

18. ❂ The drug entacapone acts on the
___________________ enzyme.
1) Monoamine oxidase (MAO-B)
2) Dopamine hydroxylase
3) DDC (dopamine decarboxylase)
4) COMT(catechol ortho-methyl transferase)

19. ❂ Which drug increases guanyl cyclase activity?
1) Epoprostenol
2) Glyceryl trinitrate
3) B2-adrenoceptor
4) Adenosine

20. ❂ The following drugs are directly acting vasodilators
except one :
1) Nifedipine
2) Diltiazem
3) Ramipril
4) Verapamil

21. ❂ Which drug is a renin inhibitor?
1) Losartan
2) Ramipril
3) Hydralazine
4) Aliskiren

22. ❂ Which antihypertensive drug class possess highest
postural hypotension side effect?
1) Thiazide diuretics
2) ACE inhibitors
3) Alpha1-adrenoceptor antagonists
4) B-adrenoceptor antagonists

23. ❂ Which antihypertensive drug class has the highest
level of impotence side effects?
1) ACE (Angiotensin-converting-enzyme) inhibitors
2) Thiazide diuretics
3) AT1 (angiotensin II type 1 receptor) antagonists
4) B-adrenoceptor antagonist

24. ❂ The normal systolic pulmonary pressure range in
adults is _________________.
1) 5 mmHg
2) 15 mmHg
3) 10 mmHg
4) 20 mmHg

25. ❂ Which medicine is used in Raynaud's disease?
1) Carvedilol
2) Bisoprolol
3) Nifedipine
4) Bosentan

26. ❂ Which lipoprotein contains the apoB-100 protein?
1) LDL particle
2) HDL particle
3) VLDL particle
4) Chylomicrons

27. ❂ Which lipoprotein contains the apoB-48 protein?
1) HDL particle
2) VLDL particle
3) LDL particle
4) Chylomicrons

28. ❂ What is the particle size of HDL (high density
lipoprotein ) ?
1) 7-20 nm
2) 20-30 nm
3) 30-80 nm
4) 100-1000 nm

29. ❂ Which condition is a risk factor for atheromatous
disease?
1) Raised low density cholesterol
2) Raised high density cholesterol
3) Reduced high density cholesterol
4) Diabetes mellitus
5) More than one option

30. ❂ HMG-COA reductase full
form is __________________________________________.
1) 3-Hydroxy -4 methyl glutaryl -coA reductase
2) 3-Hydroxy-3 methyl glutaryl -coA reductase
3) 4-Hydroxy -4 methyl glutaryl -coA reductase
4) 4-Hydroxy -3 methyl glutaryl -coA reductase

31. ❂ Nicotinic acid acts on which receptor to produce its
lipid-lowering property?
1) HM73A
2) HM74A
3) HM71A
4) HM72A

32. ❂ The following antimetabolite drugs act on the purine
pathway except one:
1) Fludarabine
2) Cladibrime
3) Tegafur
4) Nelarbime

33. ❂ Which drug is used in the treatment of germ cell
tumors?
1) Lomistine
2) Cisplatin
3) Cyclophosphamide
4) Busulfan

34. ❂ Which cytotoxic drug is used as an antiemetic agent?
1) Nabilone
2) Tamoxifen
3) Etoposide
4) Paclituxel

35. ❂ MODY (maturity onset diabetes of the Youth) is part of
which type of diabetes?
1) TYPE-2 diabetes
2) TYPE-1 diabetes
3) Gestational diabetes
4) Diabetes insipidus

36. ❂ Which drug has mixed agonist-antagonist (K agonist and mu
receptor antagonist or weak partial agonist) property?
1) Etorphine
2) Codeine
3) Nalorphine
4) Dextropropoxyphene

37. ❂ Which opioid analgesic is primarily used in postoperative
pain?
1) Codeine
2) Tramadol
3) Dextropropoxyphene
4) Remifentanil

38. ❂ Which is a long acting opioid antagonist?
1) Naltrexone
2) Naloxone
3) Pentazocine
4) Alvimopan

39. ❂ The following are typical antipsychotic drugs except
one:
1) Promazine
2) Chlorpromazine
3) Haloperidol
4) Clozapine

40. ❂ Which antipsychotic drug causes agramocytosis?
1) Amisulpride
2) Flupentixol
3) Clozapine
4) Decanoate

41. ❂ Which drug is responsible for producing jaundice?
1) Chlorpromazine
2) Clozapine
3) Olanzapine
4) Flupentixol

42. ❂ Which medicine is used in the prevention of
migraine?
1) Somatriptan
2) Fluoxetine
3) Ondansetron
4) Pizotifen

43. ❂ Which medicine is used for the treatment supraventricular
tachycardia?
1) Atropine
2) Adrenaline
3) Adenosine
4) Digoxin

44. ❂ Which medicine is used for anxiety?
1) Buspirone
2) Somatriptan
3) Ondansetron
4) Fluoxetine

45. ❂ Which medicine is used for depression?
1) Pizotifen
2) Buspirone
3) Fluoxetine
4) Somatriptan