Consciousness Society Conference Presentation: Nitric Oxide Spiking and Consciousness

Robert Wright, Jr.
Robert Wright, Jr.Stress Free Now
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Nitric Oxide Spiking and Consciousness Robert Wright, Jr., PhD, COFT Consciousness Society Conference Yale University New Haven, CT, June 5, 2015 Copyright © 2015 All Rights Reserved www.StressFreeNow.info
INSIGHT
A Special Thank You To Alan Leslie Combs, Ph.D. Doshi Professor of Consciousness Studies Director, CIIS Center for Consciousness Studies Founder, Consciousness Society Director, Conscious Evolution M.A. Program Graduate Institute of Connecticut. John Beaulieu, N.D., Ph.D. CEO, Biosonics Incorporated NYS Licensed Counselor/Psychotherapist Board Certified Naturopathic Physician Adjunct Professor Integrative Health Studies Sound Healing Emphasis, CIIS
Quotations The biggest deterrent to scientific progress is a refusal of some people, including scientists, to believe that things that seem amazing can really happen. ---George Trimble When the mind becomes attuned, it becomes capable of hearing the voice of the unknown. The sounds which are heard in such a state do not belong to any particular language, religion or tradition. ---Swami Rama After silence that which comes nearest to expressing the inexpressible is music. ---Aldous Huxley
Quotations The “problem” of consciousness—and its attendant “problem,” the nature of reality…marks the frontier of human exploration, a frontier that we may never fully conquer….But what makes solving the problem of consciousness so compelling is essentially personal: it would bring meaning for each one of us. It would answer those gnawing existential questions about who we are, how the world works, and what is “real.”….Are we alone in our own solipsistic world, or is the experience of consciousness something we share with those we are pleased to consider sentient beings?....Or is it the very fabric of the cosmos, the Absolute? --Jenny Wade, p. xiii-xiv, Forword, In Alan Combs (2009), Consciousness Explained Better
What Is Nitric Oxide? • In 1998, Robert F. Furchgott, Louis J. Ignarro, and Ferid Murad were awarded a Noble Prize in Medicine or Physiology for their nitric oxide research (Geneeskd, 1998). • Nitric oxide is a gas with the chemical formula NO. • Serves as a signaling molecule in mammals including humans. • Is a short lived endogenously produced gas. • Plays a primarily therapeutic role throughout the body. (Stefano, 2003; Stefano, & Magazine, 2001; Stefano, Benson, Frichionne, & Esch, 2005).
What Is Nitric Oxide? • Discovered as a vasodilator working guanylate cyclase. • Operates as a free radical and free radical scavenger. • Exerts anti-viral properties. • Exerts anti-bacterial properties. • Central Nervous System (CNS) involvement. (Benz, Cadet, Mantinone, et al. 2002b; Shinde, Mehta, & Goyal, 2000).
What Is Nitric Oxide • Can be a toxic air pollutant, e.g. car exhaust fumes. • Plays a major role in the regulation of blood pressure. • Helps prevent blood clotting. • Fast acting: Diffuses over 50uM in seconds. • Intra and intercellular signaling substance. (Benz, Cadet, Mantinone, et al. 2002a; Esch, Stefano, Fricchione, & Benson, 2002; Fricchione, & Stefano, 2005).
Types of Nitric Oxide • There are three (3) forms of nitric oxide (NO): cNOS, eNOS, and iNOS. • The constitutive forms of NO (cNOS and eNOS) generally engender healing effects. • The inducible variety (iNOS) typically has a pro- inflammatory effect when certain events are triggered, e.g. chronic stressors. (Erez, Ayelet, et al., 2011; Esch, Stefano, Fricchione, & Benson, 2002; Fleshner, & Laudenslager, 2004 ).
How Is Nitric Oxide Used? • Used extensively to treat various medical conditions. • Popular erectile dysfunction drugs such as Viagra, Cialis and Levitra work by regulating NO puffing. • Nitroglycerin ameliorates angina pain by supplying NO to the heart. • Controls the effects and activation of norephinephrine processes throughout the brain and CNS including synthesis, release and action potentials. (Stefano, 2003; Stefano, Fricchione, Slingsby & Benson, 2001; Tomasian, Keaney, & Vita, 2000; Young, Chen, & Weis, 2011).
Importance of Nitric Oxide “[NO is] a major biological signaling pathway that has been missed with regard to the way it controls proteins….What we see now for the first time…is that there are enzymes that are removing NO from proteins to control protein activity. This action has a broad based effect, frankly, and probably happens in virtually all cells and across all protein classes. NO is implicated in many disease processes. Sepsis, asthma, cystic fibrosis, Parkinson’s disease, heart failure, malignant hyperthermia – all of these diseases are linked to aberrant NO based signaling” (Duke University Medical Center, 2008, May).
Importance of Nitric Oxide • Protects your body and mind from disease, infections and inflammations caused by stress. • Synchronizes your internal cellular rhythms. • Scavenges free radicals in the body. • Promotes better vascular flow and a healthy heart. • Enhances cellular vitality and fluidity. (Beaulieu, 2005, 2009; Mantione, Cadet, & Zhu, 2008; Mata- Greenwood, & Chen, 2008; Samuelson, Foret, Baim, et al., 2010; Segerstrom, & Miller, 2004; Shinde, Mehta, & Goyal, 2000).
What Is Nitric Oxide Spiking? • Ordinarily cells attempt to keep a state of balance and homeostasis by regulating their release of NO which is called “puffing” or known as spiking. • When we are “in rhythm” the body naturally produces NO inside vascular, nerve and immune cells. • When the NO system is functioning properly, release of NO is cyclic and autoregulatory; generally, this makes us feel good. • This cyclic nature enhances physical and emotional well being and proactively prevents illness and disease states. Scientists use the word “spiking” to describe any process that gets “flatlined” NO to “puff” again. When NO levels spike, you immediately feel relaxed. (Beaulieu, 2005, 2009, 2010; Stefano & Magazine, 2001).
What Is Nitric Oxide Spiking? Endogenous nitric oxide spiking is sometimes referred to as “puffing.” This is gaseous NO in its cyclic and auto- regulatory form which usually takes place in a three (3) step wave phase: one ascending, a stillpoint (pause), another descending, which is a natural healing rhythm. The NO wave spike is short lived, approximately six (6) minutes in length. (Stefano, Salzet, & Magazine, 2003).
Benefits of Nitric Oxide Spiking • Enhances cellular vitality. • Enhances vascular flow especially heart healing. • Boosts immune system by destroying bacteria and viruses at the micro level. • increases ability to prevent and fight infections. • Increases resistance to stress. • Increases resistance to pain in conjunction with endogenous morphine. (Long, Light, & Talbot, 1999; Lowson, 2003; MacMillan, 2012; Northrup, 2008; Pryor, Zhu, Cadet, et al., 2005).
Benefits of Nitric Oxide Spiking • Increases energy levels. • Increases physical and mental stamina. • Sharpens mental clarity. • Diminishes states of depression due to balancing of the autonomic nervous system. • Improves digestion and natural cleansing. (Beaulieu, 2005; Benz, Cadet, Mantione, et al., 2002; Dusek, Chang, Zaki, et al., 2006; Elam, R., et al., 1989; Guoyao, & Meininger, 2000; Guoyao, & Morris, 1998).
Nitric Oxide Wave Spiked by EnRhythm
EnRhthym Nitric Oxide Wave Spiking Explanation Nitric oxide is a molecule created by a nitrogen atom bound to an oxygen atom. It is made in our cells and released into the surrounding tissues as a gas. The release of nitric oxide by our cells is termed puffing by scientists to describe the rising and falling of this gas. The puffing cycle is like a wave which takes three minutes to rise and three minutes to fall. The rising phase of the wave is the release of nitric oxide which sends a signal to our cells to relax. During the falling phase of the wave nitric oxide dissipates and our cells become more active. The calm between the rising and falling we call still point. --John Beaulieu, 2010, Nitric Oxide and Tuning Forks, Biosonics, Inc.
What Is Nitric Oxide Flatlining? • When NO production diminishes or stops completely, this is known as “flatlining.” • Typically this means the NO rhythm has been compromised, often due to unresolved stress or trauma. • Dysfunctional NO production leads to depressed immune system function. • We feel pain or distress. • Flatlined NO may be the body’s cellular response to psychological and physiological stress and stressors in the environment. (Beaulieu, 1987, 2005, 2009, 2010; Esch & Stefano, 2010).
What Is Nitric Oxide Flatlining? • Flatlined NO may be the body’s cellular response to psychological and physiological stress and stressors in the environment. • The main cause of flatlining is unresolved stress and trauma. • Over time, flatlining leads to pro-inflamation and depressed immune function which can result in tissue pathology. (Beaulieu, 2005; Simpkiss, & Devine, 2002; Stefano, & Magazine, 2001; Tseng, Mazella, Goligorsky, et al., 2000; Tomasian, Keaney, & Vita, 2000; Wright, 2012).
Consequences of NO Flatlining? Endogenous nitric oxide flatlining is a state where the cyclic constitutive NO wave is dormant. This is often experienced as pain and/or distress. Chronic flatling may lead to a pro- inflammatory response, triggering release of iNOS which if unabated, may lead to illness and/or disease states. (Beaulieu, 2009; Esch, & Stefano, 2010; Fricchione, & Stefano, 2005).
Consequences of NO Flatlining
Major Disease Byproducts of NO Flatlining • Alzheimer’s disease • Autoimmune Disorders • Motor Neuron Disease • Cancer • Erectile Dysfunction (Beaulieu, 2010, 2005; Erez, Ayelet, et al. 2011; Esch, Stefano, Fricchione & Benson, 2002).
Major Disease Byproducts of NO Flatlining • Diabetes • Depression • Stroke • Heart Attack • Arteriosclerosis (Kal, Van Wezel, Porsius, et al., 2000; Mantione, Cadet, Zhu, et al., 2008; McEwen, 2000; Salamon, Kim, Beaulieu, & Stefano, 2003) ; Seidler, Uckert, Waldkirch, et al., 2002).
Extreme Nitric Oxide Flatlined Visual
How Does Nitric Oxide Work? There are three cell types that are especially controlled by nitric oxide: immune cells, nervous system cells, and the cells that line blood vessels, which are called endothelial or vascular cells. The shape of immune cells changes in the blood stream in response to signals of inflammation. In the normal state, immune cells are round and roll along the lining of blood vessels, not sticking to any of the vascular cells for long. If there is a stress or inflammation present, the cells begin to flatten and become sticky. To make them un-stick and become round again, the immune cells and vascular cells both produce a low level of nitric oxide all the time. As long as they can do this for long enough, the immune cells un-stick and roll away. If nitric oxide release is inhibited, the immune cells begin to invade between the vascular cells and more inflammatory signals are produced. To make matters worse, the immune and vascular cells make one more attempt to release nitric oxide to restore the calm state. At higher levels, however, the nitric oxide itself causes damage to the cells. --John Beaulieu, 2011 (www.biosonics.com/uploads2011/CyclicNitricOxide.pdf)
How Does Nitric Oxide Work? NO secretions take place in a two step phase, one ascending, the other descending: “During the ascending phase of NO release the basal levels of NO may inhibit cellular activity by reducing changes in cell conformation by inhibition of actin polymerization, inactivation of NFkB, inhibition of cell adhesion, and hyperpolorization of post synaptic membranes. The descending phase of NO release may promote cell shape changes by allowing actin polymerization, depolarization, and NFkB signaling” --Stefano, Salzet, & Magazine, 2002
Relaxation Response • A protective mechanism which counteracts stress. • Physiologic counterpart to the “fight or flight” stress response. • Beneficial decreases in metabolism. • Beneficial decreases in blood pressure. • Beneficial decreases in breathing rate. • Beneficial decreases in anxiety. (Benson, 1983, 1997; Benson & Proctor, 2011; Dusek, Chang, Zaki, et al., 2006; Dusek, Out, Wohlhueter, et. al., 2008; Morita, Saito, Ohta, et al., 2005; Nakao, Myers, Fricchione, et al., 2001; Pillay, 2010, 2011).
Relaxation Response • Beneficial decreases in heart rate. • Reductions in psychological distress. • Reductions in chronic pain. • Beneficial decreases in sympathetic nervous system reactivity. • Beneficial increases in parasympathetic system reactivity. • Increases in awareness. (Epel, Blackburn, Lin, et al., 2004; Esch, Fricchione, & Stefano, 2003, 2005; Fields & Levine, 1984; Fleshner & Laudenslager, 2004; Halpern & Savary, 1985; McKinney, Antoni, Kumar, et al., 1997; Willet, 2002).
Relaxation Response • Nitric oxide spiking. • Endogenous morphine spiking. • Increases potential for whole brain synchrony. • Increases capacity for self and other compassion. • Beneficial changes in gene activity opposite those associated with stress. (Iwanaga & Tsukamoto, 1997; Jacobs, Epel, Lin, et al., 2011; Kal, Van Wezel, Porsius, et al., 2000; Kim, Koo, Lee, & Han, 2005; Lazar, Bush, Gollub, et al., 2000; Lazar, Kerr, Wasserman, et. al., 2005; Wright, 2012, 2013).
Benefits of Generating a Relaxation Response by Spiking Nitric Oxide • Provides a boost to immune system functioning, helping the body to ward off sickness and disease • Significantly lowers blood pressure. • Measurable improvements to circulatory and vascular systems. • Enhances mental clarity. • Provides boosts to abstract and spatial memory. (Beary, & Benson, 1974; Benson, 1983, 1997; Benson, & Proctor, 2011; River, 1998; Salamon, Esch, & Stefano, 2006).
Benefits of Generating a Relaxation Response by Spiking Nitric Oxide • Enhances ability to concentrate for goal attainment. • Beneficial increases in sympathetic nervous system responsiveness with resultant improvements in stress hardiness. • Helps to prevent acute stressors from accumulating as debilitating chronic stress. • Improvements in mood and overall sense of well being. (Beaulieu, 2005, 2009, 2010; Fleshner, & Laudenslager, 2004).
Benefits of Generating a Relaxation Response by Spiking Nitric Oxide • Underlies neuroendocrine release for “Flow” states for Peak Performance and Peak Experience. • Neutralizes the harmful effects of over arousal whereby excess amounts of cortisol and adrenaline can damage to the body. • Reduction of chronic pain as well beneficial epigenetic changes to DNA including reshaping amgydala fear reactivity. (Pryor, Zhu, Cadet, et al., 2005; Salamon, Esch, & Stefano, 2006; Salamon, Kim, Beaulieu, & Stefano, 2003).
Relationship Between Endogenous Cyclic Nitric Oxide Spiking and Endogenous Morphine Spiking It has been more than 30 years since morphine was discovered to be an endogenous signal molecule in the body. Since then, the word ‘endorphin’ has been adopted as an abbreviation of ‘endogenous morphine,’ referring to both morphine peptides and morphine itself. Endogenous opiates are released via the descending corticospinal tract, allowing for the body to mediate its own analgesia. Osteopathic manipulative therapy (OMT) has been found to initiate release of nitric oxide (NO), endogenous morphine’s second messenger in the body. Petrozzo et al., 2014 http://www.practicalpainmanagement.com/treatments/pharm acological/opioids/role-endogenous-morphine-nitric-oxide- pain-management
Symptoms Nitric Oxide Spiking Helps Alleviate • Aches & Pains • Headache • Inability to Control your Temper • Insomnia • Lack of Energy • Loss of Appetite
Symptoms Nitric Oxide Spiking Helps Alleviate • Low Back Pain • Low Mood • Migraine Headache • Neck Pain • Overeating • Undue Worry
Sample Conditions Caused or Aggravated by Stress Which Are Helped by NO Spiking • Anxiety • Asthma • Autoimmune Diseases • Cardiovascular Disease • Chronic Pain • Constipation • Diabetes • Diarrhea • Heartburn • High Blood Pressure
Sample Conditions Caused or Aggravated by Stress Which Are Helped by NO Spiking • Infertility • Insomnia • Loss of Sex Drive • Obesity • Skin Problems, e.g. Hives or Eczema • Stroke • Substance Abuse • Ulcers • Weight Gain or Weight Loss
What Is Consciousness? Although problematic, consciousness has been defined by some as the state or quality of awareness of an external object or something within oneself. There is no agreement within the scholarly or scientific communities as to what consciousness is or might be or whether it is essential, luminous, numinous, transcendent or illusory. The conceptual, theoretical, and paradigmatic disagreements and arguments about the true nature of consciousness are vociferous, steadfastly held positions, and often epistemologically, ontologically and teleologically polar opposite perspectives.
Sample Areas of Disagreement • Mutually Exclusive Definitions of Consciousness • Proof of Existence of Consciousness • Mutually Exclusive Definitions of Being • Mind-Body Duality Problem • Hard Problem of Consciousness
Sample Areas of Disagreement • Neural Correlates of Consciousness • Philosophy of Mind Issues • Existence/Non-Existence of a Quantum Mind • Solipsism • Role of the Unconscious in Consciousness • Existence/Non-Existence of Spirit
Consciousness Controversies “Why can’t the worlds greatest minds solve the mystery of consciousness?: Philosophers and scientists have been at war for decades over the question of what makes human beings more than complex robots.” Oliver Burkeman, Jan. 21, 2015 http://www.theguardian.com/science/2015/jan/21/-sp- why-cant-worlds-greatest-minds-solve-mystery- consciousness
Consciousness Controversies • Dangerous ideas debate with Richard Dawkins and Deepak Chopra from The Chopra Well: https://www.youtube.com/watch?v=6C1P1idmfUM • The War On Consciousness: The Talk That Gave TED Indigestion by Graham Hancock: http://www.grahamhancock.com/forum/HancockG6- TheWarOnConsciousness.php. • Capriles, E. (2009). Beyond Mind III: Further Steps to a Metatranspersonal Philosophy and Psychology. (Continuation of the Discussion on the Three Best Known Transpersonal Paradigms, with a Focus on Washburn and Grof). International Journal of Transpersonal Studies, 28(2), 1-145.
Consciousness Controversies • Is There A Scientific “Taboo” Against Parapsychology? Claims about the "taboo" status of parapsychology lack substance by Scott McGreal: https://www.psychologytoday.com/blog/unique-everybody- else/201401/is-there-scientific-taboo-against-parapsychology • Cardeña, E. (2014). A call for an open, informed study of all aspects of consciousness. Frontiers in Human Neuroscience, 8(17), 1-4. • Combs, A. (2009). Consciousness explained better: Towards an integral understanding of the multifaceted nature of consciousness. St. Paul, MN: Paragon House.
Consciousness Controversies • Cardeña, E. (2011). On wolverines and epistemological totalitarianism. J Sci Explor, 25, 539-551. • Fields, C. (2013). A whole box of Pandoras: Systems, boundaries and free will in quantum theory. Journal of Experimental & Theoretical Artificial Intelligence, 25(3), 291-302. DOI: 10.1080/0952813X.2013.782981. • Paller, K. & Sukuki, S. (2014). The source of consciousness. Trends in Cognitive Sciences, 18(8), 387- 389. DOI: http://dx.doi.org/10.1016/j.tics.2014.05.012
Neurophysiological Consciousness Controversy At this point, we would like to raise the following philosophical question: what is the relationship between the mental concept of subjective experience and the concepts or terms we use to describe the organization and function of the brain? This seems to be an important question as our mental categories are essentially responsible for the interpretation of physiological findings and thus form our picture of the mechanisms of the brain. Hinterberger, Zlabinger, & Blaser, 2014. DOI: 10.3389/ fnhum.2014.00637
What Is Attention? In the context of human information processing, attention is the process that, at a given moment, enhances some information and inhibits other information. The enhancement enables us to select some information for further processing, and the inhibition enables us to set some information aside (Stanford, 2006, p. 103). http://wwwpsych.stanford.edu/~ashas/Cognition%20Text book/chapter3.pdf
What Is Attention? • Orienting to sensory events • Detecting signals for focused processing • Maintaining a vigilant or alert state • Endogenous & exogenous attentional processing in time and space • Cocktail party effect • Motion induced blindness (Behrmann, Geng, & Shomstein, 2004; Gopher, 1993; Hirst, 1986; Paller & Suzuki, 2014; Stanford, 2006; Styles, 2005).
Attentional Quotation Humans were never meant to see the world through a lens of chronic fear or other negative emotions. We were meant to experience the world directly as it is. We were meant to form deep connections to other human beings. With attention training…we can open our hearts to experience the fullness of our senses, and reconnect with forgotten parts of ourselves. We can experience moments of unity and transcendence and find the world has been reenchanted. It will be a watershed moment in human evolution when we are able to pay attention to how we pay attention, control our attention, and take personal responsibility for the creation of our own realities. --Fehmi and Robbins 2007, p. 8
Styles of Attention • According to Dr. Les Fehmi of the Princeton Biofeedback Centre there are four main types of attention: • Diffuse • Narrow • Objective • Immersed Fehmi & Robbins, 2007, p. 46-47
Whole Brain Synchrony Viewed as a Way of Paying Attention • Experience of whole brain synchronization enhances healthy well being. • Open Focus is one way to achieve whole brain synchrony without equipment. • Prolonged and excessive stress can negatively impact almost every aspect of your life. • Maintaining a narrow focused attentional style for long periods often leads to chronic stress and pain, and left unattended to, turns into disease states. • Developing attentional flexibility gives you the capacity to enter a beneficial homeostatic state of whole brain synchronization volitionally.
Whole Brain Synchrony • Parts of brain begin to work together harmoniously. • Brain resonance where neurons vibrate at the same frequency. • Neural pathways tend to fire more rapidly. • Brainwave patterns are “in phase” or in synchronized • Also known as “Whole Head Synchrony” or “Whole Brain Functioning” or “Hemispheric Synchronization” or “Whole Brain Synchronization” (Fehmi & Robbins, 2007). (Lutz, Lachaux, Martinerie, & Varela, 2002; Lutz, Greischar, Rawlings, et al., 2004)
Why Whole Brain Synchrony is a Desired and Sought After State • Increased Creativity • Increased Insight • Increased Intuition • Increased Relaxation Response • Increased Accelerated Learning Abilities • Increased Parasympathetic Nervous System Reactivity (Buzsaki, 2006; Damasio, 1990; Fujisawa, & Busaki, 2011; Glaser, Brind, Vogelman, et al., 1992; Gold, 1999; Goleman, 1988; Gruzelier, & Egner, 2005; Gruzelier, Egner, & Vernon, 2006).
Whole Brain Synchrony as a Desired and Sought After State • Increased Mental Clarity. • Increased Ability to Problem Solve. • Increased Self Compassion. • Increased Other Compassion. • Increased Empathy. • Decreased Sympathetic Nervous System Reactivity. (Haig, De Pascalis & Gordon, 1999; Hammond, 2000; Hanajima, Terao, Hamada, et al., 2009; Hinterberger, Zlabinger, & Blaser, 2014; Hutchison, 1996; Jacobs, Epel, Lin, et al., 2011).
Elements of Peak Performance • State where individual performs to the maximum of her ability. • Enhanced level of self awareness. • High levels of confidence and focused concentration upon task completion. • Accomplishment is effortless. • Individual experiences a “flow” state or being “in the zone of excellence.” (Belluscio, M., Mizuseki, K., Schmidt, et al., 2012; Brown, & Gerbarg, 2005; Craqq, 2006; Csikszentmihalyi, 1991, 1997; Draganski, Gaser, Kempermann, et al., 2006; Pillay, 2010; 2011 ).
Elements of Peak Experience • Transpersonal and ecstatic state. • Sense of Unity, Oneness and Awe. • Sense of interconnectedness. • Time perception may be altered to witness time elongation, time quickening and/or timelessness. (Barušs, van Lier, & Ali, 2014; Bird, B., Newton, Sheer, & Ford, 1978a&b; Damasio, 1999; Farrer, & Frith, 2002; Fisher, 1971, 1973).
Elements of Peak Experience • Altered State of Consciousness (ASC). • Therapeutic increases in creativity, compassion for self and others, and personal locus of control (stress reduction). • Self actualization state or individuation (Maslow Level 5). • Personal growth, intrinsic meaning and purpose. (Gelhorn, 1970; Gendlin, 1981; Genz, 1999; Goodman, & Nauwald, 2003; Goodman, 1990; Grof, & Grof, 2010; Lilly, 1977; Maslow, 1971; Momen, 1984; Monroe, 1992; Palmer, 1998).
STILLPOINT
Sample Methods for Spiking Nitric Oxide • Ritual Body Postures • Humming • Drumming • Dietary Supplements • Medications, e.g. Viagra, Ciallis, Levetra • Aromatherapy • Meditation • Neurofeedback (Beaulieu, 2005; Dusek, Chang, Zaki, et al., 2006; Dusek, Hibberd, Buczynski, et al., 2008; Dusek, Otu, Wohlhueter, et al., 2008; Goodman, 1990; Goodman & Nauwald, 2003; Gore, 1995; Maniscalco, Sofia, Weitzberg et al., 2004; Tervaniemi, IIvonen, Karma, et al., 1997).
Sample Methods for Spiking Nitric Oxide • Foods • Yoga • Osteopathic Manipulative Therapy (OMT) • Open Focus • Music Therapy • Exercise • Sunlight (Banth & Arderbil, 2015; Fehmi & Robbins, 2007; Liu, Fernandez, Lang, et al., 2013; McKinney, Tims, Kumar, & Kumar, 1997; Mullooly, Levin, & Feldman, 1988; Narin, Pinar, Erbas, et al., 2003; Petrozzo, Mohr, Mantione, & Goldstein, 2014; Salamon, Kim, Beaulieu, & Stefano, 2003; Women’s Health Encyclopedia, 2012).
Quotation BioSonic research conducted at Cell Dynamics, Inc. demonstrates the release of Nitric Oxide (NO) from various tissue sources. Utilizing an amperometric detection system, allowing only nitric oxide to generate an upward deflection, we measure real-time NO release from living cells and demonstrate that the use the BioSonic Otto™ (128cps), OM Tuner™ (136.1cps) and Body Tuners™ (C256 & G384) tuning forks have the ability to release NO well above baseline pulsatile levels. The release of NO is visualized as a large peak of pure nitric oxide immediately following exposure of these tissues to the vibration/ sound of the tuning forks. Once NO is released it follows a well characterized signaling cascade, exhibiting established properties of NO. --John Beaulieu, 2009, p. 1
Sample Methods for Spiking Nitric Oxide • Biosonic Tuning Fork Series: • Otto 128 • Otto 64 • Otto 32 • OM Tuner • C & G Body Tuners • Fibronacci Series (Beaulieu, 1987, 2005, 2009, 2010; Biosonics, Inc., 2010).
Otto Tuning Fork 128 Hz
Otto Tuning Fork 64 Hz
Comparison of Otto Tuning Forks 128 Hz and 64 Hz
Biosonics Otto 32
Biosonics OM Tuning Fork 136.1 Hz The Swiss scientist Hans Cousto, author of the Cosmic Octave, discovered how to convert planetary cycles into musical pitches. Using his system the sa corresponds to the sound of one Earth year of the time it takes the earth to circle the Sun. To arrive at the frequency of 136.1 Hz, an earth year is reduced to a second (frequencies are measured in cycles per second). An earth year is 365.242 days and an earth day is 86,400 seconds. When the days are multiplies by seconds the answer will be 315,567,925.9747 seconds equal one earth year. To arrive at an audible sound, 315,567,925.9747 seconds are divided into one (year) and then raised 32 octaves. The result will be the audible tone of answer 32 times the result will be 136.1 Hz. The cosmic note OM. (http://www.stressfreenow.info/products/index.php?)
Biosonics OM Tuning Fork 136.1 Hz
Biosonics OM Tuning Fork 136.1 HZ • Achieve a state of deep relaxation in seconds with the primordial vibrations of “Om”. • Physically tune your body to the Om vibration and enter a state of balanced wholeness ideal for healing and higher consciousness. • Helps center the body and mind when placed on the rib heads, thoracic vertebra, sternum, sacrum and illiums. • Helps meditators and yoga practitioners achieve desired states effortlessly. (http://www.stressfreenow.info/products/index.php?main_page =product_info&cPath=1&products_id=2)
Biosonic Body Tuners C & G
Flatlining – Spiking Pathways Nitric Oxide Flatlining Stress and Distress Chronic Pain Nitric Oxide Spiking Stress Reduction Pain Dissolves Homeostatasis Allostasis Healing
Stress Interaction – Part 1 Category of Phenomena Distress Eustress Adrenaline Yes Depends Allostasis No Yes Allostatic Load Increased Diminished Cortisol Yes Diminished Dopamine Yes Depends Endogenous Morphine Yes Depends GABA Diminished Increased Grief Yes No
Stress Interaction – Part 2 Category of Phenomena Distress Eustress Grief Recovery No Yes Homeostasis No Yes HPA Axis Diminished Increased Immune Response Increased Depends Nitric Oxide Flatlined Spiked Nor Adrenaline No Depends Oxytocin Depends Depends SAM Axis Increased Diminished Serotonin Diminished Increased
Nitric Oxide Interaction – Part 1 Category of Phenomena Flatlining Spiking Adrenaline Yes Diminished Allostatic Load Increased Diminished Cortisol Yes Diminished Distress Yes No Dopamine Yes Implicit Endogenous Morphine Yes Implicit GABA Diminished Increased Grief Yes No
Nitric Oxide Interaction – Part 2 Category of Phenomena Flatlining Spiking Grief Recovery No Yes Homeostasis No Yes (Increased) HPA Axis Diminished Increased Nor Adrenaline Increased Diminished Oxytocin Depends Depends SAM Axis Increased Diminished Serotonin Diminished Yes Immune Response Increased Depends
Human Organization Stress Balancing System Homeostatic Balance Dynamic Balance Imbalance Eustress Acute Stress Chronic Stress Homeostasis Allostasis Distress Provides Pathways for Integrative and Holistic Healing Provides Pathways for Integrative and Holistic Healing Provides Pathways for Disease States and Illness Adapted from Stefano, Fricchiconne, and Esch (2006); Stefano et al. (2005).
Ergotropic Pathway Tropotropic Pathway Hyperarousal Hyper- Stimulatory Levels of Statebound Experience Hypoarousal Hypo-Stimulatory Beta Brainwave State Routine Activity Ordinary Waking Consciousness Beta Brainwave State Hi Beta Brainwave State Excitement Daydreaming/Rel axation Hypnotic Trance Alpha Brainwave State High Beta Low Gamma Brainwave State Anxiety/Mania Hypnopompic/ Hypnogogic Imagery-Twilight State Theta Brainwave State Unknown Brainwave State Mystical Experience Ecstatic Trance Bidirectionality Abreaction Mystical Experience Deep Trance or Samadhi Delta Brainwave State Statebound Experience: Comparison of Ergotropic and Tropotropic Pathways Adapted from Fisher (1971, 1973, 1975); Momen (1984).
State Bound Experiential Qualities NO Flatlining NO Spiking Fully Associated Mental Clarity Emotional Clarity Euphoria Mild Delirium Transpersonal Transcendent Experience Sense of Unity Grief/ Mourning/ Bereavement Yes No Yes No No No No No Stress Yes No Yes No No No No No Healing No Yes Yes Yes Yes Possible Possible Possible Dopamine Spike No Yes Yes Yes Yes Yes Yes No Oxytocin Spike No Yes Yes Yes Yes Yes Yes Yes Serotonin Spike No Yes Yes Yes Yes Yes Yes Possible Endorphin Spike No Yes Depends Yes Yes Yes Yes Possible Attention: Open Focus Global No Yes Depends Yes Yes Possible Possible Possible Pain Yes No Yes No No No No No Fear/Anxiety Yes No Yes No No No No No Lucid Dream State Unknown Unknown Depends Yes Depends Unknown Unknown Unknown
Statebound Experience: SAM AXIS and HPA AXIS Relationships Ergotropic Pathway Tropotropic Pathway Hyperarousal Hyper-Stimulatory Hypoarousal Hypo-Stimulatory Grief Response: Distress, Pain, Anxiety, Fear Increases Relaxation Response/Eustress: Grief, Pain, Anxiety, Fear Dissolves SAM AXIS Reactivity Increases HPA AXIS Reactivity Increases NO Flatlining: Increased Cortisol; Decreased Dopamine/Serotonin NO Spiking/Endogenous Morphine Release Allostatic Loads Increase Allostasis/Homeostasis
Comparative Still Point Induction Techniques “Chaotic Attractor” Technique Induces Still Point Rate of Induction Method Effects/Results Biosonic Otto 128Hz, 64Hz, 32Hz tuning fork Yes Immediate Kinesthetic Spikes NO cycle; boosts to immune function; spikes endogenous morphine; eliminates NO flatlining. Biosonic Otto 128Hz, 64Hz, 32Hz tuning fork Yes Immediate Auditory Sound Waves Spikes NO cycle; eliminates NO flatlining; boosts to immune function; spikes endogenous morphine. Open Focus Technique Yes Over Time as Proficiency is Achieved Auditory Verbal Objectless awareness in all sensory modalities, attending simultaneous to background and foreground globally; extreme mental clarity. Brain Pattern Interrupt Technique Yes Over Time as Proficiency is Achieved Olfactory Memory Resultant emotional and physical release phenomena disrupt negative valance memory patterns. Shift to positive energy valance can occur instantaneously or over time with repetition. Gamma Brainwave Holosync Yes Over Time as Proficiency is Achieved Auditory Sound Waves Attentional shift to states of self compassion and compassion for others: Sense of unity, oneness of being, transcendence; enhanced sense of Being. Standard Hypnosis Yes After Trance Induction Verbal Resultant reframing of negative memories into new behavioral flexibility; extinguishment of phobias or unwanted habits. Ericksonian Hypnosis Yes After Trance Induction Verbal Auditory Use of nonspecific and indirect metaphors results in reframe of negative memories into new behavioral patterns; extinguishment of unwanted behaviors; installation of new and desired behaviors and habits. Halpern Music Yes Repeated Listening Auditory Music Calming of sympathetic nervous system; boost to parasympathetic nervous system; state of relaxed reverie. Relaxation response induced.
Comparative Still Point Induction Techniques “Chaotic Attractor” Technique Induces Still Point Rate of Induction Method Effects/Results Meditation Yes Over Time as Proficiency is Achieved Chant, Mantra, or Silence Long-term meditators report heightened mental and emotional clarity, sense of oneness, unity of Being, extreme states of compassion and transcendence. Flotation Tank Yes Over Time as Proficiency is Achieved Weight- lessness Systemic boost to HPA axis and simultaneous calming of SAM axis; expansive awareness of space, silence, and timelessness. Anechoic Chamber Yes Over Time as Proficiency is Achieved Complete Silence Long term users report awareness of nervous system sounds and induction of relaxation response phenomena. Focusing Yes After Repeated Use Bodily Felt Sense/Verbal Instructions Shift in Awareness Caused by consciously and conscientiously connecting with bodily Felt Sense Alternate Nostril Breathing Yes Immediate Modulation of Breath Immediate state change caused by deep diaphragmatic breathing. Biofeedback Yes Immediate Physiological Body Feedback Increased awareness and ability to modulate aspects of autonomic functions; with practice clients learn to volitionally make beneficial autonomic changes without equipment. Neurofeedback Yes Immediate Brainwave Feedback Increased awareness of brainwave patterns connected to thoughts; with practice clients learn to flexibly modulate brain wave patterns and volitionally modify internal processes without equipment. Holotrophic Breathwork Yes Immediate Modulation of Breath Wide range of breath techniques engenders rebirthing effect; including increased awareness of pre-natal and post-natal birth experiences.
Comparative Still Point Induction Techniques “Chaotic Attractor” Technique Induces Still Point Rate of Induction Method Effects/Results Meditation Yes Over Time as Proficiency is Achieved Chant, Mantra, or Silence Long-term meditators report heightened mental and emotional clarity, sense of oneness, unity of Being, extreme states of compassion and transcendence. Flotation Tank Yes Over Time as Proficiency is Achieved Weight- lessness Systemic boost to HPA axis and simultaneous calming of SAM axis; expansive awareness of space, silence, and timelessness. Anechoic Chamber Yes Over Time as Proficiency is Achieved Complete Silence Long term users report awareness of nervous system sounds and induction of relaxation response phenomena. Focusing Yes After Repeated Use Bodily Felt Sense/Verbal Instructions Shift in Awareness Caused by consciously and conscientiously connecting with bodily Felt Sense Alternate Nostril Breathing Yes Immediate Modulation of Breath Immediate state change caused by deep diaphragmatic breathing. Biofeedback Yes Immediate Physiological Body Feedback Increased awareness and ability to modulate aspects of autonomic functions; with practice clients learn to volitionally make beneficial autonomic changes without equipment. Neurofeedback Yes Immediate Brainwave Feedback Increased awareness of brainwave patterns connected to thoughts; with practice clients learn to flexibly modulate brain wave patterns and volitionally modify internal processes without equipment. Holotrophic Breathwork Yes Immediate Modulation of Breath Wide range of breath techniques engenders rebirthing effect; including increased awareness of pre-natal and post-natal birth experiences.
Stress-Anxiety-Physical Pain Scale Rate your current state on a scale from “0” to “10” “0” you feel great, have no pain, have no distress “10” you have unbearable pain and are in distress Category Stress Anxiety Physical Pain Mental Clarity Before After
Benefits of Epigenetic Alterations of Mind-Body Equation Even if we have been set on high-reactive mode for decades or a lifetime, we can still dial it down. We can respond to life’s inevitable stressors more appropriately and shift away from an overactive inflammatory response. We can become neurobiologically resilient. We can turn bad epigenetics into good epigenetics and rescue ourselves. We have the capacity, within ourselves, to create better health. We might call this brave undertaking ‘the neurobiology of awakening’ (Nakazawa, 2015). http://aeon.co/magazine/psychology/how-childhood- biography-shapes-adult-biology/
Benefits of Epigenetic Alterations of Mind-Body Equation Today, scientists recognise a range of promising approaches to help create new neurons (known as neurogenesis), make new synaptic connections between those neurons (known as synaptogenesis), promote new patterns of thoughts and reactions, bring underconnected areas of the brain back online – and reset our stress response so that we decrease the inflammation that makes us ill (Nakazawa, 2015). http://aeon.co/magazine/psychology/how-childhood-biography- shapes-adult-biology/
Azam, M., Katz, J., Fashler, S., et al. (2015). Heart rate variability is enhanced in controls but not maladaptive perfectionists during brief mindfulness following stress induction: A stratified-randomized trial. International Journal of Psychophysiology, 96(3). Retrieved from internet: http://www.sciencedirect.com/science/article/pii/S0167876015 002159 and doi:10.1016/j.ijpsycho.2015.06.005 Banth S, Ardebil, M. (2015). Effectiveness of mindfulness meditation on pain and quality of life of patients with chronic low back pain. Int J Yoga, 8, 128-33. Retrieved from Internet: http://www.ijoy.org.in/text.asp?2015/8/2/128/1584 76 Barušs, I., van Lier, C., & Ali, D. (2014). Alterations of consciousness at a self-development. seminar: A Matrix Energetics seminar survey. Journal of Consciousness Exploration & Research, 5(11), 1064-1086. References
Bawa, F., Mercer, S. Atherton, R., et al. (2015). Does mindfulness improve outcomes in chronic pain patients?: Systemic review and meta-analysis. The British Journal of General Practice, 65(635), e387-400. DOI: 10.3399/bjgp15X685297. Retrieved from Internet: http://www.ncbi.nlm.nih.gov/pubmed/26009534 Beary, J., & Benson, H. (1974). A simple psychophysiologic technique which elicits the hypometabolic changes of the relaxation response. Psychsom Med, 36, 115-120. Beaulieu, J. (1987). Music and sound in the healing arts. Barrytown, NY: Stanton Hill Press, Inc. Beaulieu, J. (2005). The rhythm of nitric oxide: How a tiny molecule determines your overall health. Kingston, NY: EnRhythm, LLC. Beaulieu, J. (2009). BioSonics, stress science, and nitric oxide literature review. Stone Ridge, NY: BioSonic Enterprises, Ltd.
Beaulieu, J. (2010). Human tuning: Sound healing with tuning forks. Stone Ridge, NY: BioSonics Enterprises, Ltd. Behrmann, M., Geng, J., & Shomstein, S. (2004). Parietal cortex and attention. Current Opinion in Neurobiology, 14, 212-217. Belluscio, M., Mizuseki, K., Schmidt, R., Kempter, R., & Buzsaki, S. (2012). Cross-frequency phase-phase coupling between theta and gamma oscillations in the hippocampus. J Neurosci, 32(2), 423-435. Benson, H. (1983). The relaxation response: Its subjective and objective historical precedents and physiology. TINS, 6, 281- 284. Benson H. (1997). The relaxation response: Therapeutic effect. Science, 278, 1694-1695.
Benson, H., & Proctor, W. (2011). Relaxation revolution: The science and genetics of mind body healing. New York, NY: Scribner. Benz, D., Cadet, P., Mantione, K., et al. (2002a). Tonal nitric oxide and health: A free radical and scavenger of free radicals. Med Sci Monit, 8(1), RA1-RA4. Benz, D., Cadet, P., Mantione, et al. (2002b). Tonal nitric oxide and health: Anti-bacterial and viral actions and implications for HIV. Med Sci Monit, 8(2), RA:27-31. Bergaust, L., Van Spanning, R., Frostegard, A., & Bakken, L. (2011). Expression of nitrous oxide reductase in Parracoccus denitrifications is regulated by oxygen and nitric oxide through FnrP and NNR. Microbiology, 158(Pt 3), 826-834. Bhatnagar, S., & Dallman, M. (1998). Neuroanatomical basis for facilitation of hypothalamic-pituitary-adrenal responses to a novel stressor after chronic stress. Neurosci, 84, 1025-1039.
Biofeedback, (2011). What is biofeedback? Baltimore, MD: University of Maryland Medical Center. Retrieved from http://www.umm.edu/altmed/articles/biofeedback- 000349.htm. Biosonics, Inc. (2010). Tuning forks and miscellaneous information on nitric oxide spiking. Retrieved from http://www.biosonics.com. Bird, B., Newton, F., Sheer, D., & Ford, M. (1978a). Biofeedback training of 40 Hz. EEG in humans. Biofeedback & Self- Regulation, 3(1), 1-12. Bird, B., Newton, F., Sheer, D., & Ford, M. (1978b). Behavioral and electroencephalographic correlates of 40-Hz. EEG biofeedback training in humans. Biofeedback & Self-Regulation, 3(1), 13-28.
Blakeslee, S., & Blakeslee, M. (2008). The body has a mind of its own: How body maps in your brain help you do almost everything better. New York, NY: Random House. Blood, A., & Zatorre, R. (2001). Intensely pleasurable responses to music correlate with activity in brain regions implicated in reward and emotion. PNAS, 98(20), 11818-11823. Blood, A., Zatorre, R., Bermudez, P., & Evans, A. (1999). Emotional responses to pleasant and unpleasant music correlate with activity in paralimbic brain regions. Nat. Neurosci., 2, 382-387. Brown, R., & Gerbarg, P. (2005). Yogic breathing and meditation: When the thalamus quiets the cortex and rouses the limbic system. Art of Living Foundation. Retrieved from http://www.aolresearch.org/other_research.html.
Brownley, K., McMurray, R., & Hackney, A. (1995). Effects of music on physiological and affective responses to graded treadmill exercise in trained and untrained runners. International Journal of Psychophysiology, 19(3), 193-201. Burkeman, O. (2015, Jan. 21). Why can’t the world’s greatest minds solve the mystery of consciousness? TheGuardian.com. Retrieved from Internet: http://www.theguardian.com/science/2015/jan/21/-sp-why- cant-worlds-greatest-minds-solve-mystery-consciousness. Busch, N., Debener, S., Kranczioch, C., Engel, A., & Herrmann, C. (2004). Size matters: Effects of stimulus size, duration and eccentricity on the visual gamma-band response. Clinical Neurophysiology, 115(8), 1810-1820.
Buttagat, V., Eungpinichpong, W., Chatchawan, U., & Kharmwan, S. (2011). The immediate effects of traditional Thai massage on heart rate variability and stress-related parameters in patients with back pain associated with myofascial trigger points. Journal of Bodywork and Movement Therapies, 15(1), 15-23. Buzsaki, G. (2006). Rhythms in the brain. New York, NY: Oxford University Press. Cicconi, R., Mariani, F., Cavone, A., Persichini, T., Venturini, G., Ongini, E., Colizzi, V., & Colasanti, M. (2004). Inhibitory effects of NO-releasing ciprofloxacin (NCX976) on mycobacterium tuberculosis survival. Antimicrob Agents Chemother, 48(1), 368. Clark, A. (1985). Psychological causation and the concept of psychosomatic disease. In D. Stalker & C. Glymour. (Eds.). Examining holistic medicine (p. 67-106). Buffalo, NY: Prometheus Press.
Campisi, J., Leem, T., & Fleshner, M. (2002). Acute stress decreases inflammation at the site of infection: A role for nitric oxide. Physiology and Behavior, 77, 291-299. Cardeña, E. (2011). On wolverines and epistemological totalitarianism. J Sci Explor, 25, 539-551. Cardeña, E. (2014). A call for an open, informed study of all aspects of consciousness. Frontiers in Human Neuroscience, 8(17), 1-4. Centonze, D., Bracci, E., Pisani, A., Gubellini, P., Bernardi, C., & Calabresi, P. (2002). Activation of dopamine D1-like receptors excites LTS interneurons of the striatum. Eur J Neurosci, 15, 2049-2052. Collins, H. (2010). Tacit and explicit knowledge. Chicago, IL: University of Chicago Press.
Combs, A. (2002). Radiance of being: Understanding the grand integral vision: Living the integral life. (2nd ed.). St. Paul, MN: Paragon House. Combs, A. (2009). Consciousness explained better: Towards an integral understanding of the multifaceted nature of consciousness. St. Paul, MN: Paragon House. Cotman, C., & Berchtold, N. (2002). Exercise: A behavioral intervention to enhance brain health and plasticity. Trends Neurosci, 25, 295-301. Craqq, S. (2006). Meaningful silence: How dopamine listens to Ach pause. Trends Neurosci. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/16443285 Crone, N., Sinai, A., & Korzeniewska, A. (2006). A high- frequency gamma oscillations and human brain mapping with electrocorticography. Prog Brain Res, 159, 275-95.
Csikszentmihalyi, M. (1991). Flow: The psychology of optimal experience. (1st ed.). New York, NY: Harper Perennial. Csikszentmihalyi, M. (1997). Creativity: Flow and the psychology of discovery and invention. New York, NY: Harper Perennial. Csikszentmihalyi, M. (1991). Flow: The psychology of optimal experience. (1st ed.). New York, NY: Harper Perennial. Csikszentmihalyi, M. (1997). Creativity: Flow and the psychology of discovery and invention. New York, NY: Harper Perennial. Czachesz, I. (2008). Firewalking and the brain: The physiology of high-arousal rituals. In Bulbulia, J., Sosis, R., Harris, E., Genet, R., Genet, C., & Wyman, K. (Eds.). Evolution of religion: Studies, theories, and critiques (p. 189-195). Santa Monica, CA: Collins Foundation Press.
Damasio, A. (1990). Synchronous activation in multiple cortical regions: A mechanism for recall. Seminars in the Neurosciences, 2, 287-296. Damasio, A. (1999). The feeling of what happens: Body and emotion in the making of consciousness. New York, NY: Harcourt Press. Darling, C. (1935). Firewalking. Nature, 136, 152. Diederich, N., & Goetz, C. (2008). The placebo treatments in neurosciences: New insights from clinical and neuroimaging studies. Neurology, 71(9), 677-684. Doidge, N. (2007). The brain that changes itself: Stories of triumph from the frontiers of brain science. New York: Penguin Books.
Draganski B, Gaser C, Kempermann G, Kuhn, G., Winkler, J., Büchel, C., & May, A. (2006). Temporal and spatial dynamics of brain structure changes during extensive learning. J Neurosci, 26, 6314–6317. Driver, J., & Spence, C. (1998). Cross-modal links in spatial attention. Philosophical Transactions of the Royal Society of London, B, 353, 1319-1331. Drohan, M. (1999). From myth to reality: How music changes matter. Complementary Health Practices Review, 5, 25-33. Duke University Medical Center. (2008, May 23). Major ‘missed’ biochemical pathway emerges as important in virtually all cells. Science Daily. Retrieved from internet: http://www.sciencedaily.com/releases/2008/05/08052214520 9.htm.
Dusek, J., Chang, B., Zaki, J., Lazar, S., Deykin, A., Stefano, G., Wohlhueter, A., Hibberd, P., & Benson, H. (2006). Association between oxygen consumption and nitric oxide production during the relaxation response. Med Sci Monit, 12(1), CR1- CR10. Dusek, J., Hibberd, P., Buczynski, B., Chang, B., Dusek, K., Johnson, J., Wohlhueter, A., Benson, H., & Zusman, R. (2008). Stress management versus lifestyle modification on systolic hypertension and medication elimination: A randomized trial. J Altern Complement Med, 14(2), 129-138. Dusek, J., Otu, H., Wohlhueter, A., Bhasin, M., Zerbini, L. Joseph, M., Benson, H., & Liberman, T. (2008). Genomic counter-stress changes induced by the relaxation response. PLoS One, 3(7), e2576. Eccleston, C., & Crombez, G. (1999). Pain demand attention: A cognitive affective model of the interruptive function of pain. Psychological Bulletin, 125, 356-366.
Elam, R., et al. (1989). Effects of arginine and ornithine on strength, lean body mass and urinary hydroxyproline in adult males. J Sports Med Phys Fitness, 29(1), 52-56. Epel, E., Blackburn, E., Lin, J., Dhabhar, F., & Adler, N. (2004). Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci USA, 101, 17312-17315. Erez, A., et al. (2011). Requirement of argininosuccinate lyase for systemic nitric oxide production. Nature Medicine, 17, 1619– 1626. Esch, T., Guarna, M., Bianchi, E., Zhu, W., & Stefano, G. (2004). Commonalities in the central nervous system’s involvement with complementary medical therapies: Limbic morphinergic processes. Med Sci Monit, 10(6), MS6-17. PMID: 15173679. Esch, T., & Stefano, G. (2004). The neurobiology of pleasure, reward processes, addiction and their health implications. Neuroendocrinol Lett, 25(4), 235-251.
Esch, T., & Stefano, G. (2005). The neurobiology of love. Neuroendocrinol Lett, 26(3), 175-192. Esch, T., & Stefano, G. (2010). The neurobiology of stress management. Neuro Endocrinol Lett, 31(1), 19-39. Esch, T., Fricchione, G., Stefano, G. (2003). The therapeutic use of the relaxation response in stress related diseases. Med Sci Monit, 9(2), RA23-RA34. Esch, T., Stefano, G., Fricchione, G., & Benson, H. (2002). Stress- related diseases: A potential role for nitric oxide. Med Sci Monit, 8(6), RA103-RA118. Farrer, C., & Frith, C. (2002). Experiencing oneself vs. another person as being the cause of action: The neural correlates of the experience of agency. Neuroimage, 15, 596-603.
Fehmi, L., & Robbins, J. (2007). The open focus brain: Harnessing the power of attention to heal mind and body. Boston, MA: Trumpeter. Fehmi, L., & Robbins, J. (2010). Dissolving pain: Simple brain- training exercises for overcoming chronic pain. (Includes Dissolving Pain CD). Boston, MA: Trumpeter. Fisher, R. (1971). A cartography of ecstatic and meditative states. Science, 174, 897-904. Fisher, R. (1973). A cartography of the ecstatic and meditative states. Leonardo, 6(1), 59-66. Field, P. (1972). A quantitative ultra structural analysis of the distribution of amygdaloid fibers in the preoptic area and the ventromedial hypothalamic nucleus. Experimental Brain Research, 14(5), 527-538. Fields, C. (2013). A whole box of Pandoras: Systems, boundaries and free will in quantum theory. Journal of Experimental & Theoretical Artificial Intelligence, 25(3), 291-302. Retrieved from Internet: DOI: 10.1080/0952813X.2013.782981.
Fields, H., & Levine, J. (1984). Placebo analgesia: A role for endorphins? Trends in Neuroscience, Aug., 27-29. Fleshner, M., & Laudenslager, M. (2004). Psychoneuroimmunology: Then and now. Behav Cogn Neurosci Rev, 3(2), 114-130. Foote, S., Bloom, F., Aston-Jones. G. (1983). Nucleus locus coeruleus: New evidence of anatomical and physiological specificity. Physiol Rev, 63, 844–914. Ford, M., Bird, B., Newton, F., & Sheer, D. (1980). Maintenance and generalization of 40-Hz EEG biofeedback effects. Biofeedback & Self-Regulation, 5(2), 193-205. Fricchione, G., & Stefano, G. (2005). Placebo neural systems: nitric oxide, morphine and the dopamine brain reward and motivation circuitries. Medical Science Monitor, 11(5), MS54- MS65.
Fujisawa, S., & Busaki, G. (2011). A 4Hz oscillation adaptively synchronizes prefrontal, VTA, and hippocampal activities. Neuron, 72(1), 153-165. Genz, H. (1999). Nothingness: The science of empty space. (Karin Heusch, Trans.). Reading, MA: Perseus Books. Firewalking: Scientific tests. (1937). Nature, 139, 660. Fischl, B., & Dale, A. (2000). Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proc Natl Acad Sci USA, 97, 11050–5. Funderbank, J. (1977). Science studies of yoga: A review of the physiological data. Glenview, IL: Himalayan International Institute. Gelhorn, E. (1970). The emotions and ergotropic and trophotropic systems. Psychologische Forsching, 34, 68-94.
Gendlin, E. (1981). Focusing. (2nd ed.). New York, NY: Bantam Books. Geneeskd, N. (1998). Nobel prize in Medicine and Physiology 1998 for the discovery of the role of nitric oxide as a signaling molecule. Pub Med, 142(52), 2828-2830. Retrieved from internet: http://www.ncbi.nlm.nih.gov/pubmed/10065255. Geraskov, E. (1994). The internal contradiction and the unconscious sources of activity. Journal of Psychology: Interdisciplinary and Applied, 128(6), 625-634. Gerber, R. (1988). Vibrational medicine: New choices for healing ourselves. Santa Fe, NM: Bear & Company. Giorgi, A. (1997). The theory, practice, and evaluation of the phenomenological method as a qualitative research procedure. Journal of Phenomenological Psychology, 28(2), 235-260.
Glaser, J., Brind, J., Vogelman, J., Eisner, M., Dillbeck, M., Wallace, R., Chopra, D., & Orentreich, N. (1992). Elevated serum dehydroepiandrosterone sulfate levels in practitioners of the transcendental meditation (TM) and TM-Sidhi programs. J Behav Med, 15, 327–341. Gold I. (1999). Does 40-Hz oscillation play a role in visual consciousness? Conscious Cogn, 8, 186–95. Goleman, D. (1988). The Meditative Mind. Los Angeles, CA: Jeremy Tarcher. Goodman, F. (1990). Where the Spirits ride the wind: Trance journeys and other Ecstatic experiences. (A Midland Book Ed.). Bloomington, IN: Indiana University Press. Goodman, F., & Nauwald, N. (2003). Ecstatic trance: New ritual body postures. (Workbook Ed.). Havelte, Netherlands: Binkey Kok.
Gopher, D. (1993). The skill of attentional control: Acquisition and execution of attentional strategies. In S. Kornblum & D. E. Meyer (Eds.). Attention and performance, XIV: Synergies in experimental psychology, artificial intelligence and cognitive neuroscience. Cambridge, MA: MIT Press. Gore, B. (1995). Ecstatic body postures: An alternate reality workbook. (Workbook Ed.). Rochester, VT: Bear and Company. Grof, S., & Grof, C. (2010). Holotropic breathwork: A new approach to self-exploration and therapy. (SUNY Series in Transpersonal and Humanistic Psychology). Albany, NY: State University of New York Press. Gruzelier, J., & Egner, T. (2005). Critical validation studies of neurofeedback. Child Adolesc Psychiatric Clinics N Am, 14(1), 83-104.
Gruzelier, J., Egner, T., & Vernon, C. (2006). Validating the efficacy of neurofeedback for optimizing performance. Progress in Brain Research, 159, 421-431. Guastella, A., Mitchell, P., & Dads, M. (2008). Oxytocin increases gaze to the eye region of human faces. Biological Psychiatry, 305, 3-5. Guoyao, W., & Meininger, C. (2000). Arginine nutrition and cardiovascular function. J Nutr, 130, 2626-2629. Guoyao, W., & Morris, S. (1998). Arginine metabolism: Nitric oxide and beyond. Biochem J, 336, 1-17. Haig, A., De Pascalis V., & Gordon, E. (1999): Peak gamma latency correlated with reaction time in conventional oddball paradigm. Clinical Neurophysiology, 110 (1), 158-165.
Halpern, S., & Savary, L. (1985). Sound health: The music and sounds that make us whole. (1st ed.). New York, NY: Harpercollins. Hammond, C. (2000). Clinical corner: The role of 40 hertz activity and training. Journal of Neurotherapy, 4(2), 95-100. Hanajima, R., Terao, Y., Hamada, M., Okabe, S., Nakatani- Enomoto, S., Furubayashi, T., Yugeta, A., Inomata-Terada, S., & Ugawa, Y. (2009). Forty-hertz triple-pulse stimulation induces motor cortical facilitation in humans. Brain Research, 1296, 15-23. Halpern, S., & Savary, L. (1985). Sound health: The music and sounds that make us whole. (1st ed.). New York, NY: Harpercollins. Hammond, C. (2000). Clinical corner: The role of 40 hertz activity and training. Journal of Neurotherapy, 4(2), 95-100.
Hanajima, R., Terao, Y., Hamada, M., Okabe, S., Nakatani- Enomoto, S., Furubayashi, T., Yugeta, A., Inomata-Terada, S., & Ugawa, Y. (2009). Forty-hertz triple-pulse stimulation induces motor cortical facilitation in humans. Brain Research, 1296, 15-23. Hedaya, R. (2011). Laughing gas (nitrous oxide) is no laughing matter. Health Matters Blog. Retrieved from http://www.wholepsych.com/blog/?tag=/nitrous+oxide. Hays, J. (1998). How the brain talks to itself: A clinical primer of psychotherapeutic neuroscience. New York, NY: The Haworth Press. Hilgard, E. (1986). Divided consciousness: Multiple controls in human thought and action. (Expanded ed.). New York, NY: Wiley.
Hinterberger, T., Zlabinger, M., & Blaser, K. (2014). Neurophysiological correlates of various mental perspectives. Frontiers in Human Neuroscience, 8(637), 100-115. Hirst, W. (1986). The psychology of attention. In J. E. LeDoux & W. Hirst. (Eds.). Mind and brain: Dialogues in cognitive neuroscience. Cambridge, UK: Cambridge University Press. Hutchison, M. (1996). Megabrain: New tools and techniques for brain growth and mind expansion. New York, NY: Ballantine Books. Indian fire-walk. (1935). Lancet, 229, 750. Iwanaga, M., & Tsukamoto, M. (1997). Effects of excitative and sedative music on subjective and physiological relaxation. Perception Motor Skills, 85(1), 287-296.
Jacobs, T., Epel, E., Lin, J., Blackburn, E., Wolkowitz, O, Bridwell, D., Zanesco, A., Aichele, S., Sahdra, B., MacLean, K., King, B., Shaver, P., Rosenberg ,E., Ferrer, E., Wallace, B., & Saron, C. (2011). Intensive meditation training, immune cell telomerase activity and psychological mediators. Psychoneuroendocrinology, 36, 664–81. Kal, J., Van Wezel, H., Porsius, M., Vergroesen, I., & Spaan, J. (2000). Metabolic coronary-flow regulation and exogenous nitric oxide in human coronary disease: Assessment by intravenous administration of nitroglycerin. J Cardiovascular Pharm, 35(1), 7-15. Kemper, K., Mo, X.,, & Khayat, R. (2015). Are mindfulness and self compassion associated with sleep and resilience in health professionals? Journal of Alternative and Complementary Medicine. Retrieved from Internet: http://online.liebertpub.com/doi/pdfplus/10.1089/acm.2014.02 81
Kim, J., Koo, J., Lee, H., & Han, J. (2005). Amygdalar inactivation blocks stress-induced impairments in hippocampal long term potentiation and spatial memory. J Neurosci, 25, 1532-1539. Kobasa, S., Maddi, S., & Puccetti, M. (1982). Personality and exercise as buffers in the stress-illness relationship. Journal of Behavioral Medicine, 5, 391-404. Kobasa, S., Maddi, S., Puccetti, M., & Zola, M. (1985). Effectiveness of hardiness, exercise, and social support as resources against illness. J of Psychosomatic Research, 29, 525-533. Kosfeld, M., Heinrichs, M., Zak, P., Fischbacher, & Fehr, E. (2005). Oxytocin increases trust in humans. Nature, 435, 673- 676. Kossak, M. (2007). Attunement: Embodied transcendent experience explored through sound and rhythmic improvisation. (Doctoral dissertation). ProQuest UMI Dissertation Publishing. Retrieved from internet: http://pqdtopen.proquest.com/doc/304833022.html?FMT=AI Kraus, N., & Nicol, T. (2005). Brainstem origins for cortical ‘what’ and ‘where’ pathways in the auditory system. Trends Neurosci, 28(4), 176–181.
Kraus, N., Strait, D., & Parbery-Clark, A. (2012). Cognitive factors shape brain networks for auditory skills: Spotlight on auditory working memory. Annals of the NY Academy of Science, 1252, 100-107. Lawlis, G. (1996). Transpersonal medicine: The new approach to healing body-mind-spirit. Boston, MA: Shambhala. Lawlis, G., Selby, D., Hinnant, G., & McCoy, C. (1985). Reduction of postoperative pain parameters by presurgical relaxation instruction for spinal pain patients. Spine, 10, 163-171. Lazar, S., Bush, G., Gollub, R., Fricchione, G., Khalsa, G., Benson, H. (2000). Functional brain mapping of the relaxation response and meditation. Neuroreport, 11(7), 1581-1585. Lazar, S., Kerr, C., Wasserman, R., Gray, J., et al. (2005). Meditation experience is associated with increased cortical thickness. Neuroreport, 16, 1893–7.
Lebois, L., Papies, E., Gopinath, K., Cabanban, R., Quigley, K., Krishnamurthy, V., Barrett, L., & Barsalou, L. (2015). A Shift in Perspective: Decentering through Mindful Attention to Imagined Stressful Events. Neuropsychologia, Emory University and Harvard Medical School. Retrieved from Internet: http://psychology.emory.edu/cognition/barsalou/papers/Lebois _et_al-Neuropsychologia_in_press-decentering_stress.pdf Leiderman, P. (1964). Imagery and sensory deprivation. Proceedings of the Third World Congress in Psychiatry, 227- 231. LeShan, L. (1977). You can fight for your life: Emotional factors in the causation of cancer. NY: Jove Publications, Inc. Levine, P., et al. (1977). EEG coherence during the Transcendental Meditation program. Vol. I. (p. 187-207). Livingston Manor, NY: Maharishi European Research University Press.
Li, Y., Field, M., & Raisman, G. (2005). Olfactory ensheathing cells and olfactory nerve fibroblasts maintain continuous open channels for regrowth of olfactory nerve fibers. Glia, 52(3), 245-251. Li, Q., Li, P., Garcia, G., Johnson, R., & Feng, L. (2005). Genomic profiling of neutophil transcripts in Asian Qigong practitioners: A pilot study in gene regulation by mind-body interaction. J Altern Complement Med, 11, 29-39. Lilly, J. (1977). The deep self: Profound relaxation and the tank isolation technique. New York, NY: Simon and Schuster. Lipton, B. (2005). The biology of belief: Unleashing the power of consciousness, matter and miracles. Santa Rosa, CA: Mountain of Love/Elite Books.
Liu, D., Fernandez, B., Lang, N., et al. (2013). UVA lowers blood pressure and vasodialates the systemic arterial vasculature by mobilisation of cutaneous nitric oxide stores. Journal of Investigative Dermatology, 133( S212), 1247. Llinas, R., Ribary, U., Contreras, D., & Pedroarena, C. (1998). The neuronal basis for consciousness. Philosophical Society of the Royal Society of London B, 353, 1841-1849. Loehr, J., & Schwartz, T. (2003). The power of full engagement: Managing energy, not time, is the key to higher performance and personal renewal. New York, NY: Free Press. Long, R., Jones, R., Talbot, J., Mayers, I., Barrie, J., Hoskinson, M., & Light, B. (2005). Inhaled nitric oxide treatment of patients with pulmonary tuberculosis evidenced by positive sputum smears. Antimicrob Agents Chemother, 49(3), 1209- 1212.
Long, R., Light, B., & Talbot, J. (1999). Mycobacteriocidal action of exogenous nitric oxide. Antimicrob Agents Chemother, 43(2), 403-404. Lowson, S. (2003). Nitric oxide signaling and clinical alternatives to nitric oxide. Semin Cardiothorac Vasc Anesth, 7, 239-252. Ludwig, A. (1966). The formal character of therapeutic insight. American Journal of Psychotherapy, 20, 305-318. Ludwig, K. (2007). The epistemology of thought experiment: First person versus third person approaches. Midwest Studies in Philosophy, XXXI, 128-159. Lutz, A., Lachaux, J., Martinerie, J., & Varela, F. (2002). Guiding the study of brain dynamics using first person data: Synchrony patterns correlate with on-going conscious states during a simple visual task. Proceedings of the National Academy of Sciences of the USA, 99, 1586-1591.
Lutz, A., Greischar, L.L., Rawlings, N., Ricard, M., & Davidson, R.J. (2004): Long-term meditators self-induce high-amplitude gamma synchrony during mental practice. Proceedings of the National Academy of Sciences, 101(46), 16369-16373. Macaluso, E., Eimer, M., Firth, C., & Driver, J. (2003). Preparatory states in cross-modal spatial attention: Spatial specificity and possible control mechanisms. Experimental Brain Research, 149, 62-74. MacMillan, L. (2012, Jan. 20th). Studies shed new light on how nitric oxide is produced. Research News at Vanderbilt University. Retrieved from Internet: http://news.vanderbilt.edu/2012/01/nitric-oxide-productio/. Maniscalco, M., Sofia, M., Weitzberg, E., De Laurentiis, G., Stanziola, A., Rossillo, V., Lundberg, J. (2004). Humming- induced release of nasal nitric oxide for assessment of sinus obstruction in allergic rhinitis: Pilot study. Eur J Clin Invest, 34(8), 555-560.
Mantione, K. Cadet, P., Zhu, W., Kream, R., Sheehan, M., Fricchione, G., Goumon, Y., Esch, T., & Stefano, G. (2008). Endogenous morphine signaling via nitric oxide regulates the expression of the CYP2D6 and COMT: Autocrine/paracrine feedback inhibition. Addiction Biology, 13(1), 118-123. Marks, D. (1986). Intentionality and autonomy of verbal imagery in altered states of consciousness. Behavioral and Brain Science, 9(3), 529-530. Marsh, C. (1977). A framework for describing subjective states of consciousness. In N. E. Zinberg. (Ed.). Alternate states of consciousness (p. 124-144). New York, NY: MacMillan. Martin, J. (2014). Clusters of Individual Experiences form a Continuum of Persistent Non-Symbolic Experiences in Adults. Center for the Study of Non-Symbolic Consciousness. (Abstract, p. 1-37). Retrieved from Internet: www.Non- Symbolic.org; www.DrJefferyMartin.com.
Martin, R. (2001). Humor, laughter, and physical health: Methodological issues and research findings. Psychol Bull, 127, 504–519. Maslow, A. (1971). The farther reaches of human nature. New York, NY: Viking. Mata-Greenwood, E., & Chen, D. (2008). Racial differences in nitric oxide-dependent vasorelaxation. Reproductive Sciences, 15(1), 9-25. Mattingley, J., Driver, J., Beschin, N., Robertson, I. (1997). Attentional competition between modalities: Extinction between touch and vision after right hemisphere damage. Neuropsychologia, 35, 867-880. McCelland, D., Ross, G., Patel, V. (1985). The effect of an academic examination on salivary norepinephrine and immunoglobulin levels. Journal of Human Stress, 11(2), 52-59.
McEwen, B. (1998a). Protective and damaging effects of stress mediators. N Engl J Med, 338, 171-179. McEwen, B. (1998b). Stress, adaptation, and disease: Allostasis and allostatic load. Annals of the New York Academy of Sciences, 840, 33-44. McEwen, B. (2000). The neurobiology of stress: From serendipity to clinical relevance. Brain Research, 866, 172-189. McEwen, B. (2002). Sex, stress, and the hippocampus: Allostasis, allostatic load, and the aging process. Neurobiology of Aging, 23, 921-939. McEwen, B. (2007). Physiology and neurobiology of stress and adaption: Central role of the brain. Physiol Rev, 87, 873-904. Retrieved from http://physrev.physiology.org/cgi/content/full/87/3/873#BIBL.
McGaugh J. (2004). The amygdala modulates the consolidation of memories of emotionally arousing experiences. Ann Rev Neurosci, 27, 1–28. McKinney, C., Antoni, M., Kumar, M., Tims, F., & McCabe, P. (1997). Effects of guided imagery and music (GIM) therapy on mood and cortisol in healthy adults. Health Psychology, 16(4), 390-400. McKinney, C., Tims, F., Kumar, A, & Kumar, M. (1997). The effect of selected classical music and spontaneous imagery on plasma beta-endorphin. J of Behav Med, 29(1), 85-99. McLean, J., Shipley, M., Nickell, W., Aston-Jones, G., & Reyher, C. (1989). Chemoanatomical organization of the noradrenergic input from locus coeruleus to the olfactory bulb of the adult rat. J Comp Neurol, 285, 339-349. Michelon, P. (2008). Brain plasticity: How learning changes your brain. Retrieved from http://www.sharpbrains.com.
Miltner, W. H. R., Braun, C., Arnold, M., Witte, H., & Taub, E. (1999). Coherence of gamma-band EEG activity as a basis for associative learning. Nature, 397, 434-436. Momen, M. (1984). The psychology of mysticism and its relationship to the Baha’i Faith. Baha’i Studies Bulletin, 2, 4- 21. Retrieved from http://bahai- library.org/articles/mysticism.momen.html. Monroe, R. (1992). Journeys out of the body. New York, NY: Broadway Books. Montgomery, S., Sirota, A., & Buzsaki, G. (2008). Theta and gamma coordination of hippocampal networks during waking and rapid eye movement sleep. J Neurosci, 28(26), 6731- 6741.
Morita, K., Saito, T., Ohta, M., Ohmori, T., Kawai, K., Teshima- Kondo, S., &, Rokutan, K. (2005). Expression analysis of psychological stress-associated genes in peripheral blood leukocytes. Neurosci Lett, 381, 57-62. Mullooly, V., Levin, R., & Feldman, H. (1988). Music for postoperative pain and anxiety. Journal of New York State Nurses Association, 19, 4-7. Nakao, M., Myers, P., Fricchione, G., Zuttermeister, P., Barsky, A., & Benson, H. (2001). Somatization and symptom reduction through a behavioral medicine intervention in a mind/body clinic. Behav Med, 26, 169-176. Nakazawa, D. (2015). Childhood Disrupted: How Your Biography Becomes Your Biology, and How You Can Heal. Adapted and Reprinted abstract. London, UK: Aeon Media Ltd. Retrieved from Internet: http://aeon.co/magazine/psychology/how-childhood-biography- shapes-adult-biology/
Narin, O., Pinar, L., Erbas, D., Ozturk, V., Idiman, F. (2003). The effects of exercise and exercise-related changes in blood nitric oxide level on migraine headache. Clin Rehabil, 17, 624-630. Northrup, C. (2008). The secret pleasures of menopause. Carlsbad, CA: Hay House, Inc. Olson, K., & Kemper, K. (2014). Factors associated with well- being and confidence in providing compassionate care. Journal of Evidenced-Based Complementary & Alternative Medicine, 19(4), 292-296. Retrieved from Internet: http://self- compassion.org/wp- content/uploads/2015/03/Olson.Kemper.pdf and DOI: 10.1177/2156587214539977. Othmer, S. (2007/2003). Overview of neurofeedback mechanisms. The EEG Institute. Retrieved from Internet: http://www.eeginfo.com/research/research_text.html.
Overgaard, M., Gallagher, S., & Ramsoy, T. (2008). An integration of first person methodologies in cognitive science. Journal of Consciousness Studies, 15(5), 100-120. Paller, K. & Sukuki, S. (2014). The source of consciousness. Trends in Cognitive Sciences, 18(8), 387-389. Retrieved from Internet: DOI: http://dx.doi.org/10.1016/j.tics.2014.05.012 Palmer, H. (Ed.). (1998). Inner knowing: Consciousness, creativity, insight, intuition. New York, NY: Penguin Putnam Inc. Peng, C., Henry, I., Mietus, J., Hausdorff, J., Khalsa, G., Benson, H., & Goldberger, A. (2004). Heart rate dynamics during three forms of meditation. Int J Cardiol, 95, 19-27. Petrozzo, R., Mohr, J., Mantione, K., & Goldstein, L. (2014). The role of endogenous morphine and nitric oxide in pain management. Practical Pain Management, 14(9), 1-3.
Petrovic, P., Kalisch, R., Singer, T., & Dolan, R. (2008). Oxytocin attenuates evaluations of conditioned faces and amygdala activity. Journal of Neuroscience, 28, 6607-6615. Pillay, S. (2010). Life unlocked: 7 revolutionary lessons to overcome fear. New York, NY: Rodale, Inc. Pillay, S. (2011). Your brain and business: The neuroscience of great leaders. Upper Saddle River, NJ: Pearson Education, Inc. Polanyi, M. (1964). Science, faith, and society: A searching examination of the meaning and nature of scientific inquiry. Chicago, IL: University of Chicago Press. Polanyi, M. (1969). Knowing and being. M. Greene. (Ed.). Chicago, IL: University of Chicago Press. Polanyi, M. (1983). The tacit dimension. Glouster, MA: Peter Smith.
Polanyi, M., & Prosch, H. (1977). Meaning. Chicago, IL: University of Chicago Press. Pribram, K. (1979). Holographic memory: An interview by Daniel Goleman. Psychology Today, 12(9), 72. Spreekmeester, E., & Rochford, J. (2000). Selective mu and delta, but not kappa, opiate receptor antagonists inhibit the habituation of novelty-induced hypoalgesia in the rat. Psychopharmacology (Berl), 148(1), pp. 99-105. Pryor, S., Zhu, W., Cadet, P., et al. (2005). Endogenous morphine: Opening new doors for the treatment of pain and addiction. Expert Opin Biol Ther, 5, 893-906. Purves, D., Augustine, G., et al. (Eds.). (2001). Stages of sleep. Neuroscience. (2nd ed.). Sunderland, MA: Sinauer Associates.
Raghuraj, P., Ramakrishna, A., & Nagendra, H. (1998). Effect of two related yogic breathing techniques on heart rate variability. Indian J Physiol Pharmacol, 42(4), 467-472. Raisman, G. (1972). An experimental study of the projection of the amygdala to the accessory olfactory bulb and its relationship to the concept of a dual olfactory system. Experimental Brain Research, 14(4), 395-408. Raudenbush, B. (2012). WJU professor and students find jasmine odor leads to more restful sleep, decreased anxiety and greater mental performance. Wheeling, VA: Wheeling Jesuit University. Retrieved from Internet: http://www.wju.edu/about/adm_news_story.asp?iNewsID=539 &strBack=/about/adm_news_archive.asp. Rider, M., & Achterberg, J. (1989). Effect of music-assisted imagery on neutrophils and lymphocytes. Biofeedback Self- Regulation, 14(3), 247-257.
Rider, M., Achterberg, J., Lawlis, G., Goven, A., Toledo, R., & Butler, J. (1990). Effects of immune systems on secretory IgA. Biofeedback and Self-Regulation, 15(4), 317-332. River, C. (1998). Role of nitric oxide and carbon monoxide in modulating the ACTH response to immune and nonimmune signals. Neuroimmunomodulation, 5(3-4), 203-213. Rosen, J. (2004). The neurobiology of conditioned and unconditioned fear: A neurobehavioral system analysis of the amygdala. Behav Cogn Neurosci Rev, 3(1), 23-41. Rubik, B. (2011). Neurofeedback-enhanced gamma brainwaves from the prefrontal cortical region of meditators and non- meditators and associated subjective experiences. The Journal of Alternative and Complementary Medicine, 17(2), 109-115. Ruby, P., & Decety, J. (2001). Effect of subjective perspective taking during simulation of action: A PET investigation of agency. Nature Neuroscience, 4(5), 546-550.
Sabolek, H., Penley, S., Hinman, J., Bunce, J., Markus, J., Escabi, M. & Chrobak, J. (2009). Theta and gamma coherence along the septotemporal axis of the hippocampus. J Neurophysiol, 101, 1192-1200. Salamon, E., Esch, T., & Stefano, G. (2005). The role of the amygdale in mediating sexual and emotional behavior via coupled nitric oxide release. Acta Pharmacologica Sinica, 26, 389-395. Salamon, E., Esch, T., & Stefano, G. (2006). Pain and relaxation: A review. Int J Mol Med, 18(3), 465-470. Salamon, E., Kim, M., Beaulieu, J., & Stefano, G. (2003). Sound therapy induced relaxation: Down regulating stress processes and pathologies. Med Sci Monit, 9(5), RA116-RA121.
Samuelson, M., Foret, M., Baim, M., Lerner, J., Fricchione, G., Benson, H., Dusek, J., & Yeung, A. (2010). Exploring the effectiveness of a comprehensive mind-body intervention for medical symptom relief. J Altern Complement Med, 16(2), 187- 192. Sanella, L. (1976). Kundalini: Psychosis or transcendence? San Francisco, CA: H. S. Dakin Company. Sauvé, K. (1999). Gamma-band synchronous oscillations: Recent evidence regarding their functional significance. Consciousness and Cognition, 8(2), 213-224. Schacter, D. (1976). The hypnagogic state: A critical review of the literature. Psychological Bulletin, 83, 452-481. Scheffzuk, C., Kukushka, V., Vyssotski, A., Draguhn, A., Tort, A., & Brankack, J. (2011). Selective coupling between theta phase and neocortical fast gamma oscillations during REM sleep in mice. PLoS One, 6(12), e28489.
Schneider, J. (1984). Imagery and disease. In J. Achterberg & G. F. Lawlis. Imagery and disease (p. 144-154). Champaign, IL: IPAT. Schwartz, J. & Begley, S. (2002). The mind & the brain: Neuroplasticity and the power of mental force. New York, NY: Harper Perennial. Segerstrom, S., & Miller, G. (2004). Psychological stress and the human immune system: A meta-analytic study of 30 years of inquiry. Psychol Bull, 130, 601–30. Seidler, M., Uckert, S., Waldkirch E, Stief, C., Oelke, M., Tsikas, D., Sohn, M., & Jonas, U. (2002). In vitro effects of a novel class of nitric oxide (NO) donating compounds on isolated human erectile tissue. Eur Urol, 42(5), 523-528. Sela-Smith, S. (2003a). Finding the still point: Chapter one. (February). Infinite Connections. Retrieved from http://www.infiniteconnections.us/finding-the-still-point- chapter-one-february-2003#more-233.
Seligman, M. (1998). Learned optimism: How to change your mind and your life. New York, NY: Pocket Books. Selye, H. (1946). The general adaptation syndrome and diseases of adaptation. Journal of Clinical Endocrinology, 6, 111-230. Selye, H. (1974). Stress without distress. (1st ed.). Baltimore, MD: Lippincott Williams and Wilkens. Shapiro, D. (1977). A biofeedback strategy of consciousness. In N. E. Zinberg. (Ed.). Alternate states of consciousness (p. 145- 157). New York, NY: Macmillan. Shiffrin, R. (1988). Attention. In R. C. Atkinson, G. Lindzey, & R. D. Lee. (Eds.). Stevens handbook of experimental psychology: Learning and cognition. (2nd ed.). (p. 738-811). New York, NY: John Wiley & Sons, Inc.
Shinde, U., Mehta, A., & Goyal, R. (2000). Nitric oxide: A molecule of the millennium. Indian J Exp Biol, 38(3), 201-210. Siebert, A. (2005). The resiliency advantage: Master change, thrive under pressure, and bounce back from setbacks. San Francisco, CA: Berrett-Koehler. Simpkiss, J., & Devine, D. (2002). Responses of the HPA axis after chronic variable stress: Effects of novel and familiar stressors. Neuroendocrinology Letters, 24(1-2), 97-103. Simon, R., & Engstrom, M. (2015). The default mode network as a biomarker for monitoring the therapeutic effects of meditation. Frontiers in Psychology, June 9, Perspective Article. Retrieved from Internet: http://journal.frontiersin.org/article/10.3389/fpsyg.2015.0077 6/full and http://dx.doi.org/10.3389/fpsyg.2015.00776
Simpson, J., & Rholes, W. (1994). Stress and secure base relationships in adulthood. In K. Bartholomew, & D. Perlman. (Eds.). Advances in personal relationships: Attachment processes in adulthood (p. 181-204). London, UK: Kingsley. Singh, L., Lancioni, G., Karazsia, B., et al. (2015). Effects of Samantha meditation on active academic engagement and math performance of students with attention deficit/hyperactivity disorder. Mindfulness. Retrieved from Internet: http://link.springer.com/article/10.1007/s12671- 015-0424-5#page-1 and DOI: 10.1007/s12671-015-0424-5. Slobada, J. (1999). The musical mind: The cognitive psychology of music. Oxford, UK: Oxford University Press. Spanos, N., Cross, W., Lepage, M, & Coristine, M. (1986). Glossolalia as learned behavior: An experimental demonstration. Journal of Abnormal Psychology, 95, 21-23.
Spiro, S. (2012). Nitrous oxide production and consumption: Regulation of gene expression by gas-sensitive transcription factors. Phil Trans R Soc B, 367(1593), 1212-1225. Srednicki, M. (2007). Quantum field theory. Cambridge, UK: Cambridge University Press. Stanford Cognition Textbook. (2006). Chapter 3: Attention. Palo Alto, CA: Stanford University. Retrieved from Internet: http://www- psych.stanford.edu/~ashas/Cognition%20Textbook/chapter3.p df Stanford University. (2011). Quantum approaches to consciousness. Stanford Encyclopedia of Philosophy. Retrieved from Internet: http://www.plato.stanford.edu/entries/qt- consciousness. Steelman, V. (1990). Interoperative music therapy effects on anxiety, blood pressure. AORN Journal, 52, 1026-1034.
Stefano, G. (2003). Biomedical significance of nitric oxide. New York, NY: Medical Science International. Stefano, G., Benson, H., Frichionne, G., & Esch, T. (2005). The stress response: Always good and when it is bad. New York, NY: Medical Science International. Stefano, G., & Magazine, H. (2001). Nitric oxide autoregulation and its significance. Modern Aspects of Immunobiology, 1, 182- 186. Stefano, G., Salzet, M., & Magazine, H. (2003). Cyclic nitric oxide release by human granulocytes, and invertebrate ganglia and immunocytes: Nano-technological enhancement of amperometric nitric oxide determination. Med Sci Monit, 8(6), BR199-204. PMID: 12070423. Retrieved from Internet: http://www.biosonics.com/uploads2011/CyclicNitricOxide.pdf
Stein, M., Schiavi, R., Camerino, M. (1976). Influence of brain and behavior on the immune system. Science, 191, 435-440. Steiner, R. (2009). How to know higher worlds. Radford, VA: Wilder Publications. Sterling, P., & Eyer, J. (1988). Allostasis: A new paradigm to explain arousal pathology. In S. Fisher, & J. Reason. (Eds.). Handbook of Life Stress, Cognition and Health (p. 629-649). New York, NY: Wiley. Stoff, J. (1992). Chronic fatigue syndrome: The hidden epidemic. (2nd revised ed.) New York, NY: Harper Perennial. Stone, A., Cox, D., Valdimarsdottir, H., Jandorf, L., & Neale, J. (1987). Evidence the secretory IgA antibody is associated with daily mood. Journal of Personality and Social Psychology, 52, 988-993.
Styles, E. (2005). Attention perception and memory: An integrated introduction. London, UK: Routledge. Styles, E. (2006). The psychology of attention. (2nd ed.). Hove, UK: Psychology Press. Sui-Kok, C. (1991). Pranic healing. York Beach, ME: Samuel Weiser, Inc. Surani, M. (2001). Reprogramming of genome function through epigenetic inheritance. Nature, 414, 122-123. Taddei, S., Virdis, A., Ghiadoni, L., Salvetti, G., Bernini, G., Magagna, A., & Salvetti, A. Age-related reduction of NO availability and oxidative stress in humans. Hypertension, 38(2), 274-279. Tan, C., & Bullock, D. (2008). A dopamine-acetylcholine cascade: Simulating learned and lesion-induced behavior of striatal cholinergic interneurons. J Neurophysiol, 100(4), 2409-2421.
Taren, A., Gianaros, P., Greco, C., et al. (2015). Mindfulness Meditation Training Alters Stress-Related Amygdala Resting State Functional Connectivity: A Randomized Controlled Trial. Social and Cognitive Affective Neuroscience, Advance Access. Retrieved from Internet: http://scan.oxfordjournals.org/content/early/2015/06/05/scan. nsv066.abstract and DOI: 10.1093/scan/nsv066 Taub, M., Murad, F., & Oliphant, D. (2006). The wellness solution. Cleveland, OH: World Almanac Library. Taylor, J. (2008). My stroke of insight: A brain scientist’s personal journey. New York, NY: Viking. Taylor, S., Klien, C., Lewis, B., Gruenewald, T., Gurung, R., & Updegraff, J. (2000). Biobehavioral responses to stress in females: Tend-and-befriend, not fight-or-flight. Psychological Review, 107, 411-429.
Tedeschi, R., & Calhoun, L. (1995). Trauma and transformation: Growing in the aftermath of suffering. Thousand Oaks, CA: Sage. Tedeschi, R., Park, C., & Calhoun, L. (Eds.). (1998). Posttraumatic growth: Positive changes in the aftermath of crisis. Mahwah, NJ: Erlbaum. Tegmark, M. (2015). Consciousness as a state of matter. Quantum Physics, Vol 3, Cornell University Library. Retrieved from Internet: arxiv.org/pdf/1401.1219v3.pdf Tervaniemi, M., IIvonen, T. Karma, K., Albo, K, & Naatanen, R. (1997). The musical brain: Brain waves reveal the neurophysiological basis of musicality in human subjects. Neuroscience Letter, 226(1), 1-4. Thomas, E. (1934). The fire walk. Proceedings of the Society for Psychological Research, 42, 292-309.
Tomasian, D., Keaney, J., & Vita, J. (2000). Antioxidants and the bioactivity of endothelium-derived nitric oxide. Cardiovasc Res, 47(3), 426-435. Tseng, L., Mazella, J., Goligorsky, M., Riaias, C., & Stefano, G. (2000). Dopamine and morphine stimulate nitric oxide release in human endometrial glandular epithelial cells. J of the Society for Gynecologic Investigation, 7, 343-347. Van Diest, I., Proot, P., Van De Woestijne, K., Han, J., Devriese, S., Winters, W., Van, D., & Bergh, O. (2001). Critical conditions for hyperventilation responses: The role of autonomic response propositions during emotional imagery. Behav Modif, 25(4), 621-639. Van Pragg, H., Shubert, T., Zhao, C., & Gage, F. (2005). Exercise enhances learning and hippocampal neurogenesis in aged mice. J Neurosci, 25, 8680-8685.
van der Zwan, J., de Vente, W., Huizink, A., Bögels, S., & de Bruin, E. (2015). Physical Activity, Mindfulness Meditation, or Heart Rate Variability Biofeedback for Stress Reduction: A Randomized Controlled Trial. Appl Psychophysiol Biofeedback. Jun 26. [Epub ahead of print]. Retrieved from Internet: http://www.ncbi.nlm.nih.gov/pubmed/26111942 VanderArk, S., & Ely, D. (1992). Biochemical and galvanic skin responses to music stimuli by college students in biology and music. Perceptual Motor Skills, 74, 1079-1090. VanDyche, D. (2015). Speaking in tongues (Glossolalia): A theory of hemispheric proportion. Kindle Edition. Seattle, WA: VanDyche Publishing. Varela, F. (1996). Neurophenomenology. Journal of Consciousness Studies, 3(4), 330-348.
Varela, F., & Shear, J. (1999). First-person methodologies: What, why, how? Retrieved from Internet: http://www.imprint.co.uk/pdf/VFW_introduc.pdf. Villoldo, A., & Krippner, S. (1987). Healing states: A journey into the world of spiritual healing and Shamanism. New York, NY: Touchstone. Wade, J. (1996). Changes of mind: A holonomic theory of the evolution of consciousness. Albany, NY: State University of New York Press. Walston, R. (2003). The speaking in tongues controversy: The initial, physical evidence of the Baptism in the Holy Spirit debate. Maitland, FL: Xulon Press.
Watkins, L., & Mayer, D. (1986). Multiple endogenous opiate and nonopiate analgesia systems: Evidence of their existence and clinical implications. In D. Kelly. (Ed.). Stress-induced analgesia (p. 273-299). New York, NY: New York Academy of Sciences. Weiser-Cornell, A. (1996). The power of focusing: A practical guide to emotional self-healing. Oakland, CA: New Harbinger Publications, Inc. Weitzberg, E., & Lundberg, J. (2002). Humming greatly increases nasal nitric oxide. Am J Respir Crit Care Med, 166, 144-145. Wilber, K. (2002). The spectrum of consciousness. Boston, MA: Shambhala Press. Wilber, K. (2004). The simple feeling of being: Embracing your true nature. Boston, MA: Shambhala Press.
Willet, W. (2002). Balancing life-style and genomics research for disease prevention. Science, 296, 695-698. Wilson, D., & Yan, X. (2010). Sleep-like states modulate functional connectivity in the rat olfactory system. J. Neurophysiol, 104(6), 3231-3239. Wilson, M. (2002). Six views of embodied cognition. Psychonomic Bulletin Review, 9, 625-636. Wollin, S., & Jones, P. (2003). Alpha-lipoic acid and cardiovascular disease. J Nutr, 133(11), 3327-3330. Women’s Health Encyclopedia. (2012, Nov.12). Best foods containing nitric oxide. Women’s Health Topics. Retrieved from Internet: http://womenshealthency.com/articles/best-foods- containing-nitric-oxide/ Wright, P. (1994). A psychobiological approach to shamanic altered states of consciousness. ReVision, 16(4), 164-172.
Wright, R. (2007). Stress related health disparities in African American communities: Can Open Focus provide a modicum of ameliorative stress relief? (Unpublished Master’s Thesis). Montpelier, VT: Union Institute & University. Wright, R. (2012). The role of endogenous cyclic nitric oxide spiking in Motherloss and Existential grief recovery: A modified neuropsychological and psychophysiological Heuristic Self Search Inquiry approach to stress reduction, homeostasis and healing. (Doctoral Dissertation). Retrieved from ProQuest: http://gradworks.umi.com/35/39/3539752.html Wright, R. (2013). Orgasmic relaxation: Unleash the power of your mind to relax using the Tension Relieving Technique (TRT). Sunrise, FL: Quiet Lake International, LLC. Wright, R. (2014). 7 steps for avoiding stress burnout for busy entrepreneurs. Sunrise, FL: Quiet Lake International, LLC.
Wynn-Williams, G. (1992). The fullness of space. Cambridge, UK: Cambridge University Press. Young, L., Chen, Q., & Weis, M. (2011). Direct measurement of hydrogen peroxide (H2O2) or nitric oxide (NO) release: A powerful tool to assess real-time free radical production in biological models. American Journal of Biomedical Sciences, 3(1), 40-48. Zicker, J., Zicker, D., Jatzko, A., Dietzsch, J., & Nieselt, K., Schmitt, A., Bertsch, T., Fassbender, K., Spanagel, R., Northoff, H., & Gebicke-Haerter, P. (2007). Differentiated gene expression in peripheral blood of patients suffering from post- traumatic stress disorder. Mol Psychiatry, 12, 116-118. Zusne, L., & Jones, W. (1989). Anomalistic psychology: A study of magical thinking. (2nd ed.). Hillsdale, NJ: Lawrence Erlbaum Associates.
Nitric Oxide Spiking and Consciousness A Presentation by Robert Wright, Jr., Ph.D, COFT Consciousness Society Conference Yale University New Haven, CT June 5, 2015
Although nitric oxide (NO) has been researched intensively by the scientific community, a little known aspect is that NO spiking underlies shifts in Consciousness. Since ancient times, men and women have sought to achieve what we refer to as altered states of consciousness (ASC) to access, explore, and experience multiple realms of awareness and statebound knowledge including Stillpoints, self and other compassion, as well as states of illumination, transcendence, “Oneness” or “Unity.”
A little studied feature of nitric oxide spiking is that it occurs co-terminously with whole brain synchronous states and whenever a Relaxation Response is generated. Although typically measured quantitatively, NO can also be experienced qualitatively, as bodily feltsense phenomena. The Biosonic Otto 128 Hertz kinesthetic tuning fork has demonstrated its ability to consistently spike nitric oxide, subsequently creating a Relaxation Response and corresponding potentials for Whole Brain Synchrony.
In this presentation, Dr. Wright will share his views on how tuning forks and other qualitative methods work to directly and indirectly spike NO for healthy well being. Learn how you can become more qualitatively aware of ASC shifts in your own Consciousness and flexibly modify your attentional focus via tuning into your bodily feltsense by achieving a consistently beneficial elevated Relaxation Response that also dissolves stress, anxiety and chronic pain.
Robert Wright, Jr., Ph.D., COFT
www.StressFreeNow.info Robert Wright, Jr., Ph.D., COFT is an author, speaker, and Stress Management Wellness Coach. His passionate goal is translating the significance and implications of scholarly stress and nitric oxide spiking research into language and practical techniques which can improve the healthy well- being of the general public. Dr. Wright's most recent book is entitled 7 Tips for Avoiding Stress burnout for Busy Entrepreneurs and he is the author of the forthcoming book Nitric Oxide Spiking: Your Key to Well Being. You can learn more about how to reduce your stress by listening to his popular podcast series at www.StressFreeNow.info/category/podcasts/
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Consciousness Society Conference Presentation: Nitric Oxide Spiking and Consciousness

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Consciousness Society Conference June 3-5, 2015 Yale University, New Haven, CT Although nitric oxide (NO) has been researched intensively by the scientific community, a little known aspect is that NO spiking underlies shifts in Consciousness. Since ancient times, men and women have sought to achieve what we refer to as altered states of consciousness (ASC) to access, explore, and experience multiple realms of awareness and statebound knowledge including Stillpoints, self and other compassion, as well as states of illumination, transcendence, “Oneness” or “Unity.” A little studied feature of nitric oxide spiking is that it occurs co-terminously with whole brain synchronous states and whenever a Relaxation Response is generated. Although typically measured quantitatively, NO can also be experienced qualitatively, as bodily feltsense phenomena. The Biosonic Otto 128 Hertz kinesthetic tuning fork has demonstrated its ability to consistently spike nitric oxide, subsequently creating a Relaxation Response and corresponding potentials for Whole Brain Synchrony. In this presentation, Dr. Wright will share his views on how tuning forks and other qualitative methods work to directly and indirectly spike NO for healthy well being. Learn how you can become more qualitatively aware of ASC shifts in your own Consciousness and flexibly modify your attentional focus via tuning into your bodily feltsense by achieving a consistently beneficial elevated Relaxation Response that also dissolves stress, anxiety and chronic pain.

Robert Wright, Jr.
Robert Wright, Jr.Stress Free Now

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Consciousness Society Conference Presentation: Nitric Oxide Spiking and Consciousness

  • 1. Nitric Oxide Spiking and Consciousness Robert Wright, Jr., PhD, COFT Consciousness Society Conference Yale University New Haven, CT, June 5, 2015 Copyright © 2015 All Rights Reserved www.StressFreeNow.info
  • 3. A Special Thank You To Alan Leslie Combs, Ph.D. Doshi Professor of Consciousness Studies Director, CIIS Center for Consciousness Studies Founder, Consciousness Society Director, Conscious Evolution M.A. Program Graduate Institute of Connecticut. John Beaulieu, N.D., Ph.D. CEO, Biosonics Incorporated NYS Licensed Counselor/Psychotherapist Board Certified Naturopathic Physician Adjunct Professor Integrative Health Studies Sound Healing Emphasis, CIIS
  • 4. Quotations The biggest deterrent to scientific progress is a refusal of some people, including scientists, to believe that things that seem amazing can really happen. ---George Trimble When the mind becomes attuned, it becomes capable of hearing the voice of the unknown. The sounds which are heard in such a state do not belong to any particular language, religion or tradition. ---Swami Rama After silence that which comes nearest to expressing the inexpressible is music. ---Aldous Huxley
  • 5. Quotations The “problem” of consciousness—and its attendant “problem,” the nature of reality…marks the frontier of human exploration, a frontier that we may never fully conquer….But what makes solving the problem of consciousness so compelling is essentially personal: it would bring meaning for each one of us. It would answer those gnawing existential questions about who we are, how the world works, and what is “real.”….Are we alone in our own solipsistic world, or is the experience of consciousness something we share with those we are pleased to consider sentient beings?....Or is it the very fabric of the cosmos, the Absolute? --Jenny Wade, p. xiii-xiv, Forword, In Alan Combs (2009), Consciousness Explained Better
  • 6. What Is Nitric Oxide? • In 1998, Robert F. Furchgott, Louis J. Ignarro, and Ferid Murad were awarded a Noble Prize in Medicine or Physiology for their nitric oxide research (Geneeskd, 1998). • Nitric oxide is a gas with the chemical formula NO. • Serves as a signaling molecule in mammals including humans. • Is a short lived endogenously produced gas. • Plays a primarily therapeutic role throughout the body. (Stefano, 2003; Stefano, & Magazine, 2001; Stefano, Benson, Frichionne, & Esch, 2005).
  • 7. What Is Nitric Oxide? • Discovered as a vasodilator working guanylate cyclase. • Operates as a free radical and free radical scavenger. • Exerts anti-viral properties. • Exerts anti-bacterial properties. • Central Nervous System (CNS) involvement. (Benz, Cadet, Mantinone, et al. 2002b; Shinde, Mehta, & Goyal, 2000).
  • 8. What Is Nitric Oxide • Can be a toxic air pollutant, e.g. car exhaust fumes. • Plays a major role in the regulation of blood pressure. • Helps prevent blood clotting. • Fast acting: Diffuses over 50uM in seconds. • Intra and intercellular signaling substance. (Benz, Cadet, Mantinone, et al. 2002a; Esch, Stefano, Fricchione, & Benson, 2002; Fricchione, & Stefano, 2005).
  • 9. Types of Nitric Oxide • There are three (3) forms of nitric oxide (NO): cNOS, eNOS, and iNOS. • The constitutive forms of NO (cNOS and eNOS) generally engender healing effects. • The inducible variety (iNOS) typically has a pro- inflammatory effect when certain events are triggered, e.g. chronic stressors. (Erez, Ayelet, et al., 2011; Esch, Stefano, Fricchione, & Benson, 2002; Fleshner, & Laudenslager, 2004 ).
  • 10. How Is Nitric Oxide Used? • Used extensively to treat various medical conditions. • Popular erectile dysfunction drugs such as Viagra, Cialis and Levitra work by regulating NO puffing. • Nitroglycerin ameliorates angina pain by supplying NO to the heart. • Controls the effects and activation of norephinephrine processes throughout the brain and CNS including synthesis, release and action potentials. (Stefano, 2003; Stefano, Fricchione, Slingsby & Benson, 2001; Tomasian, Keaney, & Vita, 2000; Young, Chen, & Weis, 2011).
  • 11. Importance of Nitric Oxide “[NO is] a major biological signaling pathway that has been missed with regard to the way it controls proteins….What we see now for the first time…is that there are enzymes that are removing NO from proteins to control protein activity. This action has a broad based effect, frankly, and probably happens in virtually all cells and across all protein classes. NO is implicated in many disease processes. Sepsis, asthma, cystic fibrosis, Parkinson’s disease, heart failure, malignant hyperthermia – all of these diseases are linked to aberrant NO based signaling” (Duke University Medical Center, 2008, May).
  • 12. Importance of Nitric Oxide • Protects your body and mind from disease, infections and inflammations caused by stress. • Synchronizes your internal cellular rhythms. • Scavenges free radicals in the body. • Promotes better vascular flow and a healthy heart. • Enhances cellular vitality and fluidity. (Beaulieu, 2005, 2009; Mantione, Cadet, & Zhu, 2008; Mata- Greenwood, & Chen, 2008; Samuelson, Foret, Baim, et al., 2010; Segerstrom, & Miller, 2004; Shinde, Mehta, & Goyal, 2000).
  • 13. What Is Nitric Oxide Spiking? • Ordinarily cells attempt to keep a state of balance and homeostasis by regulating their release of NO which is called “puffing” or known as spiking. • When we are “in rhythm” the body naturally produces NO inside vascular, nerve and immune cells. • When the NO system is functioning properly, release of NO is cyclic and autoregulatory; generally, this makes us feel good. • This cyclic nature enhances physical and emotional well being and proactively prevents illness and disease states. Scientists use the word “spiking” to describe any process that gets “flatlined” NO to “puff” again. When NO levels spike, you immediately feel relaxed. (Beaulieu, 2005, 2009, 2010; Stefano & Magazine, 2001).
  • 14. What Is Nitric Oxide Spiking? Endogenous nitric oxide spiking is sometimes referred to as “puffing.” This is gaseous NO in its cyclic and auto- regulatory form which usually takes place in a three (3) step wave phase: one ascending, a stillpoint (pause), another descending, which is a natural healing rhythm. The NO wave spike is short lived, approximately six (6) minutes in length. (Stefano, Salzet, & Magazine, 2003).
  • 15. Benefits of Nitric Oxide Spiking • Enhances cellular vitality. • Enhances vascular flow especially heart healing. • Boosts immune system by destroying bacteria and viruses at the micro level. • increases ability to prevent and fight infections. • Increases resistance to stress. • Increases resistance to pain in conjunction with endogenous morphine. (Long, Light, & Talbot, 1999; Lowson, 2003; MacMillan, 2012; Northrup, 2008; Pryor, Zhu, Cadet, et al., 2005).
  • 16. Benefits of Nitric Oxide Spiking • Increases energy levels. • Increases physical and mental stamina. • Sharpens mental clarity. • Diminishes states of depression due to balancing of the autonomic nervous system. • Improves digestion and natural cleansing. (Beaulieu, 2005; Benz, Cadet, Mantione, et al., 2002; Dusek, Chang, Zaki, et al., 2006; Elam, R., et al., 1989; Guoyao, & Meininger, 2000; Guoyao, & Morris, 1998).
  • 17. Nitric Oxide Wave Spiked by EnRhythm
  • 18. EnRhthym Nitric Oxide Wave Spiking Explanation Nitric oxide is a molecule created by a nitrogen atom bound to an oxygen atom. It is made in our cells and released into the surrounding tissues as a gas. The release of nitric oxide by our cells is termed puffing by scientists to describe the rising and falling of this gas. The puffing cycle is like a wave which takes three minutes to rise and three minutes to fall. The rising phase of the wave is the release of nitric oxide which sends a signal to our cells to relax. During the falling phase of the wave nitric oxide dissipates and our cells become more active. The calm between the rising and falling we call still point. --John Beaulieu, 2010, Nitric Oxide and Tuning Forks, Biosonics, Inc.
  • 19. What Is Nitric Oxide Flatlining? • When NO production diminishes or stops completely, this is known as “flatlining.” • Typically this means the NO rhythm has been compromised, often due to unresolved stress or trauma. • Dysfunctional NO production leads to depressed immune system function. • We feel pain or distress. • Flatlined NO may be the body’s cellular response to psychological and physiological stress and stressors in the environment. (Beaulieu, 1987, 2005, 2009, 2010; Esch & Stefano, 2010).
  • 20. What Is Nitric Oxide Flatlining? • Flatlined NO may be the body’s cellular response to psychological and physiological stress and stressors in the environment. • The main cause of flatlining is unresolved stress and trauma. • Over time, flatlining leads to pro-inflamation and depressed immune function which can result in tissue pathology. (Beaulieu, 2005; Simpkiss, & Devine, 2002; Stefano, & Magazine, 2001; Tseng, Mazella, Goligorsky, et al., 2000; Tomasian, Keaney, & Vita, 2000; Wright, 2012).
  • 21. Consequences of NO Flatlining? Endogenous nitric oxide flatlining is a state where the cyclic constitutive NO wave is dormant. This is often experienced as pain and/or distress. Chronic flatling may lead to a pro- inflammatory response, triggering release of iNOS which if unabated, may lead to illness and/or disease states. (Beaulieu, 2009; Esch, & Stefano, 2010; Fricchione, & Stefano, 2005).
  • 22. Consequences of NO Flatlining
  • 23. Major Disease Byproducts of NO Flatlining • Alzheimer’s disease • Autoimmune Disorders • Motor Neuron Disease • Cancer • Erectile Dysfunction (Beaulieu, 2010, 2005; Erez, Ayelet, et al. 2011; Esch, Stefano, Fricchione & Benson, 2002).
  • 24. Major Disease Byproducts of NO Flatlining • Diabetes • Depression • Stroke • Heart Attack • Arteriosclerosis (Kal, Van Wezel, Porsius, et al., 2000; Mantione, Cadet, Zhu, et al., 2008; McEwen, 2000; Salamon, Kim, Beaulieu, & Stefano, 2003) ; Seidler, Uckert, Waldkirch, et al., 2002).
  • 25. Extreme Nitric Oxide Flatlined Visual
  • 26. How Does Nitric Oxide Work? There are three cell types that are especially controlled by nitric oxide: immune cells, nervous system cells, and the cells that line blood vessels, which are called endothelial or vascular cells. The shape of immune cells changes in the blood stream in response to signals of inflammation. In the normal state, immune cells are round and roll along the lining of blood vessels, not sticking to any of the vascular cells for long. If there is a stress or inflammation present, the cells begin to flatten and become sticky. To make them un-stick and become round again, the immune cells and vascular cells both produce a low level of nitric oxide all the time. As long as they can do this for long enough, the immune cells un-stick and roll away. If nitric oxide release is inhibited, the immune cells begin to invade between the vascular cells and more inflammatory signals are produced. To make matters worse, the immune and vascular cells make one more attempt to release nitric oxide to restore the calm state. At higher levels, however, the nitric oxide itself causes damage to the cells. --John Beaulieu, 2011 (www.biosonics.com/uploads2011/CyclicNitricOxide.pdf)
  • 27. How Does Nitric Oxide Work? NO secretions take place in a two step phase, one ascending, the other descending: “During the ascending phase of NO release the basal levels of NO may inhibit cellular activity by reducing changes in cell conformation by inhibition of actin polymerization, inactivation of NFkB, inhibition of cell adhesion, and hyperpolorization of post synaptic membranes. The descending phase of NO release may promote cell shape changes by allowing actin polymerization, depolarization, and NFkB signaling” --Stefano, Salzet, & Magazine, 2002
  • 28. Relaxation Response • A protective mechanism which counteracts stress. • Physiologic counterpart to the “fight or flight” stress response. • Beneficial decreases in metabolism. • Beneficial decreases in blood pressure. • Beneficial decreases in breathing rate. • Beneficial decreases in anxiety. (Benson, 1983, 1997; Benson & Proctor, 2011; Dusek, Chang, Zaki, et al., 2006; Dusek, Out, Wohlhueter, et. al., 2008; Morita, Saito, Ohta, et al., 2005; Nakao, Myers, Fricchione, et al., 2001; Pillay, 2010, 2011).
  • 29. Relaxation Response • Beneficial decreases in heart rate. • Reductions in psychological distress. • Reductions in chronic pain. • Beneficial decreases in sympathetic nervous system reactivity. • Beneficial increases in parasympathetic system reactivity. • Increases in awareness. (Epel, Blackburn, Lin, et al., 2004; Esch, Fricchione, & Stefano, 2003, 2005; Fields & Levine, 1984; Fleshner & Laudenslager, 2004; Halpern & Savary, 1985; McKinney, Antoni, Kumar, et al., 1997; Willet, 2002).
  • 30. Relaxation Response • Nitric oxide spiking. • Endogenous morphine spiking. • Increases potential for whole brain synchrony. • Increases capacity for self and other compassion. • Beneficial changes in gene activity opposite those associated with stress. (Iwanaga & Tsukamoto, 1997; Jacobs, Epel, Lin, et al., 2011; Kal, Van Wezel, Porsius, et al., 2000; Kim, Koo, Lee, & Han, 2005; Lazar, Bush, Gollub, et al., 2000; Lazar, Kerr, Wasserman, et. al., 2005; Wright, 2012, 2013).
  • 31. Benefits of Generating a Relaxation Response by Spiking Nitric Oxide • Provides a boost to immune system functioning, helping the body to ward off sickness and disease • Significantly lowers blood pressure. • Measurable improvements to circulatory and vascular systems. • Enhances mental clarity. • Provides boosts to abstract and spatial memory. (Beary, & Benson, 1974; Benson, 1983, 1997; Benson, & Proctor, 2011; River, 1998; Salamon, Esch, & Stefano, 2006).
  • 32. Benefits of Generating a Relaxation Response by Spiking Nitric Oxide • Enhances ability to concentrate for goal attainment. • Beneficial increases in sympathetic nervous system responsiveness with resultant improvements in stress hardiness. • Helps to prevent acute stressors from accumulating as debilitating chronic stress. • Improvements in mood and overall sense of well being. (Beaulieu, 2005, 2009, 2010; Fleshner, & Laudenslager, 2004).
  • 33. Benefits of Generating a Relaxation Response by Spiking Nitric Oxide • Underlies neuroendocrine release for “Flow” states for Peak Performance and Peak Experience. • Neutralizes the harmful effects of over arousal whereby excess amounts of cortisol and adrenaline can damage to the body. • Reduction of chronic pain as well beneficial epigenetic changes to DNA including reshaping amgydala fear reactivity. (Pryor, Zhu, Cadet, et al., 2005; Salamon, Esch, & Stefano, 2006; Salamon, Kim, Beaulieu, & Stefano, 2003).
  • 34. Relationship Between Endogenous Cyclic Nitric Oxide Spiking and Endogenous Morphine Spiking It has been more than 30 years since morphine was discovered to be an endogenous signal molecule in the body. Since then, the word ‘endorphin’ has been adopted as an abbreviation of ‘endogenous morphine,’ referring to both morphine peptides and morphine itself. Endogenous opiates are released via the descending corticospinal tract, allowing for the body to mediate its own analgesia. Osteopathic manipulative therapy (OMT) has been found to initiate release of nitric oxide (NO), endogenous morphine’s second messenger in the body. Petrozzo et al., 2014 http://www.practicalpainmanagement.com/treatments/pharm acological/opioids/role-endogenous-morphine-nitric-oxide- pain-management
  • 35. Symptoms Nitric Oxide Spiking Helps Alleviate • Aches & Pains • Headache • Inability to Control your Temper • Insomnia • Lack of Energy • Loss of Appetite
  • 36. Symptoms Nitric Oxide Spiking Helps Alleviate • Low Back Pain • Low Mood • Migraine Headache • Neck Pain • Overeating • Undue Worry
  • 37. Sample Conditions Caused or Aggravated by Stress Which Are Helped by NO Spiking • Anxiety • Asthma • Autoimmune Diseases • Cardiovascular Disease • Chronic Pain • Constipation • Diabetes • Diarrhea • Heartburn • High Blood Pressure
  • 38. Sample Conditions Caused or Aggravated by Stress Which Are Helped by NO Spiking • Infertility • Insomnia • Loss of Sex Drive • Obesity • Skin Problems, e.g. Hives or Eczema • Stroke • Substance Abuse • Ulcers • Weight Gain or Weight Loss
  • 39. What Is Consciousness? Although problematic, consciousness has been defined by some as the state or quality of awareness of an external object or something within oneself. There is no agreement within the scholarly or scientific communities as to what consciousness is or might be or whether it is essential, luminous, numinous, transcendent or illusory. The conceptual, theoretical, and paradigmatic disagreements and arguments about the true nature of consciousness are vociferous, steadfastly held positions, and often epistemologically, ontologically and teleologically polar opposite perspectives.
  • 40. Sample Areas of Disagreement • Mutually Exclusive Definitions of Consciousness • Proof of Existence of Consciousness • Mutually Exclusive Definitions of Being • Mind-Body Duality Problem • Hard Problem of Consciousness
  • 41. Sample Areas of Disagreement • Neural Correlates of Consciousness • Philosophy of Mind Issues • Existence/Non-Existence of a Quantum Mind • Solipsism • Role of the Unconscious in Consciousness • Existence/Non-Existence of Spirit
  • 42. Consciousness Controversies “Why can’t the worlds greatest minds solve the mystery of consciousness?: Philosophers and scientists have been at war for decades over the question of what makes human beings more than complex robots.” Oliver Burkeman, Jan. 21, 2015 http://www.theguardian.com/science/2015/jan/21/-sp- why-cant-worlds-greatest-minds-solve-mystery- consciousness
  • 43. Consciousness Controversies • Dangerous ideas debate with Richard Dawkins and Deepak Chopra from The Chopra Well: https://www.youtube.com/watch?v=6C1P1idmfUM • The War On Consciousness: The Talk That Gave TED Indigestion by Graham Hancock: http://www.grahamhancock.com/forum/HancockG6- TheWarOnConsciousness.php. • Capriles, E. (2009). Beyond Mind III: Further Steps to a Metatranspersonal Philosophy and Psychology. (Continuation of the Discussion on the Three Best Known Transpersonal Paradigms, with a Focus on Washburn and Grof). International Journal of Transpersonal Studies, 28(2), 1-145.
  • 44. Consciousness Controversies • Is There A Scientific “Taboo” Against Parapsychology? Claims about the "taboo" status of parapsychology lack substance by Scott McGreal: https://www.psychologytoday.com/blog/unique-everybody- else/201401/is-there-scientific-taboo-against-parapsychology • Cardeña, E. (2014). A call for an open, informed study of all aspects of consciousness. Frontiers in Human Neuroscience, 8(17), 1-4. • Combs, A. (2009). Consciousness explained better: Towards an integral understanding of the multifaceted nature of consciousness. St. Paul, MN: Paragon House.
  • 45. Consciousness Controversies • Cardeña, E. (2011). On wolverines and epistemological totalitarianism. J Sci Explor, 25, 539-551. • Fields, C. (2013). A whole box of Pandoras: Systems, boundaries and free will in quantum theory. Journal of Experimental & Theoretical Artificial Intelligence, 25(3), 291-302. DOI: 10.1080/0952813X.2013.782981. • Paller, K. & Sukuki, S. (2014). The source of consciousness. Trends in Cognitive Sciences, 18(8), 387- 389. DOI: http://dx.doi.org/10.1016/j.tics.2014.05.012
  • 46. Neurophysiological Consciousness Controversy At this point, we would like to raise the following philosophical question: what is the relationship between the mental concept of subjective experience and the concepts or terms we use to describe the organization and function of the brain? This seems to be an important question as our mental categories are essentially responsible for the interpretation of physiological findings and thus form our picture of the mechanisms of the brain. Hinterberger, Zlabinger, & Blaser, 2014. DOI: 10.3389/ fnhum.2014.00637
  • 47. What Is Attention? In the context of human information processing, attention is the process that, at a given moment, enhances some information and inhibits other information. The enhancement enables us to select some information for further processing, and the inhibition enables us to set some information aside (Stanford, 2006, p. 103). http://wwwpsych.stanford.edu/~ashas/Cognition%20Text book/chapter3.pdf
  • 48. What Is Attention? • Orienting to sensory events • Detecting signals for focused processing • Maintaining a vigilant or alert state • Endogenous & exogenous attentional processing in time and space • Cocktail party effect • Motion induced blindness (Behrmann, Geng, & Shomstein, 2004; Gopher, 1993; Hirst, 1986; Paller & Suzuki, 2014; Stanford, 2006; Styles, 2005).
  • 49. Attentional Quotation Humans were never meant to see the world through a lens of chronic fear or other negative emotions. We were meant to experience the world directly as it is. We were meant to form deep connections to other human beings. With attention training…we can open our hearts to experience the fullness of our senses, and reconnect with forgotten parts of ourselves. We can experience moments of unity and transcendence and find the world has been reenchanted. It will be a watershed moment in human evolution when we are able to pay attention to how we pay attention, control our attention, and take personal responsibility for the creation of our own realities. --Fehmi and Robbins 2007, p. 8
  • 50. Styles of Attention • According to Dr. Les Fehmi of the Princeton Biofeedback Centre there are four main types of attention: • Diffuse • Narrow • Objective • Immersed Fehmi & Robbins, 2007, p. 46-47
  • 51. Whole Brain Synchrony Viewed as a Way of Paying Attention • Experience of whole brain synchronization enhances healthy well being. • Open Focus is one way to achieve whole brain synchrony without equipment. • Prolonged and excessive stress can negatively impact almost every aspect of your life. • Maintaining a narrow focused attentional style for long periods often leads to chronic stress and pain, and left unattended to, turns into disease states. • Developing attentional flexibility gives you the capacity to enter a beneficial homeostatic state of whole brain synchronization volitionally.
  • 52. Whole Brain Synchrony • Parts of brain begin to work together harmoniously. • Brain resonance where neurons vibrate at the same frequency. • Neural pathways tend to fire more rapidly. • Brainwave patterns are “in phase” or in synchronized • Also known as “Whole Head Synchrony” or “Whole Brain Functioning” or “Hemispheric Synchronization” or “Whole Brain Synchronization” (Fehmi & Robbins, 2007). (Lutz, Lachaux, Martinerie, & Varela, 2002; Lutz, Greischar, Rawlings, et al., 2004)
  • 53. Why Whole Brain Synchrony is a Desired and Sought After State • Increased Creativity • Increased Insight • Increased Intuition • Increased Relaxation Response • Increased Accelerated Learning Abilities • Increased Parasympathetic Nervous System Reactivity (Buzsaki, 2006; Damasio, 1990; Fujisawa, & Busaki, 2011; Glaser, Brind, Vogelman, et al., 1992; Gold, 1999; Goleman, 1988; Gruzelier, & Egner, 2005; Gruzelier, Egner, & Vernon, 2006).
  • 54. Whole Brain Synchrony as a Desired and Sought After State • Increased Mental Clarity. • Increased Ability to Problem Solve. • Increased Self Compassion. • Increased Other Compassion. • Increased Empathy. • Decreased Sympathetic Nervous System Reactivity. (Haig, De Pascalis & Gordon, 1999; Hammond, 2000; Hanajima, Terao, Hamada, et al., 2009; Hinterberger, Zlabinger, & Blaser, 2014; Hutchison, 1996; Jacobs, Epel, Lin, et al., 2011).
  • 55. Elements of Peak Performance • State where individual performs to the maximum of her ability. • Enhanced level of self awareness. • High levels of confidence and focused concentration upon task completion. • Accomplishment is effortless. • Individual experiences a “flow” state or being “in the zone of excellence.” (Belluscio, M., Mizuseki, K., Schmidt, et al., 2012; Brown, & Gerbarg, 2005; Craqq, 2006; Csikszentmihalyi, 1991, 1997; Draganski, Gaser, Kempermann, et al., 2006; Pillay, 2010; 2011 ).
  • 56. Elements of Peak Experience • Transpersonal and ecstatic state. • Sense of Unity, Oneness and Awe. • Sense of interconnectedness. • Time perception may be altered to witness time elongation, time quickening and/or timelessness. (Barušs, van Lier, & Ali, 2014; Bird, B., Newton, Sheer, & Ford, 1978a&b; Damasio, 1999; Farrer, & Frith, 2002; Fisher, 1971, 1973).
  • 57. Elements of Peak Experience • Altered State of Consciousness (ASC). • Therapeutic increases in creativity, compassion for self and others, and personal locus of control (stress reduction). • Self actualization state or individuation (Maslow Level 5). • Personal growth, intrinsic meaning and purpose. (Gelhorn, 1970; Gendlin, 1981; Genz, 1999; Goodman, & Nauwald, 2003; Goodman, 1990; Grof, & Grof, 2010; Lilly, 1977; Maslow, 1971; Momen, 1984; Monroe, 1992; Palmer, 1998).
  • 59. Sample Methods for Spiking Nitric Oxide • Ritual Body Postures • Humming • Drumming • Dietary Supplements • Medications, e.g. Viagra, Ciallis, Levetra • Aromatherapy • Meditation • Neurofeedback (Beaulieu, 2005; Dusek, Chang, Zaki, et al., 2006; Dusek, Hibberd, Buczynski, et al., 2008; Dusek, Otu, Wohlhueter, et al., 2008; Goodman, 1990; Goodman & Nauwald, 2003; Gore, 1995; Maniscalco, Sofia, Weitzberg et al., 2004; Tervaniemi, IIvonen, Karma, et al., 1997).
  • 60. Sample Methods for Spiking Nitric Oxide • Foods • Yoga • Osteopathic Manipulative Therapy (OMT) • Open Focus • Music Therapy • Exercise • Sunlight (Banth & Arderbil, 2015; Fehmi & Robbins, 2007; Liu, Fernandez, Lang, et al., 2013; McKinney, Tims, Kumar, & Kumar, 1997; Mullooly, Levin, & Feldman, 1988; Narin, Pinar, Erbas, et al., 2003; Petrozzo, Mohr, Mantione, & Goldstein, 2014; Salamon, Kim, Beaulieu, & Stefano, 2003; Women’s Health Encyclopedia, 2012).
  • 61. Quotation BioSonic research conducted at Cell Dynamics, Inc. demonstrates the release of Nitric Oxide (NO) from various tissue sources. Utilizing an amperometric detection system, allowing only nitric oxide to generate an upward deflection, we measure real-time NO release from living cells and demonstrate that the use the BioSonic Otto™ (128cps), OM Tuner™ (136.1cps) and Body Tuners™ (C256 & G384) tuning forks have the ability to release NO well above baseline pulsatile levels. The release of NO is visualized as a large peak of pure nitric oxide immediately following exposure of these tissues to the vibration/ sound of the tuning forks. Once NO is released it follows a well characterized signaling cascade, exhibiting established properties of NO. --John Beaulieu, 2009, p. 1
  • 62. Sample Methods for Spiking Nitric Oxide • Biosonic Tuning Fork Series: • Otto 128 • Otto 64 • Otto 32 • OM Tuner • C & G Body Tuners • Fibronacci Series (Beaulieu, 1987, 2005, 2009, 2010; Biosonics, Inc., 2010).
  • 65. Comparison of Otto Tuning Forks 128 Hz and 64 Hz
  • 67. Biosonics OM Tuning Fork 136.1 Hz The Swiss scientist Hans Cousto, author of the Cosmic Octave, discovered how to convert planetary cycles into musical pitches. Using his system the sa corresponds to the sound of one Earth year of the time it takes the earth to circle the Sun. To arrive at the frequency of 136.1 Hz, an earth year is reduced to a second (frequencies are measured in cycles per second). An earth year is 365.242 days and an earth day is 86,400 seconds. When the days are multiplies by seconds the answer will be 315,567,925.9747 seconds equal one earth year. To arrive at an audible sound, 315,567,925.9747 seconds are divided into one (year) and then raised 32 octaves. The result will be the audible tone of answer 32 times the result will be 136.1 Hz. The cosmic note OM. (http://www.stressfreenow.info/products/index.php?)
  • 68. Biosonics OM Tuning Fork 136.1 Hz
  • 69. Biosonics OM Tuning Fork 136.1 HZ • Achieve a state of deep relaxation in seconds with the primordial vibrations of “Om”. • Physically tune your body to the Om vibration and enter a state of balanced wholeness ideal for healing and higher consciousness. • Helps center the body and mind when placed on the rib heads, thoracic vertebra, sternum, sacrum and illiums. • Helps meditators and yoga practitioners achieve desired states effortlessly. (http://www.stressfreenow.info/products/index.php?main_page =product_info&cPath=1&products_id=2)
  • 71. Flatlining – Spiking Pathways Nitric Oxide Flatlining Stress and Distress Chronic Pain Nitric Oxide Spiking Stress Reduction Pain Dissolves Homeostatasis Allostasis Healing
  • 72. Stress Interaction – Part 1 Category of Phenomena Distress Eustress Adrenaline Yes Depends Allostasis No Yes Allostatic Load Increased Diminished Cortisol Yes Diminished Dopamine Yes Depends Endogenous Morphine Yes Depends GABA Diminished Increased Grief Yes No
  • 73. Stress Interaction – Part 2 Category of Phenomena Distress Eustress Grief Recovery No Yes Homeostasis No Yes HPA Axis Diminished Increased Immune Response Increased Depends Nitric Oxide Flatlined Spiked Nor Adrenaline No Depends Oxytocin Depends Depends SAM Axis Increased Diminished Serotonin Diminished Increased
  • 74. Nitric Oxide Interaction – Part 1 Category of Phenomena Flatlining Spiking Adrenaline Yes Diminished Allostatic Load Increased Diminished Cortisol Yes Diminished Distress Yes No Dopamine Yes Implicit Endogenous Morphine Yes Implicit GABA Diminished Increased Grief Yes No
  • 75. Nitric Oxide Interaction – Part 2 Category of Phenomena Flatlining Spiking Grief Recovery No Yes Homeostasis No Yes (Increased) HPA Axis Diminished Increased Nor Adrenaline Increased Diminished Oxytocin Depends Depends SAM Axis Increased Diminished Serotonin Diminished Yes Immune Response Increased Depends
  • 76. Human Organization Stress Balancing System Homeostatic Balance Dynamic Balance Imbalance Eustress Acute Stress Chronic Stress Homeostasis Allostasis Distress Provides Pathways for Integrative and Holistic Healing Provides Pathways for Integrative and Holistic Healing Provides Pathways for Disease States and Illness Adapted from Stefano, Fricchiconne, and Esch (2006); Stefano et al. (2005).
  • 77. Ergotropic Pathway Tropotropic Pathway Hyperarousal Hyper- Stimulatory Levels of Statebound Experience Hypoarousal Hypo-Stimulatory Beta Brainwave State Routine Activity Ordinary Waking Consciousness Beta Brainwave State Hi Beta Brainwave State Excitement Daydreaming/Rel axation Hypnotic Trance Alpha Brainwave State High Beta Low Gamma Brainwave State Anxiety/Mania Hypnopompic/ Hypnogogic Imagery-Twilight State Theta Brainwave State Unknown Brainwave State Mystical Experience Ecstatic Trance Bidirectionality Abreaction Mystical Experience Deep Trance or Samadhi Delta Brainwave State Statebound Experience: Comparison of Ergotropic and Tropotropic Pathways Adapted from Fisher (1971, 1973, 1975); Momen (1984).
  • 78. State Bound Experiential Qualities NO Flatlining NO Spiking Fully Associated Mental Clarity Emotional Clarity Euphoria Mild Delirium Transpersonal Transcendent Experience Sense of Unity Grief/ Mourning/ Bereavement Yes No Yes No No No No No Stress Yes No Yes No No No No No Healing No Yes Yes Yes Yes Possible Possible Possible Dopamine Spike No Yes Yes Yes Yes Yes Yes No Oxytocin Spike No Yes Yes Yes Yes Yes Yes Yes Serotonin Spike No Yes Yes Yes Yes Yes Yes Possible Endorphin Spike No Yes Depends Yes Yes Yes Yes Possible Attention: Open Focus Global No Yes Depends Yes Yes Possible Possible Possible Pain Yes No Yes No No No No No Fear/Anxiety Yes No Yes No No No No No Lucid Dream State Unknown Unknown Depends Yes Depends Unknown Unknown Unknown
  • 79. Statebound Experience: SAM AXIS and HPA AXIS Relationships Ergotropic Pathway Tropotropic Pathway Hyperarousal Hyper-Stimulatory Hypoarousal Hypo-Stimulatory Grief Response: Distress, Pain, Anxiety, Fear Increases Relaxation Response/Eustress: Grief, Pain, Anxiety, Fear Dissolves SAM AXIS Reactivity Increases HPA AXIS Reactivity Increases NO Flatlining: Increased Cortisol; Decreased Dopamine/Serotonin NO Spiking/Endogenous Morphine Release Allostatic Loads Increase Allostasis/Homeostasis
  • 80. Comparative Still Point Induction Techniques “Chaotic Attractor” Technique Induces Still Point Rate of Induction Method Effects/Results Biosonic Otto 128Hz, 64Hz, 32Hz tuning fork Yes Immediate Kinesthetic Spikes NO cycle; boosts to immune function; spikes endogenous morphine; eliminates NO flatlining. Biosonic Otto 128Hz, 64Hz, 32Hz tuning fork Yes Immediate Auditory Sound Waves Spikes NO cycle; eliminates NO flatlining; boosts to immune function; spikes endogenous morphine. Open Focus Technique Yes Over Time as Proficiency is Achieved Auditory Verbal Objectless awareness in all sensory modalities, attending simultaneous to background and foreground globally; extreme mental clarity. Brain Pattern Interrupt Technique Yes Over Time as Proficiency is Achieved Olfactory Memory Resultant emotional and physical release phenomena disrupt negative valance memory patterns. Shift to positive energy valance can occur instantaneously or over time with repetition. Gamma Brainwave Holosync Yes Over Time as Proficiency is Achieved Auditory Sound Waves Attentional shift to states of self compassion and compassion for others: Sense of unity, oneness of being, transcendence; enhanced sense of Being. Standard Hypnosis Yes After Trance Induction Verbal Resultant reframing of negative memories into new behavioral flexibility; extinguishment of phobias or unwanted habits. Ericksonian Hypnosis Yes After Trance Induction Verbal Auditory Use of nonspecific and indirect metaphors results in reframe of negative memories into new behavioral patterns; extinguishment of unwanted behaviors; installation of new and desired behaviors and habits. Halpern Music Yes Repeated Listening Auditory Music Calming of sympathetic nervous system; boost to parasympathetic nervous system; state of relaxed reverie. Relaxation response induced.
  • 81. Comparative Still Point Induction Techniques “Chaotic Attractor” Technique Induces Still Point Rate of Induction Method Effects/Results Meditation Yes Over Time as Proficiency is Achieved Chant, Mantra, or Silence Long-term meditators report heightened mental and emotional clarity, sense of oneness, unity of Being, extreme states of compassion and transcendence. Flotation Tank Yes Over Time as Proficiency is Achieved Weight- lessness Systemic boost to HPA axis and simultaneous calming of SAM axis; expansive awareness of space, silence, and timelessness. Anechoic Chamber Yes Over Time as Proficiency is Achieved Complete Silence Long term users report awareness of nervous system sounds and induction of relaxation response phenomena. Focusing Yes After Repeated Use Bodily Felt Sense/Verbal Instructions Shift in Awareness Caused by consciously and conscientiously connecting with bodily Felt Sense Alternate Nostril Breathing Yes Immediate Modulation of Breath Immediate state change caused by deep diaphragmatic breathing. Biofeedback Yes Immediate Physiological Body Feedback Increased awareness and ability to modulate aspects of autonomic functions; with practice clients learn to volitionally make beneficial autonomic changes without equipment. Neurofeedback Yes Immediate Brainwave Feedback Increased awareness of brainwave patterns connected to thoughts; with practice clients learn to flexibly modulate brain wave patterns and volitionally modify internal processes without equipment. Holotrophic Breathwork Yes Immediate Modulation of Breath Wide range of breath techniques engenders rebirthing effect; including increased awareness of pre-natal and post-natal birth experiences.
  • 82. Comparative Still Point Induction Techniques “Chaotic Attractor” Technique Induces Still Point Rate of Induction Method Effects/Results Meditation Yes Over Time as Proficiency is Achieved Chant, Mantra, or Silence Long-term meditators report heightened mental and emotional clarity, sense of oneness, unity of Being, extreme states of compassion and transcendence. Flotation Tank Yes Over Time as Proficiency is Achieved Weight- lessness Systemic boost to HPA axis and simultaneous calming of SAM axis; expansive awareness of space, silence, and timelessness. Anechoic Chamber Yes Over Time as Proficiency is Achieved Complete Silence Long term users report awareness of nervous system sounds and induction of relaxation response phenomena. Focusing Yes After Repeated Use Bodily Felt Sense/Verbal Instructions Shift in Awareness Caused by consciously and conscientiously connecting with bodily Felt Sense Alternate Nostril Breathing Yes Immediate Modulation of Breath Immediate state change caused by deep diaphragmatic breathing. Biofeedback Yes Immediate Physiological Body Feedback Increased awareness and ability to modulate aspects of autonomic functions; with practice clients learn to volitionally make beneficial autonomic changes without equipment. Neurofeedback Yes Immediate Brainwave Feedback Increased awareness of brainwave patterns connected to thoughts; with practice clients learn to flexibly modulate brain wave patterns and volitionally modify internal processes without equipment. Holotrophic Breathwork Yes Immediate Modulation of Breath Wide range of breath techniques engenders rebirthing effect; including increased awareness of pre-natal and post-natal birth experiences.
  • 83. Stress-Anxiety-Physical Pain Scale Rate your current state on a scale from “0” to “10” “0” you feel great, have no pain, have no distress “10” you have unbearable pain and are in distress Category Stress Anxiety Physical Pain Mental Clarity Before After
  • 84. Benefits of Epigenetic Alterations of Mind-Body Equation Even if we have been set on high-reactive mode for decades or a lifetime, we can still dial it down. We can respond to life’s inevitable stressors more appropriately and shift away from an overactive inflammatory response. We can become neurobiologically resilient. We can turn bad epigenetics into good epigenetics and rescue ourselves. We have the capacity, within ourselves, to create better health. We might call this brave undertaking ‘the neurobiology of awakening’ (Nakazawa, 2015). http://aeon.co/magazine/psychology/how-childhood- biography-shapes-adult-biology/
  • 85. Benefits of Epigenetic Alterations of Mind-Body Equation Today, scientists recognise a range of promising approaches to help create new neurons (known as neurogenesis), make new synaptic connections between those neurons (known as synaptogenesis), promote new patterns of thoughts and reactions, bring underconnected areas of the brain back online – and reset our stress response so that we decrease the inflammation that makes us ill (Nakazawa, 2015). http://aeon.co/magazine/psychology/how-childhood-biography- shapes-adult-biology/
  • 86. Azam, M., Katz, J., Fashler, S., et al. (2015). Heart rate variability is enhanced in controls but not maladaptive perfectionists during brief mindfulness following stress induction: A stratified-randomized trial. International Journal of Psychophysiology, 96(3). Retrieved from internet: http://www.sciencedirect.com/science/article/pii/S0167876015 002159 and doi:10.1016/j.ijpsycho.2015.06.005 Banth S, Ardebil, M. (2015). Effectiveness of mindfulness meditation on pain and quality of life of patients with chronic low back pain. Int J Yoga, 8, 128-33. Retrieved from Internet: http://www.ijoy.org.in/text.asp?2015/8/2/128/1584 76 Barušs, I., van Lier, C., & Ali, D. (2014). Alterations of consciousness at a self-development. seminar: A Matrix Energetics seminar survey. Journal of Consciousness Exploration & Research, 5(11), 1064-1086. References
  • 87. Bawa, F., Mercer, S. Atherton, R., et al. (2015). Does mindfulness improve outcomes in chronic pain patients?: Systemic review and meta-analysis. The British Journal of General Practice, 65(635), e387-400. DOI: 10.3399/bjgp15X685297. Retrieved from Internet: http://www.ncbi.nlm.nih.gov/pubmed/26009534 Beary, J., & Benson, H. (1974). A simple psychophysiologic technique which elicits the hypometabolic changes of the relaxation response. Psychsom Med, 36, 115-120. Beaulieu, J. (1987). Music and sound in the healing arts. Barrytown, NY: Stanton Hill Press, Inc. Beaulieu, J. (2005). The rhythm of nitric oxide: How a tiny molecule determines your overall health. Kingston, NY: EnRhythm, LLC. Beaulieu, J. (2009). BioSonics, stress science, and nitric oxide literature review. Stone Ridge, NY: BioSonic Enterprises, Ltd.
  • 88. Beaulieu, J. (2010). Human tuning: Sound healing with tuning forks. Stone Ridge, NY: BioSonics Enterprises, Ltd. Behrmann, M., Geng, J., & Shomstein, S. (2004). Parietal cortex and attention. Current Opinion in Neurobiology, 14, 212-217. Belluscio, M., Mizuseki, K., Schmidt, R., Kempter, R., & Buzsaki, S. (2012). Cross-frequency phase-phase coupling between theta and gamma oscillations in the hippocampus. J Neurosci, 32(2), 423-435. Benson, H. (1983). The relaxation response: Its subjective and objective historical precedents and physiology. TINS, 6, 281- 284. Benson H. (1997). The relaxation response: Therapeutic effect. Science, 278, 1694-1695.
  • 89. Benson, H., & Proctor, W. (2011). Relaxation revolution: The science and genetics of mind body healing. New York, NY: Scribner. Benz, D., Cadet, P., Mantione, K., et al. (2002a). Tonal nitric oxide and health: A free radical and scavenger of free radicals. Med Sci Monit, 8(1), RA1-RA4. Benz, D., Cadet, P., Mantione, et al. (2002b). Tonal nitric oxide and health: Anti-bacterial and viral actions and implications for HIV. Med Sci Monit, 8(2), RA:27-31. Bergaust, L., Van Spanning, R., Frostegard, A., & Bakken, L. (2011). Expression of nitrous oxide reductase in Parracoccus denitrifications is regulated by oxygen and nitric oxide through FnrP and NNR. Microbiology, 158(Pt 3), 826-834. Bhatnagar, S., & Dallman, M. (1998). Neuroanatomical basis for facilitation of hypothalamic-pituitary-adrenal responses to a novel stressor after chronic stress. Neurosci, 84, 1025-1039.
  • 90. Biofeedback, (2011). What is biofeedback? Baltimore, MD: University of Maryland Medical Center. Retrieved from http://www.umm.edu/altmed/articles/biofeedback- 000349.htm. Biosonics, Inc. (2010). Tuning forks and miscellaneous information on nitric oxide spiking. Retrieved from http://www.biosonics.com. Bird, B., Newton, F., Sheer, D., & Ford, M. (1978a). Biofeedback training of 40 Hz. EEG in humans. Biofeedback & Self- Regulation, 3(1), 1-12. Bird, B., Newton, F., Sheer, D., & Ford, M. (1978b). Behavioral and electroencephalographic correlates of 40-Hz. EEG biofeedback training in humans. Biofeedback & Self-Regulation, 3(1), 13-28.
  • 91. Blakeslee, S., & Blakeslee, M. (2008). The body has a mind of its own: How body maps in your brain help you do almost everything better. New York, NY: Random House. Blood, A., & Zatorre, R. (2001). Intensely pleasurable responses to music correlate with activity in brain regions implicated in reward and emotion. PNAS, 98(20), 11818-11823. Blood, A., Zatorre, R., Bermudez, P., & Evans, A. (1999). Emotional responses to pleasant and unpleasant music correlate with activity in paralimbic brain regions. Nat. Neurosci., 2, 382-387. Brown, R., & Gerbarg, P. (2005). Yogic breathing and meditation: When the thalamus quiets the cortex and rouses the limbic system. Art of Living Foundation. Retrieved from http://www.aolresearch.org/other_research.html.
  • 92. Brownley, K., McMurray, R., & Hackney, A. (1995). Effects of music on physiological and affective responses to graded treadmill exercise in trained and untrained runners. International Journal of Psychophysiology, 19(3), 193-201. Burkeman, O. (2015, Jan. 21). Why can’t the world’s greatest minds solve the mystery of consciousness? TheGuardian.com. Retrieved from Internet: http://www.theguardian.com/science/2015/jan/21/-sp-why- cant-worlds-greatest-minds-solve-mystery-consciousness. Busch, N., Debener, S., Kranczioch, C., Engel, A., & Herrmann, C. (2004). Size matters: Effects of stimulus size, duration and eccentricity on the visual gamma-band response. Clinical Neurophysiology, 115(8), 1810-1820.
  • 93. Buttagat, V., Eungpinichpong, W., Chatchawan, U., & Kharmwan, S. (2011). The immediate effects of traditional Thai massage on heart rate variability and stress-related parameters in patients with back pain associated with myofascial trigger points. Journal of Bodywork and Movement Therapies, 15(1), 15-23. Buzsaki, G. (2006). Rhythms in the brain. New York, NY: Oxford University Press. Cicconi, R., Mariani, F., Cavone, A., Persichini, T., Venturini, G., Ongini, E., Colizzi, V., & Colasanti, M. (2004). Inhibitory effects of NO-releasing ciprofloxacin (NCX976) on mycobacterium tuberculosis survival. Antimicrob Agents Chemother, 48(1), 368. Clark, A. (1985). Psychological causation and the concept of psychosomatic disease. In D. Stalker & C. Glymour. (Eds.). Examining holistic medicine (p. 67-106). Buffalo, NY: Prometheus Press.
  • 94. Campisi, J., Leem, T., & Fleshner, M. (2002). Acute stress decreases inflammation at the site of infection: A role for nitric oxide. Physiology and Behavior, 77, 291-299. Cardeña, E. (2011). On wolverines and epistemological totalitarianism. J Sci Explor, 25, 539-551. Cardeña, E. (2014). A call for an open, informed study of all aspects of consciousness. Frontiers in Human Neuroscience, 8(17), 1-4. Centonze, D., Bracci, E., Pisani, A., Gubellini, P., Bernardi, C., & Calabresi, P. (2002). Activation of dopamine D1-like receptors excites LTS interneurons of the striatum. Eur J Neurosci, 15, 2049-2052. Collins, H. (2010). Tacit and explicit knowledge. Chicago, IL: University of Chicago Press.
  • 95. Combs, A. (2002). Radiance of being: Understanding the grand integral vision: Living the integral life. (2nd ed.). St. Paul, MN: Paragon House. Combs, A. (2009). Consciousness explained better: Towards an integral understanding of the multifaceted nature of consciousness. St. Paul, MN: Paragon House. Cotman, C., & Berchtold, N. (2002). Exercise: A behavioral intervention to enhance brain health and plasticity. Trends Neurosci, 25, 295-301. Craqq, S. (2006). Meaningful silence: How dopamine listens to Ach pause. Trends Neurosci. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/16443285 Crone, N., Sinai, A., & Korzeniewska, A. (2006). A high- frequency gamma oscillations and human brain mapping with electrocorticography. Prog Brain Res, 159, 275-95.
  • 96. Csikszentmihalyi, M. (1991). Flow: The psychology of optimal experience. (1st ed.). New York, NY: Harper Perennial. Csikszentmihalyi, M. (1997). Creativity: Flow and the psychology of discovery and invention. New York, NY: Harper Perennial. Csikszentmihalyi, M. (1991). Flow: The psychology of optimal experience. (1st ed.). New York, NY: Harper Perennial. Csikszentmihalyi, M. (1997). Creativity: Flow and the psychology of discovery and invention. New York, NY: Harper Perennial. Czachesz, I. (2008). Firewalking and the brain: The physiology of high-arousal rituals. In Bulbulia, J., Sosis, R., Harris, E., Genet, R., Genet, C., & Wyman, K. (Eds.). Evolution of religion: Studies, theories, and critiques (p. 189-195). Santa Monica, CA: Collins Foundation Press.
  • 97. Damasio, A. (1990). Synchronous activation in multiple cortical regions: A mechanism for recall. Seminars in the Neurosciences, 2, 287-296. Damasio, A. (1999). The feeling of what happens: Body and emotion in the making of consciousness. New York, NY: Harcourt Press. Darling, C. (1935). Firewalking. Nature, 136, 152. Diederich, N., & Goetz, C. (2008). The placebo treatments in neurosciences: New insights from clinical and neuroimaging studies. Neurology, 71(9), 677-684. Doidge, N. (2007). The brain that changes itself: Stories of triumph from the frontiers of brain science. New York: Penguin Books.
  • 98. Draganski B, Gaser C, Kempermann G, Kuhn, G., Winkler, J., Büchel, C., & May, A. (2006). Temporal and spatial dynamics of brain structure changes during extensive learning. J Neurosci, 26, 6314–6317. Driver, J., & Spence, C. (1998). Cross-modal links in spatial attention. Philosophical Transactions of the Royal Society of London, B, 353, 1319-1331. Drohan, M. (1999). From myth to reality: How music changes matter. Complementary Health Practices Review, 5, 25-33. Duke University Medical Center. (2008, May 23). Major ‘missed’ biochemical pathway emerges as important in virtually all cells. Science Daily. Retrieved from internet: http://www.sciencedaily.com/releases/2008/05/08052214520 9.htm.
  • 99. Dusek, J., Chang, B., Zaki, J., Lazar, S., Deykin, A., Stefano, G., Wohlhueter, A., Hibberd, P., & Benson, H. (2006). Association between oxygen consumption and nitric oxide production during the relaxation response. Med Sci Monit, 12(1), CR1- CR10. Dusek, J., Hibberd, P., Buczynski, B., Chang, B., Dusek, K., Johnson, J., Wohlhueter, A., Benson, H., & Zusman, R. (2008). Stress management versus lifestyle modification on systolic hypertension and medication elimination: A randomized trial. J Altern Complement Med, 14(2), 129-138. Dusek, J., Otu, H., Wohlhueter, A., Bhasin, M., Zerbini, L. Joseph, M., Benson, H., & Liberman, T. (2008). Genomic counter-stress changes induced by the relaxation response. PLoS One, 3(7), e2576. Eccleston, C., & Crombez, G. (1999). Pain demand attention: A cognitive affective model of the interruptive function of pain. Psychological Bulletin, 125, 356-366.
  • 100. Elam, R., et al. (1989). Effects of arginine and ornithine on strength, lean body mass and urinary hydroxyproline in adult males. J Sports Med Phys Fitness, 29(1), 52-56. Epel, E., Blackburn, E., Lin, J., Dhabhar, F., & Adler, N. (2004). Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci USA, 101, 17312-17315. Erez, A., et al. (2011). Requirement of argininosuccinate lyase for systemic nitric oxide production. Nature Medicine, 17, 1619– 1626. Esch, T., Guarna, M., Bianchi, E., Zhu, W., & Stefano, G. (2004). Commonalities in the central nervous system’s involvement with complementary medical therapies: Limbic morphinergic processes. Med Sci Monit, 10(6), MS6-17. PMID: 15173679. Esch, T., & Stefano, G. (2004). The neurobiology of pleasure, reward processes, addiction and their health implications. Neuroendocrinol Lett, 25(4), 235-251.
  • 101. Esch, T., & Stefano, G. (2005). The neurobiology of love. Neuroendocrinol Lett, 26(3), 175-192. Esch, T., & Stefano, G. (2010). The neurobiology of stress management. Neuro Endocrinol Lett, 31(1), 19-39. Esch, T., Fricchione, G., Stefano, G. (2003). The therapeutic use of the relaxation response in stress related diseases. Med Sci Monit, 9(2), RA23-RA34. Esch, T., Stefano, G., Fricchione, G., & Benson, H. (2002). Stress- related diseases: A potential role for nitric oxide. Med Sci Monit, 8(6), RA103-RA118. Farrer, C., & Frith, C. (2002). Experiencing oneself vs. another person as being the cause of action: The neural correlates of the experience of agency. Neuroimage, 15, 596-603.
  • 102. Fehmi, L., & Robbins, J. (2007). The open focus brain: Harnessing the power of attention to heal mind and body. Boston, MA: Trumpeter. Fehmi, L., & Robbins, J. (2010). Dissolving pain: Simple brain- training exercises for overcoming chronic pain. (Includes Dissolving Pain CD). Boston, MA: Trumpeter. Fisher, R. (1971). A cartography of ecstatic and meditative states. Science, 174, 897-904. Fisher, R. (1973). A cartography of the ecstatic and meditative states. Leonardo, 6(1), 59-66. Field, P. (1972). A quantitative ultra structural analysis of the distribution of amygdaloid fibers in the preoptic area and the ventromedial hypothalamic nucleus. Experimental Brain Research, 14(5), 527-538. Fields, C. (2013). A whole box of Pandoras: Systems, boundaries and free will in quantum theory. Journal of Experimental & Theoretical Artificial Intelligence, 25(3), 291-302. Retrieved from Internet: DOI: 10.1080/0952813X.2013.782981.
  • 103. Fields, H., & Levine, J. (1984). Placebo analgesia: A role for endorphins? Trends in Neuroscience, Aug., 27-29. Fleshner, M., & Laudenslager, M. (2004). Psychoneuroimmunology: Then and now. Behav Cogn Neurosci Rev, 3(2), 114-130. Foote, S., Bloom, F., Aston-Jones. G. (1983). Nucleus locus coeruleus: New evidence of anatomical and physiological specificity. Physiol Rev, 63, 844–914. Ford, M., Bird, B., Newton, F., & Sheer, D. (1980). Maintenance and generalization of 40-Hz EEG biofeedback effects. Biofeedback & Self-Regulation, 5(2), 193-205. Fricchione, G., & Stefano, G. (2005). Placebo neural systems: nitric oxide, morphine and the dopamine brain reward and motivation circuitries. Medical Science Monitor, 11(5), MS54- MS65.
  • 104. Fujisawa, S., & Busaki, G. (2011). A 4Hz oscillation adaptively synchronizes prefrontal, VTA, and hippocampal activities. Neuron, 72(1), 153-165. Genz, H. (1999). Nothingness: The science of empty space. (Karin Heusch, Trans.). Reading, MA: Perseus Books. Firewalking: Scientific tests. (1937). Nature, 139, 660. Fischl, B., & Dale, A. (2000). Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proc Natl Acad Sci USA, 97, 11050–5. Funderbank, J. (1977). Science studies of yoga: A review of the physiological data. Glenview, IL: Himalayan International Institute. Gelhorn, E. (1970). The emotions and ergotropic and trophotropic systems. Psychologische Forsching, 34, 68-94.
  • 105. Gendlin, E. (1981). Focusing. (2nd ed.). New York, NY: Bantam Books. Geneeskd, N. (1998). Nobel prize in Medicine and Physiology 1998 for the discovery of the role of nitric oxide as a signaling molecule. Pub Med, 142(52), 2828-2830. Retrieved from internet: http://www.ncbi.nlm.nih.gov/pubmed/10065255. Geraskov, E. (1994). The internal contradiction and the unconscious sources of activity. Journal of Psychology: Interdisciplinary and Applied, 128(6), 625-634. Gerber, R. (1988). Vibrational medicine: New choices for healing ourselves. Santa Fe, NM: Bear & Company. Giorgi, A. (1997). The theory, practice, and evaluation of the phenomenological method as a qualitative research procedure. Journal of Phenomenological Psychology, 28(2), 235-260.
  • 106. Glaser, J., Brind, J., Vogelman, J., Eisner, M., Dillbeck, M., Wallace, R., Chopra, D., & Orentreich, N. (1992). Elevated serum dehydroepiandrosterone sulfate levels in practitioners of the transcendental meditation (TM) and TM-Sidhi programs. J Behav Med, 15, 327–341. Gold I. (1999). Does 40-Hz oscillation play a role in visual consciousness? Conscious Cogn, 8, 186–95. Goleman, D. (1988). The Meditative Mind. Los Angeles, CA: Jeremy Tarcher. Goodman, F. (1990). Where the Spirits ride the wind: Trance journeys and other Ecstatic experiences. (A Midland Book Ed.). Bloomington, IN: Indiana University Press. Goodman, F., & Nauwald, N. (2003). Ecstatic trance: New ritual body postures. (Workbook Ed.). Havelte, Netherlands: Binkey Kok.
  • 107. Gopher, D. (1993). The skill of attentional control: Acquisition and execution of attentional strategies. In S. Kornblum & D. E. Meyer (Eds.). Attention and performance, XIV: Synergies in experimental psychology, artificial intelligence and cognitive neuroscience. Cambridge, MA: MIT Press. Gore, B. (1995). Ecstatic body postures: An alternate reality workbook. (Workbook Ed.). Rochester, VT: Bear and Company. Grof, S., & Grof, C. (2010). Holotropic breathwork: A new approach to self-exploration and therapy. (SUNY Series in Transpersonal and Humanistic Psychology). Albany, NY: State University of New York Press. Gruzelier, J., & Egner, T. (2005). Critical validation studies of neurofeedback. Child Adolesc Psychiatric Clinics N Am, 14(1), 83-104.
  • 108. Gruzelier, J., Egner, T., & Vernon, C. (2006). Validating the efficacy of neurofeedback for optimizing performance. Progress in Brain Research, 159, 421-431. Guastella, A., Mitchell, P., & Dads, M. (2008). Oxytocin increases gaze to the eye region of human faces. Biological Psychiatry, 305, 3-5. Guoyao, W., & Meininger, C. (2000). Arginine nutrition and cardiovascular function. J Nutr, 130, 2626-2629. Guoyao, W., & Morris, S. (1998). Arginine metabolism: Nitric oxide and beyond. Biochem J, 336, 1-17. Haig, A., De Pascalis V., & Gordon, E. (1999): Peak gamma latency correlated with reaction time in conventional oddball paradigm. Clinical Neurophysiology, 110 (1), 158-165.
  • 109. Halpern, S., & Savary, L. (1985). Sound health: The music and sounds that make us whole. (1st ed.). New York, NY: Harpercollins. Hammond, C. (2000). Clinical corner: The role of 40 hertz activity and training. Journal of Neurotherapy, 4(2), 95-100. Hanajima, R., Terao, Y., Hamada, M., Okabe, S., Nakatani- Enomoto, S., Furubayashi, T., Yugeta, A., Inomata-Terada, S., & Ugawa, Y. (2009). Forty-hertz triple-pulse stimulation induces motor cortical facilitation in humans. Brain Research, 1296, 15-23. Halpern, S., & Savary, L. (1985). Sound health: The music and sounds that make us whole. (1st ed.). New York, NY: Harpercollins. Hammond, C. (2000). Clinical corner: The role of 40 hertz activity and training. Journal of Neurotherapy, 4(2), 95-100.
  • 110. Hanajima, R., Terao, Y., Hamada, M., Okabe, S., Nakatani- Enomoto, S., Furubayashi, T., Yugeta, A., Inomata-Terada, S., & Ugawa, Y. (2009). Forty-hertz triple-pulse stimulation induces motor cortical facilitation in humans. Brain Research, 1296, 15-23. Hedaya, R. (2011). Laughing gas (nitrous oxide) is no laughing matter. Health Matters Blog. Retrieved from http://www.wholepsych.com/blog/?tag=/nitrous+oxide. Hays, J. (1998). How the brain talks to itself: A clinical primer of psychotherapeutic neuroscience. New York, NY: The Haworth Press. Hilgard, E. (1986). Divided consciousness: Multiple controls in human thought and action. (Expanded ed.). New York, NY: Wiley.
  • 111. Hinterberger, T., Zlabinger, M., & Blaser, K. (2014). Neurophysiological correlates of various mental perspectives. Frontiers in Human Neuroscience, 8(637), 100-115. Hirst, W. (1986). The psychology of attention. In J. E. LeDoux & W. Hirst. (Eds.). Mind and brain: Dialogues in cognitive neuroscience. Cambridge, UK: Cambridge University Press. Hutchison, M. (1996). Megabrain: New tools and techniques for brain growth and mind expansion. New York, NY: Ballantine Books. Indian fire-walk. (1935). Lancet, 229, 750. Iwanaga, M., & Tsukamoto, M. (1997). Effects of excitative and sedative music on subjective and physiological relaxation. Perception Motor Skills, 85(1), 287-296.
  • 112. Jacobs, T., Epel, E., Lin, J., Blackburn, E., Wolkowitz, O, Bridwell, D., Zanesco, A., Aichele, S., Sahdra, B., MacLean, K., King, B., Shaver, P., Rosenberg ,E., Ferrer, E., Wallace, B., & Saron, C. (2011). Intensive meditation training, immune cell telomerase activity and psychological mediators. Psychoneuroendocrinology, 36, 664–81. Kal, J., Van Wezel, H., Porsius, M., Vergroesen, I., & Spaan, J. (2000). Metabolic coronary-flow regulation and exogenous nitric oxide in human coronary disease: Assessment by intravenous administration of nitroglycerin. J Cardiovascular Pharm, 35(1), 7-15. Kemper, K., Mo, X.,, & Khayat, R. (2015). Are mindfulness and self compassion associated with sleep and resilience in health professionals? Journal of Alternative and Complementary Medicine. Retrieved from Internet: http://online.liebertpub.com/doi/pdfplus/10.1089/acm.2014.02 81
  • 113. Kim, J., Koo, J., Lee, H., & Han, J. (2005). Amygdalar inactivation blocks stress-induced impairments in hippocampal long term potentiation and spatial memory. J Neurosci, 25, 1532-1539. Kobasa, S., Maddi, S., & Puccetti, M. (1982). Personality and exercise as buffers in the stress-illness relationship. Journal of Behavioral Medicine, 5, 391-404. Kobasa, S., Maddi, S., Puccetti, M., & Zola, M. (1985). Effectiveness of hardiness, exercise, and social support as resources against illness. J of Psychosomatic Research, 29, 525-533. Kosfeld, M., Heinrichs, M., Zak, P., Fischbacher, & Fehr, E. (2005). Oxytocin increases trust in humans. Nature, 435, 673- 676. Kossak, M. (2007). Attunement: Embodied transcendent experience explored through sound and rhythmic improvisation. (Doctoral dissertation). ProQuest UMI Dissertation Publishing. Retrieved from internet: http://pqdtopen.proquest.com/doc/304833022.html?FMT=AI Kraus, N., & Nicol, T. (2005). Brainstem origins for cortical ‘what’ and ‘where’ pathways in the auditory system. Trends Neurosci, 28(4), 176–181.
  • 114. Kraus, N., Strait, D., & Parbery-Clark, A. (2012). Cognitive factors shape brain networks for auditory skills: Spotlight on auditory working memory. Annals of the NY Academy of Science, 1252, 100-107. Lawlis, G. (1996). Transpersonal medicine: The new approach to healing body-mind-spirit. Boston, MA: Shambhala. Lawlis, G., Selby, D., Hinnant, G., & McCoy, C. (1985). Reduction of postoperative pain parameters by presurgical relaxation instruction for spinal pain patients. Spine, 10, 163-171. Lazar, S., Bush, G., Gollub, R., Fricchione, G., Khalsa, G., Benson, H. (2000). Functional brain mapping of the relaxation response and meditation. Neuroreport, 11(7), 1581-1585. Lazar, S., Kerr, C., Wasserman, R., Gray, J., et al. (2005). Meditation experience is associated with increased cortical thickness. Neuroreport, 16, 1893–7.
  • 115. Lebois, L., Papies, E., Gopinath, K., Cabanban, R., Quigley, K., Krishnamurthy, V., Barrett, L., & Barsalou, L. (2015). A Shift in Perspective: Decentering through Mindful Attention to Imagined Stressful Events. Neuropsychologia, Emory University and Harvard Medical School. Retrieved from Internet: http://psychology.emory.edu/cognition/barsalou/papers/Lebois _et_al-Neuropsychologia_in_press-decentering_stress.pdf Leiderman, P. (1964). Imagery and sensory deprivation. Proceedings of the Third World Congress in Psychiatry, 227- 231. LeShan, L. (1977). You can fight for your life: Emotional factors in the causation of cancer. NY: Jove Publications, Inc. Levine, P., et al. (1977). EEG coherence during the Transcendental Meditation program. Vol. I. (p. 187-207). Livingston Manor, NY: Maharishi European Research University Press.
  • 116. Li, Y., Field, M., & Raisman, G. (2005). Olfactory ensheathing cells and olfactory nerve fibroblasts maintain continuous open channels for regrowth of olfactory nerve fibers. Glia, 52(3), 245-251. Li, Q., Li, P., Garcia, G., Johnson, R., & Feng, L. (2005). Genomic profiling of neutophil transcripts in Asian Qigong practitioners: A pilot study in gene regulation by mind-body interaction. J Altern Complement Med, 11, 29-39. Lilly, J. (1977). The deep self: Profound relaxation and the tank isolation technique. New York, NY: Simon and Schuster. Lipton, B. (2005). The biology of belief: Unleashing the power of consciousness, matter and miracles. Santa Rosa, CA: Mountain of Love/Elite Books.
  • 117. Liu, D., Fernandez, B., Lang, N., et al. (2013). UVA lowers blood pressure and vasodialates the systemic arterial vasculature by mobilisation of cutaneous nitric oxide stores. Journal of Investigative Dermatology, 133( S212), 1247. Llinas, R., Ribary, U., Contreras, D., & Pedroarena, C. (1998). The neuronal basis for consciousness. Philosophical Society of the Royal Society of London B, 353, 1841-1849. Loehr, J., & Schwartz, T. (2003). The power of full engagement: Managing energy, not time, is the key to higher performance and personal renewal. New York, NY: Free Press. Long, R., Jones, R., Talbot, J., Mayers, I., Barrie, J., Hoskinson, M., & Light, B. (2005). Inhaled nitric oxide treatment of patients with pulmonary tuberculosis evidenced by positive sputum smears. Antimicrob Agents Chemother, 49(3), 1209- 1212.
  • 118. Long, R., Light, B., & Talbot, J. (1999). Mycobacteriocidal action of exogenous nitric oxide. Antimicrob Agents Chemother, 43(2), 403-404. Lowson, S. (2003). Nitric oxide signaling and clinical alternatives to nitric oxide. Semin Cardiothorac Vasc Anesth, 7, 239-252. Ludwig, A. (1966). The formal character of therapeutic insight. American Journal of Psychotherapy, 20, 305-318. Ludwig, K. (2007). The epistemology of thought experiment: First person versus third person approaches. Midwest Studies in Philosophy, XXXI, 128-159. Lutz, A., Lachaux, J., Martinerie, J., & Varela, F. (2002). Guiding the study of brain dynamics using first person data: Synchrony patterns correlate with on-going conscious states during a simple visual task. Proceedings of the National Academy of Sciences of the USA, 99, 1586-1591.
  • 119. Lutz, A., Greischar, L.L., Rawlings, N., Ricard, M., & Davidson, R.J. (2004): Long-term meditators self-induce high-amplitude gamma synchrony during mental practice. Proceedings of the National Academy of Sciences, 101(46), 16369-16373. Macaluso, E., Eimer, M., Firth, C., & Driver, J. (2003). Preparatory states in cross-modal spatial attention: Spatial specificity and possible control mechanisms. Experimental Brain Research, 149, 62-74. MacMillan, L. (2012, Jan. 20th). Studies shed new light on how nitric oxide is produced. Research News at Vanderbilt University. Retrieved from Internet: http://news.vanderbilt.edu/2012/01/nitric-oxide-productio/. Maniscalco, M., Sofia, M., Weitzberg, E., De Laurentiis, G., Stanziola, A., Rossillo, V., Lundberg, J. (2004). Humming- induced release of nasal nitric oxide for assessment of sinus obstruction in allergic rhinitis: Pilot study. Eur J Clin Invest, 34(8), 555-560.
  • 120. Mantione, K. Cadet, P., Zhu, W., Kream, R., Sheehan, M., Fricchione, G., Goumon, Y., Esch, T., & Stefano, G. (2008). Endogenous morphine signaling via nitric oxide regulates the expression of the CYP2D6 and COMT: Autocrine/paracrine feedback inhibition. Addiction Biology, 13(1), 118-123. Marks, D. (1986). Intentionality and autonomy of verbal imagery in altered states of consciousness. Behavioral and Brain Science, 9(3), 529-530. Marsh, C. (1977). A framework for describing subjective states of consciousness. In N. E. Zinberg. (Ed.). Alternate states of consciousness (p. 124-144). New York, NY: MacMillan. Martin, J. (2014). Clusters of Individual Experiences form a Continuum of Persistent Non-Symbolic Experiences in Adults. Center for the Study of Non-Symbolic Consciousness. (Abstract, p. 1-37). Retrieved from Internet: www.Non- Symbolic.org; www.DrJefferyMartin.com.
  • 121. Martin, R. (2001). Humor, laughter, and physical health: Methodological issues and research findings. Psychol Bull, 127, 504–519. Maslow, A. (1971). The farther reaches of human nature. New York, NY: Viking. Mata-Greenwood, E., & Chen, D. (2008). Racial differences in nitric oxide-dependent vasorelaxation. Reproductive Sciences, 15(1), 9-25. Mattingley, J., Driver, J., Beschin, N., Robertson, I. (1997). Attentional competition between modalities: Extinction between touch and vision after right hemisphere damage. Neuropsychologia, 35, 867-880. McCelland, D., Ross, G., Patel, V. (1985). The effect of an academic examination on salivary norepinephrine and immunoglobulin levels. Journal of Human Stress, 11(2), 52-59.
  • 122. McEwen, B. (1998a). Protective and damaging effects of stress mediators. N Engl J Med, 338, 171-179. McEwen, B. (1998b). Stress, adaptation, and disease: Allostasis and allostatic load. Annals of the New York Academy of Sciences, 840, 33-44. McEwen, B. (2000). The neurobiology of stress: From serendipity to clinical relevance. Brain Research, 866, 172-189. McEwen, B. (2002). Sex, stress, and the hippocampus: Allostasis, allostatic load, and the aging process. Neurobiology of Aging, 23, 921-939. McEwen, B. (2007). Physiology and neurobiology of stress and adaption: Central role of the brain. Physiol Rev, 87, 873-904. Retrieved from http://physrev.physiology.org/cgi/content/full/87/3/873#BIBL.
  • 123. McGaugh J. (2004). The amygdala modulates the consolidation of memories of emotionally arousing experiences. Ann Rev Neurosci, 27, 1–28. McKinney, C., Antoni, M., Kumar, M., Tims, F., & McCabe, P. (1997). Effects of guided imagery and music (GIM) therapy on mood and cortisol in healthy adults. Health Psychology, 16(4), 390-400. McKinney, C., Tims, F., Kumar, A, & Kumar, M. (1997). The effect of selected classical music and spontaneous imagery on plasma beta-endorphin. J of Behav Med, 29(1), 85-99. McLean, J., Shipley, M., Nickell, W., Aston-Jones, G., & Reyher, C. (1989). Chemoanatomical organization of the noradrenergic input from locus coeruleus to the olfactory bulb of the adult rat. J Comp Neurol, 285, 339-349. Michelon, P. (2008). Brain plasticity: How learning changes your brain. Retrieved from http://www.sharpbrains.com.
  • 124. Miltner, W. H. R., Braun, C., Arnold, M., Witte, H., & Taub, E. (1999). Coherence of gamma-band EEG activity as a basis for associative learning. Nature, 397, 434-436. Momen, M. (1984). The psychology of mysticism and its relationship to the Baha’i Faith. Baha’i Studies Bulletin, 2, 4- 21. Retrieved from http://bahai- library.org/articles/mysticism.momen.html. Monroe, R. (1992). Journeys out of the body. New York, NY: Broadway Books. Montgomery, S., Sirota, A., & Buzsaki, G. (2008). Theta and gamma coordination of hippocampal networks during waking and rapid eye movement sleep. J Neurosci, 28(26), 6731- 6741.
  • 125. Morita, K., Saito, T., Ohta, M., Ohmori, T., Kawai, K., Teshima- Kondo, S., &, Rokutan, K. (2005). Expression analysis of psychological stress-associated genes in peripheral blood leukocytes. Neurosci Lett, 381, 57-62. Mullooly, V., Levin, R., & Feldman, H. (1988). Music for postoperative pain and anxiety. Journal of New York State Nurses Association, 19, 4-7. Nakao, M., Myers, P., Fricchione, G., Zuttermeister, P., Barsky, A., & Benson, H. (2001). Somatization and symptom reduction through a behavioral medicine intervention in a mind/body clinic. Behav Med, 26, 169-176. Nakazawa, D. (2015). Childhood Disrupted: How Your Biography Becomes Your Biology, and How You Can Heal. Adapted and Reprinted abstract. London, UK: Aeon Media Ltd. Retrieved from Internet: http://aeon.co/magazine/psychology/how-childhood-biography- shapes-adult-biology/
  • 126. Narin, O., Pinar, L., Erbas, D., Ozturk, V., Idiman, F. (2003). The effects of exercise and exercise-related changes in blood nitric oxide level on migraine headache. Clin Rehabil, 17, 624-630. Northrup, C. (2008). The secret pleasures of menopause. Carlsbad, CA: Hay House, Inc. Olson, K., & Kemper, K. (2014). Factors associated with well- being and confidence in providing compassionate care. Journal of Evidenced-Based Complementary & Alternative Medicine, 19(4), 292-296. Retrieved from Internet: http://self- compassion.org/wp- content/uploads/2015/03/Olson.Kemper.pdf and DOI: 10.1177/2156587214539977. Othmer, S. (2007/2003). Overview of neurofeedback mechanisms. The EEG Institute. Retrieved from Internet: http://www.eeginfo.com/research/research_text.html.
  • 127. Overgaard, M., Gallagher, S., & Ramsoy, T. (2008). An integration of first person methodologies in cognitive science. Journal of Consciousness Studies, 15(5), 100-120. Paller, K. & Sukuki, S. (2014). The source of consciousness. Trends in Cognitive Sciences, 18(8), 387-389. Retrieved from Internet: DOI: http://dx.doi.org/10.1016/j.tics.2014.05.012 Palmer, H. (Ed.). (1998). Inner knowing: Consciousness, creativity, insight, intuition. New York, NY: Penguin Putnam Inc. Peng, C., Henry, I., Mietus, J., Hausdorff, J., Khalsa, G., Benson, H., & Goldberger, A. (2004). Heart rate dynamics during three forms of meditation. Int J Cardiol, 95, 19-27. Petrozzo, R., Mohr, J., Mantione, K., & Goldstein, L. (2014). The role of endogenous morphine and nitric oxide in pain management. Practical Pain Management, 14(9), 1-3.
  • 128. Petrovic, P., Kalisch, R., Singer, T., & Dolan, R. (2008). Oxytocin attenuates evaluations of conditioned faces and amygdala activity. Journal of Neuroscience, 28, 6607-6615. Pillay, S. (2010). Life unlocked: 7 revolutionary lessons to overcome fear. New York, NY: Rodale, Inc. Pillay, S. (2011). Your brain and business: The neuroscience of great leaders. Upper Saddle River, NJ: Pearson Education, Inc. Polanyi, M. (1964). Science, faith, and society: A searching examination of the meaning and nature of scientific inquiry. Chicago, IL: University of Chicago Press. Polanyi, M. (1969). Knowing and being. M. Greene. (Ed.). Chicago, IL: University of Chicago Press. Polanyi, M. (1983). The tacit dimension. Glouster, MA: Peter Smith.
  • 129. Polanyi, M., & Prosch, H. (1977). Meaning. Chicago, IL: University of Chicago Press. Pribram, K. (1979). Holographic memory: An interview by Daniel Goleman. Psychology Today, 12(9), 72. Spreekmeester, E., & Rochford, J. (2000). Selective mu and delta, but not kappa, opiate receptor antagonists inhibit the habituation of novelty-induced hypoalgesia in the rat. Psychopharmacology (Berl), 148(1), pp. 99-105. Pryor, S., Zhu, W., Cadet, P., et al. (2005). Endogenous morphine: Opening new doors for the treatment of pain and addiction. Expert Opin Biol Ther, 5, 893-906. Purves, D., Augustine, G., et al. (Eds.). (2001). Stages of sleep. Neuroscience. (2nd ed.). Sunderland, MA: Sinauer Associates.
  • 130. Raghuraj, P., Ramakrishna, A., & Nagendra, H. (1998). Effect of two related yogic breathing techniques on heart rate variability. Indian J Physiol Pharmacol, 42(4), 467-472. Raisman, G. (1972). An experimental study of the projection of the amygdala to the accessory olfactory bulb and its relationship to the concept of a dual olfactory system. Experimental Brain Research, 14(4), 395-408. Raudenbush, B. (2012). WJU professor and students find jasmine odor leads to more restful sleep, decreased anxiety and greater mental performance. Wheeling, VA: Wheeling Jesuit University. Retrieved from Internet: http://www.wju.edu/about/adm_news_story.asp?iNewsID=539 &strBack=/about/adm_news_archive.asp. Rider, M., & Achterberg, J. (1989). Effect of music-assisted imagery on neutrophils and lymphocytes. Biofeedback Self- Regulation, 14(3), 247-257.
  • 131. Rider, M., Achterberg, J., Lawlis, G., Goven, A., Toledo, R., & Butler, J. (1990). Effects of immune systems on secretory IgA. Biofeedback and Self-Regulation, 15(4), 317-332. River, C. (1998). Role of nitric oxide and carbon monoxide in modulating the ACTH response to immune and nonimmune signals. Neuroimmunomodulation, 5(3-4), 203-213. Rosen, J. (2004). The neurobiology of conditioned and unconditioned fear: A neurobehavioral system analysis of the amygdala. Behav Cogn Neurosci Rev, 3(1), 23-41. Rubik, B. (2011). Neurofeedback-enhanced gamma brainwaves from the prefrontal cortical region of meditators and non- meditators and associated subjective experiences. The Journal of Alternative and Complementary Medicine, 17(2), 109-115. Ruby, P., & Decety, J. (2001). Effect of subjective perspective taking during simulation of action: A PET investigation of agency. Nature Neuroscience, 4(5), 546-550.
  • 132. Sabolek, H., Penley, S., Hinman, J., Bunce, J., Markus, J., Escabi, M. & Chrobak, J. (2009). Theta and gamma coherence along the septotemporal axis of the hippocampus. J Neurophysiol, 101, 1192-1200. Salamon, E., Esch, T., & Stefano, G. (2005). The role of the amygdale in mediating sexual and emotional behavior via coupled nitric oxide release. Acta Pharmacologica Sinica, 26, 389-395. Salamon, E., Esch, T., & Stefano, G. (2006). Pain and relaxation: A review. Int J Mol Med, 18(3), 465-470. Salamon, E., Kim, M., Beaulieu, J., & Stefano, G. (2003). Sound therapy induced relaxation: Down regulating stress processes and pathologies. Med Sci Monit, 9(5), RA116-RA121.
  • 133. Samuelson, M., Foret, M., Baim, M., Lerner, J., Fricchione, G., Benson, H., Dusek, J., & Yeung, A. (2010). Exploring the effectiveness of a comprehensive mind-body intervention for medical symptom relief. J Altern Complement Med, 16(2), 187- 192. Sanella, L. (1976). Kundalini: Psychosis or transcendence? San Francisco, CA: H. S. Dakin Company. Sauvé, K. (1999). Gamma-band synchronous oscillations: Recent evidence regarding their functional significance. Consciousness and Cognition, 8(2), 213-224. Schacter, D. (1976). The hypnagogic state: A critical review of the literature. Psychological Bulletin, 83, 452-481. Scheffzuk, C., Kukushka, V., Vyssotski, A., Draguhn, A., Tort, A., & Brankack, J. (2011). Selective coupling between theta phase and neocortical fast gamma oscillations during REM sleep in mice. PLoS One, 6(12), e28489.
  • 134. Schneider, J. (1984). Imagery and disease. In J. Achterberg & G. F. Lawlis. Imagery and disease (p. 144-154). Champaign, IL: IPAT. Schwartz, J. & Begley, S. (2002). The mind & the brain: Neuroplasticity and the power of mental force. New York, NY: Harper Perennial. Segerstrom, S., & Miller, G. (2004). Psychological stress and the human immune system: A meta-analytic study of 30 years of inquiry. Psychol Bull, 130, 601–30. Seidler, M., Uckert, S., Waldkirch E, Stief, C., Oelke, M., Tsikas, D., Sohn, M., & Jonas, U. (2002). In vitro effects of a novel class of nitric oxide (NO) donating compounds on isolated human erectile tissue. Eur Urol, 42(5), 523-528. Sela-Smith, S. (2003a). Finding the still point: Chapter one. (February). Infinite Connections. Retrieved from http://www.infiniteconnections.us/finding-the-still-point- chapter-one-february-2003#more-233.
  • 135. Seligman, M. (1998). Learned optimism: How to change your mind and your life. New York, NY: Pocket Books. Selye, H. (1946). The general adaptation syndrome and diseases of adaptation. Journal of Clinical Endocrinology, 6, 111-230. Selye, H. (1974). Stress without distress. (1st ed.). Baltimore, MD: Lippincott Williams and Wilkens. Shapiro, D. (1977). A biofeedback strategy of consciousness. In N. E. Zinberg. (Ed.). Alternate states of consciousness (p. 145- 157). New York, NY: Macmillan. Shiffrin, R. (1988). Attention. In R. C. Atkinson, G. Lindzey, & R. D. Lee. (Eds.). Stevens handbook of experimental psychology: Learning and cognition. (2nd ed.). (p. 738-811). New York, NY: John Wiley & Sons, Inc.
  • 136. Shinde, U., Mehta, A., & Goyal, R. (2000). Nitric oxide: A molecule of the millennium. Indian J Exp Biol, 38(3), 201-210. Siebert, A. (2005). The resiliency advantage: Master change, thrive under pressure, and bounce back from setbacks. San Francisco, CA: Berrett-Koehler. Simpkiss, J., & Devine, D. (2002). Responses of the HPA axis after chronic variable stress: Effects of novel and familiar stressors. Neuroendocrinology Letters, 24(1-2), 97-103. Simon, R., & Engstrom, M. (2015). The default mode network as a biomarker for monitoring the therapeutic effects of meditation. Frontiers in Psychology, June 9, Perspective Article. Retrieved from Internet: http://journal.frontiersin.org/article/10.3389/fpsyg.2015.0077 6/full and http://dx.doi.org/10.3389/fpsyg.2015.00776
  • 137. Simpson, J., & Rholes, W. (1994). Stress and secure base relationships in adulthood. In K. Bartholomew, & D. Perlman. (Eds.). Advances in personal relationships: Attachment processes in adulthood (p. 181-204). London, UK: Kingsley. Singh, L., Lancioni, G., Karazsia, B., et al. (2015). Effects of Samantha meditation on active academic engagement and math performance of students with attention deficit/hyperactivity disorder. Mindfulness. Retrieved from Internet: http://link.springer.com/article/10.1007/s12671- 015-0424-5#page-1 and DOI: 10.1007/s12671-015-0424-5. Slobada, J. (1999). The musical mind: The cognitive psychology of music. Oxford, UK: Oxford University Press. Spanos, N., Cross, W., Lepage, M, & Coristine, M. (1986). Glossolalia as learned behavior: An experimental demonstration. Journal of Abnormal Psychology, 95, 21-23.
  • 138. Spiro, S. (2012). Nitrous oxide production and consumption: Regulation of gene expression by gas-sensitive transcription factors. Phil Trans R Soc B, 367(1593), 1212-1225. Srednicki, M. (2007). Quantum field theory. Cambridge, UK: Cambridge University Press. Stanford Cognition Textbook. (2006). Chapter 3: Attention. Palo Alto, CA: Stanford University. Retrieved from Internet: http://www- psych.stanford.edu/~ashas/Cognition%20Textbook/chapter3.p df Stanford University. (2011). Quantum approaches to consciousness. Stanford Encyclopedia of Philosophy. Retrieved from Internet: http://www.plato.stanford.edu/entries/qt- consciousness. Steelman, V. (1990). Interoperative music therapy effects on anxiety, blood pressure. AORN Journal, 52, 1026-1034.
  • 139. Stefano, G. (2003). Biomedical significance of nitric oxide. New York, NY: Medical Science International. Stefano, G., Benson, H., Frichionne, G., & Esch, T. (2005). The stress response: Always good and when it is bad. New York, NY: Medical Science International. Stefano, G., & Magazine, H. (2001). Nitric oxide autoregulation and its significance. Modern Aspects of Immunobiology, 1, 182- 186. Stefano, G., Salzet, M., & Magazine, H. (2003). Cyclic nitric oxide release by human granulocytes, and invertebrate ganglia and immunocytes: Nano-technological enhancement of amperometric nitric oxide determination. Med Sci Monit, 8(6), BR199-204. PMID: 12070423. Retrieved from Internet: http://www.biosonics.com/uploads2011/CyclicNitricOxide.pdf
  • 140. Stein, M., Schiavi, R., Camerino, M. (1976). Influence of brain and behavior on the immune system. Science, 191, 435-440. Steiner, R. (2009). How to know higher worlds. Radford, VA: Wilder Publications. Sterling, P., & Eyer, J. (1988). Allostasis: A new paradigm to explain arousal pathology. In S. Fisher, & J. Reason. (Eds.). Handbook of Life Stress, Cognition and Health (p. 629-649). New York, NY: Wiley. Stoff, J. (1992). Chronic fatigue syndrome: The hidden epidemic. (2nd revised ed.) New York, NY: Harper Perennial. Stone, A., Cox, D., Valdimarsdottir, H., Jandorf, L., & Neale, J. (1987). Evidence the secretory IgA antibody is associated with daily mood. Journal of Personality and Social Psychology, 52, 988-993.
  • 141. Styles, E. (2005). Attention perception and memory: An integrated introduction. London, UK: Routledge. Styles, E. (2006). The psychology of attention. (2nd ed.). Hove, UK: Psychology Press. Sui-Kok, C. (1991). Pranic healing. York Beach, ME: Samuel Weiser, Inc. Surani, M. (2001). Reprogramming of genome function through epigenetic inheritance. Nature, 414, 122-123. Taddei, S., Virdis, A., Ghiadoni, L., Salvetti, G., Bernini, G., Magagna, A., & Salvetti, A. Age-related reduction of NO availability and oxidative stress in humans. Hypertension, 38(2), 274-279. Tan, C., & Bullock, D. (2008). A dopamine-acetylcholine cascade: Simulating learned and lesion-induced behavior of striatal cholinergic interneurons. J Neurophysiol, 100(4), 2409-2421.
  • 142. Taren, A., Gianaros, P., Greco, C., et al. (2015). Mindfulness Meditation Training Alters Stress-Related Amygdala Resting State Functional Connectivity: A Randomized Controlled Trial. Social and Cognitive Affective Neuroscience, Advance Access. Retrieved from Internet: http://scan.oxfordjournals.org/content/early/2015/06/05/scan. nsv066.abstract and DOI: 10.1093/scan/nsv066 Taub, M., Murad, F., & Oliphant, D. (2006). The wellness solution. Cleveland, OH: World Almanac Library. Taylor, J. (2008). My stroke of insight: A brain scientist’s personal journey. New York, NY: Viking. Taylor, S., Klien, C., Lewis, B., Gruenewald, T., Gurung, R., & Updegraff, J. (2000). Biobehavioral responses to stress in females: Tend-and-befriend, not fight-or-flight. Psychological Review, 107, 411-429.
  • 143. Tedeschi, R., & Calhoun, L. (1995). Trauma and transformation: Growing in the aftermath of suffering. Thousand Oaks, CA: Sage. Tedeschi, R., Park, C., & Calhoun, L. (Eds.). (1998). Posttraumatic growth: Positive changes in the aftermath of crisis. Mahwah, NJ: Erlbaum. Tegmark, M. (2015). Consciousness as a state of matter. Quantum Physics, Vol 3, Cornell University Library. Retrieved from Internet: arxiv.org/pdf/1401.1219v3.pdf Tervaniemi, M., IIvonen, T. Karma, K., Albo, K, & Naatanen, R. (1997). The musical brain: Brain waves reveal the neurophysiological basis of musicality in human subjects. Neuroscience Letter, 226(1), 1-4. Thomas, E. (1934). The fire walk. Proceedings of the Society for Psychological Research, 42, 292-309.
  • 144. Tomasian, D., Keaney, J., & Vita, J. (2000). Antioxidants and the bioactivity of endothelium-derived nitric oxide. Cardiovasc Res, 47(3), 426-435. Tseng, L., Mazella, J., Goligorsky, M., Riaias, C., & Stefano, G. (2000). Dopamine and morphine stimulate nitric oxide release in human endometrial glandular epithelial cells. J of the Society for Gynecologic Investigation, 7, 343-347. Van Diest, I., Proot, P., Van De Woestijne, K., Han, J., Devriese, S., Winters, W., Van, D., & Bergh, O. (2001). Critical conditions for hyperventilation responses: The role of autonomic response propositions during emotional imagery. Behav Modif, 25(4), 621-639. Van Pragg, H., Shubert, T., Zhao, C., & Gage, F. (2005). Exercise enhances learning and hippocampal neurogenesis in aged mice. J Neurosci, 25, 8680-8685.
  • 145. van der Zwan, J., de Vente, W., Huizink, A., Bögels, S., & de Bruin, E. (2015). Physical Activity, Mindfulness Meditation, or Heart Rate Variability Biofeedback for Stress Reduction: A Randomized Controlled Trial. Appl Psychophysiol Biofeedback. Jun 26. [Epub ahead of print]. Retrieved from Internet: http://www.ncbi.nlm.nih.gov/pubmed/26111942 VanderArk, S., & Ely, D. (1992). Biochemical and galvanic skin responses to music stimuli by college students in biology and music. Perceptual Motor Skills, 74, 1079-1090. VanDyche, D. (2015). Speaking in tongues (Glossolalia): A theory of hemispheric proportion. Kindle Edition. Seattle, WA: VanDyche Publishing. Varela, F. (1996). Neurophenomenology. Journal of Consciousness Studies, 3(4), 330-348.
  • 146. Varela, F., & Shear, J. (1999). First-person methodologies: What, why, how? Retrieved from Internet: http://www.imprint.co.uk/pdf/VFW_introduc.pdf. Villoldo, A., & Krippner, S. (1987). Healing states: A journey into the world of spiritual healing and Shamanism. New York, NY: Touchstone. Wade, J. (1996). Changes of mind: A holonomic theory of the evolution of consciousness. Albany, NY: State University of New York Press. Walston, R. (2003). The speaking in tongues controversy: The initial, physical evidence of the Baptism in the Holy Spirit debate. Maitland, FL: Xulon Press.
  • 147. Watkins, L., & Mayer, D. (1986). Multiple endogenous opiate and nonopiate analgesia systems: Evidence of their existence and clinical implications. In D. Kelly. (Ed.). Stress-induced analgesia (p. 273-299). New York, NY: New York Academy of Sciences. Weiser-Cornell, A. (1996). The power of focusing: A practical guide to emotional self-healing. Oakland, CA: New Harbinger Publications, Inc. Weitzberg, E., & Lundberg, J. (2002). Humming greatly increases nasal nitric oxide. Am J Respir Crit Care Med, 166, 144-145. Wilber, K. (2002). The spectrum of consciousness. Boston, MA: Shambhala Press. Wilber, K. (2004). The simple feeling of being: Embracing your true nature. Boston, MA: Shambhala Press.
  • 148. Willet, W. (2002). Balancing life-style and genomics research for disease prevention. Science, 296, 695-698. Wilson, D., & Yan, X. (2010). Sleep-like states modulate functional connectivity in the rat olfactory system. J. Neurophysiol, 104(6), 3231-3239. Wilson, M. (2002). Six views of embodied cognition. Psychonomic Bulletin Review, 9, 625-636. Wollin, S., & Jones, P. (2003). Alpha-lipoic acid and cardiovascular disease. J Nutr, 133(11), 3327-3330. Women’s Health Encyclopedia. (2012, Nov.12). Best foods containing nitric oxide. Women’s Health Topics. Retrieved from Internet: http://womenshealthency.com/articles/best-foods- containing-nitric-oxide/ Wright, P. (1994). A psychobiological approach to shamanic altered states of consciousness. ReVision, 16(4), 164-172.
  • 149. Wright, R. (2007). Stress related health disparities in African American communities: Can Open Focus provide a modicum of ameliorative stress relief? (Unpublished Master’s Thesis). Montpelier, VT: Union Institute & University. Wright, R. (2012). The role of endogenous cyclic nitric oxide spiking in Motherloss and Existential grief recovery: A modified neuropsychological and psychophysiological Heuristic Self Search Inquiry approach to stress reduction, homeostasis and healing. (Doctoral Dissertation). Retrieved from ProQuest: http://gradworks.umi.com/35/39/3539752.html Wright, R. (2013). Orgasmic relaxation: Unleash the power of your mind to relax using the Tension Relieving Technique (TRT). Sunrise, FL: Quiet Lake International, LLC. Wright, R. (2014). 7 steps for avoiding stress burnout for busy entrepreneurs. Sunrise, FL: Quiet Lake International, LLC.
  • 150. Wynn-Williams, G. (1992). The fullness of space. Cambridge, UK: Cambridge University Press. Young, L., Chen, Q., & Weis, M. (2011). Direct measurement of hydrogen peroxide (H2O2) or nitric oxide (NO) release: A powerful tool to assess real-time free radical production in biological models. American Journal of Biomedical Sciences, 3(1), 40-48. Zicker, J., Zicker, D., Jatzko, A., Dietzsch, J., & Nieselt, K., Schmitt, A., Bertsch, T., Fassbender, K., Spanagel, R., Northoff, H., & Gebicke-Haerter, P. (2007). Differentiated gene expression in peripheral blood of patients suffering from post- traumatic stress disorder. Mol Psychiatry, 12, 116-118. Zusne, L., & Jones, W. (1989). Anomalistic psychology: A study of magical thinking. (2nd ed.). Hillsdale, NJ: Lawrence Erlbaum Associates.
  • 151. Nitric Oxide Spiking and Consciousness A Presentation by Robert Wright, Jr., Ph.D, COFT Consciousness Society Conference Yale University New Haven, CT June 5, 2015
  • 152. Although nitric oxide (NO) has been researched intensively by the scientific community, a little known aspect is that NO spiking underlies shifts in Consciousness. Since ancient times, men and women have sought to achieve what we refer to as altered states of consciousness (ASC) to access, explore, and experience multiple realms of awareness and statebound knowledge including Stillpoints, self and other compassion, as well as states of illumination, transcendence, “Oneness” or “Unity.”
  • 153. A little studied feature of nitric oxide spiking is that it occurs co-terminously with whole brain synchronous states and whenever a Relaxation Response is generated. Although typically measured quantitatively, NO can also be experienced qualitatively, as bodily feltsense phenomena. The Biosonic Otto 128 Hertz kinesthetic tuning fork has demonstrated its ability to consistently spike nitric oxide, subsequently creating a Relaxation Response and corresponding potentials for Whole Brain Synchrony.
  • 154. In this presentation, Dr. Wright will share his views on how tuning forks and other qualitative methods work to directly and indirectly spike NO for healthy well being. Learn how you can become more qualitatively aware of ASC shifts in your own Consciousness and flexibly modify your attentional focus via tuning into your bodily feltsense by achieving a consistently beneficial elevated Relaxation Response that also dissolves stress, anxiety and chronic pain.
  • 155. Robert Wright, Jr., Ph.D., COFT
  • 156. www.StressFreeNow.info Robert Wright, Jr., Ph.D., COFT is an author, speaker, and Stress Management Wellness Coach. His passionate goal is translating the significance and implications of scholarly stress and nitric oxide spiking research into language and practical techniques which can improve the healthy well- being of the general public. Dr. Wright's most recent book is entitled 7 Tips for Avoiding Stress burnout for Busy Entrepreneurs and he is the author of the forthcoming book Nitric Oxide Spiking: Your Key to Well Being. You can learn more about how to reduce your stress by listening to his popular podcast series at www.StressFreeNow.info/category/podcasts/