This document discusses using virtual worlds for real-world innovation through avatar-based collaboration. It presents opportunities for open innovation using virtual worlds' interactive collaboration and user-generated content capabilities. Several case studies are described that involved identifying needs, concept development, testing, and launches in virtual environments. The research aims to understand what creates a compelling co-creation experience in virtual worlds by examining elements like challenge, desirability, interactivity, usability, and community. Preliminary results suggest these elements are important for effective avatar-based innovation.